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CAGEE

Software for Computational Analysis of Gene Expression Evolution

CAGEE analyzes changes in global or sample- or clade-specific gene expression taking into account phylogenetic history, and provides a statistical foundation for evolutionary inferences. The program (v1.0) uses Brownian motion to model gene expression changes across a user-specified phylogenetic tree. The reconstructed distribution of counts and their inferred evolutionary rate $\sigma^2$ generated under this model provides a basis for assessing the significance of the observed differences among taxa.

Project Status: Active – The project has reached a stable, usable state and is being actively developed.

Installation

conda create -n cagee -c bioconda cagee

If you would like to build from source code, download the latest release from the release page, and see the manual for details. CAGEE depends on CMake, Boost, and Eigen for building.

There is also a Docker container available.

Usage

See the manual for quick start and detailed usage instructions.