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Cell line expression and mutations

Josip edited this page Apr 30, 2021 · 11 revisions

Processing expressions from Cosmic:

  • CSV files containing expressions for cell lines should be saved in ./genes/expressions/ under name <cell_line_name>.csv. They should be manually downloaded from Cosmic database-a.
  • files with filtered z-scores for every cell line are saved in ./genes/expressions/ under name expression_score_<cell_line>.csv

python calculate_gene_expression_cell_line.py -g ./genes/uniprot_entries_null.txt -c MDA-MB-231

Getting mutations from Cosmic and processing them:

python get_gene_mutation_cell_line.py -g ./genes/uniprot_entries_null.txt -c MDA-MB-231

python generateMutatedFASTAseqCellLine.py -g ./genes/uniprot_entries_null.txt