wbphenotype-simple-non-classified.obo

format-version: 1.2
data-version: wbphenotype/releases/2024-09-26/wbphenotype-simple-non-classified.owl
saved-by: chris-grove
subsetdef: phenotype_slim_wb "WB phenotype slim"
default-namespace: C_elegans_phenotype_ontology
idspace: dc http://purl.org/dc/elements/1.1/ 
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
idspace: terms http://purl.org/dc/terms/ 
ontology: wbphenotype/wbphenotype-simple-non-classified
property_value: dc:description "Ontology about C. elegans and other nematode phenotypes" xsd:string
property_value: dc:title "C elegans Phenotype Ontology" xsd:string
property_value: IAO:0000700 WBPhenotype:0000886
property_value: owl:versionInfo "2024-09-26" xsd:string
property_value: terms:license http://creativecommons.org/licenses/by/4.0/

[Term]
id: WBPhenotype:0000000
name: chromosome instability
def: "Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control." [WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0000001
name: body posture variant
def: "Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered." [WB:cab, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "body posture abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000002
name: kinker
def: "The animal moves or rests with uncharacteristic loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control animals." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0000003
name: obsolete flattened locomotion path
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0001309

[Term]
id: WBPhenotype:0000004
name: constitutive egg laying
def: "Eggs are laid under conditions where egg laying is normally inhibited." [WB:cab]
comment: Liquid M9.
synonym: "Egl c" BROAD []
is_a: WBPhenotype:0000005 ! hyperactive egg laying

[Term]
id: WBPhenotype:0000005
name: hyperactive egg laying
def: "Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control." [WB:cab]
is_a: WBPhenotype:0000640 ! egg laying variant

[Term]
id: WBPhenotype:0000006
name: egg laying defective
def: "Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPaper00025054]
synonym: "Egl d" BROAD []
is_a: WBPhenotype:0000640 ! egg laying variant

[Term]
id: WBPhenotype:0000007
name: bag of worms
def: "A worm carcass is formed with retained eggs that hatch inside." [WB:cab]
synonym: "Bag" BROAD []
is_a: WBPhenotype:0000862 ! bloated

[Term]
id: WBPhenotype:0000008
name: anesthetic hypersensitive
def: "Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
synonym: "anaesthetic hypersensitive" EXACT []
is_a: WBPhenotype:0000010 ! drug hypersensitive
is_a: WBPhenotype:0000627 ! anesthetic response variant

[Term]
id: WBPhenotype:0000009
name: anesthetic resistant
def: "Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
synonym: "anaesthetic resistant" EXACT []
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0000627 ! anesthetic response variant

[Term]
id: WBPhenotype:0000010
name: drug hypersensitive
def: "Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000011
name: drug resistant
def: "Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug." [WB:WBPerson557]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000012
name: dauer constitutive
def: "Formation of dauer larvae under conditions that do not favor dauer formation." [WB:kmva]
synonym: "Daf c" BROAD []
is_a: WBPhenotype:0000637 ! dauer formation variant

[Term]
id: WBPhenotype:0000013
name: dauer defective
def: "Failure to form dauer larvae under dauer-inducing conditions." [WB:kmva]
synonym: "Daf d" BROAD []
is_a: WBPhenotype:0000637 ! dauer formation variant

[Term]
id: WBPhenotype:0000014
name: cord commissures variant
def: "Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals." [WB:WBPaper00001499, WB:WBPaper00029065, WB:WBPerson712]
synonym: "cord commissures abnormal" NARROW []
is_a: WBPhenotype:0001226 ! commissure variant

[Term]
id: WBPhenotype:0000015
name: positive chemotaxis defective
def: "Variations in the movement towards typically attractive chemicals." [WB:cab]
is_a: WBPhenotype:0000635 ! positive chemotaxis variant

[Term]
id: WBPhenotype:0000016
name: aldicarb hypersensitive
def: "Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
synonym: "Hic" BROAD []
is_a: WBPhenotype:0000500 ! acetylcholinesterase inhibitor hypersensitive
is_a: WBPhenotype:0000680 ! aldicarb response variant

[Term]
id: WBPhenotype:0000017
name: aldicarb resistant
def: "Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
synonym: "Ald R" BROAD []
synonym: "Ric" BROAD []
is_a: WBPhenotype:0000680 ! aldicarb response variant
is_a: WBPhenotype:0001289 ! acetylcholinesterase inhibitor resistant

[Term]
id: WBPhenotype:0000018
name: pharyngeal pumping increased
def: "The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals." [WB:WBPerson712]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0000019
name: pharyngeal pumping reduced
def: "Pharyngeal pumping motion occurs at a slower rate than control animals." [WB:WBPaper00001709]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0000020
name: pharyngeal pumping irregular
def: "Pharyngeal pumping motion occurs at intervals that vary from control animals." [WB:WBPaper00001709]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0000021
name: squat
def: "Squat animals are dumpy as homozygotes, but roll as heterozygotes." [WB:WBPaper00000906]
synonym: "Sqt" BROAD []
is_a: WBPhenotype:0000231 ! body size variant

[Term]
id: WBPhenotype:0000022
name: long
def: "Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31]
synonym: "Lon" BROAD []
is_a: WBPhenotype:0001726 ! body length variant

[Term]
id: WBPhenotype:0000023
name: serotonin hypersensitive
def: "Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000024
name: serotonin resistant
def: "Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000025
name: blistered
def: "Fluid-filled blisters appear on the cuticle." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497]
synonym: "Bli" BROAD []
is_a: WBPhenotype:0000948 ! cuticle morphology variant

[Term]
id: WBPhenotype:0000026
name: lipid depleted
def: "Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva." [GO:0006629, WB:WBPaper00005707, WB:WBPerson712]
synonym: "fat depleted" RELATED []
synonym: "Lpd" BROAD []
is_a: WBPhenotype:0001183 ! fat content reduced

[Term]
id: WBPhenotype:0000027
name: organism metabolism processing variant
def: "Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control." [GO:0008152, WB:WBPerson2021, WB:WBPerson557]
synonym: "organism metabolism processing abnormal" NARROW []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000028
name: RNA processing variant
def: "Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control." [GO:0006396, WB:WBPerson2021]
synonym: "RNA processing abnormal" NARROW []
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0000029
name: systemic RNAi variant
def: "Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding." [WB:WBPaper00029209, WB:WBPaper00030758, WB:WBPerson712]
synonym: "Environmental RNAi defective" RELATED []
synonym: "systemic RNAi abnormal" NARROW []
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0000030
name: growth variant
def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals." [GO:0040007, WB:WBPerson2021]
synonym: "growth abnormal" NARROW []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000031
name: slow growth
def: "Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
synonym: "Gro" BROAD []
is_a: WBPhenotype:0000043 ! general pace of development variant
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0000676 ! growth rate variant

[Term]
id: WBPhenotype:0000032
name: sick
def: "Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712]
synonym: "Sck" BROAD []
is_a: WBPhenotype:0000030 ! growth variant

[Term]
id: WBPhenotype:0000033
name: developmental timing variant
alt_id: WBPhenotype:0000437
def: "The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues." [pmid:6494891, WB:cab]
comment: Possible XP GO:0040034.
subset: phenotype_slim_wb
synonym: "developmental timing abnormal" NARROW []
synonym: "heterochronic defect" EXACT []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000034
name: embryonic polarity variant
def: "Contents or structures of an embryonic cell are not restricted/localized to the same positions (or poles) compared with control animals." [WB:WBPaper00005079, WB:WBPerson2021, WB:WBPerson712]
synonym: "embryonic polarity abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000035
name: larval body morphology variant
def: "Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "larval body morphology abnormal" NARROW []
synonym: "larval morphology abnormal" RELATED []
is_a: WBPhenotype:0000072 ! body morphology variant
is_a: WBPhenotype:0000934 ! developmental morphology variant

[Term]
id: WBPhenotype:0000036
name: adult body morphology variant
def: "Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "adult body morphology abnormal" NARROW []
is_a: WBPhenotype:0000072 ! body morphology variant
is_a: WBPhenotype:0000934 ! developmental morphology variant

[Term]
id: WBPhenotype:0000037
name: egg morphology variant
def: "Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals." [WB:WBPaper00001075, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "egg morphology abnormal" NARROW []
is_a: WBPhenotype:0000934 ! developmental morphology variant

[Term]
id: WBPhenotype:0000038
name: exploded through vulva
def: "The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture." [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712]
synonym: "burst vulva" RELATED []
synonym: "gonad eversion" RELATED []
synonym: "gonad exploded through vulva" RELATED []
synonym: "Rup" BROAD []
synonym: "rupture through vulva" RELATED []
is_a: WBPhenotype:0000619 ! epithelial system development variant

[Term]
id: WBPhenotype:0000039
name: life span phenotype
def: "Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "Age" BROAD []
synonym: "life span abnormal" EXACT []
synonym: "life span variant" EXACT []
synonym: "longevity abnormal" RELATED []
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0000040
name: one cell arrest early emb
def: "Embryos fail to divide and arrest as one-cell embryos." [WB:cab, WB:cgc5599]
synonym: "catastrophic one cell arrest" RELATED [WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "Ocs" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0000041
name: osmotic integrity variant
def: "Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control." [GO:0030104, WB:WBPerson2021]
synonym: "osmoregulation variant" RELATED []
synonym: "osmotic integrity abnormal" NARROW []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000042
name: slow embryonic development
def: "The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712]
synonym: "Sle" BROAD []
is_a: WBPhenotype:0000674 ! slow development
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000043
name: general pace of development variant
def: "Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "general pace of development abnormal" NARROW []
is_a: WBPhenotype:0000033 ! developmental timing variant

[Term]
id: WBPhenotype:0000044
name: egg size defective early emb
def: "Egg is smaller or larger compared to eggs of control animals." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0002407 ! egg size variant

[Term]
id: WBPhenotype:0000045
name: developmental delay postembryonic
def: "The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control." [WB:cab, WB:WBPaper00025054]
is_a: WBPhenotype:0000049 ! postembryonic development variant
is_a: WBPhenotype:0000848 ! developmental delay

[Term]
id: WBPhenotype:0000046
name: pace of P lineage defective early emb
def: "More than five minutes between AB and P1 divisions." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
synonym: "pace of P lineage abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000047
name: gastrulation variant
def: "Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space." [WB:WBPaper00027251, WB:WBPerson2021]
synonym: "gastrulation abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000048
name: hatching variant
def: "Variations in the ability of an animal to emerge from the protective egg shell compared to control animals." [GO:0035188, WB:WBPerson2021]
synonym: "hatching abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000049
name: postembryonic development variant
def: "Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "postembryonic development abnormal" NARROW []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000050
name: embryonic lethal
def: "Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
subset: phenotype_slim_wb
synonym: "egg lethal" RELATED []
synonym: "Emb" BROAD []
synonym: "embryonic death" RELATED []
synonym: "inviable zygote" RELATED []
is_a: WBPhenotype:0000062 ! lethal
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000051
name: embryonic terminal arrest variable emb
def: "The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal." [GO:0009790, WB:WBPaper00004811, WB:WBPaper00024944, WB:WBPerson712]
synonym: "Emb" BROAD []
synonym: "Etv" BROAD []
is_a: WBPhenotype:0000063 ! terminal arrest variable
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000052
name: maternal effect lethal emb
def: "Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis." [WB:WBPaper00001109, WB:WBPerson2021]
synonym: "Emb" BROAD []
synonym: "Mel" BROAD []
is_a: WBPhenotype:0000050 ! embryonic lethal

[Term]
id: WBPhenotype:0000053
name: paralyzed arrested elongation two fold
def: "Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894]
synonym: "active elongation arrest" RELATED []
synonym: "Pat" BROAD []
synonym: "two fold arrest" RELATED []
is_a: WBPhenotype:0000050 ! embryonic lethal
is_a: WBPhenotype:0000494 ! two fold arrest

[Term]
id: WBPhenotype:0000054
name: larval lethal
def: "The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "larval death" RELATED []
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000062 ! lethal

[Term]
id: WBPhenotype:0000055
name: early larval arrest
def: "Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development." [WB:cab]
is_a: WBPhenotype:0000059 ! larval arrest

[Term]
id: WBPhenotype:0000056
name: late larval arrest
def: "Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development." [WB:cab]
is_a: WBPhenotype:0000059 ! larval arrest

[Term]
id: WBPhenotype:0000057
name: early larval lethal
def: "Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000054 ! larval lethal

[Term]
id: WBPhenotype:0000058
name: late larval lethal
def: "Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000054 ! larval lethal

[Term]
id: WBPhenotype:0000059
name: larval arrest
def: "The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
synonym: "Lva" BROAD []
is_a: WBPhenotype:0000750 ! larval development variant
is_a: WBPhenotype:0001016 ! larval growth variant

[Term]
id: WBPhenotype:0000060
name: adult lethal
def: "Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395]
subset: phenotype_slim_wb
synonym: "Adl" BROAD [WB:WBPaper00004402, WB:WBPaper00005654]
synonym: "Let" BROAD []
is_a: WBPhenotype:0000062 ! lethal

[Term]
id: WBPhenotype:0000061
name: extended life span
def: "The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712]
synonym: "Age" BROAD []
synonym: "life span increased" RELATED []
synonym: "longevity increased" RELATED []
is_a: WBPhenotype:0000039 ! life span phenotype

[Term]
id: WBPhenotype:0000062
name: lethal
def: "Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "Let" BROAD []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000063
name: terminal arrest variable
def: "Variations that cause developmental progression to cease at different stages of the lifecycle." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Var" BROAD []
is_a: WBPhenotype:0000062 ! lethal

[Term]
id: WBPhenotype:0000064
name: sexually dimorphic lethality
def: "Animals die prematurely at any stage of the life cycle in a sex dependent manner." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Let" RELATED []
is_a: WBPhenotype:0000062 ! lethal

[Term]
id: WBPhenotype:0000065
name: X0 lethal
def: "XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals." [WB:WBPerson363, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "Let" BROAD []
synonym: "male specific lethality" RELATED []
is_a: WBPhenotype:0000064 ! sexually dimorphic lethality

[Term]
id: WBPhenotype:0000066
name: XX lethal
def: "XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals." [WB:WBPerson363, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "hermaphrodite specific lethality" RELATED []
is_a: WBPhenotype:0000064 ! sexually dimorphic lethality

[Term]
id: WBPhenotype:0000067
name: organism stress response variant
def: "Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712]
synonym: "organism stress response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000068
name: cellular oxidative stress response variant
def: "Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control." [GO:0034599, WB:WBPerson2021, WB:WBPerson557]
synonym: "oxidative stress response abnormal" NARROW []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0000069
name: progeny variant
def: "Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "progeny abnormal" NARROW []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000070
name: male tail morphology variant
def: "Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan." [WB:WBPaper00027278, WB:WBPerson712]
synonym: "Mab" BROAD []
synonym: "male tail morphology abnormal" NARROW []
is_a: WBPhenotype:0000073 ! tail morphology variant
is_a: WBPhenotype:0001024 ! male morphology variant

[Term]
id: WBPhenotype:0000071
name: head morphology variant
def: "Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "head morphology abnormal" NARROW []
is_a: WBPhenotype:0000582 ! organism segment morphology variant

[Term]
id: WBPhenotype:0000072
name: body morphology variant
def: "Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "body morphology abnormal" NARROW []
is_a: WBPhenotype:0000582 ! organism segment morphology variant

[Term]
id: WBPhenotype:0000073
name: tail morphology variant
def: "Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "tail morphology abnormal" NARROW []
is_a: WBPhenotype:0000582 ! organism segment morphology variant

[Term]
id: WBPhenotype:0000074
name: genetic pathway variant
def: "Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "genetic pathway abnormal" NARROW []
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0000075
name: cuticle attachment variant
def: "Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cuticle attachment abnormal" NARROW []
is_a: WBPhenotype:0000201 ! cuticle development variant

[Term]
id: WBPhenotype:0000076
name: epithelial attachment variant
def: "Variations in the adhesion of the layer of cells that cover the external surface of an organism which serves to protect the animal from external environment compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "epithelial attachment abnormal" NARROW []
synonym: "hypodermal attachment abnormal" RELATED []
is_a: WBPhenotype:0000608 ! epithelial system physiology variant

[Term]
id: WBPhenotype:0000077
name: cuticle shedding defect
def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement." [GO:0018996]
synonym: "cuticle shedding abnormal" NARROW []
is_a: WBPhenotype:0000638 ! molt defect

[Term]
id: WBPhenotype:0000078
name: seam cells stacked
def: "The hypodermal cells, which lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells ." [WB:WBPaper00003081]
is_a: WBPhenotype:0000703 ! epithelial morphology variant

[Term]
id: WBPhenotype:0000079
name: branched adult alae
def: "The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001412 ! alae morphology variant

[Term]
id: WBPhenotype:0000080
name: no anterior pharynx
def: "Animals lack the anterior portion of the pharynx." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Aph" BROAD []
is_a: WBPhenotype:0000115 ! anterior pharynx variant
is_a: WBPhenotype:0001646 ! no pharynx

[Term]
id: WBPhenotype:0000081
name: L1 arrest
def: "The developmental program of the animals does not continue past the first larval stage (L1)." [WB:WBPaper00003179, WB:WBPerson2021]
is_a: WBPhenotype:0000055 ! early larval arrest
is_a: WBPhenotype:0000751 ! L1 larval development variant

[Term]
id: WBPhenotype:0000082
name: L2 arrest
def: "The developmental program of the animals does not continue past the second larval stage (L2)." [WB:WBPaper00003179, WB:WBPerson2021]
is_a: WBPhenotype:0000055 ! early larval arrest
is_a: WBPhenotype:0000752 ! L2 larval development variant
is_a: WBPhenotype:0001019 ! mid larval arrest

[Term]
id: WBPhenotype:0000083
name: L3 arrest
def: "The developmental program of the animals does not continue past the third larval stage (L3)." [WB:WBPaper00004813, WB:WBPerson2021]
is_a: WBPhenotype:0000056 ! late larval arrest
is_a: WBPhenotype:0000753 ! L3 larval development variant
is_a: WBPhenotype:0001019 ! mid larval arrest

[Term]
id: WBPhenotype:0000084
name: L4 arrest
def: "The developmental program of the animals does not continue past the fourth larval stage (L4)." [WB:WBPaper00003179, WB:WBPerson2021]
is_a: WBPhenotype:0000056 ! late larval arrest
is_a: WBPhenotype:0000754 ! L4 larval development variant

[Term]
id: WBPhenotype:0000085
name: swollen intestinal lumen
def: "The intestinal lumen is expanded and can often be shown to be filled with bacteria. This swelling is distinct from distension of the entire intestine (intestinal edema)." [WB:WBPaper00026641, WB:WBPerson712]
is_a: WBPhenotype:0000710 ! intestinal morphology variant

[Term]
id: WBPhenotype:0000086
name: shrunken intestine
def: "Intestine is shrunken and may appear constricted." [WB:WBPaper00005941]
is_a: WBPhenotype:0000710 ! intestinal morphology variant

[Term]
id: WBPhenotype:0000087
name: body wall cell development variant
def: "Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "body wall cell development abnormal" NARROW []
synonym: "body wall muscle cell development abnormal" RELATED []
is_a: WBPhenotype:0000815 ! muscle cell development variant

[Term]
id: WBPhenotype:0000088
name: body muscle displaced
def: "The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body wall muscle displaced" RELATED []
is_a: WBPhenotype:0000861 ! body wall muscle development variant

[Term]
id: WBPhenotype:0000089
name: alpha amanitin resistant
def: "Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000090
name: epidermis cuticle detached
def: "Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hypodermis detached from cuticle" RELATED []
is_a: WBPhenotype:0000075 ! cuticle attachment variant
is_a: WBPhenotype:0000076 ! epithelial attachment variant

[Term]
id: WBPhenotype:0000091
name: epidermis muscle detached
def: "The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hypodermis detached from muscle" RELATED []
is_a: WBPhenotype:0000076 ! epithelial attachment variant
is_a: WBPhenotype:0000474 ! muscle attachment variant

[Term]
id: WBPhenotype:0000092
name: intestinal cell proliferation variant
def: "Any variation in the processes that govern the expansion of intestinal cell populations compared to control." [WB:WBPerson2021]
synonym: "intestinal cell proliferation abnormal" NARROW []
is_a: WBPhenotype:0000705 ! intestinal cell development variant

[Term]
id: WBPhenotype:0000093
name: lineage variant
def: "The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "Lin" BROAD []
synonym: "lineage abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000094
name: anus development variant
def: "Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "anus development abnormal" NARROW []
is_a: WBPhenotype:0000617 ! alimentary system development variant

[Term]
id: WBPhenotype:0000095
name: M lineage variant
def: "The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals.  In C. elegans the M lineage is a postembryonic mesodermal lineage." [WB:WBPerson2021]
synonym: "M lineage abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000096
name: cloacal development variant
def: "Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cloacal development abnormal" NARROW []
is_a: WBPhenotype:0000617 ! alimentary system development variant

[Term]
id: WBPhenotype:0000097
name: AB lineage variant
def: "The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPaper00001584, WB:WBPerson2021]
synonym: "AB lineage abnormal" NARROW []
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000098
name: pharyngeal intestinal valve development variant
def: "Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pharyngeal intestinal valve development abnormal" NARROW []
is_a: WBPhenotype:0000617 ! alimentary system development variant

[Term]
id: WBPhenotype:0000099
name: P lineages variant
def: "The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "P lineages abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000100
name: cell UV response variant
def: "Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "cell UV response abnormal" NARROW []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0000101
name: UV induced apoptosis increased
def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0000100 ! cell UV response variant
is_a: WBPhenotype:0000183 ! apoptosis increased

[Term]
id: WBPhenotype:0000102
name: presynaptic vesicle cluster variant
def: "Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals." [WB:WBPaper00027305]
synonym: "presynaptic vesicle cluster abnormal" NARROW []
synonym: "synaptic vesicle cluster abnormal" RELATED []
is_a: WBPhenotype:0001321 ! presynaptic region morphology variant

[Term]
id: WBPhenotype:0000103
name: gut granule development variant
def: "Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "gut granule development abnormal" NARROW []
is_a: WBPhenotype:0000705 ! intestinal cell development variant

[Term]
id: WBPhenotype:0000104
name: cell polarity variant
def: "Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "cell polarity abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000105
name: oocyte meiotic maturation variant
def: "Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly." [GO:0001556, WB:WBPaper00026997, WB:WBPerson2021]
synonym: "Oma" BROAD []
synonym: "oocyte meiotic maturation abnormal" NARROW []
is_a: WBPhenotype:0000313 ! meiotic progression during oogenesis variant

[Term]
id: WBPhenotype:0000106
name: inhibition of oocyte maturation variant
def: "Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals." [WB:WBPaper00003371, WB:WBPaper00026997, WB:WBPerson2021]
synonym: "inhibition of oocyte maturation abnormal" NARROW []
is_a: WBPhenotype:0000105 ! oocyte meiotic maturation variant

[Term]
id: WBPhenotype:0000107
name: inhibition of ovulation variant
def: "Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control." [GO:0060280, WB:WBPerson2021, WB:WBPerson557]
synonym: "inhibition of ovulation abnormal" NARROW []
is_a: WBPhenotype:0000666 ! ovulation variant

[Term]
id: WBPhenotype:0000108
name: obsolete severe dumpy
def: "OBSOLETE." []
is_obsolete: true
consider: WBPhenotype:0000583

[Term]
id: WBPhenotype:0000109
name: obsolete moderate dumpy
def: "OBSOLETE." []
is_obsolete: true
consider: WBPhenotype:0000583

[Term]
id: WBPhenotype:0000110
name: obsolete slightly dumpy
def: "OBSOLETE." []
is_obsolete: true
consider: WBPhenotype:0000583

[Term]
id: WBPhenotype:0000111
name: pattern of gene expression variant
def: "Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals." [WB:WBPerson2021]
synonym: "pattern of gene expression abnormal" NARROW []
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0000112
name: protein expression variant
def: "Variations in the biogenesis and stability of protein molecules compared to control." [WB:WBPerson2021]
synonym: "protein expression abnormal" NARROW []
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0000113
name: RNA expression variant
def: "Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control." [WB:WBPerson2021]
synonym: "RNA expression abnormal" NARROW []
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0000114
name: mRNA expression variant
def: "Variations in the biogenesis and stability of messenger RNA molecules compared to control." [GO:0050684, WB:WBPerson2021]
synonym: "mRNA expression abnormal" NARROW []
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0000115
name: anterior pharynx variant
def: "Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "anterior pharynx abnormal" NARROW []
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0000116
name: mid larval lethal
def: "Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000054 ! larval lethal

[Term]
id: WBPhenotype:0000117
name: L1 lethal
def: "Animals die at the L1 stage of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000057 ! early larval lethal

[Term]
id: WBPhenotype:0000118
name: L2 lethal
def: "L2 lethal: Animals die at the L2 stage of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000057 ! early larval lethal
is_a: WBPhenotype:0000116 ! mid larval lethal

[Term]
id: WBPhenotype:0000119
name: protein expression increased
def: "Any change that results in higher than normal levels of protein expression compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001400 ! level of protein expression variant

[Term]
id: WBPhenotype:0000120
name: protein expression reduced
def: "Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva]
is_a: WBPhenotype:0001400 ! level of protein expression variant

[Term]
id: WBPhenotype:0000121
name: translation variant
def: "Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control." [GO:0006412, WB:WBPerson2021]
synonym: "protein synthesis abnormal" RELATED []
synonym: "translation abnormal" NARROW []
is_a: WBPhenotype:0000112 ! protein expression variant

[Term]
id: WBPhenotype:0000122
name: post translational processing variant
def: "Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control." [GO:0016485, WB:WBPerson2021, WB:WBPerson557]
synonym: "post translational processing abnormal" NARROW []
synonym: "protein processing variant" RELATED []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000123
name: enzyme expression level reduced
def: "Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0000120 ! protein expression reduced

[Term]
id: WBPhenotype:0000124
name: enzyme activity reduced
def: "Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000727 ! enzyme activity variant

[Term]
id: WBPhenotype:0000125
name: enzyme activity increased
def: "Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000727 ! enzyme activity variant

[Term]
id: WBPhenotype:0000126
name: general pace of development defective early emb
def: "Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
synonym: "general pace of development abnormal" NARROW []
is_a: WBPhenotype:0000043 ! general pace of development variant

[Term]
id: WBPhenotype:0000127
name: dauer recovery variant
def: "Characteristic exit from the dauer stage is altered compared to control animals." [WB:cab]
synonym: "dauer recovery abnormal" NARROW []
is_a: WBPhenotype:0000308 ! dauer development phenotype

[Term]
id: WBPhenotype:0000128
name: temperature induced dauer formation increased
def: "Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals." [WB:cgc424]
synonym: "Hid" BROAD []
is_a: WBPhenotype:0000639 ! temperature induced dauer formation variant

[Term]
id: WBPhenotype:0000129
name: temperature induced dauer formation defective
def: "Animals do not enter dauer at a temperature that induces dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000013 ! dauer defective
is_a: WBPhenotype:0000639 ! temperature induced dauer formation variant

[Term]
id: WBPhenotype:0000130
name: pheromone induced dauer formation enhanced
def: "Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000132 ! pheromone induced dauer formation variant

[Term]
id: WBPhenotype:0000131
name: pheromone induced dauer formation defective
def: "Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Phd" BROAD []
is_a: WBPhenotype:0000013 ! dauer defective
is_a: WBPhenotype:0000132 ! pheromone induced dauer formation variant

[Term]
id: WBPhenotype:0000132
name: pheromone induced dauer formation variant
def: "Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pheromone induced dauer formation abnormal" NARROW []
is_a: WBPhenotype:0001539 ! dauer induction variant

[Term]
id: WBPhenotype:0000133
name: expression lipogenic enzyme reduced
def: "The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0000123 ! enzyme expression level reduced

[Term]
id: WBPhenotype:0000134
name: gene expression level reduced
def: "Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0002575 ! gene expression level abnormal

[Term]
id: WBPhenotype:0000135
name: gene expression level high
def: "Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0002575 ! gene expression level abnormal

[Term]
id: WBPhenotype:0000136
name: mRNA levels increased
def: "Animals exhibit elevated levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021]
is_a: WBPhenotype:0000114 ! mRNA expression variant

[Term]
id: WBPhenotype:0000137
name: mRNA levels reduced
def: "Animals exhibit decreased levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021]
is_a: WBPhenotype:0000114 ! mRNA expression variant

[Term]
id: WBPhenotype:0000138
name: lipid composition variant
def: "The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals." [WB:WBPerson712]
synonym: "fat composition abnormal" RELATED []
synonym: "fatty acid composition abnormal" RELATED []
synonym: "lipid composition abnormal" NARROW []
is_a: WBPhenotype:0000725 ! lipid metabolism variant

[Term]
id: WBPhenotype:0000139
name: stress induced lethality variant
def: "Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "stress induced lethality abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000140
name: stress induced arrest variant
def: "Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "stress induced arrest abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000141
name: stress induced lethality increased
def: "Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000139 ! stress induced lethality variant

[Term]
id: WBPhenotype:0000142
name: cell stress response variant
def: "Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GO:0033554, WB:WBPerson2021]
synonym: "cell stress response abnormal" NARROW []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0000143
name: organism UV response variant
def: "Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism UV response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000144
name: pathogen induced cell death increased
def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0000142 ! cell stress response variant
is_a: WBPhenotype:0001269 ! pathogen induced cell death variant

[Term]
id: WBPhenotype:0000145
name: fertility phenotype
def: "Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control." [GO:0000003, WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "fertility abnormal" NARROW []
synonym: "fertility variant" EXACT []
is_a: WBPhenotype:0000613 ! reproductive system physiology variant

[Term]
id: WBPhenotype:0000146
name: organism temperature response variant
def: "Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span." [WB:WBPerson712]
synonym: "organism temperature response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000147
name: organism starvation response variant
def: "Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control." [GO:0042594, WB:WBPerson2021]
synonym: "organism starvation response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000148
name: starvation induced dauer formation variant
def: "Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "starvation induced dauer formation abnormal" NARROW []
is_a: WBPhenotype:0000147 ! organism starvation response variant
is_a: WBPhenotype:0001539 ! dauer induction variant

[Term]
id: WBPhenotype:0000149
name: starvation induced dauer formation increased
def: "Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000148 ! starvation induced dauer formation variant

[Term]
id: WBPhenotype:0000150
name: starvation induced dauer formation defective
def: "Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000013 ! dauer defective
is_a: WBPhenotype:0000148 ! starvation induced dauer formation variant

[Term]
id: WBPhenotype:0000151
name: anterior pharynx extra cells
def: "Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere." [WB:WBPaper00001930, WB:WBPerson2021]
synonym: "Apx" BROAD []
is_a: WBPhenotype:0000115 ! anterior pharynx variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0000152
name: no cleavage furrow first division early emb
def: "One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0000153
name: body wall muscle contraction abnormal
def: "Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals." [WB:WBPaper00032190, WB:WBPerson712]
synonym: "body wall contraction abnormal" NARROW []
synonym: "body wall contraction variant" EXACT []
is_a: WBPhenotype:0000596 ! body behavior variant

[Term]
id: WBPhenotype:0000154
name: reduced brood size
def: "The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000673 ! brood size variant

[Term]
id: WBPhenotype:0000155
name: cell polarity reversed
def: "Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712]
is_a: WBPhenotype:0000104 ! cell polarity variant

[Term]
id: WBPhenotype:0000156
name: body wall muscle contraction interval during defecation abnormal
def: "Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body wall contraction interval abnormal" NARROW []
synonym: "body wall muscle contraction interval abnormal" RELATED []
is_a: WBPhenotype:0000210 ! defecation contraction variant

[Term]
id: WBPhenotype:0000157
name: posterior body wall contraction defecation cycle variant
def: "Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals." [WB:WBPaper00031426, WB:WBPerson712]
synonym: "pBoc" BROAD []
synonym: "posterior body contraction abnormal" RELATED []
synonym: "posterior body wall contraction abnormal" NARROW []
synonym: "posterior body wall contraction defective" RELATED []
is_a: WBPhenotype:0000210 ! defecation contraction variant

[Term]
id: WBPhenotype:0000158
name: obsolete posterior body wall shortened interval
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000209

[Term]
id: WBPhenotype:0000159
name: obsolete dauer arrest variant
def: "OBSOLETE: Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas)." [WB:WBPerson2021, WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0000308

[Term]
id: WBPhenotype:0000160
name: cleavage furrow not discrete early emb
def: "Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0000161
name: nuclear rotation variant
def: "Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control." [GO:0035047, WB:WBPerson2021, WB:WBPerson557]
synonym: "nuclear rotation abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000162
name: pale larva
def: "Larva show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557]
synonym: "translucent" RELATED []
is_a: WBPhenotype:0000890 ! larval pigmentation variant
is_a: WBPhenotype:0001261 ! pale

[Term]
id: WBPhenotype:0000163
name: clear larva
def: "Larva appear unusually transparent when compared to control." [WB:WBPerson557]
synonym: "Clr" BROAD []
synonym: "transparent" RELATED []
is_a: WBPhenotype:0000890 ! larval pigmentation variant
is_a: WBPhenotype:0001010 ! clear

[Term]
id: WBPhenotype:0000164
name: thin
def: "Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712]
synonym: "decreased girth" RELATED []
synonym: "slim" RELATED []
is_a: WBPhenotype:0001727 ! body width variant

[Term]
id: WBPhenotype:0000165
name: cell fusion variant
def: "Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing." [GO:0000768, GO:0045026, WB:WBPaper00005122, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "cell fusion abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000166
name: seam cell fusion variant
def: "Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation." [WB:WBPerson2021, WB:WBPerson557]
synonym: "seam cell fusion abnormal" NARROW []
is_a: WBPhenotype:0000165 ! cell fusion variant

[Term]
id: WBPhenotype:0000167
name: precocious seam cell fusion
def: "Seam cells fuse to form a continuous syncytium along the body wall at an earlier stage of development compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000166 ! seam cell fusion variant
is_a: WBPhenotype:0001433 ! precocious cell fusion

[Term]
id: WBPhenotype:0000168
name: alae secretion variant
def: "Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas)." [WB:WBPaper00004833, WB:WBPaper00025242, WB:WBPerson2021]
synonym: "alae formation variant" RELATED []
synonym: "alae secretion abnormal" NARROW []
is_a: WBPhenotype:0000258 ! cell secretion variant

[Term]
id: WBPhenotype:0000169
name: early exit cell cycle
def: "Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells." [GO:0010458, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0001995 ! cell cycle progression variant

[Term]
id: WBPhenotype:0000170
name: precocious alae
def: "Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage." [pmid:3428573, WB:cab]
is_a: WBPhenotype:0000168 ! alae secretion variant
is_a: WBPhenotype:0000439 ! precocious heterochronic variations

[Term]
id: WBPhenotype:0000171
name: cell proliferation variant
def: "Any aberrancy in the processes that govern expansion of cell populations compared to control animals." [GO:0008283, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "cell proliferation abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000172
name: cell proliferation increased
def: "The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased." [WB:WBPerson2021]
is_a: WBPhenotype:0000171 ! cell proliferation variant

[Term]
id: WBPhenotype:0000173
name: cell proliferation reduced
def: "The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased." [WB:WBPerson2021]
is_a: WBPhenotype:0000171 ! cell proliferation variant

[Term]
id: WBPhenotype:0000174
name: basal lamina development variant
def: "Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "basal lamina development abnormal" NARROW []
is_a: WBPhenotype:0000619 ! epithelial system development variant

[Term]
id: WBPhenotype:0000175
name: hypercontracted
def: "Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body." [WB:WBPerson363]
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0000176
name: satiety behavior variant
def: "Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated." [WB:WBPerson2021, WB:WBPerson557]
synonym: "satiety behavior abnormal" NARROW []
is_a: WBPhenotype:0000659 ! feeding behavior variant

[Term]
id: WBPhenotype:0000177
name: acetylcholinesterase reduced
def: "Any variation that results in a decrease of acetylcholine esterase levels, compared to control." [WB:WBPaper00024452, WB:WBPerson2021]
is_a: WBPhenotype:0000124 ! enzyme activity reduced

[Term]
id: WBPhenotype:0000178
name: cell degeneration
def: "Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [WB:WBPerson712]
is_a: WBPhenotype:0000729 ! cell death variant

[Term]
id: WBPhenotype:0000179
name: neuron degeneration
def: "Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles." [WB:WBperson557, WB:WBPerson712]
is_a: WBPhenotype:0000178 ! cell degeneration

[Term]
id: WBPhenotype:0000180
name: axon morphology variant
def: "Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712]
synonym: "axon morphology abnormal" NARROW []
is_a: WBPhenotype:0001398 ! neurite morphology variant

[Term]
id: WBPhenotype:0000181
name: axon trajectory variant
def: "Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals." [WB:WBPaper00001105, WB:WBPerson712]
synonym: "axon trajectory abnormal" NARROW []
is_a: WBPhenotype:0000180 ! axon morphology variant

[Term]
id: WBPhenotype:0000182
name: apoptosis reduced
def: "Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0000183
name: apoptosis increased
def: "Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals." [GO:0043066, WB:WBPerson2021]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0000184
name: apoptosis fails to occur
def: "Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712]
is_a: WBPhenotype:0000182 ! apoptosis reduced

[Term]
id: WBPhenotype:0000185
name: apoptosis protracted
def: "Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells." [WB:WBPerson712]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0000186
name: oogenesis variant
alt_id: WBPhenotype:0000896
def: "Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals." [GO:0048477, WB:WBPerson2021]
synonym: "oocyte development abnormal" RELATED []
synonym: "oocyte germ cell differentiation abnormal" EXACT []
synonym: "oogenesis abnormal" NARROW []
is_a: WBPhenotype:0000894 ! germ cell differentiation variant

[Term]
id: WBPhenotype:0000187
name: egg round
def: "The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000373 ! egg shape variable

[Term]
id: WBPhenotype:0000188
name: gonad arm morphology variant
def: "Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad." [WB:WBPerson2021, WB:WBPerson557]
synonym: "gonad arm morphology abnormal" NARROW []
is_a: WBPhenotype:0000977 ! somatic gonad morphology variant

[Term]
id: WBPhenotype:0000189
name: hypodermis disorganized
def: "Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body." [WB:WBPaper00027006, WB:WBPerson2021]
is_a: WBPhenotype:0000703 ! epithelial morphology variant

[Term]
id: WBPhenotype:0000190
name: no dauer recovery
def: "Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development." [GO:0043054, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000127 ! dauer recovery variant

[Term]
id: WBPhenotype:0000191
name: organism crowding response variant
def: "Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "organism crowding response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000192
name: constitutive enzyme activity
def: "Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000125 ! enzyme activity increased

[Term]
id: WBPhenotype:0000193
name: dominant negative enzyme
def: "Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype." [WB:WBPerson2021]
is_a: WBPhenotype:0000727 ! enzyme activity variant

[Term]
id: WBPhenotype:0000194
name: first polar body position variant
def: "Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "first polar body position abnormal" NARROW []
is_a: WBPhenotype:0000775 ! meiosis variant

[Term]
id: WBPhenotype:0000195
name: distal tip cell migration variant
def: "Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern." [GO:0040039, WB:WBPaper00003598, WB:WBPerson2021]
synonym: "distal tip cell migration abnormal" NARROW []
synonym: "DTC migration abnormal" RELATED []
is_a: WBPhenotype:0000594 ! cell migration variant

[Term]
id: WBPhenotype:0000196
name: distal tip cell morphology variant
def: "The morphological appearance of distal tip cells is varied compared to control animals." [WB:cab]
synonym: "distal tip cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000197
name: cell induction variant
def: "Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling)." [GO:0031128, WB:WBPerson2021]
synonym: "cell induction abnormal" NARROW []
is_a: WBPhenotype:0000216 ! cell fate specification variant

[Term]
id: WBPhenotype:0000198
name: obsolete vulval cell induction abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0001272

[Term]
id: WBPhenotype:0000199
name: male tail sensory ray development variant
def: "Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male tail sensory ray development abnormal" NARROW []
is_a: WBPhenotype:0001008 ! male nervous system development variant

[Term]
id: WBPhenotype:0000200
name: pericellular component development variant
def: "Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "pericellular component development abnormal" NARROW []
is_a: WBPhenotype:0000518 ! development phenotype

[Term]
id: WBPhenotype:0000201
name: cuticle development variant
def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cuticle development abnormal" NARROW []
is_a: WBPhenotype:0000200 ! pericellular component development variant

[Term]
id: WBPhenotype:0000202
name: alae variant
def: "Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "alae abnormal" NARROW []
is_a: WBPhenotype:0000201 ! cuticle development variant

[Term]
id: WBPhenotype:0000203
name: odorant adaptation variant
def: "Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals." [WB:WBPerson2021]
synonym: "odorant adaptation abnormal" NARROW []
is_a: WBPhenotype:0001048 ! odorant chemosensory response variant

[Term]
id: WBPhenotype:0000204
name: anterior body contraction defecation cycle variant
def: "Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step." [WB:WBPerson2021]
synonym: "aBoc" BROAD []
synonym: "anterior body contraction abnormal" RELATED []
synonym: "anterior body contraction defective" RELATED []
is_a: WBPhenotype:0001476 ! anterior body contraction variant

[Term]
id: WBPhenotype:0000205
name: expulsion variant
def: "Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Exp" RELATED []
synonym: "expulsion abnormal" NARROW []
is_a: WBPhenotype:0000210 ! defecation contraction variant

[Term]
id: WBPhenotype:0000206
name: autosomal nondisjunction meiosis
def: "A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog." [GO:0045143, WB:WBPerson712]
is_a: WBPhenotype:0001174 ! chromosome disjunction defective

[Term]
id: WBPhenotype:0000207
name: defecation cycle variant
def: "Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control ." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Dec" RELATED []
synonym: "defecation cycle abnormal" NARROW []
is_a: WBPhenotype:0000650 ! defecation variant

[Term]
id: WBPhenotype:0000208
name: long defecation cycle
def: "The mean time between the onset of the defecation motor program is greater than that observed for control animals." [WB:WBPaper00002315, WB:WBPaper00031896, WB:WBPerson712]
synonym: "Dec-l" RELATED []
synonym: "reduced rate of defecation" RELATED []
is_a: WBPhenotype:0000207 ! defecation cycle variant

[Term]
id: WBPhenotype:0000209
name: short defecation cycle
def: "The mean time between the onset of the defecation motor program is shorter than that observed for control animals." [WB:WBPaper00002315, WB:WBPaper00031896, WB:WBPerson712]
synonym: "Dec-s" RELATED []
synonym: "fast Dec" RELATED []
synonym: "increased rate of defecation" RELATED []
synonym: "posterior body wall shortened interval" EXACT []
is_a: WBPhenotype:0000207 ! defecation cycle variant

[Term]
id: WBPhenotype:0000210
name: defecation contraction variant
def: "Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "defecation contraction abnormal" NARROW []
is_a: WBPhenotype:0000650 ! defecation variant

[Term]
id: WBPhenotype:0000211
name: defecation contraction asynchronous
def: "The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "defecation contraction mistimed" RELATED []
is_a: WBPhenotype:0000210 ! defecation contraction variant

[Term]
id: WBPhenotype:0000212
name: body constriction
def: "Animals contain body regions that are more narrow or drawn together than adjacent body regions." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000072 ! body morphology variant

[Term]
id: WBPhenotype:0000213
name: zygotic development variant
def: "Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "zygotic development abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000214
name: alpha amanitin hypersensitive
def: "Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000215
name: no germ line
def: "Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline." [WB:WBPaper00001477, WB:WBPerson2021]
synonym: "no germline" EXACT []
is_a: WBPhenotype:0000812 ! germ cell development variant

[Term]
id: WBPhenotype:0000216
name: cell fate specification variant
def: "Any variation in the processes that govern acquisition of particular cell fates compared to control animals." [WB:kmva]
subset: phenotype_slim_wb
synonym: "cell fate specification abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000217
name: prolonged pharyngeal contraction
def: "The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000980 ! pharyngeal contraction variant

[Term]
id: WBPhenotype:0000218
name: vulval cell induction increased
def: "An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals." [WB:WBPerson2021]
synonym: "Hin" BROAD []
synonym: "overinduced" NARROW []
is_a: WBPhenotype:0001272 ! vulval cell induction variant

[Term]
id: WBPhenotype:0000219
name: vulval cell induction reduced
def: "Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals." [WB:WBPerson2021]
synonym: "underinduced" NARROW []
is_a: WBPhenotype:0001272 ! vulval cell induction variant

[Term]
id: WBPhenotype:0000220
name: vulva cell fate specification variant
def: "Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals." [WB:WBPerson2021]
synonym: "vulva cell fate specification abnormal" NARROW []
is_a: WBPhenotype:0000216 ! cell fate specification variant
is_a: WBPhenotype:0000699 ! vulva development variant

[Term]
id: WBPhenotype:0000221
name: neurotransmitter metabolism variant
def: "Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GO:0042133, WB:WBPerson557, WB:WBPerson712]
synonym: "neurotransmitter metabolism abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000222
name: serotonin metabolism variant
def: "Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control." [GO:0042428, WB:WBPerson557, WB:WBPerson712]
synonym: "serotonin metabolism abnormal" NARROW []
is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant

[Term]
id: WBPhenotype:0000223
name: acetylcholine metabolism variant
def: "Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, compared to control. Acetylcholine is the acetic acid ester of the organic base choline." [GO:0008291, WB:WBPerson557, WB:WBPerson712]
synonym: "acetylcholine metabolism abnormal" NARROW []
is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant

[Term]
id: WBPhenotype:0000224
name: serotonin deficient
def: "Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity." [WB:WBPerson712]
is_a: WBPhenotype:0000222 ! serotonin metabolism variant

[Term]
id: WBPhenotype:0000225
name: serotonin synthesis defective
def: "Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin." [GO:0042427, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000222 ! serotonin metabolism variant

[Term]
id: WBPhenotype:0000226
name: serotonin catabolism defective
def: "Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter." [GO:0042429, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000222 ! serotonin metabolism variant

[Term]
id: WBPhenotype:0000227
name: male turning defective
def: "The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail." [GO:0034607, WB:WBPaper00000392, WB:WBPaper00002109]
synonym: "male turning abnormal" NARROW []
is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant

[Term]
id: WBPhenotype:0000228
name: spontaneous mutation rate increased
def: "Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations." [WB:WBPaper00000565, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000229
name: small
def: "Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31]
synonym: "body size reduced" EXACT []
synonym: "Sma" RELATED []
is_a: WBPhenotype:0001726 ! body length variant
is_a: WBPhenotype:0001727 ! body width variant

[Term]
id: WBPhenotype:0000230
name: tail withered
def: "The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons." [WB:WBPaper00002795, WB:WBPerson2021, WB:WBPerson557]
synonym: "Wit" RELATED []
is_a: WBPhenotype:0000073 ! tail morphology variant

[Term]
id: WBPhenotype:0000231
name: body size variant
def: "Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage." [WB:WBPerson712]
comment: PATO:0000117.
synonym: "body size abnormal" NARROW []
is_a: WBPhenotype:0000072 ! body morphology variant

[Term]
id: WBPhenotype:0000232
name: CAN cell migration variant
def: "Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo." [WB:WBPaper00002795, WB:WBPerson2021]
synonym: "CAN cell migration abnormal" NARROW []
is_a: WBPhenotype:0001520 ! posterior neuron migration variant

[Term]
id: WBPhenotype:0000233
name: dopamine metabolism variant
def: "Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control." [GO:0042417, WB:WBPerson557, WB:WBPerson712]
synonym: "dopamine metabolism abnormal" NARROW []
is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant
is_a: WBPhenotype:0001518 ! biogenic amine physiology variant

[Term]
id: WBPhenotype:0000234
name: dopamine deficient
def: "Animals do not contain or are unable to maintain a the level of dopamine capable of initiating or maintaining dopamine-dependent cell activity compared to control animals." [WB:WBPerson712]
synonym: "dopamine levels decreased" RELATED []
is_a: WBPhenotype:0000233 ! dopamine metabolism variant

[Term]
id: WBPhenotype:0000235
name: dopamine synthesis defective
def: "Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine." [GO:0042416, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000233 ! dopamine metabolism variant

[Term]
id: WBPhenotype:0000236
name: dopamine catabolism defective
def: "Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GO:0042420, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000233 ! dopamine metabolism variant

[Term]
id: WBPhenotype:0000237
name: foraging hyperactive
def: "Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute." [WB:WBPaper00031455, WB:WBPaper00031570, WB:WBPerson712]
is_a: WBPhenotype:0000662 ! foraging behavior variant

[Term]
id: WBPhenotype:0000238
name: foraging reduced
def: "Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals." [WB:WBPaper00031455, WB:WBPerson712]
is_a: WBPhenotype:0000662 ! foraging behavior variant

[Term]
id: WBPhenotype:0000239
name: vulval cell lineage variant
def: "The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p." [WB:WBPaper00005610, WB:WBPerson2021]
synonym: "VPC lineage abnormal" RELATED []
synonym: "vulval cell lineage abnormal" NARROW []
is_a: WBPhenotype:0000099 ! P lineages variant

[Term]
id: WBPhenotype:0000240
name: blast cell proliferation reduced
def: "The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000173 ! cell proliferation reduced

[Term]
id: WBPhenotype:0000241
name: accumulated cell corpses
def: "Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712]
is_a: WBPhenotype:0000590 ! cell corpse number variant

[Term]
id: WBPhenotype:0000242
name: body elongation defective
def: "The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021]
is_a: WBPhenotype:0001478 ! body elongation variant

[Term]
id: WBPhenotype:0000243
name: engulfment failure by killer cell
def: "Removal of cell corpses through a dedicated engulfment pathway is defective." [WB:WBPerson712]
synonym: "corpse engulfment defective" RELATED []
synonym: "persistent cell corpses" RELATED []
is_a: WBPhenotype:0000885 ! engulfment variant

[Term]
id: WBPhenotype:0000244
name: apoptotic arrest
def: "Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712]
synonym: "apoptosis block" RELATED []
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0000245
name: SM migration variant
def: "Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad." [WB:WBPaper00003627, WB:WBPerson2021]
synonym: "SM migration abnormal" NARROW []
is_a: WBPhenotype:0001230 ! anterior cell migration defective

[Term]
id: WBPhenotype:0000246
name: defecation cycle variable length
def: "Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals." [WB:WBPaper00031896, WB:WBPerson712]
is_a: WBPhenotype:0000207 ! defecation cycle variant

[Term]
id: WBPhenotype:0000247
name: sodium chemotaxis defective
def: "Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant." [WB:cab, WB:cgc387]
synonym: "Na chemotaxis defective" RELATED []
synonym: "sodium acetate chemotaxis defective" RELATED [WB:WBPerson2021]
is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective

[Term]
id: WBPhenotype:0000248
name: obsolete sensory neuroanatomy variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "sensory neuroanatomy abnormal" NARROW []
is_obsolete: true
replaced_by: WBPhenotype:0000652

[Term]
id: WBPhenotype:0000249
name: osmotic avoidance defective
def: "Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals." [WB:cab, WB:WBPerson2021]
is_a: WBPhenotype:0000663 ! osmotic avoidance variant

[Term]
id: WBPhenotype:0000250
name: octopamine metabolism variant
def: "Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control." [GO:0046333, WB:WBPerson557, WB:WBPerson712]
synonym: "octopamine metabolism abnormal" NARROW []
is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant
is_a: WBPhenotype:0001518 ! biogenic amine physiology variant

[Term]
id: WBPhenotype:0000251
name: octopamine deficient
def: "Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity." [WB:WBPerson712]
is_a: WBPhenotype:0000250 ! octopamine metabolism variant

[Term]
id: WBPhenotype:0000252
name: caffeine resistant
def: "Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000253
name: movement erratic
def: "Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another." [WB:WBPerson2021, WB:WBPerson557]
synonym: "movement irregular" RELATED []
is_a: WBPhenotype:0001701 ! spastic locomotion

[Term]
id: WBPhenotype:0000254
name: chloride chemotaxis defective
def: "Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant." [WB:cab, WB:cgc387]
synonym: "Cl chemotaxis defective" RELATED []
is_a: WBPhenotype:0001439 ! anion positive chemotaxis defective
is_a: WBPhenotype:0001458 ! chloride chemotaxis variant

[Term]
id: WBPhenotype:0000255
name: amphid phasmid neuron morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938]
comment: WBbt:0005394, WBbt:0006753.
synonym: "amphid phasmid morphology abnormal" NARROW []
is_a: WBPhenotype:0001527 ! amphid phasmid sensillum morphology variant

[Term]
id: WBPhenotype:0000256
name: amphid neuron morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938]
comment: WBbt:0005394.
synonym: "amphid morphology abnormal" NARROW []
is_a: WBPhenotype:0000255 ! amphid phasmid neuron morphology variant

[Term]
id: WBPhenotype:0000257
name: phasmid neuron morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938]
comment: WBbt:0006753.
synonym: "phasmid morphology abnormal" NARROW []
is_a: WBPhenotype:0000255 ! amphid phasmid neuron morphology variant

[Term]
id: WBPhenotype:0000258
name: cell secretion variant
alt_id: WBPhenotype:0000723
def: "Variations in the regulated release of substances by a cell compared to control." [GO:0032940, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "cell secretion abnormal" NARROW []
synonym: "cellular secretion abnormal" EXACT []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000259
name: sheath cell secretion variant
def: "Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control." [WB:WBPaper00000822, WB:WBPerson2021]
synonym: "sheath cell secretion abnormal" NARROW []
is_a: WBPhenotype:0000258 ! cell secretion variant

[Term]
id: WBPhenotype:0000260
name: sheath cell secretion failure
def: "The regulated release of materials by sheath cells is disrupted." [WB:WBPaper00028924, WB:WBPerson2021]
is_a: WBPhenotype:0000259 ! sheath cell secretion variant

[Term]
id: WBPhenotype:0000261
name: amphid sheath secretion failure
def: "Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket." [WB:WBPaper00028924, WB:WBPerson2021]
is_a: WBPhenotype:0000260 ! sheath cell secretion failure

[Term]
id: WBPhenotype:0000262
name: axoneme morphology variant
def: "Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center." [WB:WBPaper00000932, WB:WBPerson557, WB:WBPerson712]
synonym: "axoneme morphology abnormal" NARROW []
is_a: WBPhenotype:0000615 ! cilia morphology variant

[Term]
id: WBPhenotype:0000263
name: axoneme short
def: "The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals." [WB:WBPaper00000932, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000262 ! axoneme morphology variant

[Term]
id: WBPhenotype:0000264
name: cAMP chemotaxis defective
def: "Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant." [WB:cab, WB:cgc387, WB:WBPaper00001481, WB:WBPaper00002033]
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective
is_a: WBPhenotype:0001463 ! cAMP chemotaxis variant

[Term]
id: WBPhenotype:0000265
name: odorant positive chemotaxis variant
def: "Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons." [WB:cab, WB:cgc1786, WB:WBPerson2021]
synonym: "odorant positive chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0000635 ! positive chemotaxis variant
is_a: WBPhenotype:0001048 ! odorant chemosensory response variant

[Term]
id: WBPhenotype:0000266
name: cell cleavage variant
def: "Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cell cleavage abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0000267
name: cell cleavage delayed
def: "Any variation that causes a delay in the stereotypical cleavage event compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000266 ! cell cleavage variant
is_a: WBPhenotype:0000438 ! retarded heterochronic variations

[Term]
id: WBPhenotype:0000268
name: P cell cleavage delayed
def: "Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000267 ! cell cleavage delayed

[Term]
id: WBPhenotype:0000269
name: obsolete unclassified
def: "OBSOLETE. Animals display a phenotype that has not yet been assigned to a current classification." [WB:WBPerson2021, WB:WBPerson557]
is_obsolete: true

[Term]
id: WBPhenotype:0000270
name: pleiotropic defects severe early emb
def: "Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001007 ! other abnormality early emb

[Term]
id: WBPhenotype:0000271
name: obsolete cell cycle slow
def: "OBSOLETE." []
is_obsolete: true
consider: WBPhenotype:0000318
consider: WBPhenotype:0001995

[Term]
id: WBPhenotype:0000272
name: egg laying irregular
def: "The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000640 ! egg laying variant

[Term]
id: WBPhenotype:0000273
name: thrashing reduced
def: "The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms." [WB:cab, WB:cgc7388]
is_a: WBPhenotype:0001700 ! swimming variant

[Term]
id: WBPhenotype:0000274
name: dead eggs laid
def: "Animals lay eggs that are inviable." [WB:cab]
is_a: WBPhenotype:0000640 ! egg laying variant
is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant

[Term]
id: WBPhenotype:0000275
name: organism UV hypersensitive
def: "Organisms respond to UV at a lower dose or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000143 ! organism UV response variant

[Term]
id: WBPhenotype:0000276
name: organism X ray response variant
def: "Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism X ray response abnormal" NARROW []
is_a: WBPhenotype:0000686 ! organism ionizing radiation response variant

[Term]
id: WBPhenotype:0000277
name: rhythm slow
def: "The timing of a biological cycle that recurs with regularity is delayed compared to control." [GO:0048511, WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000278
name: body region pigmentation phenotype
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency or translucency of a particular body region." [WB:WBPerson557]
synonym: "body region pigmentation abnormal" EXACT []
synonym: "body region pigmentation variant" EXACT []
is_a: WBPhenotype:0000521 ! pigmentation phenotype

[Term]
id: WBPhenotype:0000279
name: spicule insertion defective
def: "Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [GO:0034609, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001414 ! male mating defective
is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant

[Term]
id: WBPhenotype:0000280
name: breaks in alae
def: "The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "gapped alae" EXACT []
is_a: WBPhenotype:0001412 ! alae morphology variant

[Term]
id: WBPhenotype:0000281
name: male sex muscle development variant
def: "Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male sex muscle development abnormal" NARROW []
is_a: WBPhenotype:0000669 ! sex muscle development variant

[Term]
id: WBPhenotype:0000282
name: hermaphrodite sex muscle development variant
def: "Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hermaphrodite sex muscle development abnormal" NARROW []
is_a: WBPhenotype:0000669 ! sex muscle development variant

[Term]
id: WBPhenotype:0000283
name: vulva uterus connection defective
def: "Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals." [WB:WBPaper00003386, WB:WBPaper00006298, WB:WBPaper00027236, WB:WBPaper00027316, WB:WBPerson712]
synonym: "AC block" NARROW []
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000284
name: sperm transfer defective
def: "Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract." [GO:0007320, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001414 ! male mating defective
is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant

[Term]
id: WBPhenotype:0000285
name: ray tips swollen
def: "The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000505 ! male ray morphology variant

[Term]
id: WBPhenotype:0000286
name: embryo disorganized
def: "Embryos fail to be organized in the same manner as observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000287
name: obsolete vulval invagination L4 abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000510

[Term]
id: WBPhenotype:0000288
name: distal germline variant
def: "Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "distal germ line abnormal" RELATED []
synonym: "distal germline abnormal" NARROW []
is_a: WBPhenotype:0000812 ! germ cell development variant

[Term]
id: WBPhenotype:0000289
name: uterus morphology variant
def: "Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "uterus morphology abnormal" NARROW []
is_a: WBPhenotype:0001335 ! hermaphrodite reproductive system morphology variant

[Term]
id: WBPhenotype:0000290
name: sperm absent
def: "Animals lack fully specialized male gametes that are competent for fertilization." [WB:WBPerson2021]
synonym: "no sperm" RELATED []
is_a: WBPhenotype:0000395 ! no differentiated gametes

[Term]
id: WBPhenotype:0000291
name: no oocytes
def: "Hermaphrodites lack fully specialized female gametes that are competent for fertilization." [WB:WBPerson2021]
synonym: "oocytes absent" RELATED []
is_a: WBPhenotype:0000395 ! no differentiated gametes

[Term]
id: WBPhenotype:0000292
name: organ system pigmentation phenotype
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system." [WB:WBPerson557]
synonym: "organ system pigmentation abnormal" EXACT []
synonym: "organ system pigmentation variant" EXACT []
is_a: WBPhenotype:0000521 ! pigmentation phenotype

[Term]
id: WBPhenotype:0000293
name: alimentary system pigmentation variant
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system." [WB:WBPerson557]
synonym: "alimentary system pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000292 ! organ system pigmentation phenotype

[Term]
id: WBPhenotype:0000294
name: intestine dark
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine." [WB:WBPerson557]
synonym: "Din" BROAD []
is_a: WBPhenotype:0000293 ! alimentary system pigmentation variant

[Term]
id: WBPhenotype:0000295
name: thermotolerance increased
def: "Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals." [WB:WBPaper00005836, WB:WBPerson712]
synonym: "intrinsic thermotolerance increased" NARROW []
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0000296
name: spicules crumpled
def: "The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000443 ! spicule morphology variant

[Term]
id: WBPhenotype:0000297
name: rays fused
alt_id: WBPhenotype:0001241
def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ray fusion" EXACT []
is_a: WBPhenotype:0000165 ! cell fusion variant
is_a: WBPhenotype:0000199 ! male tail sensory ray development variant
is_a: WBPhenotype:0000505 ! male ray morphology variant

[Term]
id: WBPhenotype:0000298
name: rays displaced
def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000505 ! male ray morphology variant

[Term]
id: WBPhenotype:0000299
name: sensillum morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712]
synonym: "chemosensory cell morphology abnormal" RELATED []
synonym: "sensillum morphology abnormal" NARROW []
is_a: WBPhenotype:0000604 ! nervous system morphology variant

[Term]
id: WBPhenotype:0000300
name: amphid sheath cell morphology variant
def: "Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000822, WB:WBPerson712]
synonym: "amphid sheath cell morphology abnormal" NARROW []
is_a: WBPhenotype:0001527 ! amphid phasmid sensillum morphology variant

[Term]
id: WBPhenotype:0000301
name: distal tip cell reflex failure
def: "A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm." [WB:WBPaper00029151, WB:WBPerson2021]
is_a: WBPhenotype:0000195 ! distal tip cell migration variant

[Term]
id: WBPhenotype:0000302
name: benzaldehyde chemotaxis defective
def: "Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive." [WB:WBPaper00001786]
is_a: WBPhenotype:0001060 ! AWC odorant chemotaxis defective
is_a: WBPhenotype:0001468 ! benzaldehyde chemotaxis variant

[Term]
id: WBPhenotype:0000303
name: diacetyl chemotaxis defective
def: "Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive." [WB:WBPaper00001786]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001470 ! diacetyl chemotaxis variant

[Term]
id: WBPhenotype:0000304
name: isoamyl alcohol chemotaxis defective
def: "Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive." [WB:cab, WB:cgc1786]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001472 ! isoamyl alcohol chemotaxis variant

[Term]
id: WBPhenotype:0000305
name: pheromone sensation variant
def: "Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals." [GO:0043695, WB:WBPerson2021, WB:WBPerson557]
synonym: "pheromone sensation abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000306
name: transgene expression variant
def: "Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "transgene expression abnormal" NARROW []
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0000307
name: dauer pheromone sensation defective
def: "Animals fail to detect a pheromone stimulus that induces dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001479 ! dauer pheromone sensation variant

[Term]
id: WBPhenotype:0000308
name: dauer development phenotype
alt_id: WBPhenotype:0000159
def: "Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage." [WB:kmva]
synonym: "dauer arrest abnormal" RELATED []
synonym: "dauer arrest variant" RELATED []
synonym: "dauer development abnormal" EXACT []
synonym: "dauer development variant" EXACT []
synonym: "diapause variant" RELATED []
is_a: WBPhenotype:0000750 ! larval development variant
is_a: WBPhenotype:0002527 ! dauer larva physiology variant

[Term]
id: WBPhenotype:0000309
name: SDS sensitive dauer
def: "Any variation that decreases the ability of dauer larva to tolerate the exposure to sodium dodecyl sulfate (a detergent) compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0001546 ! dauer resistance to harsh conditions variant
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0000310
name: cilia absent
def: "Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals." [WB:WBPaper00000932, WB:WBPerson712]
is_a: WBPhenotype:0000615 ! cilia morphology variant

[Term]
id: WBPhenotype:0000311
name: obsolete semi sterile
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000688

[Term]
id: WBPhenotype:0000312
name: dauer pheromone production defective
def: "Animals are incapable of synthesizing pheromones that induce dauer formation in control animals." [GO:0042446, WB:WBPerson2021]
is_a: WBPhenotype:0000191 ! organism crowding response variant
is_a: WBPhenotype:0001547 ! dauer metabolism phenotype

[Term]
id: WBPhenotype:0000313
name: meiotic progression during oogenesis variant
def: "Developing oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis)." [WB:WBPaper00026997, WB:WBPerson2021]
synonym: "meiotic progression during oogenesis abnormal" NARROW []
is_a: WBPhenotype:0000186 ! oogenesis variant

[Term]
id: WBPhenotype:0000314
name: scrawny
def: "Animals are slight or meager in body size compared to control animals at the same developmental stage." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000231 ! body size variant

[Term]
id: WBPhenotype:0000315
name: mechanosensation variant
alt_id: WBPhenotype:0000513
def: "Any variation with respect to perception or response to mechanical stimuli compared to control animals." [WB:cab]
subset: phenotype_slim_wb
synonym: "Mec" BROAD []
synonym: "mechanosensation abnormal" NARROW []
synonym: "touch response abnormal" EXACT []
is_a: WBPhenotype:0000525 ! organism behavior variant
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000316
name: touch resistant tail
def: "Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans, animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail." [WB:WBPaper00000502, WB:WBPaper00001133, WB:WBPaper00001705, WB:WBPerson557]
synonym: "touch insensitive tail" RELATED []
synonym: "touch resistant posterior body" BROAD []
is_a: WBPhenotype:0000456 ! touch resistant

[Term]
id: WBPhenotype:0000317
name: head withdrawal defective
def: "Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0000318
name: cell cycle delayed
def: "Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells." [WB:WBPerson712]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0001995 ! cell cycle progression variant

[Term]
id: WBPhenotype:0000319
name: large
def: "Animals have increased girth and increased length compared to control animals at the same developmental stage." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body size enlarged" EXACT []
is_a: WBPhenotype:0000231 ! body size variant

[Term]
id: WBPhenotype:0000320
name: reduced viability after freezing
def: "Animals show a decrease in survivorship after thawing compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000141 ! stress induced lethality increased

[Term]
id: WBPhenotype:0000321
name: nose morphology variant
def: "Animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "nose morphology abnormal" NARROW []
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0000322
name: nose rounded
def: "The extreme anterior part of the body appears blunted in shape." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000321 ! nose morphology variant

[Term]
id: WBPhenotype:0000323
name: head swollen
def: "The most anterior portion of the animal appears bloated or distended." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0000324
name: short
def: "Animals exhibit a decreased body length compared to control animals of the same developmental stage." [WB:WBPerson712]
is_a: WBPhenotype:0001726 ! body length variant

[Term]
id: WBPhenotype:0000325
name: arecoline hypersensitive
def: "Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001579 ! cholinergic agonist hypersensitive

[Term]
id: WBPhenotype:0000326
name: arecoline resistant
def: "Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001578 ! cholinergic agonist resistant

[Term]
id: WBPhenotype:0000327
name: corpus contraction defect
def: "Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000747 ! pharyngeal contraction defective

[Term]
id: WBPhenotype:0000328
name: terminal bulb contraction variant
def: "Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine." [WB:WBPaper00001696]
synonym: "terminal bulb contraction abnormal" NARROW []
is_a: WBPhenotype:0000980 ! pharyngeal contraction variant

[Term]
id: WBPhenotype:0000329
name: pumping asynchronous
def: "The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously." [WB:WBPaper00001696]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0000330
name: pharyngeal relaxation defective
def: "Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid." [WB:WBPaper00001709]
is_a: WBPhenotype:0001004 ! pharyngeal relaxation variant

[Term]
id: WBPhenotype:0000331
name: inhibitors of na k atpase resistant
def: "Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2021]
synonym: "ouabain resistant" NARROW []
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000332
name: inhibitors of sodium potassium ATPase hypersensitive
def: "Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000333
name: pharyngeal pumps brief
def: "The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0000334
name: isthmus corpus slippery
def: "Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx." [WB:WBPaper00001696]
is_a: WBPhenotype:0000335 ! pharynx slippery

[Term]
id: WBPhenotype:0000335
name: pharynx slippery
def: "Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen." [WB:WBPaper00001696]
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0000336
name: terminal bulb relaxation variant
def: "Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position." [WB:WBPaper00001696]
synonym: "terminal bulb relaxation abnormal" NARROW []
is_a: WBPhenotype:0000330 ! pharyngeal relaxation defective

[Term]
id: WBPhenotype:0000337
name: grinder relaxation defective
def: "Failure of the grinder to come to a full relaxed position between pumps compared to control." [WB:WBPaper00001709]
is_a: WBPhenotype:0001480 ! grinder relaxation variant

[Term]
id: WBPhenotype:0000338
name: tail swelling
def: "Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum." [WB:cab, WB:WBPaper00026735]
synonym: "Dar" BROAD []
synonym: "deformed anal region" RELATED []
is_a: WBPhenotype:0000073 ! tail morphology variant

[Term]
id: WBPhenotype:0000339
name: transient bloating
def: "Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000862 ! bloated

[Term]
id: WBPhenotype:0000340
name: imipramine resistant
def: "Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0001598 ! inhibitor of serotonin uptake variant

[Term]
id: WBPhenotype:0000341
name: imipramine hypersensitive
def: "Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000342
name: bursa morphology variant
def: "Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "bursa morphology abnormal" NARROW []
is_a: WBPhenotype:0000070 ! male tail morphology variant

[Term]
id: WBPhenotype:0000343
name: obsolete cloaca morphology abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000908

[Term]
id: WBPhenotype:0000344
name: cloacal structures protrude
def: "Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000908 ! cloacal morphology variant

[Term]
id: WBPhenotype:0000345
name: VPC cell division variant
def: "Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "VPC cell division abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0000346
name: adult pigmentation variant
def: "Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals." [WB:WBPerson557]
synonym: "adult pigmentation abnormal" NARROW []
is_a: WBPhenotype:0001009 ! developmental pigmentation variant

[Term]
id: WBPhenotype:0000347
name: rectal development variant
def: "Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system." [WB:WBPerson2021, WB:WBPerson557]
synonym: "rectal development abnormal" NARROW []
is_a: WBPhenotype:0000617 ! alimentary system development variant

[Term]
id: WBPhenotype:0000348
name: obsolete muscle activation defective
def: "OBSOLETE." []
is_obsolete: true
consider: WBPhenotype:0001735

[Term]
id: WBPhenotype:0000349
name: flaccid
def: "A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "floppy" RELATED []
synonym: "limp" RELATED []
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0000350
name: hermaphrodite tail spike variant
def: "Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000968 ! tail spike variant

[Term]
id: WBPhenotype:0000351
name: failure to hatch
def: "Animals fail to emerge from an egg shell." [GO:0035188, WB:WBPerson2021]
is_a: WBPhenotype:0000048 ! hatching variant
is_a: WBPhenotype:0000050 ! embryonic lethal

[Term]
id: WBPhenotype:0000352
name: backing uncoordinated
def: "Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion." [WB:WBPaper00001709]
is_a: WBPhenotype:0001005 ! backward locomotion variant

[Term]
id: WBPhenotype:0000353
name: backing increased
def: "Animals spend more time backing compared to control animals." [WB:cab]
is_a: WBPhenotype:0001005 ! backward locomotion variant

[Term]
id: WBPhenotype:0000354
name: cell differentiation variant
def: "Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "cell differentiation abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000355
name: HSN differentiation precocious
def: "Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000354 ! cell differentiation variant
is_a: WBPhenotype:0000439 ! precocious heterochronic variations

[Term]
id: WBPhenotype:0000356
name: spermatogenesis delayed
def: "The progression of immature germ cells to functional sperm is retarded compared to control." [WB:WBPaper00005566, WB:WBPerson2021]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0000357
name: unfertilized oocytes laid
def: "Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm." [WB:WBPaper00001075, WB:WBPerson2021]
is_a: WBPhenotype:0000640 ! egg laying variant

[Term]
id: WBPhenotype:0000358
name: extra cell division postembryonic
def: "Animals execute supernumerary cell divisions post-hatching." [WB:WBPerson2021, WB:WBPerson557]
synonym: "supernumerary cell divisions" RELATED []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000359
name: tunicamycin response variant
def: "Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response." [WB:WBPaper00030877, WB:WBperson557]
synonym: "tunicamycin response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000360
name: cytoplasmic streaming defective
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired." [GO:0099636, WB:WBPaper00050908, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
is_a: WBPhenotype:0002612 ! cytoplasmic streaming phenotype

[Term]
id: WBPhenotype:0000361
name: lima bean arrest
def: "Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "arrest during epiboly" RELATED []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000867 ! embryonic arrest

[Term]
id: WBPhenotype:0000362
name: blastocoel variant
def: "Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "blastocoel abnormal" NARROW []
is_a: WBPhenotype:0000047 ! gastrulation variant

[Term]
id: WBPhenotype:0000363
name: cell division slow
def: "Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0000364
name: gut granule birefringence misplaced
def: "The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen." [WB:WBPaper00025094]
is_a: WBPhenotype:0002240 ! gut granule morphology variant

[Term]
id: WBPhenotype:0000365
name: embryo osmotic integrity defective early emb
def: "Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
synonym: "Eos" BROAD []
is_a: WBPhenotype:0001178 ! egg integrity defective early emb

[Term]
id: WBPhenotype:0000366
name: three fold arrest
def: "Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo." [WB:WBPerson101]
synonym: "active elongation arrest" RELATED []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000779 ! late embryonic arrest

[Term]
id: WBPhenotype:0000367
name: comma arrest emb
def: "Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "end of epiboly arrest" RELATED []
is_a: WBPhenotype:0000864 ! early elongation arrest

[Term]
id: WBPhenotype:0000368
name: one point five fold arrest emb
def: "Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo." [WB:WBPerson101]
synonym: "arrest beginning elongation" RELATED []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000864 ! early elongation arrest

[Term]
id: WBPhenotype:0000369
name: pretzel arrest
def: "Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "end of elongation arrest" RELATED []
is_a: WBPhenotype:0000779 ! late embryonic arrest

[Term]
id: WBPhenotype:0000370
name: egg long
def: "The fertilized oocytes have a greater than standard length measured end to end compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000373 ! egg shape variable

[Term]
id: WBPhenotype:0000371
name: cell division incomplete
def: "The physical partitioning and separation of a cell into daughter cells is interupted." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0000372
name: no polar body formation
def: "Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000775 ! meiosis variant

[Term]
id: WBPhenotype:0000373
name: egg shape variable
def: "The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000037 ! egg morphology variant

[Term]
id: WBPhenotype:0000374
name: early divisions prolonged
def: "The time interval in which early embryonic cell divisions occur is increased compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000375
name: later divisions prolonged
def: "The time interval in which late embryonic cell divisions occur is increased compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000376
name: no uterine cavity
def: "Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000289 ! uterus morphology variant

[Term]
id: WBPhenotype:0000377
name: canal lumen morphology variant
def: "Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "canal lumen morphology abnormal" NARROW []
is_a: WBPhenotype:0000704 ! excretory canal morphology variant

[Term]
id: WBPhenotype:0000378
name: pharyngeal pumping shallow
def: "Pharyngeal muscle contractions show less displacement than that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0000379
name: head notched
def: "The most anterior portion of the animal contains a V-shaped indentation." [WB:WBPaper00000031]
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0000380
name: expulsion infrequent
def: "The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. elegans specialized enteric muscles contract to expel the contents of the gut through the anus." [WB:WBPaper00002315, WB:WBPerson712]
is_a: WBPhenotype:0000996 ! expulsion defective

[Term]
id: WBPhenotype:0000381
name: serotonin reuptake inhibitor resistant
def: "Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000382
name: serotonin reuptake inhibitor hypersensitive
def: "Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000383
name: lipid synthesis defective
def: "The de novo synthesis of any lipid species is reduced compared to that observed in control animals." [WB:WBPerson712]
synonym: "lipid synthesis decreased" RELATED []
is_a: WBPhenotype:0000725 ! lipid metabolism variant

[Term]
id: WBPhenotype:0000384
name: axon guidance variant
def: "Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021]
synonym: "axon guidance abnormal" NARROW []
synonym: "axon pathfinding abnormal" RELATED []
is_a: WBPhenotype:0001224 ! axon outgrowth variant

[Term]
id: WBPhenotype:0000385
name: sperm excess
def: "Animals produce an increased sperm population compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0000386
name: genotoxic chemical induced apoptosis variant
def: "Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals." [WB:WBPaper00032006, WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson712]
synonym: "DNA damage induced apoptosis abnormal" RELATED []
synonym: "genotoxic induced apoptosis abnormal" NARROW []
is_a: WBPhenotype:0002152 ! mutagen induced apoptosis variant

[Term]
id: WBPhenotype:0000387
name: sperm nonmotile
def: "The mature male gametes lack self-propelled movement." [GO:0030317, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000987 ! germ cell physiology variant

[Term]
id: WBPhenotype:0000388
name: sperm morphology variant
def: "Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "sperm morphology abnormal" NARROW []
is_a: WBPhenotype:0000900 ! germ cell morphology variant

[Term]
id: WBPhenotype:0000389
name: hermaphrodite sperm fertilization defective
def: "Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte." [WB:WBPaper00001075, WB:WBPerson2021]
synonym: "Fer" BROAD []
synonym: "Spe" BROAD []
is_a: WBPhenotype:0000694 ! hermaphrodite sterile
is_a: WBPhenotype:0002440 ! sperm fertility defective

[Term]
id: WBPhenotype:0000390
name: spermatid activation defective
def: "Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases." [WB:WBPaper00000884, WB:WBPaper00027300, WB:WBPerson2021]
synonym: "spermiogenesis defective" RELATED []
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0000391
name: defecation missing motor steps
def: "Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000650 ! defecation variant

[Term]
id: WBPhenotype:0000392
name: intestinal fluorescence increased
def: "Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson557]
is_a: WBPhenotype:0000293 ! alimentary system pigmentation variant

[Term]
id: WBPhenotype:0000393
name: cell migration failure
def: "Characteristic movement of cells from one site to another is abolished compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000594 ! cell migration variant

[Term]
id: WBPhenotype:0000394
name: electrophoretic variant protein
def: "Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000112 ! protein expression variant

[Term]
id: WBPhenotype:0000395
name: no differentiated gametes
def: "Animals are agametic (lack mature germ cells)." [WB:WBPerson2021]
is_a: WBPhenotype:0000894 ! germ cell differentiation variant

[Term]
id: WBPhenotype:0000396
name: non reflexed gonad arms
def: "Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern." [WB:WBPaper00005086, WB:WBPaper00029151, WB:WBPerson2021]
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0000397
name: harsh body touch resistant
def: "Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls." [WB:WBPaper00000502]
synonym: "harsh body touch insensitive" RELATED []
is_a: WBPhenotype:0000456 ! touch resistant

[Term]
id: WBPhenotype:0000398
name: light body touch resistant
def: "Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls." [WB:WBPaper00000502]
synonym: "light body touch insensitive" RELATED []
is_a: WBPhenotype:0000456 ! touch resistant

[Term]
id: WBPhenotype:0000399
name: somatic gonad development variant
def: "Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "somatic gonad development abnormal" NARROW []
is_a: WBPhenotype:0000691 ! gonad development variant

[Term]
id: WBPhenotype:0000400
name: somatic gonad primordium development defective
def: "The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0000401
name: no uterus
def: "Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000402
name: avoids bacterial lawn
def: "Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021]
is_a: WBPhenotype:0000659 ! feeding behavior variant
is_a: WBPhenotype:0002545 ! response to bacteria variant

[Term]
id: WBPhenotype:0000403
name: sperm transfer initiation defective
def: "Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control." [WB:WBPaper00028400]
is_a: WBPhenotype:0000284 ! sperm transfer defective

[Term]
id: WBPhenotype:0000404
name: delayed hatching
def: "The emergence of larvae from their protective egg shells is retarded compared to control animals." [GO:0035188, WB:WBPerson2021]
is_a: WBPhenotype:0000048 ! hatching variant
is_a: WBPhenotype:0000438 ! retarded heterochronic variations

[Term]
id: WBPhenotype:0000405
name: giant oocytes
def: "The size of haploid female germ cells (oocytes) are significantly larger compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "oocytes large" RELATED []
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0000406
name: lumpy
def: "Animals have protrusions or bumps on their exterior which are not characteristic of control animals." [WB:WBPerson557]
synonym: "Lpy" BROAD []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0000407
name: obsolete ray loss
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0001509

[Term]
id: WBPhenotype:0000408
name: dauer recovery inhibited
def: "The process through which a dauer larva reverts to normal developmental programs is blocked." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000127 ! dauer recovery variant

[Term]
id: WBPhenotype:0000409
name: organism morphology variable
def: "Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Vab" BROAD []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0000410
name: no defecation cycle
def: "Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000207 ! defecation cycle variant

[Term]
id: WBPhenotype:0000411
name: rod like larval lethal
def: "Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell." [WB:WBPaper00001366, WB:WBPaper00002764, WB:WBPerson2021]
synonym: "Let" RELATED []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000035 ! larval body morphology variant
is_a: WBPhenotype:0000054 ! larval lethal

[Term]
id: WBPhenotype:0000412
name: octanol chemotaxis defective
def: "Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant." [WB:WBPaper00002314]
is_a: WBPhenotype:0001448 ! odorant negative chemotaxis defective
is_a: WBPhenotype:0001452 ! octanol chemotaxis variant

[Term]
id: WBPhenotype:0000413
name: pharyngeal muscle paralyzed
def: "Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation." [WB:cab, WB:WBPerson557]
is_a: WBPhenotype:0000980 ! pharyngeal contraction variant

[Term]
id: WBPhenotype:0000414
name: cell fate transformation
def: "The cell takes on a different identity from which it was initially committed." [GO:0045165, WB:WBPaper00002924, WB:WBPerson712]
is_a: WBPhenotype:0000216 ! cell fate specification variant

[Term]
id: WBPhenotype:0000415
name: necrotic cell death variant
def: "Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control." [GO:0070265, WB:WBPerson712]
synonym: "necrotic cell death abnormal" NARROW []
is_a: WBPhenotype:0000729 ! cell death variant

[Term]
id: WBPhenotype:0000416
name: yolk synthesis variant
def: "Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "vitellogenin synthesis abnormal" RELATED []
synonym: "yolk synthesis abnormal" NARROW []
is_a: WBPhenotype:0001093 ! intestinal physiology variant

[Term]
id: WBPhenotype:0000417
name: cell division failure
def: "The process of physical partitioning and separation of a cell into daughter cells is abolished." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0000418
name: intestinal cell division failure
def: "The physical partitioning and separation of an intestinal cell into daughter cells is abolished." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000417 ! cell division failure

[Term]
id: WBPhenotype:0000419
name: L3 lethal
def: "Animals die at the L3 stage of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000058 ! late larval lethal
is_a: WBPhenotype:0000116 ! mid larval lethal

[Term]
id: WBPhenotype:0000420
name: levamisole hypersensitive
def: "Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist." [WB:WBPerson557]
synonym: "tetramisole hypersensitive" RELATED []
is_a: WBPhenotype:0000845 ! levamisole response variant
is_a: WBPhenotype:0001579 ! cholinergic agonist hypersensitive

[Term]
id: WBPhenotype:0000421
name: levamisole resistant
def: "Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc." [WB:WBPaper00000484, WB:WBPerson2021]
synonym: "Lev R" BROAD []
synonym: "tetramisole resistant" RELATED []
is_a: WBPhenotype:0000845 ! levamisole response variant
is_a: WBPhenotype:0001578 ! cholinergic agonist resistant

[Term]
id: WBPhenotype:0000422
name: twitcher
def: "Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion." [WB:WBPaper00000484]
is_a: WBPhenotype:0001701 ! spastic locomotion

[Term]
id: WBPhenotype:0000423
name: head muscle contraction variant
def: "Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control." [WB:WBPerson557]
synonym: "head muscle contraction abnormal" NARROW []
is_a: WBPhenotype:0000611 ! muscle system physiology variant

[Term]
id: WBPhenotype:0000424
name: antibody staining variant
def: "Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "antibody staining abnormal" NARROW []
is_a: WBPhenotype:0000112 ! protein expression variant

[Term]
id: WBPhenotype:0000425
name: antibody staining reduced
def: "Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000424 ! antibody staining variant

[Term]
id: WBPhenotype:0000426
name: antibody staining increased
def: "Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000424 ! antibody staining variant

[Term]
id: WBPhenotype:0000427
name: no cuticle
def: "Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000201 ! cuticle development variant

[Term]
id: WBPhenotype:0000428
name: no adult cuticle
def: "Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000427 ! no cuticle

[Term]
id: WBPhenotype:0000429
name: copulatory structure development variant
def: "Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "copulatory structure development abnormal" NARROW []
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000430
name: male copulatory structure development variant
def: "Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male copulatory structure development abnormal" NARROW []
is_a: WBPhenotype:0000429 ! copulatory structure development variant

[Term]
id: WBPhenotype:0000431
name: hermaphrodite copulatory structure development variant
def: "Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hermaphrodite copulatory structure development abnormal" NARROW []
is_a: WBPhenotype:0000429 ! copulatory structure development variant

[Term]
id: WBPhenotype:0000432
name: male copulatory structure absent
def: "Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000430 ! male copulatory structure development variant

[Term]
id: WBPhenotype:0000433
name: DNA synthesis variant
def: "Variations in the processes involving the production of new DNA strands compared to control." [GO:0006260, WB:WBPerson2021]
synonym: "DNA synthesis abnormal" NARROW []
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0000434
name: sexual maturation defective
def: "The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired." [GO:0003006, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000435
name: obsolete protein localization abnormal
def: "OBSOLETE. Any change in the subcellular localization of a protein." []
is_obsolete: true
replaced_by: WBPhenotype:0000436

[Term]
id: WBPhenotype:0000436
name: protein subcellular localization variant
alt_id: WBPhenotype:0000435
def: "Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557]
synonym: "protein localization abnormal" EXACT []
synonym: "protein subcellular localization abnormal" NARROW []
is_a: WBPhenotype:0001408 ! pattern protein expression variant

[Term]
id: WBPhenotype:0000437
name: obsolete heterochronic defect
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000033

[Term]
id: WBPhenotype:0000438
name: retarded heterochronic variations
def: "Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control." [GO:0040034, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000033 ! developmental timing variant

[Term]
id: WBPhenotype:0000439
name: precocious heterochronic variations
def: "Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control." [GO:0040034, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000033 ! developmental timing variant

[Term]
id: WBPhenotype:0000440
name: excretory canals long
def: "The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "long excretory canals" RELATED []
is_a: WBPhenotype:0000704 ! excretory canal morphology variant

[Term]
id: WBPhenotype:0000441
name: tail rounded
def: "Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000073 ! tail morphology variant

[Term]
id: WBPhenotype:0000442
name: larval development retarded
def: "The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0000750 ! larval development variant

[Term]
id: WBPhenotype:0000443
name: spicule morphology variant
def: "Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "spicule morphology abnormal" NARROW []
is_a: WBPhenotype:0001024 ! male morphology variant

[Term]
id: WBPhenotype:0000444
name: bursa elongated
def: "The length of the adult male tail, including the lateral fan and rays, is extended compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000342 ! bursa morphology variant

[Term]
id: WBPhenotype:0000445
name: yolk synthesis in males
def: "Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells." [WB:WBPerson2021, WB:WBPerson557]
synonym: "vitellogenin synthesis in males" RELATED []
is_a: WBPhenotype:0000416 ! yolk synthesis variant

[Term]
id: WBPhenotype:0000446
name: supernumerary molt
def: "Animals execute extra larval molts compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0002041 ! molt variant

[Term]
id: WBPhenotype:0000447
name: adult development variant
def: "Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "adult development abnormal" NARROW []
is_a: WBPhenotype:0000049 ! postembryonic development variant

[Term]
id: WBPhenotype:0000448
name: adult cuticle development variant
def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "adult cuticle development abnormal" NARROW []
is_a: WBPhenotype:0000447 ! adult development variant

[Term]
id: WBPhenotype:0000449
name: second adult cuticle
def: "A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells." [WB:WBPaper00001439]
is_a: WBPhenotype:0000448 ! adult cuticle development variant

[Term]
id: WBPhenotype:0000450
name: obsolete swollen male tail
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000506

[Term]
id: WBPhenotype:0000451
name: head protrusion
def: "Any irregular swelling in discrete regions of the head." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0000452
name: tail protrusions
def: "Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000073 ! tail morphology variant

[Term]
id: WBPhenotype:0000453
name: body protrusions
def: "Any irregular swelling in discrete regions of the body region between the head and the tail." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000072 ! body morphology variant

[Term]
id: WBPhenotype:0000454
name: head twisted
def: "The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0000455
name: jerky movement
def: "Animals exhibit abrupt transitions while traveling from one location to another." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001701 ! spastic locomotion

[Term]
id: WBPhenotype:0000456
name: touch resistant
def: "Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals." [WB:WBPerson557]
synonym: "touch insensitive" RELATED []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0000457
name: organism starvation hypersensitive
def: "Animals show enhanced suceptibility to deprivation of nourishment, compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000147 ! organism starvation response variant

[Term]
id: WBPhenotype:0000458
name: starvation resistant
def: "Animals show enhanced tolerance to deprivation of nourishment, compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000147 ! organism starvation response variant

[Term]
id: WBPhenotype:0000459
name: pesticide response variant
def: "Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals." [WB:WBPerson557]
synonym: "pesticide response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000460
name: paraquat response variant
def: "Animals exhibit variations in their response to paraquat compared to that observed in control animals." [WB:WBPerson557]
synonym: "methyl viologen response abnormal" RELATED []
synonym: "paraquat response abnormal" NARROW []
is_a: WBPhenotype:0000459 ! pesticide response variant
is_a: WBPhenotype:0001620 ! organism oxidative stress response variant

[Term]
id: WBPhenotype:0000461
name: paraquat resistant
def: "Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000460 ! paraquat response variant

[Term]
id: WBPhenotype:0000462
name: paraquat hypersensitive
def: "Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
synonym: "reactive oxygen species hypersensitive" BROAD [WB:WBPaper00031296]
is_a: WBPhenotype:0000460 ! paraquat response variant

[Term]
id: WBPhenotype:0000463
name: metabolic pathway variant
def: "Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GO:0008152, WB:WBPerson712]
synonym: "metabolic pathway abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000464
name: oxygen response variant
def: "Animals exhibit variations in their response to oxygen compared to that observed in control animals." [WB:WBPerson557]
synonym: "oxygen response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000465
name: high oxygen resistant
def: "Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0000464 ! oxygen response variant

[Term]
id: WBPhenotype:0000466
name: high oxygen hypersensitive
def: "Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control." [GO:0055093, WB:WBPerson2021]
is_a: WBPhenotype:0000464 ! oxygen response variant

[Term]
id: WBPhenotype:0000467
name: age associated fluorescence increased
def: "Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021]
is_a: WBPhenotype:0001009 ! developmental pigmentation variant

[Term]
id: WBPhenotype:0000468
name: age associated fluorescence reduced
def: "Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0001009 ! developmental pigmentation variant

[Term]
id: WBPhenotype:0000469
name: Q neuroblast lineage migration variant
def: "The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals." [WB:WBPaper00001954, WB:WBPaper00031356, WB:WBPerson712]
synonym: "Q neuroblast lineage migration abnormal" NARROW []
is_a: WBPhenotype:0001140 ! neuron migration variant

[Term]
id: WBPhenotype:0000470
name: HSN migration variant
def: "Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals." [WB:WBPaper00001836, WB:WBPerson2021]
synonym: "HSN migration abnormal" NARROW []
is_a: WBPhenotype:0001229 ! anterior neuron migration defective

[Term]
id: WBPhenotype:0000471
name: ALM migration variant
def: "Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals." [WB:WBPaper00001304, WB:WBPaper00003058, WB:WBPerson2021]
synonym: "ALM migration abnormal" NARROW []
is_a: WBPhenotype:0001520 ! posterior neuron migration variant

[Term]
id: WBPhenotype:0000472
name: endoderm absent
def: "Animals lack the early blast cells that give rise to the gut tissue (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "gutless" EXACT []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000473
name: progressive paralysis
def: "Animals become increasingly sluggish/immobilized as they age." [WB:WBPaper00001709]
is_a: WBPhenotype:0000644 ! paralyzed

[Term]
id: WBPhenotype:0000474
name: muscle attachment variant
def: "Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Mua" BROAD []
synonym: "muscle attachment abnormal" NARROW []
is_a: WBPhenotype:0000622 ! muscle system development variant

[Term]
id: WBPhenotype:0000475
name: muscle detached
def: "Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000474 ! muscle attachment variant

[Term]
id: WBPhenotype:0000476
name: progressive muscle detachment
def: "The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000474 ! muscle attachment variant

[Term]
id: WBPhenotype:0000477
name: nucleolus refraction variant
def: "Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus." [WB:WBPerson2021, WB:WBPerson557]
synonym: "nucleolus refraction abnormal" NARROW []
is_a: WBPhenotype:0000722 ! nucleolus variant

[Term]
id: WBPhenotype:0000478
name: isothermal tracking behavior variant
def: "Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature." [WB:WBPaper00002214]
subset: phenotype_slim_wb
synonym: "isothermal tracking behavior abnormal" NARROW []
synonym: "thermotaxis abnormal" RELATED []
is_a: WBPhenotype:0002513 ! thermotaxis variant

[Term]
id: WBPhenotype:0000479
name: egg pale
def: "Eggs show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000970 ! embryonic pigmentation variant
is_a: WBPhenotype:0001261 ! pale

[Term]
id: WBPhenotype:0000480
name: pyrazine chemotaxis defective
def: "Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant." [WB:WBPaper00001786]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001474 ! pyrazine chemotaxis variant

[Term]
id: WBPhenotype:0000481
name: negative chemotaxis variant
def: "Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals." [GO:0050919, WB:cab]
synonym: "chemical avoidance abnormal" RELATED []
synonym: "chemoaversion abnormal" RELATED []
synonym: "negative chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001434 ! chemotaxis variant

[Term]
id: WBPhenotype:0000482
name: garlic chemotaxis defective
def: "Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent." [WB:WBPaper00001374]
is_a: WBPhenotype:0001449 ! aqueous negative chemotaxis defective
is_a: WBPhenotype:0001451 ! garlic chemotaxis variant

[Term]
id: WBPhenotype:0000483
name: no gut granules
def: "Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000103 ! gut granule development variant

[Term]
id: WBPhenotype:0000484
name: embryo small
def: "The organism's size during the embryonic developmental stage is decreased compared to that observed in control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001136 ! embryonic morphology variant

[Term]
id: WBPhenotype:0000485
name: dauer death increased
def: "The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced." [WB:WBPerson2021, WB:WBPerson557]
synonym: "reduced dauer survival" RELATED []
is_a: WBPhenotype:0002527 ! dauer larva physiology variant

[Term]
id: WBPhenotype:0000486
name: colchicine hypersensitive
def: "Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000487
name: colchicine resistant
def: "Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000488
name: chloroquine hypersensitive
def: "Animals respond to chloroquine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000489
name: chloroquine resistant
def: "Animals fail to respond to the concentration of chloroquine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000490
name: pharynx disorganized
def: "The components of the feeding organ fail to be arranged in the same manner as control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0000491
name: isthmus morphology defective
def: "Any observed morphological defects of the isthmus." [WB:WBPerson2021]
synonym: "isthmus malformed" RELATED []
synonym: "isthmus morphology abnormal" NARROW []
is_a: WBPhenotype:0000709 ! pharyngeal morphology variant

[Term]
id: WBPhenotype:0000492
name: corpus morphology defective
def: "Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas)." [WB:WBPerson2021]
synonym: "corpus malformed" RELATED []
synonym: "corpus morphology abnormal" NARROW []
is_a: WBPhenotype:0000709 ! pharyngeal morphology variant

[Term]
id: WBPhenotype:0000493
name: metacorpus morphology defective
def: "Any variation in the form, structure or composition of the first pharyngeal bulb compared to control." [WB:WBPerson2021]
synonym: "metacarpas malformed" RELATED []
synonym: "metacorpus morphology abnormal" NARROW []
is_a: WBPhenotype:0000709 ! pharyngeal morphology variant

[Term]
id: WBPhenotype:0000494
name: two fold arrest
def: "Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo." [WB:WBPerson101]
is_a: WBPhenotype:0000779 ! late embryonic arrest

[Term]
id: WBPhenotype:0000495
name: ray ectopic
def: "Animals have finger-like sensory sensilla (rays) that are present in places they are normally not found, when compared to the location in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000199 ! male tail sensory ray development variant
is_a: WBPhenotype:0002498 ! ectopic organ

[Term]
id: WBPhenotype:0000496
name: male postdeirid sensilla absent
def: "Males lack the specialized sensory papillae that lie along the posterior half of the body." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001008 ! male nervous system development variant

[Term]
id: WBPhenotype:0000497
name: organism gamma ray response variant
def: "Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism gamma ray response abnormal" NARROW []
is_a: WBPhenotype:0000686 ! organism ionizing radiation response variant

[Term]
id: WBPhenotype:0000498
name: methyl methanesulfonate response variant
def: "Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals." [WB:WBPerson557]
synonym: "methyl methanesulfonate response abnormal" NARROW []
synonym: "MMS response abnormal" RELATED []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000499
name: ethyl methanesulfonate response variant
def: "Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals." [WB:WBPerson557]
synonym: "EMS response abnormal" RELATED []
synonym: "ethyl methanesulfonate response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000500
name: acetylcholinesterase inhibitor hypersensitive
def: "Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive
is_a: WBPhenotype:0001290 ! acetylcholinesterase inhibitor response variant

[Term]
id: WBPhenotype:0000501
name: left handed roller
def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Rol" RELATED []
is_a: WBPhenotype:0000645 ! roller

[Term]
id: WBPhenotype:0000502
name: right handed roller
def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the right-handed direction. In liquid media, wave propogation is helical rather than planar." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Rol" BROAD []
is_a: WBPhenotype:0000645 ! roller

[Term]
id: WBPhenotype:0000503
name: endoreduplication variant
def: "Any variation in the multiple rounds of DNA replication that take place without chromosome condensation, segregation or cytokinesis compared to control. In C. elegans this process is normally seen in intestinal nuclei during each larval lethargus which results in adult intestinal nuclei with 32 copies (32C) of each chromosome(Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "endoreduplication abnormal" NARROW []
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0000504
name: nuclear division variant
def: "Any variation in the process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei, compared to control." [WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
subset: phenotype_slim_wb
synonym: "karyokinesis abnormal" RELATED []
synonym: "nuclear division abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000505
name: male ray morphology variant
def: "Animals exhibit variations in the structure or organization of any of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control animals. In C. elegans, nine bilateral rays project from the tail in a radial pattern with a smooth and slightly tapered appearance. Although one neuronal member of each ray sensillum is exposed to the outside, male rays rarely take up dye." [WB:WBPaper00000932, WB:WBPaper00001328, WB:WBPaper00002149, WB:WBPaper00029016, WB:WBPerson712]
synonym: "male ray morphology abnormal" NARROW []
synonym: "Ram" BROAD []
is_a: WBPhenotype:0000299 ! sensillum morphology variant
is_a: WBPhenotype:0001358 ! male nervous system morphology variant

[Term]
id: WBPhenotype:0000506
name: bursa swollen
def: "The adult male tail, including the lateral fan and rays, appears bloated or distended." [WB:WBPerson2021, WB:WBPerson557]
synonym: "swollen male tail" EXACT []
is_a: WBPhenotype:0000342 ! bursa morphology variant

[Term]
id: WBPhenotype:0000507
name: acetylcholine levels variant
def: "Animals exhibit variations in the amount of acetylcholine compared to control animals at a defined stage. Acetylcholine is the acetic acid ester of the organic base choline." [WB:WBPerson2021, WB:WBPerson557]
synonym: "acetylcholine levels abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000508
name: nonsense mRNA accumulation
def: "Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail." [GO:0070478, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000509
name: sperm pseudopod variant
def: "Variation in the morphological appearance or composition of the pseudopod, a cellular projection that facilitates motility of the spermatozoa." [WB:WBPaper00001075, WB:WBPerson2021]
synonym: "sperm pseudopod abnormal" NARROW []
is_a: WBPhenotype:0000388 ! sperm morphology variant

[Term]
id: WBPhenotype:0000510
name: vulval invagination variant L4
alt_id: WBPhenotype:0000287
def: "The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered." [WB:WBPaper00001738, WB:WBPerson2021]
synonym: "vulval invagination abnormal" NARROW []
synonym: "vulval invagination L4 abnormal" NARROW []
synonym: "vulval invagination L4 variant" RELATED []
is_a: WBPhenotype:0000695 ! vulva morphology variant
is_a: WBPhenotype:0000699 ! vulva development variant

[Term]
id: WBPhenotype:0000511
name: nuclear positioning variant
def: "Variations in the directed movement of the nucleus to a specific location within a cell compared to control." [GO:0007097, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
subset: phenotype_slim_wb
synonym: "nuclear migration variant" RELATED []
synonym: "nuclear positioning abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0000512
name: VNC nuclear positioning variant
def: "Variations in spacing or location were observed between adjacent ventral cord nuclei or between ventral cord nuclei and another nucleus used as a reference point. In C. elegans, these nuclei are distributed equally and predictably, such that they can be unambiguously distinguished by their position." [WB:WBPaper00031891, WB:WBPerson712]
synonym: "VNC nuclear migration variant" RELATED []
synonym: "VNC nuclear positioning abnormal" NARROW []
is_a: WBPhenotype:0000511 ! nuclear positioning variant

[Term]
id: WBPhenotype:0000513
name: obsolete touch response abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000315

[Term]
id: WBPhenotype:0000514
name: rubber band
def: "When prodded on the head, worm contracts and then relaxes along its entire body without moving backwards, compared to a control worm which contracts its anterior end and backs away in response to prodding." [WB:WBPaper00006135, WB:WBPerson2021]
synonym: "Rbr" BROAD []
synonym: "rubberband" EXACT []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0000515
name: ventral nerve cord development variant
def: "Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord." [WB:WBPerson557]
synonym: "ventral nerve cord development abnormal" NARROW []
is_a: WBPhenotype:0000945 ! neuropil development variant

[Term]
id: WBPhenotype:0000516
name: ventral cord disorganized
def: "The longitudinal nerve cord of the midbody region, connecting the nerve ring and tail ganglia, is not arranged in the same manner as control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000976 ! ventral cord patterning variant

[Term]
id: WBPhenotype:0000517
name: behavior phenotype
def: "Variations in the specific actions or reactions in response to external or internal stimuli compared to that observed in control animals." [GO:0007610, WB:WBPerson557]
synonym: "behavior abnormal" EXACT []
synonym: "behavior variant" EXACT []
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0000518
name: development phenotype
def: "Variations in the progression of an integrated living unit (a cell, tissue, organ or organism) over time from an initial condition to a later condition compared to control animals." [GO:0032502, WB:WBPerson2021]
synonym: "development abnormal" EXACT []
synonym: "development variant" EXACT []
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0000519
name: physiology phenotype
def: "Animals exhibit variations in any physical or chemical process required for the cell, tissue, organ system or organism to carry out its normal functions and activities or be able to perceive and respond to stimuli compared to control animals." [WB:WBPerson712]
synonym: "physiology abnormal" EXACT []
synonym: "physiology variant" EXACT []
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0000520
name: morphology phenotype
def: "Animals exhibit variations in the form, structure or composition of any of its parts compared to control animals." [WB:WBPerson712]
synonym: "morphology abnormal" EXACT []
synonym: "morphology variant" EXACT []
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0000521
name: pigmentation phenotype
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "pigmentation abnormal" EXACT []
synonym: "pigmentation variant" EXACT []
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0000522
name: organism region behavior variant
def: "Variations in the specific actions or reactions of a certain defined body area of an animal in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "organism region behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000523
name: chemical response variant
def: "Animals exhibit variations in their response to a specific chemical compared to that observed in control animals." [WB:WBPerson557]
synonym: "chemical response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000524
name: bleach response variant
def: "Animals exhibit variations in their response to bleach compared to that observed in control animals." [WB:WBPerson557]
synonym: "bleach response abnormal" NARROW []
is_a: WBPhenotype:0001379 ! organism toxic chemical response variant

[Term]
id: WBPhenotype:0000525
name: organism behavior variant
def: "Variations in the specific actions or reactions of an organism in response to external or internal stimuli compared to that observed in control organisms." [GO:0007610, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "organism behavior abnormal" NARROW []
is_a: WBPhenotype:0000517 ! behavior phenotype

[Term]
id: WBPhenotype:0000526
name: cell pigmentation phenotype
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a cell." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "cell pigmentation abnormal" EXACT []
synonym: "cell pigmentation variant" EXACT []
is_a: WBPhenotype:0000521 ! pigmentation phenotype

[Term]
id: WBPhenotype:0000527
name: organism pigmentation phenotype
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "Abnormal Coloration" RELATED []
synonym: "organism pigmentation abnormal" EXACT []
synonym: "organism pigmentation variant" EXACT []
is_a: WBPhenotype:0000521 ! pigmentation phenotype

[Term]
id: WBPhenotype:0000528
name: body region development variant
def: "Variations in the progression of the overall structure or appearance of a discrete region of an animal's anatomy over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body region development abnormal" NARROW []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000529
name: cell development variant
def: "Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals." [GO:0048468, WB:cab]
subset: phenotype_slim_wb
synonym: "cell development abnormal" NARROW []
is_a: WBPhenotype:0000518 ! development phenotype

[Term]
id: WBPhenotype:0000530
name: organ system development variant
def: "Any variation in the progression of an organismal system from its formation to the mature structure when compared to control animals." [GO:0048731, WB:cab]
subset: phenotype_slim_wb
synonym: "organ system development abnormal" NARROW []
is_a: WBPhenotype:0000518 ! development phenotype

[Term]
id: WBPhenotype:0000531
name: organism development variant
def: "Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab]
subset: phenotype_slim_wb
synonym: "organism development abnormal" NARROW []
is_a: WBPhenotype:0000518 ! development phenotype

[Term]
id: WBPhenotype:0000532
name: body region morphology variant
def: "Animals exhibit variations in the form, structure or composition of a discrete region of their anatomy compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body region morphology abnormal" NARROW []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0000533
name: cell morphology variant
def: "Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GO:0005623, WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000520 ! morphology phenotype

[Term]
id: WBPhenotype:0000534
name: organ system morphology variant
def: "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that comprise a specific organ system." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "organ system morphology abnormal" NARROW []
is_a: WBPhenotype:0000520 ! morphology phenotype

[Term]
id: WBPhenotype:0000535
name: organism morphology variant
def: "Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
subset: phenotype_slim_wb
synonym: "Bmd" BROAD []
synonym: "body morphology defects" RELATED []
synonym: "organism morphology abnormal" NARROW []
is_a: WBPhenotype:0000520 ! morphology phenotype

[Term]
id: WBPhenotype:0000536
name: cell physiology phenotype
def: "Animals exhibit variations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for the cell to carry out its normal functions or be able to perceive and respond to stimuli, compared to control animals." [GO:0009987]
subset: phenotype_slim_wb
synonym: "cell physiology abnormal" EXACT []
synonym: "cell physiology variant" EXACT []
is_a: WBPhenotype:0000519 ! physiology phenotype

[Term]
id: WBPhenotype:0000537
name: obsolete synaptic input abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000584

[Term]
id: WBPhenotype:0000538
name: obsolete synaptic output abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000584

[Term]
id: WBPhenotype:0000539
name: dorsal nerve cord development variant
def: "Variations in the progression of the anatomical structures that consist of processes of ventral cord motor neurons that send commissures to the dorsal side, as well as processes of certain head and tail neurons, over time from initial formation to mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dorsal nerve cord development abnormal" NARROW []
is_a: WBPhenotype:0000945 ! neuropil development variant

[Term]
id: WBPhenotype:0000540
name: muscle arm development variant
def: "Variations in the progression of the process extension from the muscle belly by which the muscle cells reach to the nerve cords to obtain innervation over time from initial formation to mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712]
synonym: "muscle arm development abnormal" NARROW []
synonym: "muscle arm extension variant" RELATED []
is_a: WBPhenotype:0000087 ! body wall cell development variant

[Term]
id: WBPhenotype:0000541
name: cord commissures fail to reach target
def: "Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords." [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712]
is_a: WBPhenotype:0000014 ! cord commissures variant

[Term]
id: WBPhenotype:0000542
name: fat
def: "Animals exhibit an increased girth compared to a control animal of the same developmental stage." [WB:WBPerson2021, WB:WBPerson557]
synonym: "increased girth" RELATED []
synonym: "thick" RELATED []
is_a: WBPhenotype:0001727 ! body width variant

[Term]
id: WBPhenotype:0000543
name: forward kinker
def: "Forward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves forward with uncharacteristic loss of smooth sinusoidal motion or body posture (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000002 ! kinker

[Term]
id: WBPhenotype:0000544
name: backward kinker
def: "Backward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves backward with uncharacteristic loss of smooth sinusoidal motion or body posture (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000002 ! kinker

[Term]
id: WBPhenotype:0000545
name: egg retention
def: "Eggs are retained in the uterus at a later stage when compared with control animals." [WB:cab]
synonym: "late eggs laid" RELATED []
synonym: "Ret" BROAD []
is_a: WBPhenotype:0000006 ! egg laying defective

[Term]
id: WBPhenotype:0000546
name: early eggs laid
def: "Eggs are laid at an earlier stage of development when compared with control animals." [WB:cab]
is_a: WBPhenotype:0000005 ! hyperactive egg laying
is_a: WBPhenotype:0000439 ! precocious heterochronic variations

[Term]
id: WBPhenotype:0000547
name: starved
def: "Animals exhibit morphological characteristics that are the outcome of nutrient deprivation. In C. elegans, starved worms have fewer refractile granules in intestinal cells, making them appear pale. Strongly starved mutants are small and thin, and tend to retain fewer eggs than control animals." [WB:WBPaper00001709, WB:WBPerson2021]
synonym: "Eat" RELATED []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000548
name: muscle dystrophy
def: "Progressive degeneration of muscle." [WB:cab]
is_a: WBPhenotype:0000611 ! muscle system physiology variant

[Term]
id: WBPhenotype:0000549
name: head muscle dystrophy
def: "Progressive degeneration of the head muscle." [WB:cab]
is_a: WBPhenotype:0000548 ! muscle dystrophy
is_a: WBPhenotype:0001002 ! head muscle behavior variant

[Term]
id: WBPhenotype:0000550
name: body muscle dystrophy
def: "Progressive degeneration of muscle along the body wall." [WB:cab]
synonym: "body wall muscle dystrophy" RELATED []
is_a: WBPhenotype:0000548 ! muscle dystrophy
is_a: WBPhenotype:0000596 ! body behavior variant

[Term]
id: WBPhenotype:0000551
name: omega turns variant
def: "Animals exhibit variations in the rate of sharp head to tail turns compared to control animals." [WB:WBPaper00000075, WB:WBPaper00006375, WB:WBPerson712]
synonym: "omega turns abnormal" NARROW []
is_a: WBPhenotype:0002311 ! turning variant

[Term]
id: WBPhenotype:0000552
name: GABA levels variant
def: "Animals exhibit variations in the amount of GABA compared to control animals at a defined stage." [WB:WBPerson2021, WB:WBPerson557]
synonym: "GABA levels abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000553
name: muscle birefringence variant
alt_id: WBPhenotype:0000714
def: "Animals exhibit a weak and abnormal birefringency pattern in muscle fibers when examined using polarized optics." [WB:WBPerson557]
comment: Disorganized muscle fibers display a weak and abnormal birefringency pattern when examined using polarized optics.
synonym: "Dim" EXACT []
synonym: "disorganized muscle" EXACT []
synonym: "muscle birefringence abnormal" RELATED []
is_a: WBPhenotype:0000926 ! body wall muscle morphology variant

[Term]
id: WBPhenotype:0000554
name: hypoosmotic shock hypersensitive
def: "Any variation in the ability to adjust to a decline in ambient solute concentrations, thereby causing the body to swell and explode." [WB:WBPaper00000484, WB:WBPerson2021]
is_a: WBPhenotype:0000041 ! osmotic integrity variant

[Term]
id: WBPhenotype:0000555
name: drug adaptation variant
def: "Animals show variations in their decreased responsiveness after prolonged or repeated exposure to a drug compared to that in control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "drug adaptation abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000556
name: dopamine adaptation variant
def: "Animals show variations in their decreased responsiveness after prolonged or repeated exposure to dopamine compared to that in control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dopamine adaptation abnormal" NARROW []
is_a: WBPhenotype:0000555 ! drug adaptation variant

[Term]
id: WBPhenotype:0000557
name: dopamine adaptation defective
def: "Animals do not exhibit decreased responsiveness after prolonged or repeated exposure to dopamine." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000556 ! dopamine adaptation variant

[Term]
id: WBPhenotype:0000558
name: calcium channel modulator response variant
def: "Animals exhibit variations in their response to specific calcium channel modulators compared to that observed in control animals." [WB:WBPerson557]
synonym: "calcium channel modulator response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant
is_a: WBPhenotype:0001833 ! membrane trafficking variant
is_a: WBPhenotype:0002170 ! calcium mediated signaling variant

[Term]
id: WBPhenotype:0000559
name: calcium channel modulator hypersensitive
def: "Animals respond to a calcium channel modulator at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive
is_a: WBPhenotype:0000558 ! calcium channel modulator response variant

[Term]
id: WBPhenotype:0000560
name: calcium channel modulator resistant
def: "Animals fail to respond to the concentration of calcium channel modulators that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0000558 ! calcium channel modulator response variant

[Term]
id: WBPhenotype:0000561
name: head levamisole resistant
def: "The heads of animals fail to respond to the concentration of levamisole that elicits a response in control animals. In C. elegans, heads contract at >10uM for intact animals and >1uM for cut animals." [WB:WBPaper00000484]
synonym: "head tetramisole resistant" RELATED []
is_a: WBPhenotype:0000421 ! levamisole resistant

[Term]
id: WBPhenotype:0000562
name: body levamisole resistant
def: "The bodies of animals fail to respond to the concentration of levamisole that elicits a response in control animals." [WB:WBPaper00000484]
synonym: "body tetramisole resistant" RELATED []
is_a: WBPhenotype:0000421 ! levamisole resistant

[Term]
id: WBPhenotype:0000563
name: shrinker
def: "The whole body undergoes longitudinal shortening in response to head touch or tail touch (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001701 ! spastic locomotion

[Term]
id: WBPhenotype:0000564
name: echo defecation cycle
def: "Muscle contractions that make up the defecation motor program are repeated before the onset of the next cycle unlike in control animals." [WB:WBPaper00002305, WB:WBPaper00003765, WB:WBPerson712]
is_a: WBPhenotype:0000207 ! defecation cycle variant

[Term]
id: WBPhenotype:0000565
name: coiler
def: "The body of an animal assumes a coil-like shape when it attempts to move." [WB:WBPerson363]
synonym: "curler" RELATED []
is_a: WBPhenotype:0002297 ! coiling variant
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0000566
name: ventral coiler
def: "A coiling body that bends ventrally." [WB:WBPerson363]
synonym: "ventral curler" RELATED []
is_a: WBPhenotype:0000565 ! coiler

[Term]
id: WBPhenotype:0000567
name: dorsal coiler
def: "A coiling body that bends dorsally." [WB:WBperson363]
synonym: "dorsal curler" RELATED []
is_a: WBPhenotype:0000565 ! coiler

[Term]
id: WBPhenotype:0000568
name: axon ultrastructure variant
def: "Animals display variations in the structure or organization of the components of the axon, compared to that observed in control animals." [WB:WBPaper00001499, WB:WBPerson712]
synonym: "axon ultrastructure abnormal" NARROW []
is_a: WBPhenotype:0000180 ! axon morphology variant

[Term]
id: WBPhenotype:0000569
name: axon varicosities
def: "Animals display markedly swollen areas along their axons, which are larger than synaptic varicosities in control animals." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712]
is_a: WBPhenotype:0000568 ! axon ultrastructure variant

[Term]
id: WBPhenotype:0000570
name: axon cisternae
def: "Axons of animals contain flattened membrane-bound compartments. In C. elegans, these cisternae-like structures are typically absent." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712]
is_a: WBPhenotype:0000568 ! axon ultrastructure variant

[Term]
id: WBPhenotype:0000571
name: axon vesicle variant
def: "Axons of animals exhibit variations in the gross structure or organization of its spherical, membrane-bound, fluid-filled organelles, compared to that observed in control animals." [WB:WBPaper00001499, WB:WBPerson712]
synonym: "abnormal axon vesicle" NARROW []
is_a: WBPhenotype:0000568 ! axon ultrastructure variant

[Term]
id: WBPhenotype:0000572
name: neuronal outgrowth variant
def: "Any variation in the processes that govern the extension of neuronal projections." [WB:WBPerson2021]
synonym: "neuronal outgrowth abnormal" NARROW []
is_a: WBPhenotype:0000816 ! neuron development variant

[Term]
id: WBPhenotype:0000573
name: obsolete neuronal branching variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "neuronal branching abnormal" NARROW []
is_obsolete: true
consider: WBPhenotype:0000633
consider: WBPhenotype:0001398

[Term]
id: WBPhenotype:0000574
name: excretory canal short
def: "The structure made by the processes of the excretory canal cell is reduced in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000704 ! excretory canal morphology variant

[Term]
id: WBPhenotype:0000575
name: organ system physiology phenotype
def: "Animals exhibit variations in a physical or chemical process required for organs or tissues to carry out their normal functions or for their ability to perceive and respond to stimuli compared to control." [GO:0003008]
subset: phenotype_slim_wb
synonym: "organ system physiology abnormal" EXACT []
synonym: "organ system physiology variant" EXACT []
is_a: WBPhenotype:0000519 ! physiology phenotype

[Term]
id: WBPhenotype:0000576
name: organism physiology phenotype
def: "Animals exhibit variations in any physical or chemical process required for the organism to carry out its normal function or be able to perceive and respond to stimuli." [WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "organism physiology abnormal" EXACT []
synonym: "organism physiology variant" EXACT []
is_a: WBPhenotype:0000519 ! physiology phenotype

[Term]
id: WBPhenotype:0000577
name: organism homeostasis metabolism variant
def: "Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the organism compared to control." [GO:0048871, WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "organism homeostasis metabolism abnormal" NARROW []
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0000578
name: body axis development variant
def: "Variations in the progression of a discrete axis of an animal's anatomy over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body axis development abnormal" NARROW []
is_a: WBPhenotype:0000528 ! body region development variant

[Term]
id: WBPhenotype:0000579
name: organism segment development variant
def: "Variations in the progression of the overall structure or appearance of any anterior/posterior section of an animal's anatomy over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "organism segment development abnormal" NARROW []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000580
name: organism segment behavior variant
def: "Variations in the specific actions or reactions of a certain body region of an animal in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "organism segment behavior abnormal" NARROW []
is_a: WBPhenotype:0000522 ! organism region behavior variant

[Term]
id: WBPhenotype:0000581
name: body axis morphology variant
def: "Animals exhibit variations in the form, structure or composition of a discrete axis (dorsal/ventral/anterior/posterior/transverse) of their anatomy, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body axis morphology abnormal" NARROW []
is_a: WBPhenotype:0000532 ! body region morphology variant

[Term]
id: WBPhenotype:0000582
name: organism segment morphology variant
def: "Animals exhibit variations in the form, structure or composition of any anterior/posterior section of their anatomy compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "organism segment morphology abnormal" NARROW []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0000583
name: dumpy
def: "Worms are shorter and stouter than control animals at the same developmental stage." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497]
synonym: "Dpy" BROAD []
is_a: WBPhenotype:0001726 ! body length variant
is_a: WBPhenotype:0001727 ! body width variant

[Term]
id: WBPhenotype:0000584
name: synaptic transmission variant
alt_id: WBPhenotype:0000537
alt_id: WBPhenotype:0000538
def: "Any variation in the process of communication across a synapse between a neuron and a target cell (neuron, muscle, or secretory cell) compared to control animals." [GO:0007268, WB:cab]
synonym: "synaptic input abnormal" NARROW []
synonym: "synaptic input variant" EXACT []
synonym: "synaptic output abnormal" NARROW []
synonym: "synaptic output variant" EXACT []
synonym: "synaptic transmission abnormal" NARROW []
is_a: WBPhenotype:0002020 ! transmission of nerve impulse variant

[Term]
id: WBPhenotype:0000585
name: cell homeostasis metabolism variant
def: "Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the cell compared to control." [GO:0019725, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "cell homeostasis metabolism abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000586
name: bleach hypersensitive
def: "Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000524 ! bleach response variant

[Term]
id: WBPhenotype:0000587
name: obsolete lectin staining variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "lectin staining abnormal" NARROW []
is_obsolete: true
consider: WBPhenotype:0002072

[Term]
id: WBPhenotype:0000588
name: obsolete no male variantity scored
def: "OBSOLETE." [WB:WBPerson557]
comment: This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype.
synonym: "no male abnormal" NARROW []
is_obsolete: true

[Term]
id: WBPhenotype:0000589
name: obsolete no hermaphrodite variantity scored
def: "OBSOLETE." [WB:WBPerson557]
comment: This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype.
synonym: "no hermaphrodite abnormal" NARROW []
is_obsolete: true

[Term]
id: WBPhenotype:0000590
name: cell corpse number variant
def: "Animals exhibit differences in the number of cell corpses compared to controls at the same developmental life stage." [WB:WBPerson712]
synonym: "cell corpse number abnormal" NARROW []
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0000591
name: metal response variant
def: "Animals exhibit variations in their response to a specific metal compared to that observed in control animals." [WB:WBPerson557]
synonym: "metal response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000592
name: copper response variant
def: "Animals exhibit variations in their response to copper compared to that observed in control animals." [WB:WBPerson557]
synonym: "copper response abnormal" NARROW []
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0000593
name: copper hypersensitive
def: "Animals respond to copper at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000592 ! copper response variant

[Term]
id: WBPhenotype:0000594
name: cell migration variant
def: "Any variation in the orderly movement of a cell from one site to another." [GO:0016477, WB:cab]
subset: phenotype_slim_wb
synonym: "cell migration abnormal" NARROW []
synonym: "Mig" BROAD []
synonym: "migration of cells abnormal" RELATED []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000595
name: head behavior variant
def: "Variations in the specific actions or reactions of the head in response to external or internal stimuli compared to that observed in control animals." [WB:cab, WB:WBPerson2021, WB:WBPerson557]
synonym: "head behavior abnormal" NARROW []
is_a: WBPhenotype:0000580 ! organism segment behavior variant

[Term]
id: WBPhenotype:0000596
name: body behavior variant
def: "Activity characteristic of the body is altered compared to control." [WB:cab]
synonym: "body behavior abnormal" NARROW []
is_a: WBPhenotype:0000580 ! organism segment behavior variant

[Term]
id: WBPhenotype:0000597
name: tail behavior variant
def: "Variations in the specific actions or reactions of the tail in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "tail behavior abnormal" NARROW []
is_a: WBPhenotype:0000580 ! organism segment behavior variant

[Term]
id: WBPhenotype:0000598
name: alimentary system morphology variant
def: "Variations in the form, structure or composition of the series of related tissues lying within the body cavity and devoted to feeding and digestion compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "alimentary system morphology abnormal" NARROW []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000599
name: coelomic system morphology variant
def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the coelomic system, compared to control. The coelom is the fluid compartment that is in contact with internal organ." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "coelomic system morphology abnormal" NARROW []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000600
name: epithelial system morphology variant
def: "Variations in the form, composition or structure of the epithelial system that serves to protect the organism from the external environment compared to control." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "epithelial system morphology abnormal" NARROW []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000601
name: excretory secretory system morphology variant
alt_id: WBPhenotype:0000602
def: "Variations in the form, structure or composition of related tissues that allow the animal to secrete saline fluid and maintain a proper salt balance compared to control. In C. elegans, four cell types (1 pore cell, 1 duct cell, 1 canal cell and a fused pair of gland cells) make up the excretory system (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "excretory secretory system morphology abnormal" NARROW []
synonym: "excretory system morphology abnormal" NARROW []
synonym: "excretory system morphology variant" EXACT []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000602
name: obsolete excretory system morphology abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000601

[Term]
id: WBPhenotype:0000603
name: muscle system morphology variant
def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the muscle system, compared to control. The muscle system consists of tissues made up of various elongated cells that are specialized to contract and produce movement and mechanical work." [GO:0007517, WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "muscle system morphology abnormal" NARROW []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000604
name: nervous system morphology variant
def: "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson712]
comment: WB:WBbt:0005735.
subset: phenotype_slim_wb
synonym: "nervous system morphology abnormal" NARROW []
synonym: "neuroanatomical defective" RELATED []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000605
name: reproductive system morphology variant
def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "reproductive system morphology abnormal" NARROW []
is_a: WBPhenotype:0000534 ! organ system morphology variant

[Term]
id: WBPhenotype:0000606
name: alimentary system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the alimentary system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "alimentary system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000607
name: coelomic system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the coelomic system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "coelomic system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000608
name: epithelial system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the epithelial system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "epithelial system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000609
name: excretory secretory system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the excretory/secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "excretory secretory system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000610
name: excretory system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "excretory system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000611
name: muscle system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "muscle system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000612
name: nervous system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the nervous system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "nervous system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000613
name: reproductive system physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the reproductive system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "reproductive system physiology abnormal" NARROW []
is_a: WBPhenotype:0000575 ! organ system physiology phenotype

[Term]
id: WBPhenotype:0000614
name: GLR development variant
def: "Any variation in the progression of the GLR accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "GLR development abnormal" NARROW []
is_a: WBPhenotype:0000942 ! accessory cell development variant

[Term]
id: WBPhenotype:0000615
name: cilia morphology variant
def: "Animals exhibit variations in the structure or organization of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. In C. elegans, cilia are classified as channel cilia or wing cilia depending on their placement within the sensillum. Channel cilia of control animals are cylindrical, extend into the sensillum pore and are exposed to the outside. Wing cilia of control animals vary in shape, are embedded in the sensillum sheath cell and are not typically refractory to dyes indicating exposure to the outside." [WB:WBPaper00000214, WB:WBPaper00000932, WB:WBPerson712]
synonym: "cilia morphology abnormal" NARROW []
synonym: "defective dye filling of cilia" RELATED []
is_a: WBPhenotype:0001526 ! ciliated neuron morphology variant

[Term]
id: WBPhenotype:0000616
name: synapse morphology variant
def: "Animals display variations in the appearance of the subcellular junctional structure composed of a presynaptic terminal directly opposite the post-synaptic target and separated by a synaptic cleft." [GO:0045202, WB:WBPaper00027305, WB:WBPerson712]
synonym: "synapse morphology abnormal" NARROW []
is_a: WBPhenotype:0000604 ! nervous system morphology variant

[Term]
id: WBPhenotype:0000617
name: alimentary system development variant
def: "Any variation in the progression of the alimentary system over time, from its formation to its mature state compared to control. The alimentary system includes all the body structures involved in preparing food for absorption into the body and excretion of waste products." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "alimentary system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000618
name: coelomic system development variant
def: "Any variation in the progression of the coelomic system over time, from its formation to its mature state compared to control." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "coelomic system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000619
name: epithelial system development variant
def: "Any variation in the progression of the epithelial system over time, from its formation to its mature state compared to control." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "epithelial system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000620
name: excretory secretory system development variant
def: "Any variation in the progression of the excretory secretory system over time, from its formation to its mature state compared to control. The excretory secretory system consists of the excretory system and its associated glands." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "excretory secretory system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000621
name: excretory system development variant
def: "Variations in the progression of the excretory system over time, from its formation to the mature structure. The excretory system is required for the elimination of metabolic waste. In C. elegans, the excretory system is comprised of the excretory cell, excretory duct cell and excretory socket cell." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "excretory system development abnormal" NARROW []
is_a: WBPhenotype:0000620 ! excretory secretory system development variant

[Term]
id: WBPhenotype:0000622
name: muscle system development variant
def: "Any variation in the progression of the muscle system over time, from its formation to its mature state compared to control." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "muscle system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000623
name: nervous system development variant
def: "Any variation in the progression of nervous tissue over time, from its formation to its mature state compared to control." [GO:0007399, WB:cab]
subset: phenotype_slim_wb
synonym: "nervous system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000624
name: reproductive system development variant
def: "Any variation in the progression of the reproductive system over time, from its formation to its mature state compared to control." [WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "reproductive defect" RELATED []
synonym: "reproductive system development abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0000625
name: synaptogenesis variant
def: "Any variation in the biosynthesis of a synapse compared to control." [GO:0007416, WB:cab]
synonym: "synapse development variant" EXACT [WB:WBPerson712]
synonym: "synaptogenesis abnormal" NARROW []
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0000626
name: habituation variant
def: "Any variation in the decrease in a behavioral response to a repeated stimulus compared to control." [GO:0046959, WB:cab]
subset: phenotype_slim_wb
synonym: "habituation abnormal" NARROW []
synonym: "non associative learning variant" RELATED []
is_a: WBPhenotype:0000525 ! organism behavior variant
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0000627
name: anesthetic response variant
def: "Animals exhibit variations in their response to a specific anesthetic compared to that observed in control animals." [WB:WBPerson557]
synonym: "anaesthetic response variant" EXACT []
synonym: "anesthetic response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000628
name: spindle assembly defective early emb
def: "Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GO:0051225, WB:cab, WB:cgc7141, WB:WBPerson2021]
comment: Possible XP.
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb
is_a: WBPhenotype:0002415 ! spindle assembly defective

[Term]
id: WBPhenotype:0000629
name: excess neurite outgrowth
def: "Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated." [WB:WBPerson2021]
is_a: WBPhenotype:0000572 ! neuronal outgrowth variant

[Term]
id: WBPhenotype:0000630
name: quinine chemotaxis defective
def: "Failure to execute the characteristic response to the bitter tastant quinine, as defined by control animals. In C. elegans, quinine is typically repellent." [WB:WBPaper00006481, WB:WBPaper00035961, WB:WBPerson712]
is_a: WBPhenotype:0001449 ! aqueous negative chemotaxis defective
is_a: WBPhenotype:0001454 ! quinine chemotaxis variant

[Term]
id: WBPhenotype:0000631
name: drug response variant
def: "Any variation in the characteristic response(s) to drug(s) as defined by control animals." [WB:cab]
synonym: "drug response abnormal" RELATED []
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0000632
name: axon fasciculation variant
def: "The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised." [GO:0007413, WB:WBPerson2021, WB:WBPerson557]
synonym: "axon fasciculation abnormal" NARROW []
is_a: WBPhenotype:0000880 ! axon development variant

[Term]
id: WBPhenotype:0000633
name: axon branching variant
def: "Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals." [GO:0048755, WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712]
synonym: "axon branching abnormal" NARROW []
is_a: WBPhenotype:0000180 ! axon morphology variant
is_a: WBPhenotype:0001224 ! axon outgrowth variant

[Term]
id: WBPhenotype:0000634
name: pharyngeal pumping variant
def: "Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to control." [GO:0043050, WB:cab]
subset: phenotype_slim_wb
synonym: "pharyngeal pumping abnormal" NARROW []
is_a: WBPhenotype:0002056 ! eating variant

[Term]
id: WBPhenotype:0000635
name: positive chemotaxis variant
def: "Any variation in the directed movement of an animal in response to chemical attractants as defined by control animals." [GO:0050918, WB:cab, WB:cgc122, WB:cgc387]
synonym: "positive chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001434 ! chemotaxis variant

[Term]
id: WBPhenotype:0000636
name: neuron degeneration variant
def: "Any variation in the ability of neurons to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles under conditions that ellicit this response in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "neuron degeneration abnormal" NARROW []
is_a: WBPhenotype:0000612 ! nervous system physiology variant

[Term]
id: WBPhenotype:0000637
name: dauer formation variant
def: "Characteristic entry into the dauer stage is altered compared to control animals." [WB:cab]
synonym: "Daf" BROAD []
synonym: "dauer formation abnormal" NARROW []
is_a: WBPhenotype:0000308 ! dauer development phenotype

[Term]
id: WBPhenotype:0000638
name: molt defect
def: "Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage." [GO:0018996, WB:WBPerson712]
synonym: "Mlt" BROAD []
synonym: "Mult" BROAD []
is_a: WBPhenotype:0002041 ! molt variant

[Term]
id: WBPhenotype:0000639
name: temperature induced dauer formation variant
def: "Animals exhibit variations in the entry into the dauer stage when exposed to temperatures that induce dauer formation in control animals. In C. elegans, many Daf-c animals enter dauer at 25C, whereas Hid animals enter dauer at 27C." [WB:WBPaper00006103, WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712]
synonym: "Hid" RELATED []
synonym: "temperature induced dauer formation abnormal" NARROW []
is_a: WBPhenotype:0000146 ! organism temperature response variant
is_a: WBPhenotype:0001539 ! dauer induction variant

[Term]
id: WBPhenotype:0000640
name: egg laying variant
def: "Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control." [pmid:11813735, pmid:9697864, WB:cab]
comment: Visual inspection.
subset: phenotype_slim_wb
synonym: "egg laying abnormal" NARROW []
synonym: "Egl" BROAD []
synonym: "oviposition abnormal" RELATED [GO:0018991]
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000641
name: activity level variant
def: "Any variation in the degree of movement compared to control animals." [WB:cab]
synonym: "activity level abnormal" NARROW []
is_a: WBPhenotype:0000643 ! locomotion variant

[Term]
id: WBPhenotype:0000642
name: hyperactive
def: "Worms move forward or backward with an increased rate of body bends per minute compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00006395]
synonym: "Hya" BROAD []
is_a: WBPhenotype:0000641 ! activity level variant

[Term]
id: WBPhenotype:0000643
name: locomotion variant
def: "Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "locomotion abnormal" NARROW []
synonym: "movement defect" RELATED []
synonym: "Unc" BROAD []
synonym: "uncoordinated" RELATED []
is_a: WBPhenotype:0001206 ! movement variant

[Term]
id: WBPhenotype:0000644
name: paralyzed
def: "Animals do not move and are not responsive to external mechanical stimulation." [WB:cab]
subset: phenotype_slim_wb
synonym: "Prl" BROAD []
synonym: "Prz" RELATED []
is_a: WBPhenotype:0001213 ! locomotion reduced

[Term]
id: WBPhenotype:0000645
name: roller
def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern. In liquid media, wave propogation is helical rather than planar." [WB:cab, WB:cgc31]
synonym: "Rol" BROAD []
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0000646
name: sluggish
def: "Animals move more slowly compared with control animals." [WB:cab]
synonym: "lethargic" RELATED []
synonym: "slow" RELATED []
synonym: "Slu" BROAD []
is_a: WBPhenotype:0001213 ! locomotion reduced

[Term]
id: WBPhenotype:0000647
name: copulation variant
def: "Animals exhibit variations in any processes that lead to the successful transfer of sperm from one organism to another." [GO:0007620, WB:cab]
subset: phenotype_slim_wb
synonym: "copulation abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000648
name: male mating variant
def: "Any variation in the specific actions or reactions of the male that are associated with reproduction compared to control." [GO:0060179, WB:cab]
synonym: "Cod" BROAD []
synonym: "male mating abnormal" NARROW []
is_a: WBPhenotype:0000647 ! copulation variant
is_a: WBPhenotype:0000888 ! male behavior variant

[Term]
id: WBPhenotype:0000649
name: vulva location variant
def: "Any variation in the male's ability to locate his partner's vulva when backing along the ventral side of the partner during mating compared to control. In C. elegans the male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [GO:0034608, WB:WBPerson2021, WB:WBPerson557]
synonym: "Lov" RELATED []
synonym: "vulva location abnormal" NARROW []
is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant

[Term]
id: WBPhenotype:0000650
name: defecation variant
def: "Animals exhibit variations in the processes involved in eliminating gut contents compared to control animals. In C. elegans the sequence of events during defecation includes posterior body contraction (pBoc), relaxation, anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp), and intercycle period (Wormatlas)." [GO:0030421, WB:cab, WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "defecation abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000651
name: constipated
def: "Animals exhibit delayed or infrequent passage and/or expulsion of fecal matter." [WB:WBPerson2021]
synonym: "Con" BROAD []
is_a: WBPhenotype:0000650 ! defecation variant

[Term]
id: WBPhenotype:0000652
name: sensory system variant
alt_id: WBPhenotype:0000248
def: "Variations in the progression of a set of interacting or interdependent entities forming the sensory system over time from an initial condition to a later condition compared to control animals. The sensory system is involved in the perception of a stimuli, its conversion into a signal and the recognition and characterization of the resulting signal." [WB:WBPerson2021, WB:WBPerson557]
synonym: "sensory system abnormal" NARROW []
is_a: WBPhenotype:0000612 ! nervous system physiology variant

[Term]
id: WBPhenotype:0000653
name: mechanosensory system variant
def: "Variations in the progression of a set of interacting or interdependent entities forming the mechanosensory system over time from an initial condition to a later condition compared to control animals. The mechanosensory system is involved in the perception of a mechanical stimuli, its conversion into a signal and the recognition and characterization of the resulting signal." [WB:WBPerson2021, WB:WBPerson557]
synonym: "mechanosensory system abnormal" NARROW []
is_a: WBPhenotype:0000652 ! sensory system variant

[Term]
id: WBPhenotype:0000654
name: synaptic vesicle exocytosis variant
def: "Animals exhibit variations in the fusion of intracellular neurotransmitter-filled membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell compared to control." [GO:0016079, WB:WBPerson712]
synonym: "synaptic vesicle exocytosis abnormal" NARROW []
is_a: WBPhenotype:0000728 ! exocytosis variant
is_a: WBPhenotype:0001684 ! synaptic vesicle homeostasis variant

[Term]
id: WBPhenotype:0000655
name: GABA synaptic transmission variant
def: "Animals exhibit variations in the process of GABA neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control." [GO:0007268, WB:WBPerson712]
synonym: "GABA synaptic transmission abnormal" NARROW []
is_a: WBPhenotype:0000584 ! synaptic transmission variant

[Term]
id: WBPhenotype:0000656
name: acetylcholine synaptic transmission variant
def: "Animals exhibit variations in the process of acetylcholine neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control." [GO:0007268, WB:WBPerson712]
synonym: "acetylcholine synaptic transmission abnormal" NARROW []
is_a: WBPhenotype:0000584 ! synaptic transmission variant

[Term]
id: WBPhenotype:0000657
name: neuronal synaptic transmission variant
def: "Any variation in the process of information transfer between two neurons; usually in reference to chemical synapses, but can also be used to refer to electrical synapses compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "neuronal synaptic transmission abnormal" NARROW []
is_a: WBPhenotype:0000584 ! synaptic transmission variant

[Term]
id: WBPhenotype:0000658
name: neuromuscular synaptic transmission variant
def: "Any variation in the process of communication across a synapse between a neuron and a target muscle cell compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "neuromuscular synaptic transmission abnormal" NARROW []
is_a: WBPhenotype:0000584 ! synaptic transmission variant

[Term]
id: WBPhenotype:0000659
name: feeding behavior variant
def: "Behavior associated with the intake of food is altered compared to control." [GO:0007631, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "feeding behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000660
name: social feeding increased
def: "Worms are found in clumps and/or crowded at the border of the bacterial lawn more frequently than control animals. This behavior is not due to mobility defects." [WB:WBPerson712]
synonym: "bordering increased" RELATED []
synonym: "social behavior enhanced" RELATED []
is_a: WBPhenotype:0000659 ! feeding behavior variant
is_a: WBPhenotype:0001291 ! social behavior variant

[Term]
id: WBPhenotype:0000661
name: solitary feeding increased
def: "Animals disperse across a bacterial lawn and feed alone. When food is limiting, they can aggregate into swarms or clumps, but disperse once again when food is absent." [WB:WBPaper00003187, WB:WBPaper00032342, WB:WBPerson712]
synonym: "solitary behavior enhanced" RELATED []
synonym: "solitary forager on food" RELATED []
is_a: WBPhenotype:0000659 ! feeding behavior variant
is_a: WBPhenotype:0001291 ! social behavior variant

[Term]
id: WBPhenotype:0000662
name: foraging behavior variant
def: "Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [GO:0060756, WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "Fab" BROAD []
synonym: "foraging behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000663
name: osmotic avoidance variant
def: "Animals exhibit variations in the avoidance response to solutions of a particular osmotic strength compared to control. In C. elegans, animals typically avoid solutions of high osmotic strength." [WB:WBPerson2021]
synonym: "Osm" RELATED []
synonym: "osmotic avoidance abnormal" NARROW []
is_a: WBPhenotype:0000481 ! negative chemotaxis variant

[Term]
id: WBPhenotype:0000664
name: exaggerated body bends
alt_id: WBPhenotype:0004021
def: "The maximum ventral and dorsal flex of the animal is greater than that observed for control animals." [WB:WBPerson712]
synonym: "loopy" RELATED []
is_a: WBPhenotype:0001703 ! body bend variant

[Term]
id: WBPhenotype:0000665
name: connection of gonad variant
def: "Any variation that disrupts the connectivity between the somatic gonad and the adjoining tissues compared to control. In C. elegans this connnection is between the somatic gonad and the vulva in hermaphrodites and between the somatic gonad and proctodeum in males." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Cog" RELATED []
synonym: "connection of gonad abnormal" NARROW []
is_a: WBPhenotype:0000605 ! reproductive system morphology variant

[Term]
id: WBPhenotype:0000666
name: ovulation variant
def: "Any variation that disrupts the release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control." [GO:0030728, WB:WBPaper00003017, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "ovulation abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000667
name: gonad displaced
def: "The specialized tissue of the reproductive tract that produces gamete is shifted from its customary place as defined by control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ectopic gonad" RELATED []
is_a: WBPhenotype:0000977 ! somatic gonad morphology variant

[Term]
id: WBPhenotype:0000668
name: endomitotic oocytes
def: "Any variation that results in the presence of mature oocytes with distended polyploid nuclei. In C. elegans, such oocytes mature and exit diakinesis, but are often not properly ovulated or fertilized." [WB:kmva]
synonym: "arrest in meiosis I" RELATED []
synonym: "Emo" BROAD []
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0000669
name: sex muscle development variant
def: "Variations in the progression of the muscles of the adult reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "sex muscle development abnormal" NARROW []
is_a: WBPhenotype:0000624 ! reproductive system development variant
is_a: WBPhenotype:0000860 ! nonstriated muscle development variant

[Term]
id: WBPhenotype:0000670
name: spermatogenesis variant
def: "Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control." [GO:0007283, WB:WBPaper00027300, WB:WBPerson2021]
synonym: "Spe" BROAD []
synonym: "spermatocyte germ cell differentiation abnormal" EXACT []
synonym: "spermatogenesis abnormal" NARROW []
is_a: WBPhenotype:0000894 ! germ cell differentiation variant

[Term]
id: WBPhenotype:0000671
name: resistant to copper
def: "Animals fail to respond to the concentration of copper that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to copper to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000592 ! copper response variant

[Term]
id: WBPhenotype:0000672
name: presynaptic vesicle cluster localization variant
def: "Animals display variations in the distribution of transmitter-filled vesicles in relation to the electron-dense membrane specialization of the neuron,compared to that observed in control animals." [WB:WBPaper00027305, WB:WBPaper00027711, WB:WBPerson712]
synonym: "presynaptic vesicle cluster localization abnormal" NARROW []
synonym: "synaptic vesicle cluster localization abnormal" RELATED []
is_a: WBPhenotype:0000102 ! presynaptic vesicle cluster variant

[Term]
id: WBPhenotype:0000673
name: brood size variant
def: "The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557]
synonym: "brood size abnormal" NARROW []
is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant

[Term]
id: WBPhenotype:0000674
name: slow development
def: "The developmental progression of an animal, from its formation to its mature structure occurs over a longer time period compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "retarded development" RELATED []
is_a: WBPhenotype:0000438 ! retarded heterochronic variations

[Term]
id: WBPhenotype:0000675
name: zygotic lethal
def: "Animals die after fusion of gametes without dividing." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" RELATED []
is_a: WBPhenotype:0000213 ! zygotic development variant

[Term]
id: WBPhenotype:0000676
name: growth rate variant
def: "The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals." [GO:0040007, WB:WBPerson712]
synonym: "growth rate abnormal" NARROW []
is_a: WBPhenotype:0000030 ! growth variant

[Term]
id: WBPhenotype:0000677
name: chemosensation defective
def: "Animals fail to receive, process or recognize a sensory chemical stimulus in the same manner as control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001050 ! chemosensation variant

[Term]
id: WBPhenotype:0000678
name: obsolete no copper sensitivity
def: "OBSOLETE." [WB:WBPerson557]
comment: This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype.
is_obsolete: true

[Term]
id: WBPhenotype:0000679
name: transgene subcellular localization variant
def: "Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
synonym: "transgene subcellular localization abnormal" NARROW []
is_a: WBPhenotype:0000961 ! pattern of transgene expression variant

[Term]
id: WBPhenotype:0000680
name: aldicarb response variant
def: "Animals exhibit variations in their response to aldicarb compared to that observed in control animals." [WB:WBPerson557]
synonym: "aldicarb response abnormal" NARROW []
is_a: WBPhenotype:0001290 ! acetylcholinesterase inhibitor response variant

[Term]
id: WBPhenotype:0000681
name: DMPP response variant
def: "Animals exhibit variations in their response to DMPP compared to that observed in control animals." [WB:WBPerson557]
synonym: "DMPP response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000682
name: feminization of germline
def: "Hermaphrodites are transformed into fertile females; In C. elegans, XO fog animals are somatically male but produce oocytes instead of, or in addition to, sperm." [pmid:3396865, WB:cab]
synonym: "feminization of germ line" EXACT []
synonym: "Fog" BROAD []
is_a: WBPhenotype:0000687 ! feminization of XX and XO animals
is_a: WBPhenotype:0000812 ! germ cell development variant

[Term]
id: WBPhenotype:0000683
name: masculinization of germline
def: "The germ line is sexually transformed from hermaphrodite to male. In C. elegans, XX mog animals are somatically hermaphrodite, but germ cells that normally would become oocytes are transformed into sperm." [WB:WBPaper00001710, WB:WBPerson2021]
synonym: "masculinization of germ line" EXACT []
synonym: "Mog" BROAD []
is_a: WBPhenotype:0000812 ! germ cell development variant
is_a: WBPhenotype:0001572 ! masculinized

[Term]
id: WBPhenotype:0000684
name: fewer germ cells
def: "Germ cell populations are reduced compared to control animals." [WB:cab, WB:WBPerson2021]
synonym: "Fgc" BROAD []
synonym: "germline underproliferation" RELATED []
is_a: WBPhenotype:0000823 ! germline proliferation variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0000685
name: larval growth slow
def: "Any variation that causes a reduction in growth rate during larval stages compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0000676 ! growth rate variant
is_a: WBPhenotype:0001016 ! larval growth variant

[Term]
id: WBPhenotype:0000686
name: organism ionizing radiation response variant
def: "Animals exhibit variations in their response ionizing radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism ionizing radiation response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000687
name: feminization of XX and XO animals
def: "Both hermaphrodites and males develop into fertile females." [WB:cab]
synonym: "Fem" BROAD []
is_a: WBPhenotype:0000049 ! postembryonic development variant
is_a: WBPhenotype:0000624 ! reproductive system development variant
is_a: WBPhenotype:0000822 ! sex determination variant

[Term]
id: WBPhenotype:0000688
name: sterile
def: "Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "semi sterile" EXACT []
synonym: "Ste" BROAD []
is_a: WBPhenotype:0001384 ! fertility reduced

[Term]
id: WBPhenotype:0000689
name: maternal sterile
def: "Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
synonym: "Reduced fecundity of injected worm" EXACT [WB:cgc5599]
synonym: "Ste" BROAD []
synonym: "sterile F0 fertility problems" RELATED []
is_a: WBPhenotype:0000694 ! hermaphrodite sterile

[Term]
id: WBPhenotype:0000690
name: gonad migration variant
def: "Variations in the gross movement of the whole structure of the gonad along the body wall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Gom" BROAD []
synonym: "gonad migration abnormal" NARROW []
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000691
name: gonad development variant
def: "Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control." [GO:0008406, WB:WBPerson2021]
synonym: "Gon" RELATED []
synonym: "gonad development abnormal" NARROW []
synonym: "gonadogenesis abnormal" RELATED []
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000692
name: male sterile
def: "X0 animals fail to generate viable cross-progeny." [WB:WBPerson2021]
is_a: WBPhenotype:0000688 ! sterile
is_a: WBPhenotype:0000863 ! male fertility reduced

[Term]
id: WBPhenotype:0000693
name: male sperm fertilization defect
def: "Any perturbation that renders male derived sperm ineffective at fertilizing an oocyte." [WB:WBPaper00001075, WB:WBPerson2021]
synonym: "Fer" BROAD []
is_a: WBPhenotype:0000692 ! male sterile

[Term]
id: WBPhenotype:0000694
name: hermaphrodite sterile
def: "Hermaphrodites fail to generate viable self-progeny and/or cross-progeny." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000688 ! sterile
is_a: WBPhenotype:0001259 ! hermaphrodite fertility reduced

[Term]
id: WBPhenotype:0000695
name: vulva morphology variant
def: "Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control." [WB:WBPerson712]
synonym: "vulva morphology abnormal" NARROW []
is_a: WBPhenotype:0001335 ! hermaphrodite reproductive system morphology variant

[Term]
id: WBPhenotype:0000696
name: everted vulva
def: "The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva)." [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261]
synonym: "Evl" BROAD []
is_a: WBPhenotype:0000695 ! vulva morphology variant

[Term]
id: WBPhenotype:0000697
name: protruding vulva
def: "Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021]
synonym: "Pvl" BROAD []
synonym: "Pvu" BROAD []
is_a: WBPhenotype:0000695 ! vulva morphology variant

[Term]
id: WBPhenotype:0000698
name: vulvaless
def: "No vulval tissue is produced. In C. elegans, this is usually a result of all six vulval precursor cells adopting a tertiary fate." [WB:WBPaper00001182, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "underinduced" EXACT []
synonym: "Vul" BROAD []
is_a: WBPhenotype:0000219 ! vulval cell induction reduced

[Term]
id: WBPhenotype:0000699
name: vulva development variant
def: "Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GO:0040025, WB:IA, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "vulva development abnormal" NARROW []
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000700
name: multivulva
def: "Multiple vulva-like protrusions are present along the ventral side of the animal. In C. elegans, this is usually a result of all six vulval precursor cells adopting primary or secondary vulval fates." [WB:WBPaper00001182, WB:WBPerson2021]
synonym: "Muv" BROAD []
synonym: "overinduced" EXACT []
is_a: WBPhenotype:0000218 ! vulval cell induction increased

[Term]
id: WBPhenotype:0000701
name: epithelial development variant
def: "Any variation in the progression of the epithelia over time, from its formation to its mature state compared to control. This process involves autonomously generated changes in epidermal cell shape and position, and interactions with internal tissues, including the developing nervous system and body wall muscles to affect epidermal enclosure, cell intercalation, and epidermal elongation." [WB:WBPerson2021, WB:WBPerson557]
synonym: "epidermal morphogenesis variant" RELATED []
synonym: "epithelial development abnormal" NARROW []
is_a: WBPhenotype:0000619 ! epithelial system development variant

[Term]
id: WBPhenotype:0000702
name: epithelial cell fusion failure
def: "Any perturbation that renders epithelial cells incompetent at undergoing membrane fusion during development." [WB:WBPaper00005122, WB:WBPerson2021]
xref: PMID:15341747
is_a: WBPhenotype:0000165 ! cell fusion variant
is_a: WBPhenotype:0000701 ! epithelial development variant

[Term]
id: WBPhenotype:0000703
name: epithelial morphology variant
def: "Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "epithelial morphology abnormal" NARROW []
synonym: "hypodermal morphology abnormal" RELATED []
is_a: WBPhenotype:0000600 ! epithelial system morphology variant

[Term]
id: WBPhenotype:0000704
name: excretory canal morphology variant
def: "Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "excretory canal morphology abnormal" NARROW []
is_a: WBPhenotype:0000916 ! excretory cell morphology variant

[Term]
id: WBPhenotype:0000705
name: intestinal cell development variant
def: "Any variation in the progression of an intestinal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "intestinal cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant
is_a: WBPhenotype:0000708 ! intestinal development variant

[Term]
id: WBPhenotype:0000706
name: gut granule biogenesis reduced
def: "Animals lack birefringent containing compartments in embryonic intestinal cells; however, these compartments appear in adult stages." [WB:WBPaper00032168, WB:WBPerson712]
synonym: "Glo" BROAD []
synonym: "gut granule loss" RELATED []
xref: PMID:15843430
is_a: WBPhenotype:0000103 ! gut granule development variant
is_a: WBPhenotype:0001430 ! lysosome organization biogenesis variant

[Term]
id: WBPhenotype:0000707
name: pharyngeal development variant
def: "Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb)." [GO:0043282, WB:WBPerson2021]
synonym: "pharyngeal development abnormal" NARROW []
is_a: WBPhenotype:0000617 ! alimentary system development variant

[Term]
id: WBPhenotype:0000708
name: intestinal development variant
def: "Variations in the progression of the intestine over time from its initial formation to its mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "endoderm development abnormal" RELATED []
synonym: "gut development abnormal" RELATED []
synonym: "intestinal development abnormal" NARROW []
is_a: WBPhenotype:0000617 ! alimentary system development variant

[Term]
id: WBPhenotype:0000709
name: pharyngeal morphology variant
def: "Variations in the form or composition of the mouthparts at the anterior end of the digestive tract which contain a series of radial muscles, related neurons and epithelial cells, and several gland cells which may aid in digestion compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pharyngeal morphology abnormal" NARROW []
is_a: WBPhenotype:0000598 ! alimentary system morphology variant

[Term]
id: WBPhenotype:0000710
name: intestinal morphology variant
def: "Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "intestinal morphology abnormal" NARROW []
is_a: WBPhenotype:0000598 ! alimentary system morphology variant

[Term]
id: WBPhenotype:0000711
name: organism hypersensitive ionizing radiation
def: "Animals exhibit increased sensitivity to the effects of ion producing radiation compared to control animals." [WB:WBPaper00000565, WB:WBPerson712]
is_a: WBPhenotype:0000686 ! organism ionizing radiation response variant

[Term]
id: WBPhenotype:0000712
name: germ cell ionizing radiation response variant
def: "Germ cells exhibit variations in their response to ionizing radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "germ cell ionizing radiation response abnormal" NARROW []
is_a: WBPhenotype:0000987 ! germ cell physiology variant

[Term]
id: WBPhenotype:0000713
name: obsolete spermatocyte division abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000981

[Term]
id: WBPhenotype:0000714
name: obsolete disorganized muscle
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000553

[Term]
id: WBPhenotype:0000715
name: muscle excess
def: "Animals exhibit a greater number of embryonic muscle cells compared to control." [WB:kmva, WB:WBPaper00001584]
synonym: "Mex" BROAD [WB:WBPaper00001584]
is_a: WBPhenotype:0000622 ! muscle system development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0000716
name: muscle cell attachment variant
def: "Any variation in the connection of a cell whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "muscle cell attachment abnormal" NARROW []
is_a: WBPhenotype:0000990 ! muscle cell physiology variant

[Term]
id: WBPhenotype:0000717
name: gene expression variant
def: "Variations in the processes that convert a gene's sequence into a mature gene product or products (proteins or RNA), compared to control." [GO:0010467, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "gene expression abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000718
name: dosage compensation variant
def: "Variations in the process of normalizing the expression level of X-linked genes between XX and XO animals compared to control." [GO:0007549, WB:WBPerson363]
comment: Possible XP GO:0007549.
synonym: "dosage compensation abnormal" NARROW []
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0000719
name: obsolete reporter gene expression variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "reporter gene expression abnormal" NARROW []
is_obsolete: true
consider: WBPhenotype:0000306
consider: WBPhenotype:0000717

[Term]
id: WBPhenotype:0000720
name: obsolete pattern of reporter gene expression variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "pattern of reporter gene expression abnormal" NARROW []
is_obsolete: true
consider: WBPhenotype:0000111
consider: WBPhenotype:0000961

[Term]
id: WBPhenotype:0000721
name: obsolete level of reporter gene expression variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "level of reporter gene expression abnormal" EXACT []
is_obsolete: true
consider: WBPhenotype:0000962

[Term]
id: WBPhenotype:0000722
name: nucleolus variant
def: "Animals exhibit variations in the appearance of nucleoli compared to control animals." [WB:cab]
subset: phenotype_slim_wb
synonym: "nucleolus abnormal" NARROW []
is_a: WBPhenotype:0001028 ! nuclear appearance variant

[Term]
id: WBPhenotype:0000723
name: obsolete cellular secretion abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000258

[Term]
id: WBPhenotype:0000724
name: protein secretion variant
def: "Variations in the regulated release of proteins from a cell or group of cells compared to control." [GO:0009306, WB:WBPerson2021]
synonym: "protein secretion abnormal" NARROW []
is_a: WBPhenotype:0000258 ! cell secretion variant

[Term]
id: WBPhenotype:0000725
name: lipid metabolism variant
def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of lipid within the organism or cell compared to control." [GO:0055088, WB:WBPaper00032000, WB:WBPaper00032082, WB:WBPerson712]
synonym: "lipid metabolism abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000726
name: ligand binding variant
def: "Any variation of the specific binding of a molecule to its partner, which typically results in a change in cell activity, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ligand binding abnormal" NARROW []
is_a: WBPhenotype:0000727 ! enzyme activity variant

[Term]
id: WBPhenotype:0000727
name: enzyme activity variant
def: "Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557]
synonym: "enzyme activity abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0000728
name: exocytosis variant
def: "Variations in the process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, compared to control." [GO:0006887, WB:WBPerson2021]
synonym: "exocytosis abnormal" NARROW []
is_a: WBPhenotype:0000258 ! cell secretion variant

[Term]
id: WBPhenotype:0000729
name: cell death variant
def: "Animals exhibit variations in any of the processes that lead to the termination of vital functions of a cell." [GO:0008219, WB:cab]
subset: phenotype_slim_wb
synonym: "Ced" BROAD []
synonym: "cell death abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000730
name: apoptosis variant
def: "Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021]
synonym: "apoptosis abnormal" NARROW []
synonym: "Ced" BROAD []
is_a: WBPhenotype:0001172 ! programmed cell death variant

[Term]
id: WBPhenotype:0000731
name: germ cell hypersensitive ionizing radiation
def: "Germ cells exhibit increased sensitivity to the effects of ion producing radiation compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000712 ! germ cell ionizing radiation response variant
is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant

[Term]
id: WBPhenotype:0000732
name: DNA metabolism variant
def: "Variations in any process that involves the maintenance, biosynthesis or accumulation of DNA in the organism compared to control." [WB:WBPerson2021]
synonym: "DNA metabolism abnormal" NARROW []
is_a: WBPhenotype:0000463 ! metabolic pathway variant
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0000733
name: catalysis variant
def: "Any variation in the catalysis of a biochemical reaction compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557]
synonym: "catalysis abnormal" NARROW []
is_a: WBPhenotype:0000727 ! enzyme activity variant

[Term]
id: WBPhenotype:0000734
name: hypodermal cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the hypodermal system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "hypodermal cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000608 ! epithelial system physiology variant

[Term]
id: WBPhenotype:0000735
name: endoreduplication of hypodermal nuclei variant
def: "Any variation in the regulated re-replication of DNA in the hypodermal cells during a single cell cycle, compared to control." [GO:0042023, WB:WBPerson2021, WB:WBPerson557]
synonym: "endoreduplication of hypodermal nuclei abnormal" NARROW []
is_a: WBPhenotype:0000734 ! hypodermal cell physiology variant

[Term]
id: WBPhenotype:0000736
name: autophagy variant
def: "Animals exhibit variations in the process by which their cells digest parts of their own cytoplasm, compared to control." [GO:0006914, WB:WBPerson712]
synonym: "autophagy abnormal" EXACT []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0000737
name: germ cell resistant ionizing radiation
def: "Germ cells fail to respond to the dosage of ion producing radiation that elicits a response in control animals. Alternatively, germ cells require a higher dosage or a longer exposure to ion producing radiation to elicit the same response as control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000712 ! germ cell ionizing radiation response variant
is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant

[Term]
id: WBPhenotype:0000738
name: organism environmental stimulus response variant
def: "The response to a change in the environment is altered compared to control." [WB:cab]
subset: phenotype_slim_wb
synonym: "organism environmental stimulus response abnormal" NARROW []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000739
name: DNA damage response variant
def: "Variations in the activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism, compared to control." [GO:0006974, WB:WBPerson2021]
synonym: "DNA damage response abnormal" NARROW []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0000740
name: cell cycle variant
def: "Cells of the animals exhibit variations in the initiation, progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals." [GO:0007049, WB:WBPerson557, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "cell cycle abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000741
name: DNA damage checkpoint variant
def: "Mitotic cells exhibit variations in the execution of cell-cycle arrest in response to DNA damage." [WB:WBPaper00029085, WB:WBPerson2021]
synonym: "DNA damage checkpoint abnormal" NARROW []
is_a: WBPhenotype:0000740 ! cell cycle variant

[Term]
id: WBPhenotype:0000742
name: DNA recombination variant
def: "Variations in the process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents, compared to control." [GO:0006310, WB:WBPerson2021]
synonym: "DNA recombination abnormal" NARROW []
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0000743
name: RNAi response variant
def: "Animals exhibit variations in their response to gene silencing triggered by double stranded RNA (RNAi), compared to control." [GO:0016246, WB:WBPerson2021]
synonym: "Rde" BROAD []
synonym: "RNAi response abnormal" NARROW []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0000744
name: transgene induced cosuppression variant
def: "Animals exhibit variations in the silencing of endogenous genes after introduction of repetitive exogenous cognate DNA compared to control." [WB:WBPaper00025139, WB:WBPerson2021, WB:WBPerson557]
synonym: "transgene induced cosuppression abnormal" NARROW []
is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant

[Term]
id: WBPhenotype:0000745
name: transposon silencing variant
def: "Animals exhibit variations in the activity of endogenous transposons compared to control. In C. elegans transposon activity is often measured by the rate of reversion of mutations induced by transposon insertions." [GO:0000335, WB:WBPaper00031962, WB:WBPerson712]
synonym: "transposon silencing abnormal" NARROW []
is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant

[Term]
id: WBPhenotype:0000746
name: cell division variant
def: "Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control." [GO:0051301, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "cell division abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000747
name: pharyngeal contraction defective
def: "Any defects in the muscle contractions that control feeding. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPaper00001696]
is_a: WBPhenotype:0000980 ! pharyngeal contraction variant

[Term]
id: WBPhenotype:0000748
name: asymmetric cell division defective early emb
def: "Symmetric (PAR-like) divisions or excessive posterior displacement (zyg-8 like phenotypes)." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0001585 ! asymmetric cell division variant

[Term]
id: WBPhenotype:0000749
name: embryonic development variant
def: "Variations in the progression of an embryo over time, from zygote formation to hatching compared to control." [GO:0009790, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "developmental defects detected in embryos" RELATED []
synonym: "embryonic development abnormal" NARROW []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000750
name: larval development variant
def: "Variations in the progression of a larva over time, from its formation to the mature structure compared to control. The larva is the early, immature form of an animal between hatching and adulthood." [GO:0002164, WB:WBPerson2021]
synonym: "larval development abnormal" NARROW []
is_a: WBPhenotype:0000049 ! postembryonic development variant

[Term]
id: WBPhenotype:0000751
name: L1 larval development variant
def: "Variations in the progression of a newly hatched animal through the first larval molt compared to control." [WB:WBPerson2021]
synonym: "L1 larval development abnormal" NARROW []
is_a: WBPhenotype:0000750 ! larval development variant

[Term]
id: WBPhenotype:0000752
name: L2 larval development variant
def: "Variations in the progression of the second larval stage compared to control." [WB:WBPerson557]
synonym: "L2 larval development abnormal" NARROW []
is_a: WBPhenotype:0000750 ! larval development variant

[Term]
id: WBPhenotype:0000753
name: L3 larval development variant
def: "Variations in the progression of the third larval stage compared to control." [WB:WBPerson557]
synonym: "L3 larval development abnormal" NARROW []
is_a: WBPhenotype:0000750 ! larval development variant

[Term]
id: WBPhenotype:0000754
name: L4 larval development variant
def: "Variations in the progression of the fourth larval stage compared to control." [WB:WBPerson557]
synonym: "L4 larval development abnormal" NARROW []
is_a: WBPhenotype:0000750 ! larval development variant

[Term]
id: WBPhenotype:0000755
name: L1 L2 molt defect
def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L1 to L2 transition." [GO:0018996]
synonym: "L1 L2 molt abnormal" NARROW []
synonym: "L1 molt" RELATED []
is_a: WBPhenotype:0000638 ! molt defect

[Term]
id: WBPhenotype:0000756
name: L2 L3 molt defect
def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L2 to L3 transition." [GO:0018996]
synonym: "L2 L3 molt abnormal" NARROW []
synonym: "L2 molt" RELATED []
is_a: WBPhenotype:0000638 ! molt defect

[Term]
id: WBPhenotype:0000757
name: L3 L4 molt defect
def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L3 to L4 transition." [GO:0018996]
synonym: "L3 L4 molt abnormal" NARROW []
synonym: "L3 molt" RELATED []
is_a: WBPhenotype:0000638 ! molt defect

[Term]
id: WBPhenotype:0000758
name: L4 adult molt defect
def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L4 to adult transition." [GO:0018996]
synonym: "L4 adult molt abnormal" NARROW []
synonym: "L4 molt" RELATED []
is_a: WBPhenotype:0000638 ! molt defect

[Term]
id: WBPhenotype:0000759
name: spindle defective early emb
def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubules and associated molecules that form between opposite poles of a eukaryotic cell during a cell cycle." [GO:0007051, WB:WBPerson2021]
comment: Possible XP.
synonym: "Emb" BROAD []
synonym: "Spd" BROAD []
is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0000760
name: spindle orientation defective early emb
def: "The alignment of the spindle relative to other cellular structures in the cells of an embryo varies from that observed in control animals." [WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "Spn" BROAD []
is_a: WBPhenotype:0000761 ! spindle position orientation defective early emb
is_a: WBPhenotype:0001681 ! spindle orientation variant

[Term]
id: WBPhenotype:0000761
name: spindle position orientation defective early emb
def: "Early embryos exhibit defects in the placement or the alignment of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "Spi" RELATED []
synonym: "Spo" BROAD []
is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb

[Term]
id: WBPhenotype:0000762
name: spindle position defective early emb
def: "Early embryos exhibit defects in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0051653, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "Abs" BROAD []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000761 ! spindle position orientation defective early emb
is_a: WBPhenotype:0002416 ! spindle position variant

[Term]
id: WBPhenotype:0000763
name: embryonic cell physiology variant
def: "Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for an embryonic cell to carry out its normal function and activities or be able to perceive and respond to stimuli." [GO:0009987, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "embryonic cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000764
name: embryonic cell organization biogenesis variant
def: "Variations in the processes that are carried out at in the embryo which results in its formation or the arrangement of constituent parts, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "embryonic cell organization biogenesis abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant
is_a: WBPhenotype:0000763 ! embryonic cell physiology variant
is_a: WBPhenotype:0010002 ! cell organization biogenesis variant

[Term]
id: WBPhenotype:0000765
name: spindle elongation integrity defective early emb
def: "The embryos exhibit defects in the cell cycle process whereby the distance is lengthened between poles of the spindle." [GO:0051231, WB:cab, WB:cgc7141, WB:WBPerson2021]
comment: Possible XP.
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb

[Term]
id: WBPhenotype:0000766
name: centrosome pair and associated pronuclear rotation variant
def: "Any variation in the rotation of the centrosome-pronuclear complex after its migration toward the center of the embryo, compared to control." [WB:WBPaper00004895, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "centrosome pair and associated pronuclear rotation abnormal" NARROW []
synonym: "Rot" BROAD []
is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant

[Term]
id: WBPhenotype:0000767
name: integrity of membranous organelles defective early emb
def: "Sparse or enlarged yolk granules." [WB:cab, WB:WBPaper00025054]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0000768
name: cytoplasmic structure defective early emb
def: "Areas devoid of yolk granules throughout the embryo." [WB:cab, WB:cgc7141]
synonym: "Aberrant Cytoplasmic Structure" RELATED []
synonym: "cellular structure disorganized" RELATED []
synonym: "cytoplasmic structure abnormal" NARROW []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001081 ! cytoplasmic morphology defective early emb

[Term]
id: WBPhenotype:0000769
name: cytoplasmic appearance defective early emb
def: "Embryos exhibit defects in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control embryos." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0001427 ! cytoplasmic appearance variant

[Term]
id: WBPhenotype:0000770
name: embryonic cell morphology variant
def: "Animals exhibit variations in the appearance of embryonic cells compared to control." [WB:cab]
subset: phenotype_slim_wb
synonym: "embryonic cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000771
name: centrosome attachment defective early emb
def: "Centrosomes detach from the male pronucleus." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000770 ! embryonic cell morphology variant
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0001903 ! centrosome biogenesis variant

[Term]
id: WBPhenotype:0000772
name: sister chromatid segregation defective early emb
def: "Daughter nuclei are deformed and stay close to central cortex, cytokinesis defects." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000773 ! chromosome segregation variant
is_a: WBPhenotype:0001078 ! cytokinesis defective early emb

[Term]
id: WBPhenotype:0000773
name: chromosome segregation variant
def: "Any variation in the processes that regulate the apportionment of chromosomes to each of two daughter cells compared to control." [GO:0007059, WB:kmva, WB:WBPerson2021, WB:WBPerson557]
synonym: "chromosome segregation abnormal" NARROW []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0000774
name: gametogenesis variant
def: "Any variation in the processes that govern the generation and maintenance of gametes compared to control." [GO:0007276, WB:WBPerson2021]
synonym: "gametogenesis abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000775
name: meiosis variant
def: "Variations in the specialized nuclear and cytoplasmic divisions of a single diploid cell, whose specific outcome is the formation of four haploid daughter cells compared to control. Meiosis occurs during the formation of gametes." [GO:0051321, WB:WBPerson2021]
synonym: "germ cell meiosis abnormal" RELATED []
synonym: "germ cell meiosis variant" RELATED []
synonym: "Mei" RELATED []
synonym: "meiosis abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant
is_a: WBPhenotype:0000812 ! germ cell development variant

[Term]
id: WBPhenotype:0000776
name: passage through meiosis defective early emb
def: "Male and female PNs not visible; embryo often fills egg shell completely." [WB:cab, WB:cgc71441]
synonym: "Emb" BROAD []
synonym: "passage through meiosis abnormal" NARROW []
is_a: WBPhenotype:0001041 ! meiosis defective early emb

[Term]
id: WBPhenotype:0000777
name: polar body extrusion defective early emb
def: "Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
synonym: "polar body extrusion abnormal" NARROW []
is_a: WBPhenotype:0000775 ! meiosis variant
is_a: WBPhenotype:0001147 ! polar body defective early emb

[Term]
id: WBPhenotype:0000778
name: feeding inefficient
def: "Animals are unable to ingest nutrients at a rate similar to control animals." [WB:WBPaper00032342, WB:WBPerson712]
is_a: WBPhenotype:0000659 ! feeding behavior variant

[Term]
id: WBPhenotype:0000779
name: late embryonic arrest
def: "Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation." [WB:WBPerson101]
is_a: WBPhenotype:0000867 ! embryonic arrest

[Term]
id: WBPhenotype:0000780
name: shaker
def: "Animals rotate back and forth around their longitudinal axes." [WB:cab, WB:cgc914]
is_a: WBPhenotype:0001701 ! spastic locomotion

[Term]
id: WBPhenotype:0000781
name: body wall muscle thin filament variant
def: "Any variation in the extremely thin elongated cytoplasmic filament, usually composed principally of actin protein to form a myofilament lattice, as in muscle cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "thin filament abnormal" NARROW []
synonym: "thin filament variant" RELATED []
is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant

[Term]
id: WBPhenotype:0000782
name: body wall muscle thick filament variant
def: "Animals exhibit variations in the form, structure or composition of a robust elongated cytoplasmic filament composed principally of myosin protein compared to control animals. In C. elegans, thick filaments also contain paramyosin and twitchin (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "thick filament abnormal" NARROW []
synonym: "thick filament variant" RELATED []
is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant

[Term]
id: WBPhenotype:0000783
name: M line absent
def: "Animals lack the planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001891 ! M line variant

[Term]
id: WBPhenotype:0000784
name: male fertility variant
def: "Males exhibit variations in the time of onset or duration of the fertile period owing to differences in sperm competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male fertility abnormal" NARROW []
is_a: WBPhenotype:0000145 ! fertility phenotype

[Term]
id: WBPhenotype:0000785
name: body part pigmentation variant
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular body part compared to control animals." [WB:WBPerson557]
synonym: "body part pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000278 ! body region pigmentation phenotype

[Term]
id: WBPhenotype:0000786
name: body axis pigmentation variant
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency along a particular body axis compared to control." [WB:WBPerson557]
synonym: "body axis pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000278 ! body region pigmentation phenotype

[Term]
id: WBPhenotype:0000787
name: posterior pale
def: "Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the posterior body axis compared to control." [WB:WBPerson557]
is_a: WBPhenotype:0000984 ! posterior pigmentation variant
is_a: WBPhenotype:0001261 ! pale

[Term]
id: WBPhenotype:0000788
name: anterior pale
def: "Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the anterior body axis compared to control." [WB:WBPerson557]
is_a: WBPhenotype:0000971 ! anterior pigmentation variant
is_a: WBPhenotype:0001261 ! pale

[Term]
id: WBPhenotype:0000789
name: fluoxetine hypersensitive
def: "Animals respond to fluoxetine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0000790
name: fluoxetine resistant
def: "Animals fail to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0000791
name: nose resistant to fluoxetine
def: "The nose of an animal fails to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000790 ! fluoxetine resistant

[Term]
id: WBPhenotype:0000792
name: anterior body morphology variant
def: "Animals exhibit variations in the form, structure or composition of the anatomy contained in the anterior region, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "anterior body morphology abnormal" NARROW []
synonym: "anterior region morphology abnormal" NARROW []
synonym: "anterior region morphology variant" EXACT []
is_a: WBPhenotype:0000072 ! body morphology variant
is_a: WBPhenotype:0000581 ! body axis morphology variant

[Term]
id: WBPhenotype:0000793
name: posterior body morphology variant
alt_id: WBPhenotype:0001490
def: "Animals exhibit variations in the form, structure or composition of the anatomy contained in the posterior region, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "posterior body morphology abnormal" NARROW []
synonym: "posterior region morphology abnormal" NARROW []
synonym: "posterior region morphology variant" EXACT []
is_a: WBPhenotype:0000072 ! body morphology variant
is_a: WBPhenotype:0000581 ! body axis morphology variant

[Term]
id: WBPhenotype:0000794
name: posterior body thin
def: "The posterior part of the worm exhibits a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000793 ! posterior body morphology variant

[Term]
id: WBPhenotype:0000795
name: body axis behavior variant
def: "Variations in the specific actions or reactions of one of the longitudinal axes of the extended body of the worm in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body axis behavior abnormal" NARROW []
is_a: WBPhenotype:0000522 ! organism region behavior variant

[Term]
id: WBPhenotype:0000796
name: posterior body uncoordinated
def: "The movement of the posterior part of the worm is not coordinated with the rest of the body." [WB:cab]
is_a: WBPhenotype:0000797 ! posterior body behavior variant

[Term]
id: WBPhenotype:0000797
name: posterior body behavior variant
def: "Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the tail of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "posterior body behavior abnormal" NARROW []
is_a: WBPhenotype:0000795 ! body axis behavior variant

[Term]
id: WBPhenotype:0000798
name: anterior body behavior variant
def: "Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the head of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "anterior body behavior abnormal" NARROW []
is_a: WBPhenotype:0000795 ! body axis behavior variant

[Term]
id: WBPhenotype:0000799
name: anterior region development variant
def: "Variations in the progression of an animal's anatomy contained in the anterior region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "anterior region development abnormal" NARROW []
is_a: WBPhenotype:0000578 ! body axis development variant

[Term]
id: WBPhenotype:0000800
name: posterior region development variant
def: "Variations in the progression of an animal's anatomy contained in the posterior region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "posterior region development abnormal" NARROW []
is_a: WBPhenotype:0000578 ! body axis development variant

[Term]
id: WBPhenotype:0000801
name: ventral region development variant
def: "Variations in the progression of an animal's anatomy contained in the ventral region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ventral region development abnormal" NARROW []
is_a: WBPhenotype:0000578 ! body axis development variant

[Term]
id: WBPhenotype:0000802
name: dorsal region development variant
def: "Variations in the progression of an animal's anatomy contained in the dorsal region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dorsal region development abnormal" NARROW []
is_a: WBPhenotype:0000578 ! body axis development variant

[Term]
id: WBPhenotype:0000803
name: head development variant
def: "Variations in the progression of the anterior end of the animal over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "head development abnormal" NARROW []
is_a: WBPhenotype:0000579 ! organism segment development variant

[Term]
id: WBPhenotype:0000804
name: body development variant
def: "Variations in the progression of the overall structure or appearance of the animal over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body development abnormal" NARROW []
is_a: WBPhenotype:0000579 ! organism segment development variant

[Term]
id: WBPhenotype:0000805
name: tail development variant
def: "Any variation in the process whose specific outcome is the progression of the tail over time, from its formation to the mature structure, compared to control. The tail includes the posterior region that spans from the rectum to the end." [WB:WBPerson2021]
synonym: "tail development abnormal" NARROW []
is_a: WBPhenotype:0000579 ! organism segment development variant

[Term]
id: WBPhenotype:0000806
name: hermaphrodite fertility variant
def: "Hermaphrodites exhibit variations in the time of onset or duration of the fertile period, or variations in the production of viable offspring, including number and state of fertilized eggs laid, compared to controls." [WB:WBPerson712]
synonym: "hermaphrodite fertility abnormal" NARROW []
is_a: WBPhenotype:0000145 ! fertility phenotype

[Term]
id: WBPhenotype:0000807
name: G lineages variant
def: "The descendants of the G1 or G2 exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "G lineages abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000808
name: K lineage variant
def: "The descendants of the K precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "K lineage abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000809
name: male specific lineage variant
def: "The descendants of a male specific precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "male specific lineage abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000810
name: blast cell development variant
def: "Any variation in the progression of a blast cell (precursor cell) over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "blast cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000811
name: epithelial cell development variant
def: "Any variation in the progression of an epithelial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "epithelial cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000812
name: germ cell development variant
def: "Variations in the progression of the immature germ cell over time, from its formation from precursors to the mature structure (gamete) compared to control." [GO:0007281, WB:WBPerson2021]
synonym: "germ cell development abnormal" NARROW []
synonym: "germline development abnormal" RELATED []
is_a: WBPhenotype:0000774 ! gametogenesis variant

[Term]
id: WBPhenotype:0000813
name: gland cell development variant
def: "Any variation in the progression of a gland cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "gland cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0000814
name: marginal cell development variant
def: "Any variation in the progression of a marginal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A marginal cell is a pharyngeal cell that connects the basement membrane to the apices of the triangle-shaped pharyngeal lumen." [WB:WBPerson2021]
synonym: "marginal cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant
is_a: WBPhenotype:0000619 ! epithelial system development variant
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0000815
name: muscle cell development variant
def: "Any variation in the progression of a muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "muscle cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant
is_a: WBPhenotype:0000622 ! muscle system development variant

[Term]
id: WBPhenotype:0000816
name: neuron development variant
def: "Variations in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [GO:0048666, WB:WBPerson2021]
synonym: "neuron development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0000817
name: uterine vulval cell development variant
def: "Variations in the progression of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) over time from an initial condition to a later condition compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "uterine vulval cell development abnormal" NARROW []
is_a: WBPhenotype:0000529 ! cell development variant
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0000818
name: adult behavior variant
def: "Activity characteristic of an adult worm is altered compared to control." [WB:cab]
synonym: "adult behavior abnormal" NARROW []
is_a: WBPhenotype:0000819 ! postembryonic behavior variant

[Term]
id: WBPhenotype:0000819
name: postembryonic behavior variant
def: "Behavior characteristic of postembryonic stage(s) is altered compared to control." [WB:cab]
synonym: "postembryonic behavior abnormal" NARROW []
is_a: WBPhenotype:0001000 ! developmental behavior variant

[Term]
id: WBPhenotype:0000820
name: embryonic behavior variant
def: "Activity characteristic of an embryo is altered compared to control." [WB:cab]
synonym: "embryonic behavior abnormal" NARROW []
is_a: WBPhenotype:0001000 ! developmental behavior variant

[Term]
id: WBPhenotype:0000821
name: sexually dimorphic behavior variant
def: "Animals exhibit variations in sex-specific behaviors compared to control." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "sexually dimorphic behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0000822
name: sex determination variant
def: "Any variation in the processes that govern the sexually dimorphic development of germline or somatic tissue compared to control." [WB:kmva]
synonym: "sex determination abnormal" NARROW []
synonym: "sex specific development abnormal" RELATED []
is_a: WBPhenotype:0000930 ! sexually dimorphic development variant

[Term]
id: WBPhenotype:0000823
name: germline proliferation variant
def: "Nuclear divisions in the germ line are either expanded are reduced compared to control." [WB:cab]
synonym: "germ cell proliferation abnormal" RELATED []
synonym: "germ line proliferation abnormal" EXACT []
synonym: "germline proliferation abnormal" NARROW []
synonym: "Glp" BROAD []
is_a: WBPhenotype:0000812 ! germ cell development variant

[Term]
id: WBPhenotype:0000824
name: embryonic cell lineage variant
def: "The descendants of an embryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "embryonic cell lineage abnormal" NARROW []
is_a: WBPhenotype:0000093 ! lineage variant

[Term]
id: WBPhenotype:0000825
name: postembryonic cell lineage variant
def: "The descendants of a postembryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "postembryonic cell lineage abnormal" NARROW []
is_a: WBPhenotype:0000093 ! lineage variant

[Term]
id: WBPhenotype:0000826
name: H lineages variant
def: "The descendants of H1 or H2 cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "H lineages abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000827
name: V lineages variant
def: "The descendants of any of the V precursor cells (V1-V6) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "V lineages abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000828
name: T lineages variant
def: "The descendants of TL or TR cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "T lineages abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000829
name: Q lineage variant
def: "The descendants of Q L or QR cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "Q lineage abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000830
name: B lineage variant
def: "The descendants of the B cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "B lineage abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000831
name: Y lineage variant
def: "The descendants of the Y cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "Y lineage abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000832
name: C lineage variant
def: "The descendants of the C blastomere exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPaper00001584, WB:WBPerson2021]
synonym: "C lineage abnormal" NARROW []
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000833
name: U lineage variant
def: "The descendants of the U cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "U lineage abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000834
name: E lineage variant
def: "The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPaper00002870, WB:WBPerson2021]
synonym: "E lineage abnormal" NARROW []
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000835
name: F lineage variant
def: "The descendants of the F cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "F lineage abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000836
name: gonadal lineage variant
def: "The descendants of a gonadal precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "gonadal lineage abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000837
name: hermaphrodite gonadal lineage variant
def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "hermaphrodite gonadal lineage abnormal" NARROW []
is_a: WBPhenotype:0000836 ! gonadal lineage variant

[Term]
id: WBPhenotype:0000838
name: male gonadal lineage variant
def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "male gonadal lineage abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant
is_a: WBPhenotype:0000836 ! gonadal lineage variant

[Term]
id: WBPhenotype:0000839
name: Z1 hermaphrodite lineage variant
def: "Z1 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "Z1 hermaphrodite lineage abnormal" NARROW []
is_a: WBPhenotype:0000837 ! hermaphrodite gonadal lineage variant

[Term]
id: WBPhenotype:0000840
name: Z4 hermaphrodite lineage variant
def: "Z4 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "Z4 hermaphrodite lineage abnormal" NARROW []
is_a: WBPhenotype:0000837 ! hermaphrodite gonadal lineage variant

[Term]
id: WBPhenotype:0000841
name: Z1 male lineage variant
def: "Z1 descendents exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "Z1 male lineage abnormal" NARROW []
is_a: WBPhenotype:0000838 ! male gonadal lineage variant

[Term]
id: WBPhenotype:0000842
name: Z4 male lineage variant
def: "Z4 descendants exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "Z4 male lineage abnormal" NARROW []
is_a: WBPhenotype:0000838 ! male gonadal lineage variant

[Term]
id: WBPhenotype:0000843
name: male mating efficiency reduced
def: "The number of cross progeny sired by males is reduced compared to control." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557]
is_a: WBPhenotype:0000648 ! male mating variant

[Term]
id: WBPhenotype:0000844
name: serotonin induced pumping variant
def: "Pharyngeal pumping is not influenced by serotonin treatment in the same manner as control animals." [WB:WBPerson2021]
synonym: "serotonin induced pumping abnormal" NARROW []
is_a: WBPhenotype:0000024 ! serotonin resistant
is_a: WBPhenotype:0001232 ! serotonin response variant
is_a: WBPhenotype:0001285 ! induced pharyngeal pumping variant

[Term]
id: WBPhenotype:0000845
name: levamisole response variant
def: "Animals exhibit variations in the response to the addition of levamisole compared to that observed in control animals. Levamisole is a cholinergic agonist." [WB:WBPerson557]
synonym: "levamisole response abnormal" NARROW []
synonym: "tetramisole response abnormal" RELATED []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0000846
name: presynaptic region physiology variant
def: "Animals exhibit variations in any physical or chemical process in the region of the vesicle-filled varicosities of the synapse compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "presynaptic region physiology abnormal" NARROW []
is_a: WBPhenotype:0000584 ! synaptic transmission variant

[Term]
id: WBPhenotype:0000847
name: presynaptic component localization variant
def: "Animals display variations in the distribution of the constituents that make up the synaptic machinery such as those required for priming, docking or fusion of vesicles at the active zone, compared to that observed in control animals." [WB:WBPaper00027305, WB:WBPerson712]
synonym: "presynaptic component localization abnormal" NARROW []
synonym: "synaptic component localization abnormal" RELATED []
synonym: "synaptic machinery localization abnormal" RELATED []
is_a: WBPhenotype:0001321 ! presynaptic region morphology variant

[Term]
id: WBPhenotype:0000848
name: developmental delay
def: "The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations

[Term]
id: WBPhenotype:0000849
name: amphid physiology variant
def: "Animals exhibit variations in any physical or chemical process required for an amphid to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557]
synonym: "amphid physiology abnormal" NARROW []
is_a: WBPhenotype:0000652 ! sensory system variant

[Term]
id: WBPhenotype:0000850
name: touch resistant anterior body
def: "Animal does not respond to stroking in the anterior body region with a hair or similar fiber compared to control. In C. elegans, the anterior region is defined as the body region that lies between the posterior bulb of the pharynx and the vulva." [WB:WBPaper00000502, WB:WBPaper00001705, WB:WBPerson557]
synonym: "touch insensitive anterior body" RELATED []
is_a: WBPhenotype:0000456 ! touch resistant

[Term]
id: WBPhenotype:0000851
name: ciliated neuron physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the ciliated neuron to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "ciliated neuron physiology abnormal" NARROW []
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0000852
name: coelomocyte development variant
def: "Variations in the progression of a free-floating spherical cell lying in the pseudocoelomic cavity of animals that can endocytose many compounds, possibly for immune surveillance, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "coelomocyte development abnormal" NARROW []
is_a: WBPhenotype:0000618 ! coelomic system development variant

[Term]
id: WBPhenotype:0000853
name: intraflagellar transport variant
def: "Variations in the bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum, compared to control." [GO:0042073, WB:WBPerson2021]
synonym: "IFT abnormal" RELATED []
synonym: "intraflagellar transport abnormal" NARROW []
is_a: WBPhenotype:0000851 ! ciliated neuron physiology variant

[Term]
id: WBPhenotype:0000854
name: intraflagellar transport defective
def: "Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is disrupted." [WB:WBPerson2021]
synonym: "ift defective" RELATED []
is_a: WBPhenotype:0000853 ! intraflagellar transport variant

[Term]
id: WBPhenotype:0000855
name: pseudocoelom development variant
def: "Variations in the progression of the fluid-filled space which separates the body wall from internal organs over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pseudocoelom development abnormal" NARROW []
is_a: WBPhenotype:0000200 ! pericellular component development variant

[Term]
id: WBPhenotype:0000856
name: excretory gland cell development variant
def: "Any variation in the progression of a gland cell of the secretory-excretory system over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "excretory gland cell development abnormal" NARROW []
is_a: WBPhenotype:0000620 ! excretory secretory system development variant
is_a: WBPhenotype:0000813 ! gland cell development variant

[Term]
id: WBPhenotype:0000857
name: excretory cell development variant
def: "Variations in the progression of a protokidney cell with an internal lumen that is suggested to collect and secrete salt solutions outward via the excretory sinus, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "excretory canal cell development abnormal" RELATED []
synonym: "excretory cell development abnormal" NARROW []
is_a: WBPhenotype:0000621 ! excretory system development variant

[Term]
id: WBPhenotype:0000858
name: excretory duct cell development variant
def: "Variations in the progression of an interfacial epithelial cell which forms a lumen to receive the outflow of the excretory gland and excretory canal cells, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "excretory duct cell development abnormal" NARROW []
is_a: WBPhenotype:0000621 ! excretory system development variant

[Term]
id: WBPhenotype:0000859
name: excretory socket cell development variant
def: "Variations in the progression of an interfacial epithelial cell which links excretory duct to hypodermis, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "excretory pore cell development abnormal" RELATED []
synonym: "excretory socket cell development abnormal" NARROW []
is_a: WBPhenotype:0000621 ! excretory system development variant

[Term]
id: WBPhenotype:0000860
name: nonstriated muscle development variant
def: "Variations in the progression of muscle cells that lack transverse striations in its constituent fibers and are almost always involuntary, over time from an initial condition to a later condition compared to control animals." [GO:0051145, WB:WBPerson2021, WB:WBPerson557]
synonym: "nonstriated muscle development abnormal" NARROW []
is_a: WBPhenotype:0000622 ! muscle system development variant

[Term]
id: WBPhenotype:0000861
name: body wall muscle development variant
def: "Any variation in the progression of the principal muscle cell type whose contractile activity generates body motion in the nematode over time compared to control. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the body wall (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body wall muscle cell development abnormal" NARROW []
synonym: "body wall muscle cell development variant" NARROW []
synonym: "body wall muscle development abnormal" EXACT []
synonym: "muscle belly development abnormal" RELATED []
synonym: "somatic muscle development abnormal" RELATED []
synonym: "striated muscle development abnormal" RELATED []
is_a: WBPhenotype:0000921 ! striated muscle development variant

[Term]
id: WBPhenotype:0000862
name: bloated
def: "Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000545 ! egg retention

[Term]
id: WBPhenotype:0000863
name: male fertility reduced
def: "Males exhibit a reduction in the production of new individuals owing to defects in sperm competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000784 ! male fertility variant

[Term]
id: WBPhenotype:0000864
name: early elongation arrest
def: "Cessation of development during the initial period of elongation. In C. elegans, this period refers to the conversion of the bean-shaped embryo into the two-fold- shaped embryo." [WB:WBPaper00027244]
is_a: WBPhenotype:0000867 ! embryonic arrest

[Term]
id: WBPhenotype:0000865
name: amphid sheath cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for a amphid sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557]
synonym: "amphid sheath cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000849 ! amphid physiology variant

[Term]
id: WBPhenotype:0000866
name: germ cell arrest
def: "Germ cells fail to undergo meiotic differentiation to form mature gametes." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000823 ! germline proliferation variant

[Term]
id: WBPhenotype:0000867
name: embryonic arrest
def: "Cessation of development during any stage occurring after fertilization and until hatching compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0000868
name: paralyzed body
def: "All parts of the animal are immobilized except for the head." [WB:cab]
is_a: WBPhenotype:0000644 ! paralyzed

[Term]
id: WBPhenotype:0000869
name: obsolete mitochondria morphology variant muscle
def: "OBSOLETE." [WB:WBPerson557]
is_obsolete: true
consider: WBPhenotype:0001401

[Term]
id: WBPhenotype:0000870
name: obsolete mitochondria morphology variant epithelial
def: "OBSOLETE." [WB:WBPerson557]
is_obsolete: true
consider: WBPhenotype:0001401

[Term]
id: WBPhenotype:0000871
name: obsolete connected mitochondria epithelial
def: "OBSOLETE." [WB:WBPerson557]
is_obsolete: true
consider: WBPhenotype:0001402

[Term]
id: WBPhenotype:0000872
name: obsolete connected mitochodria muscle
def: "OBSOLETE." [WB:WBPerson557]
is_obsolete: true
consider: WBPhenotype:0001402

[Term]
id: WBPhenotype:0000873
name: G1 checkpoint variant
def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G1 phase of the mitotic cell cycle just before entry into S phase, compared to control cells." [GO:0007089, WB:WBPerson557, WB:WBPerson712]
synonym: "G1 checkpoint abnormal" NARROW []
is_a: WBPhenotype:0000741 ! DNA damage checkpoint variant

[Term]
id: WBPhenotype:0000874
name: G2 checkpoint variant
def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G2 phase of the mitotic cell cycle just before entry into M phase, nuclear division, compared to control cells." [GO:0000075, WB:WBPerson557, WB:WBPerson712]
synonym: "G2 checkpoint abnormal" NARROW []
is_a: WBPhenotype:0000741 ! DNA damage checkpoint variant

[Term]
id: WBPhenotype:0000875
name: S phase checkpoint variant
def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the S phase of the mitotic cell cycle, which ensures DNA replication is complete, compared to control cells." [GO:0033314, WB:WBPerson712]
synonym: "S phase checkpoint abnormal" NARROW []
is_a: WBPhenotype:0000741 ! DNA damage checkpoint variant

[Term]
id: WBPhenotype:0000876
name: organism osmotic stress response variant
def: "Animals exhibit variations in their response to osmotic stress compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism osmotic stress response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0000877
name: amphid sheath cell development variant
def: "Any variation in the progression of a sheath cell of the amphid sensillum over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "amphid sheath cell development abnormal" NARROW []
is_a: WBPhenotype:0000950 ! neuronal sheath cell development variant

[Term]
id: WBPhenotype:0000878
name: chemosensory neuron development variant
def: "Any variation in the progression of a chemosensory neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "chemosensory neuron development abnormal" NARROW []
is_a: WBPhenotype:0000816 ! neuron development variant

[Term]
id: WBPhenotype:0000879
name: telomere length regulation variant
def: "Animals exhibit variations in the processes that are required to maintain the length of telomeric DNA from generation to generation compared to control." [GO:0032204, WB:WBPaper00031585, WB:WBPerson712]
synonym: "telomere length regulation abnormal" NARROW []
is_a: WBPhenotype:0001673 ! telomere homeostasis variant

[Term]
id: WBPhenotype:0000880
name: axon development variant
def: "Any variation in the processes that influence the generation of neuronal extensions, that carry efferent (outgoing) action potentials from the cell body towards target cells compared to control." [GO:0007409, WB:WBPerson2021, WB:WBPerson557]
synonym: "axon development abnormal" NARROW []
synonym: "axonogenesis abnormal" RELATED []
is_a: WBPhenotype:0000944 ! neurite development variant

[Term]
id: WBPhenotype:0000881
name: cilia mislocalized
def: "Animals exhibit variations in the placement of the microtuble-based dendritic projections in relation to the sensillum neuron, from that observed in control animals." [WB:WBPerson712]
is_a: WBPhenotype:0001526 ! ciliated neuron morphology variant

[Term]
id: WBPhenotype:0000882
name: dendrite development variant
def: "Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control." [GO:0016358, WB:WBPerson2021]
synonym: "dendrite development abnormal" NARROW []
is_a: WBPhenotype:0000944 ! neurite development variant

[Term]
id: WBPhenotype:0000883
name: nerve ring development variant
def: "Variations in the progression of the major zone of overlapping axons in the head, which encircles the isthmus of the pharynx to form a tightly packed ring-like structure on the outside of the pharynx, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "nerve ring development abnormal" NARROW []
is_a: WBPhenotype:0000945 ! neuropil development variant

[Term]
id: WBPhenotype:0000884
name: AWB morphology variant
def: "Animals exhibit variations in the structure or organization of either of a set of two ciliated wing neurons, AWBL or AWBR, of the amphid sensilla, compared to that observed in control animals." [WB:WBPaper00000938, WB:WBPerson712]
comment: WBbt:0005671.
synonym: "AWB morphology abnormal" NARROW []
is_a: WBPhenotype:0000256 ! amphid neuron morphology variant

[Term]
id: WBPhenotype:0000885
name: engulfment variant
def: "Any variation in the removal of a cell corpse, by a neighboring cell or a phagocyte compared to control." [GO:0043652, WB:WBPerson2021]
synonym: "engulfment abnormal" NARROW []
synonym: "phagocytosis abnormal" RELATED []
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0000886
name: nematode phenotype
def: "Animals exhibit variations compared to a given control." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "Abnormal" EXACT []
synonym: "not wildtype" RELATED []
synonym: "not WT" RELATED []
synonym: "variant" EXACT []

[Term]
id: WBPhenotype:0000887
name: hermaphrodite behavior variant
def: "Animals exhibit variations in hermaphrodite-specific behaviors compared to control." [WB:WBPerson557]
synonym: "hermaphrodite behavior abnormal" NARROW []
is_a: WBPhenotype:0000821 ! sexually dimorphic behavior variant

[Term]
id: WBPhenotype:0000888
name: male behavior variant
def: "Animals exhibit variations in male-specific behaviors compared to control." [WB:WBPerson557]
synonym: "male behavior abnormal" NARROW []
is_a: WBPhenotype:0000821 ! sexually dimorphic behavior variant

[Term]
id: WBPhenotype:0000889
name: sexually dimorphic physiology variant
def: "Animals exhibit variations in any physical or chemical process required to carry out sex-specific activities or to be able to perceive and respond to sex-specific stimuli compared to control." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "sexually dimorphic physiology abnormal" NARROW []
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0000890
name: larval pigmentation variant
def: "Larva exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals." [WB:WBPerson557]
synonym: "larval pigmentation abnormal" NARROW []
is_a: WBPhenotype:0001009 ! developmental pigmentation variant

[Term]
id: WBPhenotype:0000891
name: clear adult
def: "Adult animals appear unusually transparent when compared to control." [WB:WBPerson557]
synonym: "Clr" BROAD []
is_a: WBPhenotype:0000346 ! adult pigmentation variant
is_a: WBPhenotype:0001010 ! clear

[Term]
id: WBPhenotype:0000892
name: hermaphrodite germline proliferation variant
def: "Nuclear divisions in the germ line of hermaphrodites are either expanded are reduced compared to control." [WB:WBPerson2021]
synonym: "hermaphrodite germ cell proliferation abnormal" RELATED []
synonym: "hermaphrodite germ line proliferation abnormal" RELATED []
synonym: "hermaphrodite germline proliferation abnormal" NARROW []
is_a: WBPhenotype:0000823 ! germline proliferation variant

[Term]
id: WBPhenotype:0000893
name: male germline proliferation variant
def: "Nuclear divisions in the germ line of male animals are either expanded are reduced compared to control." [WB:WBPerson2021]
synonym: "male germ cell proliferation abnormal" RELATED []
synonym: "male germ line proliferation abnormal" RELATED []
synonym: "male germline proliferation abnormal" NARROW []
is_a: WBPhenotype:0000823 ! germline proliferation variant

[Term]
id: WBPhenotype:0000894
name: germ cell differentiation variant
def: "Variations in the ability of a relatively unspecialized cell to acquire the specialized features of a mature gamete compared to control." [WB:WBPerson2021]
synonym: "germ cell differentiation abnormal" NARROW []
is_a: WBPhenotype:0000774 ! gametogenesis variant

[Term]
id: WBPhenotype:0000895
name: obsolete spermatocyte germ cell differentiation abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000670

[Term]
id: WBPhenotype:0000896
name: obsolete oocyte germ cell differentiation abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000186

[Term]
id: WBPhenotype:0000897
name: connective tissue development variant
def: "Variations in the material made up of fibers forming a framework and support structure for body tissues and organs compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "connective tissue abnormal" NARROW []
is_a: WBPhenotype:0000200 ! pericellular component development variant

[Term]
id: WBPhenotype:0000898
name: blast cell morphology variant
def: "Any variation in the morphological appearance of blast cells compared to control animals." [WB:cab]
synonym: "blast cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000899
name: epithelial cell morphology variant
def: "Any variation in the morphological appearance of epithelial cells compared to control animals." [WB:WBPerson557]
synonym: "epithelial cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000900
name: germ cell morphology variant
def: "Any variation in the morphological appearance of germ cells compared to control animals." [WB:cab]
synonym: "germ cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000901
name: gland cell morphology variant
def: "Any variation in the morphological appearance of gland cells compared to control animals." [WB:cab]
synonym: "gland cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000902
name: intestinal cell morphology variant
def: "Any variation in the morphological appearance of intestinal cells compared to control animals." [WB:cab]
synonym: "intestinal cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000710 ! intestinal morphology variant
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000903
name: marginal cell morphology variant
def: "Any variation in the morphological appearance of marginal cells compared to control animals." [WB:cab]
synonym: "marginal cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000904
name: muscle cell morphology variant
def: "Any variation in the morphological appearance of muscle cells compared to control animals." [WB:cab]
synonym: "muscle cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000603 ! muscle system morphology variant
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000905
name: neuron morphology variant
def: "Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses." [WB:cab, WB:WBPerson712]
comment: WBbt:0003679.
synonym: "neuron morphology abnormal" NARROW []
is_a: WBPhenotype:0000604 ! nervous system morphology variant
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000906
name: uterine vulval cell morphology variant
def: "Animals exhibit variations in the form, structure or composition of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "uterine vulval cell morphology abnormal" NARROW []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0000907
name: anus morphology variant
def: "Any variation in the structural appearance of the caudal opening of the rectum in the tail compared to control animals." [WB:WBPerson557]
synonym: "anus morphology abnormal" NARROW []
is_a: WBPhenotype:0000598 ! alimentary system morphology variant

[Term]
id: WBPhenotype:0000908
name: cloacal morphology variant
alt_id: WBPhenotype:0000343
def: "Any variation in the structural appearance of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) compared to control animals." [WB:WBPerson557]
synonym: "cloaca morphology abnormal" EXACT []
synonym: "cloacal morphology abnormal" NARROW []
is_a: WBPhenotype:0000598 ! alimentary system morphology variant
is_a: WBPhenotype:0000605 ! reproductive system morphology variant

[Term]
id: WBPhenotype:0000909
name: pharyngeal intestinal valve morphology variant
def: "Any variation in the structure or appearance of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas)." [WB:WBPerson557]
synonym: "pharyngeal intestinal valve morphology abnormal" NARROW []
is_a: WBPhenotype:0000598 ! alimentary system morphology variant

[Term]
id: WBPhenotype:0000910
name: rectal morphology variant
def: "Any variation in the morphological appearance of the rectum compared to control animals." [WB:WBPerson557]
synonym: "rectal morphology abnormal" NARROW []
is_a: WBPhenotype:0000598 ! alimentary system morphology variant

[Term]
id: WBPhenotype:0000911
name: coelomocyte morphology variant
def: "Any variation in the morphological appearance of coelomocytes compared to control animals." [WB:WBPerson557]
synonym: "coelomocyte morphology abnormal" NARROW []
is_a: WBPhenotype:0000599 ! coelomic system morphology variant

[Term]
id: WBPhenotype:0000912
name: pericellular component morphology variant
def: "Any variation in the morphological appearance of pericellular components compared to control animals." [WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "pericellular component morphology abnormal" NARROW []
is_a: WBPhenotype:0000520 ! morphology phenotype

[Term]
id: WBPhenotype:0000913
name: basal lamina morphology variant
def: "Any variation in the morphological appearance of the basal lamina compared to control animals." [WB:WBPerson557]
synonym: "basal lamina morphology abnormal" NARROW []
is_a: WBPhenotype:0000600 ! epithelial system morphology variant

[Term]
id: WBPhenotype:0000914
name: excretory gland cell morphology variant
def: "Animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "excretory gland cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant

[Term]
id: WBPhenotype:0000915
name: pale adult
def: "Adults show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000346 ! adult pigmentation variant
is_a: WBPhenotype:0001261 ! pale

[Term]
id: WBPhenotype:0000916
name: excretory cell morphology variant
def: "Any variation in the morphological appearance of the excretory cell compared to control animals." [WB:WBPerson557]
synonym: "excretory canal cell morphology abnormal" RELATED []
synonym: "excretory cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant

[Term]
id: WBPhenotype:0000917
name: excretory duct cell morphology variant
def: "Any variation in the morphological appearance of the excretory duct cell compared to control animals." [WB:WBPerson557]
synonym: "excretory duct cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant

[Term]
id: WBPhenotype:0000918
name: excretory socket cell morphology variant
def: "Any variation in the morphological appearance of the excretory socket cell compared to control animals." [WB:WBPerson557]
synonym: "excretory socket cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant

[Term]
id: WBPhenotype:0000919
name: body wall muscle cell spindle development variant
def: "Any variation in the progression of the region of a body wall muscle cell that contains the myofilament lattice (adjacent to the hypodermis) over time, from its initial state to the fully differentiated state compared to control." [WB:WBPaper00000461, WB:WBPerson2021, WB:WBPerson557]
synonym: "filament lattice body wall muscle cell development abnormal" RELATED []
synonym: "spindle body wall muscle cell development abnormal" NARROW []
synonym: "spindle body wall muscle cell development variant" RELATED []
is_a: WBPhenotype:0000087 ! body wall cell development variant

[Term]
id: WBPhenotype:0000920
name: obsolete body wall muscle cell development variant
def: "OBSOLETE." [WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0000861

[Term]
id: WBPhenotype:0000921
name: striated muscle development variant
def: "Variations in the progression of muscle cells that contain fibers that are divided by transverse bands into striations, over time from an initial condition to a later condition compared to control animals." [GO:0055002, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "striated muscle development abnormal" NARROW []
is_a: WBPhenotype:0000622 ! muscle system development variant

[Term]
id: WBPhenotype:0000922
name: male longitudinal muscle development variant
def: "Any variation in the progression of somatic (striated) muscles that run longitudinally in males over time from its initial formation to its mature form compared to control. In C. elegans males have 3 additional sets of sex-specific longitudinal muscles (anterior and posterior outer, anterior and posterior inner, and caudal) that contribute to the body wall musculature (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male longitudinal muscle development abnormal" NARROW []
is_a: WBPhenotype:0000921 ! striated muscle development variant

[Term]
id: WBPhenotype:0000923
name: nonstriated muscle morphology variant
def: "Any variation in the morphological appearance of the nonstriated muscle compared to control animals." [WB:WBPerson557]
synonym: "nonstriated muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0000603 ! muscle system morphology variant

[Term]
id: WBPhenotype:0000924
name: striated muscle morphology variant
def: "Any variation in the morphological appearance of the striated muscle compared to control animals." [WB:WBPerson557]
synonym: "striated muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0000603 ! muscle system morphology variant

[Term]
id: WBPhenotype:0000925
name: sex muscle morphology variant
def: "Any variation in the morphological appearance of the sex muscles compared to control animals." [WB:WBPerson557]
synonym: "sex muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0000923 ! nonstriated muscle morphology variant

[Term]
id: WBPhenotype:0000926
name: body wall muscle morphology variant
def: "Any variation in the morphological appearance of the body wall muscle compared to control animals." [WB:WBPerson557]
synonym: "body wall muscle morphology abnormal" NARROW []
synonym: "Dim" RELATED []
is_a: WBPhenotype:0000924 ! striated muscle morphology variant

[Term]
id: WBPhenotype:0000927
name: male longitudinal muscle morphology variant
def: "Any variation in the morphological appearance of the male longitudinal muscle compared to control animals." [WB:WBPerson557]
synonym: "male longitudinal muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0000924 ! striated muscle morphology variant

[Term]
id: WBPhenotype:0000928
name: male physiology variant
def: "Animals exhibit variations in any physical or chemical process required to carry out male-specific activities or to be able to perceive and respond to male-specific stimuli compared to control." [WB:WBPerson557]
synonym: "male physiology abnormal" NARROW []
is_a: WBPhenotype:0000889 ! sexually dimorphic physiology variant

[Term]
id: WBPhenotype:0000929
name: hermaphrodite physiology variant
def: "Animals exhibit variations in any physical or chemical process required to carry out hermaphrodite-specific activities or to be able to perceive and respond to hermaphrodite-specific stimuli compared to control." [WB:WBPerson557]
synonym: "hermaphrodite physiology abnormal" NARROW []
is_a: WBPhenotype:0000889 ! sexually dimorphic physiology variant

[Term]
id: WBPhenotype:0000930
name: sexually dimorphic development variant
def: "Variations in the progression of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "sexually dimorphic development abnormal" NARROW []
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0000931
name: bisphenol A response variant
def: "Animals exhibit variations in their response to bisphenol A compared to that observed in control animals." [WB:WBPerson557]
synonym: "bisphenol A response abnormal" NARROW []
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0000932
name: bisphenol A hypersensitive
def: "Animals respond to bisphenol A at a lower concentration or a shorter exposure time compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000931 ! bisphenol A response variant

[Term]
id: WBPhenotype:0000933
name: MS lineage variant
def: "The descendants of the MS blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPaper00002330, WB:WBPerson2021]
synonym: "MS lineage abnormal" NARROW []
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000934
name: developmental morphology variant
def: "Animals exhibit variations in the form, structure or composition of any of its parts during a given developmental stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "developmental morphology abnormal" NARROW []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0000935
name: D lineage variant
def: "The descendants of the D blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPaper00002572, WB:WBPerson2021]
synonym: "D lineage abnormal" NARROW []
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000936
name: P4 lineage variant
def: "The descendants of the P4 blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "P4 lineage abnormal" NARROW []
is_a: WBPhenotype:0000824 ! embryonic cell lineage variant

[Term]
id: WBPhenotype:0000937
name: W lineage variant
def: "The descendants of the W precursor cell exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "W lineage abnormal" NARROW []
is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant

[Term]
id: WBPhenotype:0000938
name: male V lineages variant
def: "The descendants of any of the V precursor cells (V1-V6) in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "male V lineages abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000939
name: male T lineages variant
def: "The descendants of TL or TR cells in male animals exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "male T lineages abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000940
name: male P lineages variant
def: "The descendants of any of the P precursor cells (P1-P12) in male animals exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "male P lineages abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000941
name: male M lineage variant
def: "The descendants of the M precursor cell in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021]
synonym: "male M lineage abnormal" NARROW []
is_a: WBPhenotype:0000809 ! male specific lineage variant

[Term]
id: WBPhenotype:0000942
name: accessory cell development variant
def: "Any variation in the progression of an accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. An accessory cell supports sensory neurons." [WB:WBPerson2021, WB:WBPerson557]
synonym: "accessory cell development abnormal" NARROW []
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0000943
name: ganglion development variant
def: "Any variation in the progression of a cluster of neuron cell bodies (somata) over time from its initial formation to its mature form compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0000944
name: neurite development variant
def: "Variations in the progression of a neuronal extension (such as axons or dendrites) over time, from its formation to the mature structure compared to control." [GO:0031175, WB:WBPerson2021]
synonym: "neurite development abnormal" NARROW []
is_a: WBPhenotype:0000816 ! neuron development variant

[Term]
id: WBPhenotype:0000945
name: neuropil development variant
def: "Any variation in the progression of a dense feltwork of interwoven cytoplasmic processes of nerve cells (dendrites and axons) and support cells, over time from an initial condition to a later condition, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "neuropil development abnormal" NARROW []
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0000946
name: pharyngeal nervous system development variant
def: "Variations in the progression of a set of interacting or interdependent entities forming the pharyngeal nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses." [GO:0007420, WB:WBPerson2021, WB:WBPerson557]
synonym: "pharyngeal nervous system development abnormal" NARROW []
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0000947
name: connective tissue morphology variant
def: "Variations in the form, structure or composition of the material made up of fibers forming a framework and support structure for body tissues and organs compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "connective tissue morphology abnormal" NARROW []
is_a: WBPhenotype:0000912 ! pericellular component morphology variant

[Term]
id: WBPhenotype:0000948
name: cuticle morphology variant
def: "Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cuticle morphology abnormal" NARROW []
is_a: WBPhenotype:0000912 ! pericellular component morphology variant

[Term]
id: WBPhenotype:0000949
name: pseudocoelom morphology variant
def: "Any variation in the appearance of the body cavity compared to control. In C. elegans , an aberrancy in the psedocoelom can involve an accumulation of fluids or fluorescent reporters." [WB:WBPerson712]
synonym: "pseudocoelom morphology abnormal" NARROW []
is_a: WBPhenotype:0000912 ! pericellular component morphology variant

[Term]
id: WBPhenotype:0000950
name: neuronal sheath cell development variant
def: "Any variation in the progression of a neuronal sheath cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A neuronal sheath cell is a structural cell that forms a specialized environment surrounding the sensory endings of a neuron." [WB:WBPerson2021]
synonym: "neuronal sheath cell development abnormal" NARROW []
is_a: WBPhenotype:0000942 ! accessory cell development variant

[Term]
id: WBPhenotype:0000951
name: socket cell development variant
def: "Any variation in the progression of a socket cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021]
synonym: "socket cell development abnormal" NARROW []
is_a: WBPhenotype:0000942 ! accessory cell development variant

[Term]
id: WBPhenotype:0000952
name: anterior ganglion development variant
def: "Any variation in the progression of a cluster of neuron somata located close to the nerve ring over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "anterior ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000953
name: dorsal ganglion development variant
def: "Any variation in the progression of the ganglion that lies dorsally beside the nerve ring in the head over time from its initial formation to its mature form compared to control. In C. elegans, It contains neuron cell bodies that send their neuronal processes into the ring and longitudinal nerves, but form no local neuropil separate from the nerve ring. The dorsal ganglion is in close contact with the dorsal hypodermal cord (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dorsal ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000954
name: dorsorectal ganglia development variant
def: "Any variation in the progression of the ganglion which lies above and behind the rectum in the tail, in close continuity with the anal hypodermal ridge over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dorsorectal ganglia development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000955
name: lateral ganglia development variant
def: "Any variation in the progression of the left and right lateral ganglia which lie beside the nerve ring in the head over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "lateral ganglia development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000956
name: lumbar ganglia development variant
def: "Any variation in the progression of the left and right lumbar ganglia which lie behind the pre-anal ganglion in the tail, in lateral positions over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "lumbar ganglia development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000957
name: posterior lateral ganglion development variant
def: "Any variation in the progression of the neuron somata associated with the post-deirid over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "posterior lateral ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000958
name: preanal ganglion development variant
def: "Any variation in the progression of the ganglion which lies at the posterior limit of the ventral nerve cord in the tail over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "preanal ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000959
name: retrovesicular ganglion development variant
def: "Any variation in the progression of the ganglion which lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "retrovesicular ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000960
name: ventral ganglion development variant
def: "Any variation in the progression of the ganglion which lies ventrally beside the nerve ring in the head, just anterior of the retrovesicular ganglion over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ventral ganglion development abnormal" NARROW []
is_a: WBPhenotype:0000943 ! ganglion development variant

[Term]
id: WBPhenotype:0000961
name: pattern of transgene expression variant
def: "Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
synonym: "pattern of transgene expression abnormal" NARROW []
is_a: WBPhenotype:0000111 ! pattern of gene expression variant
is_a: WBPhenotype:0000306 ! transgene expression variant

[Term]
id: WBPhenotype:0000962
name: level of transgene expression variant
def: "Any variation in the measured expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
synonym: "level of transgene expression abnormal" NARROW []
is_a: WBPhenotype:0000306 ! transgene expression variant
is_a: WBPhenotype:0002575 ! gene expression level abnormal

[Term]
id: WBPhenotype:0000963
name: male pigmentation variant
def: "Males exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism compared to control animals." [WB:WBPerson557]
synonym: "male pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000527 ! organism pigmentation phenotype

[Term]
id: WBPhenotype:0000964
name: DMPP resistant
def: "Animals fail to respond to the concentration of DMPP that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000681 ! DMPP response variant

[Term]
id: WBPhenotype:0000965
name: somatic cell death variant
def: "Animals exhibit variations in the programmed cell death pathway that is triggered in cells other than germ cells and that is not subject to upstream checkpoint regulation." [WB:WBPaper00032243, WB:WBPerson712]
synonym: "somatic cell death abnormal" NARROW []
is_a: WBPhenotype:0001172 ! programmed cell death variant

[Term]
id: WBPhenotype:0000966
name: germline mortal
def: "Progressive decrease in brood size culminating, over generations, in the loss of reproductive ability and thus becoming effectively sterile." [WB:WBPaper00003886, WB:WBPaper00027026, WB:WBPerson712]
synonym: "Mrt" BROAD []
is_a: WBPhenotype:0000987 ! germ cell physiology variant

[Term]
id: WBPhenotype:0000967
name: obsolete male tail spike
def: "OBSOLETE." []
comment: In the WS193 and WS200 versions of WormBase WBPhenotype:0000967 has term name "male tail spike"; In some older records the term ID WBPhenotype:0000967 had the term name "male distal tip cell behavior abnormal", which may reflect an earlier (now deprecated) usage of the term ID.
is_obsolete: true
replaced_by: WBPhenotype:0001431

[Term]
id: WBPhenotype:0000968
name: tail spike variant
def: "Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the tail compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000073 ! tail morphology variant

[Term]
id: WBPhenotype:0000969
name: accessory cell morphology variant
def: "Animals exhibit variations in the structure, organization or placement of the cells that support sensory neurons, compared to that observed in control animals. In C. elegans, this category collectively refers to socket cells, sheath cells, and structural cells, or their processes." [WB:WBPerson557, WB:WBPerson712]
comment: WBbt:0005762.
synonym: "accessory cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000604 ! nervous system morphology variant

[Term]
id: WBPhenotype:0000970
name: embryonic pigmentation variant
def: "Embryos exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals ." [WB:WBPerson557]
synonym: "embryonic pigmentation abnormal" NARROW []
is_a: WBPhenotype:0001009 ! developmental pigmentation variant

[Term]
id: WBPhenotype:0000971
name: anterior pigmentation variant
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the anterior body axis compared to control." [WB:WBPerson557]
synonym: "anterior pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000786 ! body axis pigmentation variant

[Term]
id: WBPhenotype:0000972
name: neuronal sheath cell morphology variant
alt_id: WBPhenotype:0001529
def: "Animals exhibit variations in the structure or composition of the glia-like support cell of neuronal sensilla that ensheathes the dendrite tips and or processes of neurons, from that observed in control animals. In C. elegans, sheath cells have highly invaginated and vesiculated surfaces, which provide a specialized environment for dendritic structures." [WB:WBPaper00000822, WB:WBPaper00000938, WB:WBPerson712]
synonym: "neuronal sheath cell morphology abnormal" NARROW []
synonym: "sensilium sheath cell morphology abnormal" NARROW []
synonym: "sensilium sheath cell morphology variant" EXACT []
is_a: WBPhenotype:0000969 ! accessory cell morphology variant
is_a: WBPhenotype:0001528 ! sensillum accessory cell morphology variant

[Term]
id: WBPhenotype:0000973
name: homologous recombination increased
def: "Animals exhibit an increased frequency of exchange of genetic material between non-sister chromatids of a pair of homologues." [GO:0007131, WB:WBPerson712]
is_a: WBPhenotype:0000742 ! DNA recombination variant

[Term]
id: WBPhenotype:0000974
name: accessory cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required by a subset of interfacial cells to carry out its normal function or be able to perceive and respond to stimuli, compared to control. It can refer to socket cells, sheath cells and structural cells or their processes (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "accessory cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000612 ! nervous system physiology variant

[Term]
id: WBPhenotype:0000975
name: neuronal sheath cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for a neuronal sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557]
synonym: "neuronal sheath cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000974 ! accessory cell physiology variant

[Term]
id: WBPhenotype:0000976
name: ventral cord patterning variant
def: "Any variation in the developmental process that results in the creation of defined areas or spaces within the ventral cord to which cells respond and eventually are instructed to differentiate compared to control." [GO:0007389, WB:WBPerson2021, WB:WBPerson557]
synonym: "ventral cord patterning abnormal" NARROW []
is_a: WBPhenotype:0000515 ! ventral nerve cord development variant

[Term]
id: WBPhenotype:0000977
name: somatic gonad morphology variant
def: "Animals exhibit variations in the form, structure or composition of the components of the gonad that are separate from the germline proper compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "somatic gonad morphology abnormal" NARROW []
is_a: WBPhenotype:0001355 ! gonad morphology variant

[Term]
id: WBPhenotype:0000978
name: spermatheca physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the spermatheca to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "spermatheca physiology abnormal" NARROW []
is_a: WBPhenotype:0001197 ! somatic gonad physiology variant

[Term]
id: WBPhenotype:0000979
name: spermatheca dilation defective
def: "Animals exhibit defects in any physical or chemical process involved in the dilation of the distal spermatheca which is required for the oocyte exit from the gonad arm." [WB:WBPaper00003371, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000978 ! spermatheca physiology variant

[Term]
id: WBPhenotype:0000980
name: pharyngeal contraction variant
def: "Any variation in the muscle contractions that control feeding compared to control. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pharyngeal contraction abnormal" NARROW []
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0000981
name: spermatocyte meiosis variant
alt_id: WBPhenotype:0000713
def: "Animals exhibit variations in the meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids (non-motile sperm) compared to control." [GO:0048137, WB:WBPaper00027300, WB:WBPerson2021]
synonym: "spermatocyte division abnormal" NARROW []
synonym: "spermatocyte division variant" EXACT []
synonym: "spermatocyte meiosis abnormal" NARROW []
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0000982
name: spermatid maturation variant
def: "Animals exhibit variations in the ability of a relatively unspecialized spermatocyte to acquire the properties of a spermatid cell compared to control." [WB:WBPaper00027300, WB:WBPerson2021]
synonym: "spermatid maturation abnormal" NARROW []
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0000983
name: fertilization defective
def: "Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) during sexual reproduction." [GO:0009566, WB:WBPerson2021]
is_a: WBPhenotype:0000613 ! reproductive system physiology variant

[Term]
id: WBPhenotype:0000984
name: posterior pigmentation variant
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency of the posterior body axis compared to control." [WB:WBPerson557]
synonym: "posterior pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000786 ! body axis pigmentation variant

[Term]
id: WBPhenotype:0000985
name: blast cell physiology phenotype
def: "Animals exhibit variations in any physical or chemical process required for the blast cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "blast cell physiology abnormal" NARROW []
synonym: "blast cell physiology variant" EXACT []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000986
name: epithelial cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the epithelial cell to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "epithelial cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000987
name: germ cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the germ cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "germ cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000988
name: gland cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the gland cell to carry out its normal functions or activities or be able to perceive and respond to signals, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "gland cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000989
name: marginal cell physiology variant
def: "Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for a marginal cell to carry out its normal function and activities or be able to perceive and respond to stimuli." [GO:0009987, WB:WBPerson557]
synonym: "marginal cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000990
name: muscle cell physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the muscle cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "muscle cell physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0000991
name: obsolete neuron physiology variant
def: "OBSOLETE: Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes." [WB:WBPaper00032221, WB:WBPerson712]
is_obsolete: true
replaced_by: WBPhenotype:0002563

[Term]
id: WBPhenotype:0000992
name: high sodium chloride concentration osmotic avoidance defective
def: "Failure to execute the characteristic response to high concentrations of sodium chloride solution. C. elegans typically avoids high concentrations of sodium chloride solution." [WB:WBPerson2021]
is_a: WBPhenotype:0000249 ! osmotic avoidance defective
is_a: WBPhenotype:0001453 ! high sodium chloride concentration osmotic avoidance variant

[Term]
id: WBPhenotype:0000993
name: anal depressor contraction defect
def: "Animals fail to contract the anal depressor muscle." [WB:WBPaper00001256]
synonym: "Exp" BROAD []
is_a: WBPhenotype:0001092 ! larval defecation defect

[Term]
id: WBPhenotype:0000994
name: intestinal contractions variant
def: "Any variations in the contraction of the enteric muscles that are involved in defecation motor program compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emc" RELATED []
synonym: "enteric muscle contraction variant" RELATED []
synonym: "intestinal contractions abnormal" NARROW []
is_a: WBPhenotype:0000210 ! defecation contraction variant

[Term]
id: WBPhenotype:0000995
def: "OBSOLETE." []
comment: WBPhenotype:0000995 an alt_id for "sodium chloride chemotaxis defective" (WBPhenotype:0001084) (WS193 OBO and WS200 site) AND has term name "pos body wall contraction defect" (dump_phenotype_ace.pl)
is_obsolete: true

[Term]
id: WBPhenotype:0000996
name: expulsion defective
def: "Animals exhibit defects in the expulsion of gut contents. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPaper00001256, WB:WBPaper00031246, WB:WBPerson712]
synonym: "Emc" BROAD []
synonym: "Exp" BROAD []
is_a: WBPhenotype:0000205 ! expulsion variant

[Term]
id: WBPhenotype:0000997
name: cryophilic
def: "Animals tend to track and stay within low temperature environments." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant

[Term]
id: WBPhenotype:0000998
name: thermophilic
def: "Animals tend to track and stay within high temperature environments." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant

[Term]
id: WBPhenotype:0000999
name: athermotactic
def: "The responses of an animal towards temperature are not influenced by its cultivation temperature." [WB:WBPerson363]
is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant

[Term]
id: WBPhenotype:0001000
name: developmental behavior variant
def: "Any variation in the behavior characteristic during certain developmental stage(s) compared to control." [WB:cab]
subset: phenotype_slim_wb
synonym: "developmental behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001001
name: dauer behavior variant
def: "Variations in the specific actions or reactions of dauer stage animals in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer behavior abnormal" NARROW []
is_a: WBPhenotype:0000819 ! postembryonic behavior variant

[Term]
id: WBPhenotype:0001002
name: head muscle behavior variant
def: "Variations in the specific actions or reactions of the head muscles in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "head muscle behavior abnormal" NARROW []
is_a: WBPhenotype:0000595 ! head behavior variant

[Term]
id: WBPhenotype:0001003
name: L4 lethal
def: "Animals die at the L4 stage of the life cycle." [WB:WBPerson2021]
synonym: "Let" BROAD []
synonym: "Lvl" BROAD []
is_a: WBPhenotype:0000058 ! late larval lethal

[Term]
id: WBPhenotype:0001004
name: pharyngeal relaxation variant
def: "Any variation in the relaxation of pharyngeal muscles after contraction events compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pharyngeal relaxation abnormal" NARROW []
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0001005
name: backward locomotion variant
def: "Variations in the spontaneous or induced backward crawling locomotion of an animal compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "backward locomotion abnormal" NARROW []
is_a: WBPhenotype:0002320 ! reversal variant

[Term]
id: WBPhenotype:0001006
name: pharyngeal pumping rate variant
def: "The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals." [WB:WBPaper00001709, WB:WBPerson712]
synonym: "feeding rate dynamics abnormal" RELATED []
synonym: "pharyngeal pumping rate abnormal" NARROW []
synonym: "pumping rate dynamics abnormal" RELATED []
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0001007
name: other abnormality early emb
def: "Unclassified abnormality in the inviable one- to four-cell embryo." [WB:cab]
synonym: "Emb" BROAD []
synonym: "Oth" BROAD []
synonym: "other abnormal" NARROW []
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001008
name: male nervous system development variant
def: "Variations in the progression of a set of interacting or interdependent entities forming the male nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses." [GO:0007420, WB:WBPerson2021, WB:WBPerson557]
synonym: "male nervous system development abnormal" NARROW []
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0001009
name: developmental pigmentation variant
def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular developmental stage of the amimal compared to control animals." [WB:WBPerson557]
synonym: "developmental pigmentation abnormal" NARROW []
is_a: WBPhenotype:0000527 ! organism pigmentation phenotype

[Term]
id: WBPhenotype:0001010
name: clear
def: "Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654]
synonym: "Clr" BROAD []
is_a: WBPhenotype:0000527 ! organism pigmentation phenotype

[Term]
id: WBPhenotype:0001011
name: complex phenotype early emb
def: "Population of unhatched eggs exhibit a complex combination of defects that do not match other class definitions." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001007 ! other abnormality early emb

[Term]
id: WBPhenotype:0001012
name: organism pathogen response variant
def: "Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack." [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712]
synonym: "bacterial load variant" NARROW []
synonym: "organism pathogen response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0001013
name: pathogen susceptibility increased
def: "Animals are more prone to infection compared to control." [WB:cab, WB:WBPaper00005370, WB:WBPaper00024299]
synonym: "enhanced susceptibility to pathogens" RELATED []
synonym: "Esp" BROAD []
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0001014
name: pathogen resistance increased
def: "Animals are less prone to infection compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pathogen susceptibility decreased" RELATED []
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0001015
name: developmental growth variant
def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during any development stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "developmental growth abnormal" NARROW []
is_a: WBPhenotype:0000030 ! growth variant

[Term]
id: WBPhenotype:0001016
name: larval growth variant
def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the larval stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "larval growth abnormal" NARROW []
is_a: WBPhenotype:0001015 ! developmental growth variant

[Term]
id: WBPhenotype:0001017
name: adult growth variant
def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the adult stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "adult growth abnormal" NARROW []
is_a: WBPhenotype:0001015 ! developmental growth variant

[Term]
id: WBPhenotype:0001018
name: cytokinesis variant emb
def: "Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control." [GO:0000910, WB:WBPerson2021]
synonym: "Cyk" BROAD []
is_a: WBPhenotype:0000050 ! embryonic lethal
is_a: WBPhenotype:0002408 ! cytokinesis variant

[Term]
id: WBPhenotype:0001019
name: mid larval arrest
def: "Animals arrest during the stage between early and late larval development. In C. elegans, mid larval arrest occurs during the L2 to L3 stages of development." [WB:cab]
is_a: WBPhenotype:0000059 ! larval arrest

[Term]
id: WBPhenotype:0001020
name: embryonic lethal late emb
def: "Animals die during the final stages of embryogenesis. In C. elegans, this lethality refers to death during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation." [WB:WBPerson101]
synonym: "Emb" BROAD []
synonym: "Led" BROAD []
is_a: WBPhenotype:0000050 ! embryonic lethal

[Term]
id: WBPhenotype:0001021
name: male sexual development variant
def: "Genetically male animals exhibit deviations in the sexual program specific to males. In C. elegans, this often refers to XO animals being transformed into fertile hermaphrodites." [WB:WBPaper00000498, WB:WBPerson2021]
synonym: "Her" BROAD []
synonym: "male sexual development abnormal" NARROW []
is_a: WBPhenotype:0000822 ! sex determination variant

[Term]
id: WBPhenotype:0001022
name: hermaphrodite sexual development variant
def: "Genetically hermaphrodite animals exhibit deviations in the sexual program specific to hermaphrodites. In C. elegans, this refers to XX animals that develop as males or intersexuals instead of self-fertile hermaphrodites." [WB:WBPerson2021]
synonym: "hermaphrodite sexual development abnormal" NARROW []
is_a: WBPhenotype:0000822 ! sex determination variant

[Term]
id: WBPhenotype:0001023
name: sexually dimorphic morphology variant
def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, from that observed for control animals." [GO:0009886, WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "sexually dimorphic morphology abnormal" NARROW []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0001024
name: male morphology variant
def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a male in the population, from that observed for control males." [GO:0009886, WB:WBPerson712]
synonym: "male morphology abnormal" NARROW []
is_a: WBPhenotype:0001023 ! sexually dimorphic morphology variant

[Term]
id: WBPhenotype:0001025
name: hermaphrodite morphology variant
def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a hermaphrodite in the population, from that observed for control hermaphrodites." [GO:0009886, WB:WBPerson712]
synonym: "hermaphrodite morphology abnormal" NARROW []
is_a: WBPhenotype:0001023 ! sexually dimorphic morphology variant

[Term]
id: WBPhenotype:0001026
name: nuclear morphology variation early emb
def: "Animals exhibit variations in the form, structure or composition of the membrane enclosed organelle which contains most of the cell's genetic material during the early embryonic stage compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "Nmo" BROAD []
is_a: WBPhenotype:0001028 ! nuclear appearance variant
is_a: WBPhenotype:0001035 ! nuclear appearance number defective early emb

[Term]
id: WBPhenotype:0001027
name: nuclear position defective early emb
def: "Embryos show defects in the placement of the nucleus to a specific location within the cell." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "Npo" BROAD []
synonym: "nuclear position abnormal" NARROW []
is_a: WBPhenotype:0000511 ! nuclear positioning variant
is_a: WBPhenotype:0001138 ! nucleus defective early emb

[Term]
id: WBPhenotype:0001028
name: nuclear appearance variant
def: "The morphological appearance of nuclei differs from control animals." [WB:cab]
subset: phenotype_slim_wb
synonym: "nuclear appearance abnormal" NARROW []
synonym: "nuclear morphology variant" RELATED []
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0001029
name: patchy coloration
def: "Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Pch" BROAD []
is_a: WBPhenotype:0000527 ! organism pigmentation phenotype

[Term]
id: WBPhenotype:0001030
name: pronuclear envelope defective early emb
def: "Any deficiency in the lipid bilayer, the equivalent of the nuclear envelope, that surrounds each pronucleus within gametes and within the early zygote after pronuclear reformation (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "Pna" BROAD []
synonym: "pronuclear envelope abnormal" NARROW []
is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb

[Term]
id: WBPhenotype:0001031
name: pronuclear migration reduced early emb
def: "Any variation in the movement/fusion of pronuclei in the fertilized oocyte compared to control. For example, lack of male pronuclear migration, female pronuclear migration variable, sometimes multiple female pronuclei, no or small spindle." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb

[Term]
id: WBPhenotype:0001032
name: larval behavior variant
def: "Variations in the specific actions or reactions of a larvae in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "larval behavior abnormal" NARROW []
is_a: WBPhenotype:0000819 ! postembryonic behavior variant

[Term]
id: WBPhenotype:0001033
name: proximal germ cell proliferation variant
def: "Any variation in the spatial pattern of proliferation and differentiation in the germ line compared to control. In C. elegans, this refers to an ectopic mass of proliferating germ cells that occupies the proximal adult germ line, a region normally occupied by gametes." [WB:WBPaper00006484, WB:WBPerson2021]
synonym: "Pro" BROAD []
synonym: "proximal germ cell proliferation abnormal" NARROW []
is_a: WBPhenotype:0001215 ! germ cell mitosis variant

[Term]
id: WBPhenotype:0001034
name: pronuclear nuclear appearance defective early emb
def: "The morphology of pronuclei and nuclei are defective in the early embryo. In C. elegans, this defect is often characterized by pronuclei and nuclei that are small or missing altogether and are often accompanied by spindle defects." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
synonym: "pronuclear nuclear appearance abnormal" NARROW []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0001374 ! pronuclear nuclear appearance variant emb

[Term]
id: WBPhenotype:0001035
name: nuclear appearance number defective early emb
def: "The size, number and organization of the components of the nuclei in the early embryo deviate from control . In C. elegans, this is characterized by nuclei that are completely missing or are significantly smaller than normal; often accompanied by spindle and cytokinesis defects." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
synonym: "nuclear appearance number abnormal" NARROW []
synonym: "nucleus abnormal emb" RELATED []
is_a: WBPhenotype:0000770 ! embryonic cell morphology variant
is_a: WBPhenotype:0001138 ! nucleus defective early emb

[Term]
id: WBPhenotype:0001036
name: sterile F1
def: "Any variation that compromises the reproductive ability of an F1 generation animal." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001037 ! sterile progeny

[Term]
id: WBPhenotype:0001037
name: sterile progeny
def: "Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Stp" BROAD []
is_a: WBPhenotype:0000069 ! progeny variant
is_a: WBPhenotype:0000688 ! sterile

[Term]
id: WBPhenotype:0001038
name: tumorous germline
def: "Germ cells do not exit the mitotic cycle, resulting in a expansion of the unspecialized germ cell population compared to control." [WB:WBPaper00002730, WB:WBPerson2021]
synonym: "Tum" BROAD []
synonym: "tumorous germ line" EXACT []
is_a: WBPhenotype:0000823 ! germline proliferation variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001039
name: embryonic growth variant
def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the embryonic stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "embryonic growth abnormal" NARROW []
is_a: WBPhenotype:0001015 ! developmental growth variant

[Term]
id: WBPhenotype:0001040
name: chemosensory response variant
def: "Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus, compared to control." [GO:0042221, WB:cab, WB:cgc3824, WB:WBPerson2021]
synonym: "chemosensory response abnormal" NARROW []
is_a: WBPhenotype:0000523 ! chemical response variant
is_a: WBPhenotype:0001049 ! chemosensory behavior variant

[Term]
id: WBPhenotype:0001041
name: meiosis defective early emb
def: "Animals exhibit defects in the progression of meiosis which ultimately result in embryonic lethality." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "Mei" BROAD []
is_a: WBPhenotype:0000775 ! meiosis variant
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001042
name: neuron function reduced
def: "Neurons show impaired ability in the detection, transmission, coordination or their response to information about an animal's internal and external environments." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0001043
name: interphase entry defective early emb
def: "Embryos do not enter or take longer to enter first interphase compared to control." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000740 ! cell cycle variant
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001044
name: cortical dynamics defective early emb
def: "Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141]
synonym: "cortical dynamics abnormal" NARROW []
synonym: "Cpa" BROAD []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001045
name: sporadic pumping
def: "Pharyngeal pumping contractions are brief and occur arhythmically in response to stimulus compared to control." [WB:WBPaper00001709]
is_a: WBPhenotype:0000019 ! pharyngeal pumping reduced

[Term]
id: WBPhenotype:0001046
name: pharyngeal muscle morphology variant
def: "Any variations associated with the characteristic morphology of the pharyngeal muscle such as shape, birefringence etc compared to control." [WB:WBPaper00001709]
synonym: "pharyngeal muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0000923 ! nonstriated muscle morphology variant

[Term]
id: WBPhenotype:0001047
name: aqueous positive chemotaxis variant
def: "Animals exhibit variations in the movement towards typically attractive water-soluble chemicals compared to control." [WB:cab, WB:cgc3824]
synonym: "aqueous positive chemotaxis abnormal" NARROW []
synonym: "water soluble chemotaxis abnormal" RELATED []
is_a: WBPhenotype:0000635 ! positive chemotaxis variant
is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant

[Term]
id: WBPhenotype:0001048
name: odorant chemosensory response variant
def: "Animals exhibit variations in the chemosensory response to volatile organic compounds compared to control." [WB:WBPerson2021]
synonym: "odorant chemosensory response abnormal" NARROW []
synonym: "Odr" BROAD []
synonym: "volatile chemosensory response abnormal" RELATED []
is_a: WBPhenotype:0001040 ! chemosensory response variant

[Term]
id: WBPhenotype:0001049
name: chemosensory behavior variant
def: "Variations in behavior that is dependent upon the sensation of chemicals, compared to control." [GO:0007635, WB:WBPerson2021]
subset: phenotype_slim_wb
synonym: "chemosensory behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001050
name: chemosensation variant
def: "Animals exhibit variations in any of a series of events in which an organism receives a sensory chemical stimulus, converts it to a molecular signal, and recognizes and characterizes the signal, compared to control." [GO:0007606, WB:WBPerson2021]
synonym: "chemosensation abnormal" NARROW []
is_a: WBPhenotype:0001049 ! chemosensory behavior variant

[Term]
id: WBPhenotype:0001051
name: cation positive chemotaxis variant
def: "Animals exhibit variations in the characteristic movement towards typically attractive cations compared to control." [WB:cab, WB:cgc387, WB:WBPaper00000387]
synonym: "cation positive chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001052
name: anion positive chemotaxis variant
def: "Animals exhibit variations in the characteristic movement towards typically attractive anions compared to control." [WB:cab, WB:cgc387, WB:WBPaper00000387]
synonym: "anion positive chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001053
name: cyclic nucleotide positive chemotaxis variant
def: "Animals exhibit variations in the characteristic movement towards cyclic nucleotides compared to control." [WB:cab, WB:cgc387]
synonym: "cyclic nucleotide positive chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001054
name: cGMP chemotaxis defective
def: "Animals fail to exhibit the same taxis behavior as control animals in response to cGMP. In C. elegans, this is characterized by the failure to move towards cGMP." [WB:cab, WB:cgc387, WB:WBPerson2021]
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective
is_a: WBPhenotype:0001464 ! cGMP chemotaxis variant

[Term]
id: WBPhenotype:0001055
name: bromide chemotaxis defective
def: "Animals fail to exhibit the same taxis behavior as control animals in response to bromide. In C. elegans, this is characterized by the failure to move towards bromide." [WB:cab, WB:cgc387]
is_a: WBPhenotype:0001439 ! anion positive chemotaxis defective
is_a: WBPhenotype:0001457 ! bromide chemotaxis variant

[Term]
id: WBPhenotype:0001056
name: iodide chemotaxis defective
def: "Animals fail to exhibit the same taxis behavior as control animals in response to iodide. In C. elegans, this is characterized by the failure to move towards iodide." [WB:cab, WB:cgc387]
is_a: WBPhenotype:0001439 ! anion positive chemotaxis defective
is_a: WBPhenotype:0001459 ! iodide chemotaxis variant

[Term]
id: WBPhenotype:0001057
name: lithium chemotaxis defective
def: "Animals fail to exhibit the same taxis behavior as control animals in response to lithium. In C. elegans, this is characterized by the failure to move towards lithium." [WB:cab, WB:cgc387]
is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective

[Term]
id: WBPhenotype:0001058
name: potassium chemotaxis defective
def: "Animals fail to exhibit the same taxis behavior as control animals in response to potassium. In C. elegans, this is characterized by the failure of the animals to move towards potassium." [WB:cab, WB:cgc387]
is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective

[Term]
id: WBPhenotype:0001059
name: magnesium chemotaxis defective
def: "Animals fail to exhibit the same taxis behavior as control animals in response to magnesium. In C. elegans, this is characterized by the failure to move towards magnesium." [WB:cab, WB:cgc387]
is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective

[Term]
id: WBPhenotype:0001060
name: AWC odorant chemotaxis defective
def: "In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWC compared to control." [WB:WBPerson2021]
synonym: "AWC volatile chemotaxis defective" RELATED []
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective

[Term]
id: WBPhenotype:0001061
name: AWA odorant chemotaxis defective
def: "In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWA compared to control." [WB:WBPerson2021]
synonym: "AWA volatile chemotaxis defective" RELATED []
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective

[Term]
id: WBPhenotype:0001062
name: late paralysis arrested elongation two fold
def: "In C. elegans, movement and elongation stop nearly simultaneously soon after the twofold stage of elongation. However, mutant embryos twitch at the one-and-a-half-fold stage of elongation, like control animals, and move as well as control animals at the two- fold stage." [WB:cab, WB:cgc1894]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0001063
name: egg laying phases variant
def: "Fluctuation pattern between inactive, active, and egg-laying states is atypical, based on the analysis of the distribution of the log intervals of egg-laying events compared to control." [pmid:10757762, pmid:9697864, WB:cab]
synonym: "egg laying phases abnormal" NARROW []
is_a: WBPhenotype:0000272 ! egg laying irregular

[Term]
id: WBPhenotype:0001064
name: inactive phase long
def: "Animals display uncharacteristically long periods during which they do not lay eggs compared to control, usually based on the analysis of the distribution of the log intervals of egg-laying events. In C. elegans, long inactive phases can be observed in HSN-ablated and serotonin-deficient animals." [pmid:10757762, pmid:9697864, WB:cab]
is_a: WBPhenotype:0000006 ! egg laying defective
is_a: WBPhenotype:0001066 ! inactive phase variant

[Term]
id: WBPhenotype:0001065
name: fewer egg laying events during active
def: "Fewer egg-laying events occur within the active phase of egg laying, based on the analysis of the distribution of the log intervals of egg-laying events, compared to control." [pmid:9697864, WB:cab]
is_a: WBPhenotype:0000006 ! egg laying defective
is_a: WBPhenotype:0001067 ! active phase variant

[Term]
id: WBPhenotype:0001066
name: inactive phase variant
def: "The period during which the animal is less likely to lay eggs is not typical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab]
synonym: "inactive phase abnormal" NARROW []
is_a: WBPhenotype:0001063 ! egg laying phases variant

[Term]
id: WBPhenotype:0001067
name: active phase variant
def: "The active phase of egg-laying, the period during which animals are more likely to display multiple egg-laying events, is atypical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab]
synonym: "active phase abnormal" NARROW []
is_a: WBPhenotype:0001063 ! egg laying phases variant

[Term]
id: WBPhenotype:0001068
name: egg laying serotonin resistant
def: "Animals are not induced to lay eggs in reponse to exogenous serotonin. Serotonin stimulates egg-laying in C. elegans." [WB:WBPaper00000635, WB:WBPaper00031293, WB:WBPerson712]
is_a: WBPhenotype:0000024 ! serotonin resistant
is_a: WBPhenotype:0001629 ! egg laying serotonin variant

[Term]
id: WBPhenotype:0001069
name: increased egg laying events during active
def: "More eggs are laid during the active phase compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab]
is_a: WBPhenotype:0001067 ! active phase variant

[Term]
id: WBPhenotype:0001070
name: inactive phase short
def: "The period during which a worm usually does not lay eggs is short compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab]
is_a: WBPhenotype:0001066 ! inactive phase variant

[Term]
id: WBPhenotype:0001071
name: active phase switch defective
def: "Activation of the active phase of egg laying is defective, leading to an abnormally long inactive phase, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab]
is_a: WBPhenotype:0001064 ! inactive phase long

[Term]
id: WBPhenotype:0001072
name: response to food variant
def: "Any variation in the state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to a food stimulus, compared to control." [GO:0032094, WB:WBPerson2021]
synonym: "response to food abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0001073
name: egg laying response to food variant
def: "Animals exhibit variations in egg-laying behavior in response to food compared to control. In C. elegans, well-fed animals lay more eggs compared with starved animals." [pmid:10757762, WB:cab]
synonym: "egg laying response to food abnormal" NARROW []
is_a: WBPhenotype:0000640 ! egg laying variant
is_a: WBPhenotype:0001072 ! response to food variant

[Term]
id: WBPhenotype:0001074
name: vulval muscle unresponsive to serotonin
def: "The vulval muscle does not respond to serotonin in the same manner as control animals. This phenotype is often assayed by imaging of calcium transients in response to serotonin." [pmid:14588249, WB:cab]
is_a: WBPhenotype:0001068 ! egg laying serotonin resistant
is_a: WBPhenotype:0001076 ! vulval muscle homeostasis metabolism variant

[Term]
id: WBPhenotype:0001075
name: vulval muscle physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the vulva muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "vulval muscle physiology abnormal" NARROW []
is_a: WBPhenotype:0000613 ! reproductive system physiology variant

[Term]
id: WBPhenotype:0001076
name: vulval muscle homeostasis metabolism variant
def: "Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium within the vulval muscles compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "vulval muscle homeostasis metabolism abnormal" NARROW []
is_a: WBPhenotype:0001075 ! vulval muscle physiology variant

[Term]
id: WBPhenotype:0001077
name: chromosome segregation variant karyomeres early emb
def: "Karyomeres in AB or P1 often accompanied by weak/thin wobbly spindle." [WB:cab, WB:cgc7141]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000773 ! chromosome segregation variant
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001078
name: cytokinesis defective early emb
def: "Cytokinesis is abnormal in the first or second stages of cell division." [WB:cab, WB:cgc7141]
synonym: "Cyk" BROAD []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001018 ! cytokinesis variant emb
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001079
name: cytoplasmic dynamics defective early emb
def: "Cytoplasmic movements are atypical." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000360 ! cytoplasmic streaming defective
is_a: WBPhenotype:0000769 ! cytoplasmic appearance defective early emb

[Term]
id: WBPhenotype:0001080
name: excessive blebbing early emb
def: "Excessive shaking and movements are seen in the cell membrane or cytoplasm of one-cell or two-cell embryos." [cgc:5599, WB:cab]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001079 ! cytoplasmic dynamics defective early emb

[Term]
id: WBPhenotype:0001081
name: cytoplasmic morphology defective early emb
def: "Morphology of the cytoplasm differs from control animals." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000769 ! cytoplasmic appearance defective early emb

[Term]
id: WBPhenotype:0001082
name: large cytoplasmic granules early emb
def: "Abnormally large granules are observed in the cytoplasm of P0." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001081 ! cytoplasmic morphology defective early emb

[Term]
id: WBPhenotype:0001083
name: multiple cytoplasmic cavities early emb
def: "Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001081 ! cytoplasmic morphology defective early emb

[Term]
id: WBPhenotype:0001084
name: sodium chloride chemotaxis defective
def: "Failure to execute characteristic response to sodium chloride compared to control. In C. elegans, animals move towards attractive concentrations of sodium chloride." [WB:WBPaper00000119]
synonym: "NaCl chemotaxis defective" EXACT []
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective
is_a: WBPhenotype:0001462 ! sodium chloride chemotaxis variant

[Term]
id: WBPhenotype:0001085
name: butanone chemotaxis defective
def: "Failure to execute characteristic response to butanone compared to control. In C. elegans, animals move towards typically attractive concentrations of butanone." [WB:WBPaper00001786]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001469 ! butanone chemotaxis variant

[Term]
id: WBPhenotype:0001086
name: trimethylthiazole chemotaxis defective
def: "Failure to execute characteristic response to trimethylthiazole compared to control. In C. elegans, animals move towards typically attractive concentrations of trimethylthiazole." [WB:WBPaper00001786]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001475 ! trimethylthiazole chemotaxis variant

[Term]
id: WBPhenotype:0001087
name: acetone chemotaxis defective
def: "Failure to execute characteristic response to acetone compared to control. In C. elegans, animals move towards typically attractive concentrations of acetone." [WB:WBPaper00024240]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001465 ! acetone chemotaxis variant

[Term]
id: WBPhenotype:0001088
name: pentanol chemotaxis defective
def: "Failure to execute characteristic response to pentanol compared to control. In C. elegans, animals move towards typically attractive concentrations of pentanol." [WB:WBPerson2021]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001473 ! pentanol chemotaxis variant

[Term]
id: WBPhenotype:0001089
name: hexanol chemotaxis defective
def: "Failure to execute characteristic response to hexanol compared to control. In C. elegans, animals move towards typically attractive concentrations of hexanol." [WB:WBPerson2021]
is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective
is_a: WBPhenotype:0001471 ! hexanol chemotaxis variant

[Term]
id: WBPhenotype:0001090
name: thermotolerance reduced
def: "Animals are not able to survive at temperatures above standard cultivation temperatures to the same extent as control animals." [WB:WBPerson712]
synonym: "intrinsic thermotolerance reduced" NARROW []
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0001091
name: larval defecation variant
def: "Animals exhibit variations in the elimination of fecal matter during the larval stage compared to control animals." [WB:WBPerson2021]
synonym: "larval defecation abnormal" NARROW []
is_a: WBPhenotype:0000650 ! defecation variant

[Term]
id: WBPhenotype:0001092
name: larval defecation defect
def: "Animals fail to expel fecal matter during the larval stage." [WB:WBPerson2021]
is_a: WBPhenotype:0001091 ! larval defecation variant

[Term]
id: WBPhenotype:0001093
name: intestinal physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the intestine to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "intestinal physiology abnormal" NARROW []
is_a: WBPhenotype:0000606 ! alimentary system physiology variant

[Term]
id: WBPhenotype:0001094
name: obsolete NaCl response variant
def: "OBSOLETE. Organismal response to NaCl differs from control animals." [WB:cab]
synonym: "NaCl response abnormal" NARROW []
is_obsolete: true
consider: WBPhenotype:0000523

[Term]
id: WBPhenotype:0001095
name: organism high sodium chloride hypersensitive
def: "Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab]
is_a: WBPhenotype:0000876 ! organism osmotic stress response variant

[Term]
id: WBPhenotype:0001096
name: protrusion at vulval region
def: "Large protrusion at the normal position of the vulva, as seen in C. elegans lin-12 null animals." [cgc:646, WB:cab]
synonym: "ventral protrusion" NARROW []
is_a: WBPhenotype:0000695 ! vulva morphology variant

[Term]
id: WBPhenotype:0001097
name: premature spermatocyte germ cell differentiation
def: "Unspecialized male germ cells (spermatocytes) prematurely acquire the specialized properties of functional sperm." [cgc:4207, WB:cab, WB:WBPerson2021]
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0001098
name: no rectum
def: "Animals lack the passage connecting the posterior intestine to the rectal valve." [WB:WBPaper00001423, WB:WBPerson2021]
comment: WBbt:0005773.
is_a: WBPhenotype:0000910 ! rectal morphology variant

[Term]
id: WBPhenotype:0001099
name: nose twisted
def: "The extreme anterior part of the body appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000321 ! nose morphology variant

[Term]
id: WBPhenotype:0001100
name: early embryonic lethal
def: "Animal dies prior to the gastrulation stage of embryogenesis." [WB:WBPerson2021]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000050 ! embryonic lethal

[Term]
id: WBPhenotype:0001101
name: egg laying response to drug variant
def: "Characteristic response to drugs with respect to egg-laying behavior varies compared to control." [WB:cab]
synonym: "egg laying response to drug abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant
is_a: WBPhenotype:0000640 ! egg laying variant

[Term]
id: WBPhenotype:0001102
name: mitotic spindle defective early emb
def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a mitotic cell cycle." [GO:0007052, WB:WBPerson2021]
comment: Possible XP.
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000759 ! spindle defective early emb

[Term]
id: WBPhenotype:0001103
name: spindle absent early emb
def: "Early embryos lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0005819, WB:WBPerson2021]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb
is_a: WBPhenotype:0002418 ! spindle absent

[Term]
id: WBPhenotype:0001104
name: P0 spindle absent early emb
def: "No mitotic spindle is seen in P0." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001103 ! spindle absent early emb

[Term]
id: WBPhenotype:0001105
name: P0 spindle position abnormal
def: "Altered P0 spindle placement causes either a symmetric first division, a division in which P1 is larger than AB, or a division in which the asymmetry is exaggerated such that AB is much larger than normal." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "P0 spindle position phenotype" NARROW []
is_a: WBPhenotype:0000762 ! spindle position defective early emb

[Term]
id: WBPhenotype:0001106
name: spindle orientation variant AB or P1 early emb
def: "The orientation of the spindle is aberrant in either the AB or the P1 cell." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000760 ! spindle orientation defective early emb

[Term]
id: WBPhenotype:0001107
name: spindle rotation defective early emb
def: "Rotation of the embryonic spindle is aberrant." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb
is_a: WBPhenotype:0002417 ! spindle rotation variant

[Term]
id: WBPhenotype:0001108
name: P0 spindle rotation failure early emb
def: "P0 spindle fails to rotate and extends perpendicular to the long axis of the embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001107 ! spindle rotation defective early emb

[Term]
id: WBPhenotype:0001109
name: P0 spindle rotation delayed early emb
def: "P0 spindle rotates late in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0001107 ! spindle rotation defective early emb

[Term]
id: WBPhenotype:0001110
name: aster defective early emb
def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores." [GO:0005818, WB:WBPerson2021, WB:WBPerson557]
synonym: "aster abnormal" NARROW []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0002419 ! spindle aster variant

[Term]
id: WBPhenotype:0001111
name: aster AB defective early emb
def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the AB cell." [WB:WBPerson2021, WB:WBPerson557]
synonym: "aster AB abnormal" NARROW []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001110 ! aster defective early emb

[Term]
id: WBPhenotype:0001112
name: aster AB resembles P1 aster early emb
def: "The morphology of the AB aster resembles that of the P1 aster in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001111 ! aster AB defective early emb

[Term]
id: WBPhenotype:0001113
name: P1 aster defective early emb
def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the P1 cell." [WB:cab, WB:cgc5599, WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
synonym: "P1 aster abnormal" NARROW []
is_a: WBPhenotype:0001110 ! aster defective early emb

[Term]
id: WBPhenotype:0001114
name: cell cycle defective early emb
def: "The progression of biochemical and morphological processes that occur during successive replication or nuclear replication events is disrupted during the early embryonic stage." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000740 ! cell cycle variant
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001115
name: cell cycle timing defective early emb
def: "Cell cycle timing is abnormal during the first four cell divisions." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001114 ! cell cycle defective early emb

[Term]
id: WBPhenotype:0001116
name: absolute cell cycle timing defective early emb
def: "Absolute cell cycle timing during the first four cell divisions is aberrant." [WB:WBPerson557]
synonym: "absolute cell cycle timing abnormal" NARROW []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001115 ! cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001117
name: cell cell contacts abnormal early emb
def: "Cell-cell contacts are abnormal in the early embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0002404 ! cell cell contacts abnormal

[Term]
id: WBPhenotype:0001118
name: cell position defective early emb
def: "Cell position is abnormal in the early embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0002402 ! cell position defective

[Term]
id: WBPhenotype:0001119
name: cell cycle slow early emb
def: "Embryos take longer to divide during the first and second cell divisions." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0001116 ! absolute cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001120
name: relative cell cycle timing defective early emb
def: "Relative cell cycle timing during the first four cell divisions is aberrant." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "relative cell cycle timing abnormal" NARROW []
is_a: WBPhenotype:0001115 ! cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001121
name: exaggerated asynchrony early emb
def: "Asynchrony of the second division is exaggerated and P1 divides more slowly than normal." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001122
name: reversed asynchrony early emb
def: "P1 divides before AB." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001123
name: synchronous second division early emb
def: "AB and P1 divide synchronously." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001124
name: ABa ABp EMS synchronous division early emb
def: "EMS divides at the same time that ABa and ABp divide." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001125
name: P2 EMS synchronous division early emb
def: "P2 and EMS divide synchronously." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001126
name: cell cell contacts abnormal in four cell embryo
def: "Aba, ABp, EMS, or P1 contacts fewer of its sister cells than in control embryos." [WB:cab, WB:cgc5599]
synonym: "cell cell contacts abnormal" NARROW []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001117 ! cell cell contacts abnormal early emb

[Term]
id: WBPhenotype:0001127
name: EMS anterior extension fails early emb
def: "The EMS blastomere fails to extend anteriorly and make extensive contact (hug) with the ABa blastomere." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001118 ! cell position defective early emb

[Term]
id: WBPhenotype:0001128
name: EMS anterior extension extreme early emb
def: "EMS extends too far anteriorly at the four cell stage." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001118 ! cell position defective early emb

[Term]
id: WBPhenotype:0001129
name: cleavage furrow defective early emb
def: "Embryos exhibit defects in the formation, maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson2987, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001078 ! cytokinesis defective early emb
is_a: WBPhenotype:0002410 ! cleavage furrow defective

[Term]
id: WBPhenotype:0001130
name: cytokinesis fails early emb
def: "Cells of the embryo attempt to divide but fail to form two daughter cells." [WB:cab, WB:cgc5599]
synonym: "Cyk" BROAD []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001078 ! cytokinesis defective early emb
is_a: WBPhenotype:0002391 ! cytokinesis failure

[Term]
id: WBPhenotype:0001131
name: loose mitotic furrow early emb
def: "Once formed, the mitotic furrow can \"slide\"laterally." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0001132
name: extra cleavage furrow early emb
def: "One or more extra cleavage furrows are seen in one or more cells of a one-cell to four-cell embryo" [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0001133
name: division axis defective
def: "The cell division axis is not normal." [WB:cab, WB:WBPerson1815]
synonym: "division axis abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0001134
name: Aba ABp division axis defective early emb
def: "ABa or ABp divide in the wrong orientation." [WB:cab, WB:cgc5599]
synonym: "Aba ABp division axis abnormal" NARROW []
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0001133 ! division axis defective

[Term]
id: WBPhenotype:0001135
name: embryonic morphology defective early emb
def: "Animals exhibit defects in the form, structure or composition of any of its parts during the early embryonic stage." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0001136 ! embryonic morphology variant

[Term]
id: WBPhenotype:0001136
name: embryonic morphology variant
def: "Animals exhibit variations in the form, structure or composition of any of its parts during any developmental stage ranging from zygote formation to hatching compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "embryonic morphology abnormal" NARROW []
is_a: WBPhenotype:0000037 ! egg morphology variant

[Term]
id: WBPhenotype:0001137
name: embryos small early emb
def: "Embryos are produced that are less than fifty percent of the size of control embryos." [WB:cab, WB:WBPaper00005599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001135 ! embryonic morphology defective early emb

[Term]
id: WBPhenotype:0001138
name: nucleus defective early emb
def: "Nucleus is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "nucleus abnormal" NARROW []
is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant

[Term]
id: WBPhenotype:0001139
name: nuclear envelope assembly variant early emb
def: "Nuclear envelope does not reassemble properly." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "nuclear reassembly defective early emb" RELATED []
is_a: WBPhenotype:0001138 ! nucleus defective early emb
is_a: WBPhenotype:0002037 ! nuclear envelope organization variant

[Term]
id: WBPhenotype:0001140
name: neuron migration variant
def: "Any variation in the normal orderly movement of neurons from one site to another compared to control." [WB:WBPerson2021]
synonym: "neuron migration abnormal" NARROW []
is_a: WBPhenotype:0000594 ! cell migration variant
is_a: WBPhenotype:0000816 ! neuron development variant

[Term]
id: WBPhenotype:0001141
name: nucleus reforms cell division remnant early emb
def: "After division of either one-cell or two-cell embryos, the nuclei reappear next to the cell division remnant." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001027 ! nuclear position defective early emb

[Term]
id: WBPhenotype:0001142
name: nuclear number defective early emb
def: "Nuclear number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001035 ! nuclear appearance number defective early emb
is_a: WBPhenotype:0001894 ! nuclear number variant

[Term]
id: WBPhenotype:0001143
name: multiple nuclei early emb
def: "Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "karyomeres" RELATED []
synonym: "Mul" BROAD []
synonym: "multiple nuclei in early embryo emb" RELATED []
is_a: WBPhenotype:0000746 ! cell division variant
is_a: WBPhenotype:0001142 ! nuclear number defective early emb
is_a: WBPhenotype:0002413 ! multiple nuclei

[Term]
id: WBPhenotype:0001144
name: polar body number size early emb
def: "Defects are either seen in the number or size of the polar bodies in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001147 ! polar body defective early emb

[Term]
id: WBPhenotype:0001145
name: polar body number defective early emb
def: "Polar body number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "polar body number abnormal" NARROW []
is_a: WBPhenotype:0001144 ! polar body number size early emb

[Term]
id: WBPhenotype:0001146
name: polar body size defective early emb
def: "Polar body size is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "polar body size abnormal" NARROW []
is_a: WBPhenotype:0001144 ! polar body number size early emb

[Term]
id: WBPhenotype:0001147
name: polar body defective early emb
def: "Polar bodies are abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "polar body abnormal" NARROW []
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001148
name: polar body reabsorbed early emb
def: "Polar body is reabsorbed in the one- to four-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000777 ! polar body extrusion defective early emb

[Term]
id: WBPhenotype:0001149
name: obsolete polar body reabsorbed first early emb
def: "OBSOLETE." [WB:WBPerson557]
synonym: "Emb" BROAD []
is_obsolete: true
consider: WBPhenotype:0001148

[Term]
id: WBPhenotype:0001150
name: polar body reabsorbed one two early emb
def: "A polar body is reabsorbed in either the one cell- or the two-cell embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001148 ! polar body reabsorbed early emb

[Term]
id: WBPhenotype:0001151
name: pronucleus centrosomes defective early emb
def: "Pronucleus is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "pronucleus centrosomes abnormal" NARROW []
is_a: WBPhenotype:0001034 ! pronuclear nuclear appearance defective early emb

[Term]
id: WBPhenotype:0001152
name: pronuclear migration defective early emb
def: "Pronucleus migration is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "pronuclear migration abnormal" NARROW []
is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb

[Term]
id: WBPhenotype:0001153
name: pronuclear migration failure early emb
def: "Neither of the pronuclei migrate and they never meet." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb

[Term]
id: WBPhenotype:0001154
name: paternal pronucleus migrates early emb
def: "Instead of the maternal pronucleus migrating to the posterior end of the one-cell embryo, the paternal pronucleus migrates to meet the maternal pronucleus in the anterior end." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb

[Term]
id: WBPhenotype:0001155
name: pronuclei meet centrally early emb
def: "The maternal and paternal pronuclei meet more centrally instead of meeting in the posterior end of the embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb

[Term]
id: WBPhenotype:0001156
name: pronuclear size defective early emb
def: "Maternal or paternal pronucleus is either too small or too large." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "pronuclear size abnormal" NARROW []
is_a: WBPhenotype:0001159 ! pronuclear morphology defective early emb

[Term]
id: WBPhenotype:0001157
name: pronuclear breakdown defective early emb
def: "Pronuclear breakdown is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "pronuclear breakdown abnormal" NARROW []
is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb

[Term]
id: WBPhenotype:0001158
name: pronuclear breakdown asynchronous early emb
def: "Instead of breaking down synchronously, the two pronuclei break down asynchronously in the inviable one-cell embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001157 ! pronuclear breakdown defective early emb

[Term]
id: WBPhenotype:0001159
name: pronuclear morphology defective early emb
def: "Pronucleus morphology is atypical in the inviable embryo." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "pronuclear morphology abnormal" NARROW []
is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb

[Term]
id: WBPhenotype:0001160
name: pronuclear envelope morphology defective early emb
def: "Morphology of the pronuclear envelope is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "pronuclear envelope morphology abnormal" NARROW []
is_a: WBPhenotype:0001159 ! pronuclear morphology defective early emb

[Term]
id: WBPhenotype:0001161
name: maternal pronucleus indistinct early emb
def: "Maternal pronucleus has a blurry appearance. The nuclear envelope does not have a crisp circular shape." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001160 ! pronuclear envelope morphology defective early emb

[Term]
id: WBPhenotype:0001162
name: pronuclear number defective early emb
def: "There are more than two pronuclei in the inviable embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "pronuclear number abnormal" NARROW []
is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb

[Term]
id: WBPhenotype:0001163
name: pronucleus formation failure early emb
def: "Either the maternal or paternal pronucleus is absent." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001162 ! pronuclear number defective early emb

[Term]
id: WBPhenotype:0001164
name: excess pronucleus early emb
def: "There is either more than one maternal or paternal pronucleus in the inviable embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001162 ! pronuclear number defective early emb
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001165
name: excess maternal pronucleus early emb
def: "One-cell embryos have two or more maternal pronuclei." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001164 ! excess pronucleus early emb

[Term]
id: WBPhenotype:0001166
name: excess paternal pronucleus variant centrosome early emb
def: "More than one paternal pronucleus is present in the inviable one-cell embryo or there is a defect in centrosome structure." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "excess paternal pronucleus abnormal" NARROW []
is_a: WBPhenotype:0001164 ! excess pronucleus early emb

[Term]
id: WBPhenotype:0001167
name: pseudocleavage defective early emb
def: "Pseudocleavage is atypical in the inviable one-cell embryo." [WB:cab, WB:WBPerson1815]
synonym: "Emb" BROAD []
synonym: "pseudocleavage abnormal" NARROW []
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001168
name: pseudocleavage absent early emb
def: "No pseudocleavage is observed before or during pronuclear migration." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "no pseudocleavage" RELATED []
is_a: WBPhenotype:0001167 ! pseudocleavage defective early emb

[Term]
id: WBPhenotype:0001169
name: pseudocleavage exaggerated early emb
def: "Embryos have more pronounced pseudocleavage than normal." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001167 ! pseudocleavage defective early emb

[Term]
id: WBPhenotype:0001170
name: sterile F0 48 hours post injection
def: "Injected worm stops producing embryos 48 hours after RNAi injection and contains no live/developing embryos at this time." [WB:cab, WB:cgc5599]
synonym: "P0 sterile" NARROW []
synonym: "Ste" BROAD []
is_a: WBPhenotype:0000689 ! maternal sterile

[Term]
id: WBPhenotype:0001171
name: shortened life span
def: "The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712]
synonym: "Age" BROAD []
synonym: "life span reduced" RELATED []
synonym: "longevity decreased" RELATED []
is_a: WBPhenotype:0000039 ! life span phenotype

[Term]
id: WBPhenotype:0001172
name: programmed cell death variant
def: "Developmentally regulated termination of a cell or cell group does not occur as in control animals." [WB:WBPerson712]
synonym: "programmed cell death abnormal" NARROW []
is_a: WBPhenotype:0000729 ! cell death variant

[Term]
id: WBPhenotype:0001173
name: non apoptotic cell death variant
def: "Animals exhibit variations in the specific activation or halting of processes within a cell that occur through necrosis or programmed cell death pathways different from apoptosis, so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death, compared to control." [GO:0008219, WB:WBPerson712]
synonym: "non apoptotic cell death abnormal" NARROW []
is_a: WBPhenotype:0001172 ! programmed cell death variant

[Term]
id: WBPhenotype:0001174
name: chromosome disjunction defective
def: "Chromosomes fail to segregate away from their homolog, resulting in gametes with no or extra copies of the chromosome." [WB:WBPerson712]
synonym: "chromosome disjunction abnormal" NARROW []
is_a: WBPhenotype:0001499 ! meiotic chromosome segregation variant
is_a: WBPhenotype:0001882 ! aneuploidy
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0001175
name: high incidence male progeny
def: "Higher numbers of male progeny occur in the population compared to control populations. In C. elegans, the high incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an increase in X chromosome nondisjunction." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712]
synonym: "high frequency X chromosome nondisjunction" RELATED []
synonym: "Him" BROAD []
is_a: WBPhenotype:0001664 ! X chromosome nondisjunction

[Term]
id: WBPhenotype:0001176
name: one cell shape defective early emb
def: "One-cell embryos have an altered shape." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
synonym: "one cell shape abnormal" NARROW []
is_a: WBPhenotype:0001135 ! embryonic morphology defective early emb

[Term]
id: WBPhenotype:0001177
name: embryo osmotic pressure sensitive early emb
def: "Embryos rupture when placed on a 2% agar pad and covered with a coverslip." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001178 ! egg integrity defective early emb

[Term]
id: WBPhenotype:0001178
name: egg integrity defective early emb
def: "The structure of the egg is impaired, flawed or no longer intact." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001100 ! early embryonic lethal
is_a: WBPhenotype:0002075 ! eggshell formation variant

[Term]
id: WBPhenotype:0001179
name: obsolete No variantity scored
def: "OBSOLETE. Phenotypic examination of worms did not reveal an obvious abnormality compared with control animals." [WB:cab]
comment: The phenotype ontology was restructured such that "Abnormal" is now the root term.  The term "Abnormal" with a "Not" qualifier is a suggested replacement for this term.
comment: This phenotype was intended to reflect a lack of any phenotypic abnormality in the individuals in question. The C. elegans phenotype ontology no longer has terms specifically used to assert negation of a phenotype.
synonym: "No abnormal" NARROW []
synonym: "WT" RELATED []
is_obsolete: true

[Term]
id: WBPhenotype:0001180
name: accumulated germline cell corpses
def: "Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712]
is_a: WBPhenotype:0000241 ! accumulated cell corpses

[Term]
id: WBPhenotype:0001181
name: accumulated somatic cell corpses
def: "Animals exhibit an increase in the quantity of non-germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712]
is_a: WBPhenotype:0000241 ! accumulated cell corpses

[Term]
id: WBPhenotype:0001182
name: fat content variant
def: "Animals exhibit variations in the amount of fat or lipids present in the organism compared to control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
synonym: "fat content abnormal" NARROW []
synonym: "lipid content abnormal" RELATED []
synonym: "lipid content variant" RELATED []
is_a: WBPhenotype:0000725 ! lipid metabolism variant

[Term]
id: WBPhenotype:0001183
name: fat content reduced
def: "Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
synonym: "lipid content reduced" RELATED []
is_a: WBPhenotype:0001182 ! fat content variant

[Term]
id: WBPhenotype:0001184
name: fat content increased
def: "Animals exhibit a greater amount of fat or lipids than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
synonym: "lipid content increased" RELATED []
is_a: WBPhenotype:0001182 ! fat content variant

[Term]
id: WBPhenotype:0001185
name: embryonic developmental delay early emb
def: "The developmental progression of an early embryo over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0000848 ! developmental delay
is_a: WBPhenotype:0001100 ! early embryonic lethal

[Term]
id: WBPhenotype:0001186
name: embryo delayed at pronuclear contact early emb
def: "Embryos are either delayed or arrested at pronuclear contact." [WB:cab, WB:cgc5599]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001185 ! embryonic developmental delay early emb

[Term]
id: WBPhenotype:0001187
name: division EMS before P2 early emb
def: "EMS divides before P2." [WB:WBPerson557]
synonym: "Emb" BROAD []
is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb

[Term]
id: WBPhenotype:0001188
name: radial filament structure variant pharynx
def: "Animals exhibit variations in the form, structure or composition of radial arrangement of actin within the pharyngeal muscle compared to control animals." [WB:WBPaper00026850, WB:WBPerson2021, WB:WBPerson557]
synonym: "radial filament structure abnormal" NARROW []
is_a: WBPhenotype:0001046 ! pharyngeal muscle morphology variant

[Term]
id: WBPhenotype:0001189
name: adherens junctions variant pharyngeal muscle
def: "Any variation in the cell junctions of the pharyngeal muscle at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control." [WB:WBPaper00026850, WB:WBPerson2021, WB:WBPerson557]
synonym: "adherens junctions abnormal" NARROW []
is_a: WBPhenotype:0001046 ! pharyngeal muscle morphology variant
is_a: WBPhenotype:0001745 ! adherens junction variant

[Term]
id: WBPhenotype:0001190
name: pharyngeal physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the pharynx to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "pharyngeal physiology abnormal" NARROW []
is_a: WBPhenotype:0000606 ! alimentary system physiology variant

[Term]
id: WBPhenotype:0001191
name: pharyngeal muscle physiology variant
def: "Animals exhibit variations in any physical or chemical process required for muscles in the pharynx to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "pharyngeal muscle physiology abnormal" NARROW []
is_a: WBPhenotype:0001190 ! pharyngeal physiology variant

[Term]
id: WBPhenotype:0001192
name: calcium signaling in pharynx variant
def: "Any variation in the series of molecular signals in which a pharyngeal cell uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "calcium signaling pharynx abnormal" NARROW []
is_a: WBPhenotype:0001191 ! pharyngeal muscle physiology variant
is_a: WBPhenotype:0002170 ! calcium mediated signaling variant

[Term]
id: WBPhenotype:0001193
name: disorganized pharyngeal EPG
def: "Electropharyngeograms do not show a similar pattern as control animals. C. elegans animals show a repeating regular pattern in which each pump is associated with an excitatory depolarizing wave, often punctuated by brief negative spikes, followed by a plateau phase, and ending with an inhibitory hyperpolarizing wave." [WB:cab, WB:cgc7545]
is_a: WBPhenotype:0000980 ! pharyngeal contraction variant

[Term]
id: WBPhenotype:0001194
name: extra and ectopic neuron
def: "Animals have one or more extra neurons, which are present in places they are normally not found, when compared to the number and location of these neurons in control animals." [WB:WBPaper00027335, WB:WBPerson712]
is_a: WBPhenotype:0001303 ! extra and ectopic cell

[Term]
id: WBPhenotype:0001195
name: generation calcium signal defective pharynx
def: "Rhythmic calcium increases in the pharynx are observed less often than in control animals. In C. elegans, rhythmic increases in intracellular calcium are often observed using a transgenically expressed cameleon, a ratiometric calcium indicator." [WB:cab, WB:cgc4194, WB:cgc7545]
is_a: WBPhenotype:0001192 ! calcium signaling in pharynx variant

[Term]
id: WBPhenotype:0001196
name: synchronization calcium signal defective pharynx
def: "Calcium spikes lack synchrony in the musculature of the corpus and the terminal bulb as seen in control." [WB:cab, WB:cgc7545]
is_a: WBPhenotype:0001192 ! calcium signaling in pharynx variant

[Term]
id: WBPhenotype:0001197
name: somatic gonad physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic gonad to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "somatic gonad physiology abnormal" NARROW []
is_a: WBPhenotype:0000613 ! reproductive system physiology variant

[Term]
id: WBPhenotype:0001198
name: somatic sheath physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic sheath system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "somatic sheath physiology abnormal" NARROW []
is_a: WBPhenotype:0001197 ! somatic gonad physiology variant

[Term]
id: WBPhenotype:0001199
name: gonad sheath contractions variant
def: "Animals exhibit variations in any physical or chemical process required for the contraction of a thin continuous tube surrounding the proximal portions of the ovary and covering the maturing oocytes to the near portion of the distal gonad arm, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "gonad sheath contractions abnormal" NARROW []
is_a: WBPhenotype:0001198 ! somatic sheath physiology variant

[Term]
id: WBPhenotype:0001200
name: gonad sheath contraction rate reduced
def: "Basal contraction rate and or peak contraction rate of the gonadal sheath is reduced relative to control animals." [WB:cab, WB:cgc7545]
is_a: WBPhenotype:0001199 ! gonad sheath contractions variant

[Term]
id: WBPhenotype:0001201
name: no expulsion defecation
def: "Animals lack the stereotyped muscle contractions that result in the opening of anus." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000391 ! defecation missing motor steps

[Term]
id: WBPhenotype:0001202
name: nicotine hypersensitive
def: "Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist." [WB:cab, WB:cgc7388, WB:WBPerson557]
is_a: WBPhenotype:0001573 ! nicotine response variant
is_a: WBPhenotype:0001579 ! cholinergic agonist hypersensitive

[Term]
id: WBPhenotype:0001203
name: nicotine resistant
def: "Animals fail to respond to the concentration of nicotine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:cab, WB:cgc7388, WB:WBPerson557]
is_a: WBPhenotype:0001573 ! nicotine response variant
is_a: WBPhenotype:0001578 ! cholinergic agonist resistant

[Term]
id: WBPhenotype:0001204
name: muscimol resistant
def: "Animals fail to respond to the concentration of muscimol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0002047 ! muscimol response variant

[Term]
id: WBPhenotype:0001205
name: muscimol hypersensitive
def: "Animals respond to muscimol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive
is_a: WBPhenotype:0002047 ! muscimol response variant

[Term]
id: WBPhenotype:0001206
name: movement variant
def: "Variations in the process by which an organism travels from one location to another compared to control." [WB:WBPerson2021, WB:WBPerson557]
subset: phenotype_slim_wb
synonym: "movement abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001207
name: protein signaling variant
def: "Any variation in a series of protein mediated signals that help relay information within the cell, and thereby affecting changes in the functioning of the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "protein signaling abnormal" NARROW []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0001208
name: RNAi resistant
def: "Animals show reduced susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021]
synonym: "Rde" BROAD []
synonym: "RNAi deficient" EXACT []
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001209
name: skiddy
def: "Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735]
synonym: "Skd" BROAD []
is_a: WBPhenotype:0001701 ! spastic locomotion

[Term]
id: WBPhenotype:0001210
name: pericellular component physiology phenotype
def: "Animals exhibit variations in any physical or chemical process taking place in extracellular spaces within or associated with the organism, from that observed for control animals." [WB:WBPerson712]
subset: phenotype_slim_wb
synonym: "pericellular component physiology abnormal" EXACT []
synonym: "pericellular component physiology variant" EXACT []
is_a: WBPhenotype:0000519 ! physiology phenotype

[Term]
id: WBPhenotype:0001211
name: cuticle integrity variant
def: "The physical strength or function of the cuticle varies from that observed for control animals." [WB:WBPerson712]
synonym: "cuticle integrity abnormal" NARROW []
is_a: WBPhenotype:0001678 ! cuticle physiology variant

[Term]
id: WBPhenotype:0001212
name: cuticle fragile
def: "The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds." [WB:WBPerson712]
is_a: WBPhenotype:0002640 ! cuticle integrity decreased

[Term]
id: WBPhenotype:0001213
name: locomotion reduced
alt_id: WBPhenotype:0001288
def: "Animals exhibit a decrease in any parameter used to measure locomotion compared to control animals." [WB:cab]
synonym: "movement reduced" EXACT []
is_a: WBPhenotype:0000641 ! activity level variant

[Term]
id: WBPhenotype:0001214
name: obsolete metaphase to anaphase transition fails
def: "OBSOLETE." [WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0001496

[Term]
id: WBPhenotype:0001215
name: germ cell mitosis variant
def: "Variations in the mitotic expansion of germ cell populations or in the appearance of nuclei during development in the premeiotic region of the germline compared to control." [WB:WBPaper00001007, WB:WBPaper00005486, WB:WBPerson2021]
synonym: "germ cell mitosis abnormal" NARROW []
is_a: WBPhenotype:0000823 ! germline proliferation variant

[Term]
id: WBPhenotype:0001216
name: meiosis metaphase to anaphase transition block
def: "Oocyte chromosomes arrest in metaphase of meiosis I without transitioning to anaphase or producing polar bodies." [pmid:11134076, WB:cab]
synonym: "Mat" BROAD []
is_a: WBPhenotype:0000775 ! meiosis variant
is_a: WBPhenotype:0001496 ! metaphase to anaphase transition defect

[Term]
id: WBPhenotype:0001217
name: germ cell mitosis metaphase to anaphase transition block
def: "Germ line cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0001215 ! germ cell mitosis variant
is_a: WBPhenotype:0001497 ! mitotic metaphase to anaphase transition defect

[Term]
id: WBPhenotype:0001218
name: cell death sexually dimorphic variant
def: "Animals exhibit variations in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712]
synonym: "cell death sexually dimorphic abnormal" NARROW []
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0001219
name: cell survival sexually dimorphic increased
def: "Animals exhibit a decrease in the rate or extent of programmed cell death and thus an increase in cell survival, as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712]
is_a: WBPhenotype:0001218 ! cell death sexually dimorphic variant

[Term]
id: WBPhenotype:0001220
name: cell death sexually dimorphic increased
def: "Animals exhibit in increase in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712]
is_a: WBPhenotype:0001218 ! cell death sexually dimorphic variant

[Term]
id: WBPhenotype:0001221
name: nose touch defective
def: "Animal fails to exhibit characteristic response after a nose-on collision with an object compared to control. In C. elegans, this is usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal." [WB:WBPaper00001705, WB:WBPerson557]
synonym: "Not" BROAD []
is_a: WBPhenotype:0000456 ! touch resistant
is_a: WBPhenotype:0004026 ! nose touch variant

[Term]
id: WBPhenotype:0001222
name: transposon mutator
def: "Animals exhibit an increase in frequency of transposition events (DNA movement to different positions within the genome of a single cell) causing an accumulation of lesions within the genome, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Mut" RELATED []
synonym: "mutator" RELATED []
is_a: WBPhenotype:0000228 ! spontaneous mutation rate increased

[Term]
id: WBPhenotype:0001223
name: germline RNAi resistant
def: "Animals show reduced susceptibility to gene silencing in the germline triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001208 ! RNAi resistant

[Term]
id: WBPhenotype:0001224
name: axon outgrowth variant
def: "Any variation in the processes that govern the extension of axons compared to control." [GO:0048675, WB:WBPerson2021]
synonym: "axon migration variant" RELATED []
synonym: "axon outgrowth abnormal" NARROW []
is_a: WBPhenotype:0000572 ! neuronal outgrowth variant

[Term]
id: WBPhenotype:0001225
name: phasmid socket absent
def: "Animals are missing the interfacial hypodermal cell (socket cell) of the phasmid sensillum pore." [WB:WBPaper00000938, WB:WBPaper00004350, WB:WBPaper00026656, WB:WBPerson712]
synonym: "Psa" RELATED []
is_a: WBPhenotype:0001527 ! amphid phasmid sensillum morphology variant

[Term]
id: WBPhenotype:0001226
name: commissure variant
def: "Animals display variations in the structure, organization or path of the part of the axon that forms a bridge between body regions, compared to that in control animals." [WB:WBPaper00000938, WB:WBPaper00001576, WB:WBPaper00029065, WB:WBPerson712]
synonym: "commissure abnormal" NARROW []
is_a: WBPhenotype:0000181 ! axon trajectory variant

[Term]
id: WBPhenotype:0001227
name: commissure absent
def: "Animals are missing any one of its commissures, an axon tract that connects one body part to another." [WB:WBPaper00027335, WB:WBPerson712]
is_a: WBPhenotype:0001226 ! commissure variant

[Term]
id: WBPhenotype:0001228
name: alae absent
def: "Animals lack the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000202 ! alae variant

[Term]
id: WBPhenotype:0001229
name: anterior neuron migration defective
def: "The orderly movement of neurons along the anterior axis of the animal is abolished, misdirected or incomplete compared to control." [WB:WBPerson2021]
synonym: "abnormal anterior neuron migration" NARROW []
is_a: WBPhenotype:0001140 ! neuron migration variant

[Term]
id: WBPhenotype:0001230
name: anterior cell migration defective
def: "The orderly movement of cells along the anterior axis of the animal is abolished, misdirected or incomplete compared to control." [WB:WBPerson2021]
synonym: "abnormal anterior cell migration" NARROW []
is_a: WBPhenotype:0000594 ! cell migration variant

[Term]
id: WBPhenotype:0001231
name: intraflagellar transport accelerated
def: "The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is increased compared to control." [WB:WBPerson2021]
synonym: "ift accelerated" RELATED []
is_a: WBPhenotype:0000853 ! intraflagellar transport variant

[Term]
id: WBPhenotype:0001232
name: serotonin response variant
def: "Animals exhibit variations in the response to the addition of serotonin compared to that observed in control animals. Serotonin is a monoamine neurotransmitter." [WB:WBPerson557]
synonym: "serotonin response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001233
name: DAPI staining variant
def: "Animals exhibit variations in the pattern of a chemical nuclear stain which is commonly used in fixed specimens and produces a bright blue label, compared to control. DAPI (4'-6-Diamidino-2-phenylindole) forms fluorescent complexes with natural double-stranded DNA (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "DAPI staining abnormal" NARROW []
is_a: WBPhenotype:0010002 ! cell organization biogenesis variant

[Term]
id: WBPhenotype:0001234
name: nonanone chemotaxis defective
def: "Failure to execute the characteristic response to nonanone compared to control. In C. elegans, nonanone is a repellant." [WB:WBPaper00002917]
is_a: WBPhenotype:0001448 ! odorant negative chemotaxis defective
is_a: WBPhenotype:0001456 ! nonanone chemotaxis variant

[Term]
id: WBPhenotype:0001235
name: cell division polarity variant
def: "Any variation in the orientation of the physical partitioning and separation of a cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cell division polarity abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0001236
name: transgene expression increased
def: "Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000962 ! level of transgene expression variant

[Term]
id: WBPhenotype:0001237
name: excess axon outgrowth
def: "Any perturbation that causes an increase in the frequency of axon outgrowth compared to control. As a result, an excess number of axonal projections are generated." [GO:0030517, WB:WBPerson2021]
is_a: WBPhenotype:0000629 ! excess neurite outgrowth
is_a: WBPhenotype:0001224 ! axon outgrowth variant

[Term]
id: WBPhenotype:0001238
name: male mating latency variant
def: "Any variation in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900, WB:cab]
synonym: "male mating latency abnormal" NARROW []
is_a: WBPhenotype:0000648 ! male mating variant

[Term]
id: WBPhenotype:0001239
name: mating latency increased
def: "Any increase in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900]
is_a: WBPhenotype:0001238 ! male mating latency variant
is_a: WBPhenotype:0001414 ! male mating defective

[Term]
id: WBPhenotype:0001240
name: male tail sensory ray differentiation variant
def: "Variations in the processes leading to the specialization of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male tail sensory ray differentiation abnormal" NARROW []
is_a: WBPhenotype:0000199 ! male tail sensory ray development variant

[Term]
id: WBPhenotype:0001241
name: obsolete ray fusion
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000297

[Term]
id: WBPhenotype:0001242
name: intraflagellar transport slow
def: "The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is lower compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0000854 ! intraflagellar transport defective

[Term]
id: WBPhenotype:0001243
name: intraflagellar transport distance short
def: "The bidirectional transport of molecules (cargo) along axonemal microtubules is reduced compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001247 ! anterograde transport defective

[Term]
id: WBPhenotype:0001244
name: intraflagellar transport absent
def: "Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is completely abolished." [WB:WBPerson2021]
is_a: WBPhenotype:0000854 ! intraflagellar transport defective

[Term]
id: WBPhenotype:0001245
name: no transport middle segment cilia
def: "The bidirectional transport of molecules along the middle segment of axonemal microtubules of the cilia is absent." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001243 ! intraflagellar transport distance short

[Term]
id: WBPhenotype:0001246
name: no transport distal segment cilia
def: "The bidirectional transport of molecules along the distal segment of axonemal microtubules of the cilia is absent." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001243 ! intraflagellar transport distance short

[Term]
id: WBPhenotype:0001247
name: anterograde transport defective
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons is disrupted." [WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
is_a: WBPhenotype:0000854 ! intraflagellar transport defective
is_a: WBPhenotype:0001477 ! anterograde transport variant

[Term]
id: WBPhenotype:0001248
name: wing cilia morphology variant
def: "Animals exhibit variations in the structure or organization of the microtuble-based projections that in control animals invaginate individually into the sheath cell of the neuronal sensillum rather than projecting through the socket cell to the outside. In C. elegans, the cilia of each wing cell has its own unique shape and as they are not exposed to the outside, they do not typically take up dyes." [WB:WBPaper00000932, WB:WBPaper00029016, WB:WBPerson712]
synonym: "AWC cilia morphology abnormal" RELATED []
synonym: "wing cilia morphology abnormal" NARROW []
is_a: WBPhenotype:0000615 ! cilia morphology variant

[Term]
id: WBPhenotype:0001249
name: amphid channel cilia morphology variant
def: "Animals exhibit variations in the structure or composition of the dendritic projections of the amphid sensory neurons that traverse the sensillum pore to connect with the outside of the animal, compared to that observed in control animals. In C. elegans, amphid channel cilia morphology is frequently assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000932, WB:WBPerson712]
synonym: "amphid channel cilia morphology abnormal" NARROW []
is_a: WBPhenotype:0000615 ! cilia morphology variant

[Term]
id: WBPhenotype:0001250
name: amphid channel axoneme morphology variant
def: "Animals exhibit variations in the structure or composition of the microtuble-based fibrillar core, axoneme, of the cilia of the neurons that project through the sensillum pore to the outside of the animal, compared to that observed in control animals." [WB:WBPaper00000932, WB:WBPerson557, WB:WBPerson712]
synonym: "amphid channel axoneme morphology abnormal" NARROW []
is_a: WBPhenotype:0000262 ! axoneme morphology variant
is_a: WBPhenotype:0001249 ! amphid channel cilia morphology variant

[Term]
id: WBPhenotype:0001251
name: amphid channel axoneme short
def: "The microtuble-based fibrillar-bundles of the amphid sensory cilia are reduced in length compared to those in control animals." [WB:WBPaper00000932, WB:WBPaper00027116, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0001250 ! amphid channel axoneme morphology variant

[Term]
id: WBPhenotype:0001252
name: wing cilia axoneme morphology variant
def: "Animals exhibit variations in the structure or organization of the microtubule-based fibrillar section, axoneme, of the cilia of the flat sheet-like cells associated with sensory function, from that observed in control animals." [WB:WBPerson712]
synonym: "wing cilia axoneme morphology abnormal" NARROW []
is_a: WBPhenotype:0001248 ! wing cilia morphology variant

[Term]
id: WBPhenotype:0001253
name: wing cilia axoneme short
def: "The microtuble-based fibrillar-bundle, axoneme, of the wing cell cilia are reduced in length and do not extend into the sheath cell as far as they do in control animals." [WB:WBPerson712]
is_a: WBPhenotype:0001252 ! wing cilia axoneme morphology variant

[Term]
id: WBPhenotype:0001254
name: amphid channel cilia bulbous
def: "The dendritic processes that normally extend through the amphid sensillum pore to the outside are truncated and have swollen ends as opposed to the extended and finger-like tips of channel cilia in control animals." [WB:WBPaper00027116, WB:WBPerson712]
is_a: WBPhenotype:0001249 ! amphid channel cilia morphology variant

[Term]
id: WBPhenotype:0001255
name: wing cilia bulbous
def: "Animals exhibit wing cell sensory cilia that are truncated and swollen unlike that observed in control animals." [WB:WBPaper00027116, WB:WBPerson712]
is_a: WBPhenotype:0001248 ! wing cilia morphology variant

[Term]
id: WBPhenotype:0001256
name: DNA damage induced focus formation variant
def: "Variations in the aggregation of molecules at the site of DNA strand breakage or damage compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "DNA damage induced focus formation abnormal" NARROW []
synonym: "DNA repair induced focus formation" RELATED []
is_a: WBPhenotype:0000739 ! DNA damage response variant

[Term]
id: WBPhenotype:0001257
name: cross link induced focus formation variant
def: "Variations in the generation of foci that mark sites of aberrant bonding of molecules to the DNA strand, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cross link induced focus formation abnormal" NARROW []
is_a: WBPhenotype:0001256 ! DNA damage induced focus formation variant

[Term]
id: WBPhenotype:0001258
name: RNAi enhanced
def: "Animals show increased susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021]
synonym: "Eri" RELATED []
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001259
name: hermaphrodite fertility reduced
def: "Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant

[Term]
id: WBPhenotype:0001260
name: oocyte morphology variant
def: "Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021]
synonym: "oocyte morphology abnormal" NARROW []
is_a: WBPhenotype:0000900 ! germ cell morphology variant

[Term]
id: WBPhenotype:0001261
name: pale
def: "Animals show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000527 ! organism pigmentation phenotype

[Term]
id: WBPhenotype:0001262
name: vulval development incomplete
def: "The developmental progression of the egg-laying organ of female and hermaphrodite nematodes is halted prior to the formation of the mature structure." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000699 ! vulva development variant

[Term]
id: WBPhenotype:0001263
name: peroxisome morphology variant
def: "The morphological appearance of peroxisomes is variant compared to control animals." [WB:cab]
synonym: "peroxisome morphology abnormal" NARROW []
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0001264
name: peroxisome physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the peroxisome to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "peroxisome physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001265
name: head movement variant
def: "The anterior portion of the animal exhibits variations in its movement compared to control." [WB:WBPaper00000214]
synonym: "Erratic head vibration" NARROW []
synonym: "head movement abnormal" NARROW []
is_a: WBPhenotype:0001699 ! localized movement variant

[Term]
id: WBPhenotype:0001266
name: genetic pathway activation variant
def: "Any variation in triggering of the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "genetic pathway activation abnormal" NARROW []
is_a: WBPhenotype:0000074 ! genetic pathway variant

[Term]
id: WBPhenotype:0001267
name: induced contraction rate variant
def: "Any variation in the frequency of gonad sheath contractions triggered by internal or external stimuli compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "induced contraction rate abnormal" NARROW []
is_a: WBPhenotype:0001199 ! gonad sheath contractions variant

[Term]
id: WBPhenotype:0001268
name: induced cell death variant
def: "Animals exhibit variations in the extent of activation of programmed cell death, compared to control." [WB:WBPerson712]
synonym: "induced cell death abnormal" NARROW []
is_a: WBPhenotype:0000729 ! cell death variant

[Term]
id: WBPhenotype:0001269
name: pathogen induced cell death variant
def: "Animals exhibit variations in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712]
synonym: "pathogen induced cell death abnormal" NARROW []
is_a: WBPhenotype:0001268 ! induced cell death variant

[Term]
id: WBPhenotype:0001270
name: pathogen induced cell death reduced
def: "Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0001269 ! pathogen induced cell death variant

[Term]
id: WBPhenotype:0001271
name: pathogen induced death increased
def: "Animals are more prone to lethality as a result of infection compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001013 ! pathogen susceptibility increased

[Term]
id: WBPhenotype:0001272
name: vulval cell induction variant
def: "Vulval precursor cells inappropriately adopt fates that are normally restricted to other vulval precursor cells compared to control." [WB:WBPerson2021]
synonym: "vulval cell induction abnormal" NARROW []
synonym: "vulval precursor cell induction abnormal" EXACT []
is_a: WBPhenotype:0000220 ! vulva cell fate specification variant

[Term]
id: WBPhenotype:0001273
name: organism heat response variant
def: "Any variation in the state or activity of an organism (in terms of movement, gene expression, etc.) in response to heat (high temperatures above the optimal temperature for that organism), compared to control." [GO:0009408, WB:WBPerson2021]
synonym: "organism heat response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0001274
name: organism heat hypersensitive
def: "Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001273 ! organism heat response variant

[Term]
id: WBPhenotype:0001275
name: increased genetic pathway signal
def: "Any variation that increases the magnitude of a signal generated by a set of gene interactions in a given pathway, compared to control." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000074 ! genetic pathway variant

[Term]
id: WBPhenotype:0001276
name: ectopic expression transgene
def: "Any variation in the cellular expression of a gene product produced by exogenous DNA that has been introduced into the organism such that it now expresses in cells/tissues not seen when compared to the expression of that gene product in control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000961 ! pattern of transgene expression variant

[Term]
id: WBPhenotype:0001277
name: transformer
def: "XX animals are transformed into males or pseudomales ." [WB:cab, WB:WBPerson712]
synonym: "Tra" RELATED []
is_a: WBPhenotype:0001572 ! masculinized

[Term]
id: WBPhenotype:0001278
name: transgene expression reduced
def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000962 ! level of transgene expression variant

[Term]
id: WBPhenotype:0001279
name: transgene expression reduced male
def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the male, that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001278 ! transgene expression reduced

[Term]
id: WBPhenotype:0001280
name: transgene expression reduced hermaphrodite
def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the hermaphrodite, that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001278 ! transgene expression reduced

[Term]
id: WBPhenotype:0001281
name: stuffed pharynx
def: "Pharynx becomes clogged with food. In C. elegans, this is often a result of pharyngeal pumping defects." [WB:cab]
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant
is_a: WBPhenotype:0000778 ! feeding inefficient

[Term]
id: WBPhenotype:0001282
name: mitochondrial metabolism variant
def: "Variations in the chemical reactions and pathways of the mitochondria compared to control." [WB:WBPerson2021]
synonym: "mitochondrial metabolism abnormal" NARROW []
is_a: WBPhenotype:0001283 ! organelle metabolism variant

[Term]
id: WBPhenotype:0001283
name: organelle metabolism variant
def: "Variations in the chemical reactions and pathways of an organelle compared to control." [WB:WBPerson2021]
synonym: "organelle metabolism abnormal" NARROW []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0001284
name: coenzyme Q depleted
def: "Animals contain a lower level of coenzyme Q, an oil-soluble vitamin-like substance present in most eukaryotic cells, primarily in the mitochondria, compared to control. It is a component of the electron transport chain and participates in aerobic cellular respiration." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000026 ! lipid depleted
is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant

[Term]
id: WBPhenotype:0001285
name: induced pharyngeal pumping variant
def: "Pharyngeal pumping is not influenced by treatment with specific compounds (eg: serotonin) in the same manner as control animals." [WB:WBPerson2021]
synonym: "induced pharyngeal pumping abnormal" NARROW []
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0001286
name: food suppressed pumping variant
def: "Exposure to food does not reduce pharyngeal pumping to the same extent as observed in control animals." [WB:WBPerson2021]
synonym: "food suppressed pumping abnormal" NARROW []
is_a: WBPhenotype:0001072 ! response to food variant
is_a: WBPhenotype:0001287 ! suppressed pharyngeal pumping defective

[Term]
id: WBPhenotype:0001287
name: suppressed pharyngeal pumping defective
def: "Animals do not exhibit a decrease in pumping rate when treated with specific compounds (such as pheromones) as is observed for control animals." [WB:WBPaper00032082, WB:WBPerson712]
synonym: "suppressed pharyngeal pumping abnormal" NARROW []
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0001288
def: "OBSOLETE." []
comment: is alternative id for "locomotion reduced" (WBPhenotype:0001213); may have originally had term name "movement reduced"
is_obsolete: true
replaced_by: WBPhenotype:0001213

[Term]
id: WBPhenotype:0001289
name: acetylcholinesterase inhibitor resistant
def: "Animals fail to respond to the concentration of acetylcholinesterase inhibitor that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0001290 ! acetylcholinesterase inhibitor response variant

[Term]
id: WBPhenotype:0001290
name: acetylcholinesterase inhibitor response variant
def: "Animals exhibit variations in their response to a specific acetylcholinesterase inhibitor compared to that observed in control animals." [WB:WBPerson557]
synonym: "acetylcholinesterase inhibitor response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001291
name: social behavior variant
def: "Animals exhibit variations in actions and responses that occurs predominantly, or only, in individuals that are part of a group, from that observed for animals in a control group." [GO:0035176, WB:WBPerson712]
synonym: "social behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001292
name: body wall muscle physiology variant
def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the body wall muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "body wall muscle physiology abnormal" NARROW []
is_a: WBPhenotype:0000611 ! muscle system physiology variant

[Term]
id: WBPhenotype:0001293
name: larval physiology phenotype
def: "Animals exhibit variations in any physical or chemical process required for the larva to carry out its normal metabolic functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712]
synonym: "larval physiology abnormal" EXACT []
synonym: "larval physiology variant" EXACT []
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0001294
name: head bent
def: "The most anterior portion of the animal is not aligned with the axis of the body." [WB:WBPaper00000031]
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0001295
name: body twisted
def: "Any portion of the animal, between the head and the tail, appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000072 ! body morphology variant

[Term]
id: WBPhenotype:0001296
name: lannate resistant
def: "Animals fail to respond to the concentration of lannate that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
synonym: "methomyl resistant" EXACT []
is_a: WBPhenotype:0001289 ! acetylcholinesterase inhibitor resistant

[Term]
id: WBPhenotype:0001297
name: male tail development variant
def: "Any variation in the process whose specific outcome is the progression of the male tail over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021]
synonym: "male tail development abnormal" NARROW []
is_a: WBPhenotype:0000805 ! tail development variant

[Term]
id: WBPhenotype:0001298
name: hindgut morphology variant
def: "Animals exhibit variations in the form, structure or composition of the more posterior portion of the intestine, just anterior to the sphincter valve, which is subject to squeezing by the somatal-intestinal muscles compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hindgut morphology abnormal" NARROW []
is_a: WBPhenotype:0000710 ! intestinal morphology variant

[Term]
id: WBPhenotype:0001299
name: cell division variant male
def: "Any variation that alters the physical partitioning and separation of a cell into daughter cells in male animals compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cell division abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0001300
name: germ cell cytoplasmic morphology variant
def: "Any variation in the composition or structure of the contents within a germ cell, excluding the plasma membrane and nucleus, compared to control. Germ cells include sperm, oocytes, and their precursors." [GO:0005737, WB:WBPerson2021, WB:WBPerson557]
synonym: "germ cell cytoplasmic morphology abnormal" NARROW []
is_a: WBPhenotype:0000900 ! germ cell morphology variant

[Term]
id: WBPhenotype:0001301
name: P granule abnormal
def: "Localization or structural appearance of P-granules is altered compared to control. P-granules are cytoplasmic structures associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle." [pmid:11262230, WB:cab]
is_a: WBPhenotype:0001300 ! germ cell cytoplasmic morphology variant

[Term]
id: WBPhenotype:0001302
name: P granule localization defective
def: "The restricted localization of P granules to germ cells or germ cell precursors is altered compared to control." [WB:WBPaper00001477, WB:WBPerson2021]
synonym: "germ granule localization defective" RELATED []
synonym: "P granule localization abnormal" NARROW []
is_a: WBPhenotype:0001301 ! P granule abnormal

[Term]
id: WBPhenotype:0001303
name: extra and ectopic cell
def: "Animals have one or more extra cells of a particular type, which are present in places they are normally not found, when compared to the number and location of these cells in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0002175 ! cell number increased
is_a: WBPhenotype:0002493 ! ectopic cell

[Term]
id: WBPhenotype:0001304
name: hindgut damaged
def: "The terminal portion of the intestine exhibits structural defects such as scarring or blockage." [WB:cab, WB:WBPaper00003719]
synonym: "Scar" BROAD []
is_a: WBPhenotype:0001298 ! hindgut morphology variant

[Term]
id: WBPhenotype:0001305
name: hook morphology variant
def: "Any variation in the form or composition of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hook morphology abnormal" NARROW []
is_a: WBPhenotype:0000070 ! male tail morphology variant

[Term]
id: WBPhenotype:0001306
name: male reproductive system morphology variant
def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the male reproductive system compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male reproductive system morphology abnormal" NARROW []
is_a: WBPhenotype:0000605 ! reproductive system morphology variant

[Term]
id: WBPhenotype:0001307
name: reduced body bend
def: "The maximum ventral and dorsal flex of the animal is reduced compared to that observed for control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001703 ! body bend variant

[Term]
id: WBPhenotype:0001308
name: weak pumping
def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding is not as robust as compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0001309
name: amplitude of sinusoidal movement decreased
alt_id: WBPhenotype:0000003
def: "Animals exhibit a decrease in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPaper00043908, WB:WBPerson2021, WB:WBPerson2987, WB:WBPerson557]
synonym: "amplitude of body bends decreased" EXACT []
synonym: "flat locomotion path" EXACT []
synonym: "flattened locomotion path" EXACT []
is_a: WBPhenotype:0004022 ! amplitude of sinusoidal movement variant

[Term]
id: WBPhenotype:0001310
name: neuron positioning variant
def: "The placement of neuronal cells, as a whole or of a specific class of neuron in the animal, deviates from that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "neuron positioning abnormal" NARROW []
is_a: WBPhenotype:0000604 ! nervous system morphology variant

[Term]
id: WBPhenotype:0001311
name: protein expression reduced hermaphrodite
def: "Variations that result in a decrease in protein expression in hermaphrodites compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0000120 ! protein expression reduced

[Term]
id: WBPhenotype:0001312
name: neuron number variant
def: "The quantity of neuronal cells, as a whole or of a specific class of neuron in the animal deviates from that observed in control animals." [WB:WBPaper00027711, WB:WBPerson712]
synonym: "neuron number abnormal" NARROW []
is_a: WBPhenotype:0000604 ! nervous system morphology variant

[Term]
id: WBPhenotype:0001313
name: uterine muscle variant
def: "Any variation in the progression of the sex-specific muscles of the hermaphrodite, over time, whose contractions squeeze on the uterus to help move eggs towards the vulval opening compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "uterine muscle abnormal" NARROW []
is_a: WBPhenotype:0000282 ! hermaphrodite sex muscle development variant

[Term]
id: WBPhenotype:0001314
name: vulval muscle variant
def: "Any variation in the progression of the sex-specific muscles in the hermaphrodite, over time, that are specialized for egg-laying compared to control. In C. elegans the contractions of the vulval muscles open the lips of the vulva to help in expelling an egg from the uterus (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "vulval muscle abnormal" NARROW []
is_a: WBPhenotype:0000282 ! hermaphrodite sex muscle development variant

[Term]
id: WBPhenotype:0001315
name: electrophysiology phenotype
def: "Animals exhibit variations in the electrical properties of any of its cells or tissues compared to control." [WB:WBPerson2021]
synonym: "electrophysiology abnormal" EXACT []
synonym: "electrophysiology variant" EXACT []
is_a: WBPhenotype:0000519 ! physiology phenotype

[Term]
id: WBPhenotype:0001316
name: evoked postsynaptic current variant
def: "Variations in the synaptic currents that are elicited by firing an action potential in a population of axons, compared to control." [pmid:14735116, WB:WBPerson2021]
synonym: "evoked postsynaptic current abnormal" NARROW []
is_a: WBPhenotype:0002014 ! current measurement variant

[Term]
id: WBPhenotype:0001317
name: evoked postsynaptic amplitude reduced
def: "The amplitudes of synaptic currents that are elicited by firing an action potential in a population of axons are decreased, compared to those observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001316 ! evoked postsynaptic current variant

[Term]
id: WBPhenotype:0001318
name: endogenous synaptic events variant
def: "Any variation in the currents observed in the absence of presynaptic action potentials and that are elicited by fusion of a single endogenous vesicle of transmitter compared to control." [pmid:14735116, WB:WBPerson2021]
synonym: "endogenous synaptic events abnormal" NARROW []
is_a: WBPhenotype:0002014 ! current measurement variant

[Term]
id: WBPhenotype:0001319
name: endogenous synaptic event frequency reduced
def: "The rate (frequency) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is decreased compared to control. Changes in frequency are indicative of presynaptic modifications." [pmid:14735116, WB:WBPaper00026938, WB:WBPerson2021]
is_a: WBPhenotype:0001318 ! endogenous synaptic events variant

[Term]
id: WBPhenotype:0001320
name: endogenous synaptic amplitude variant
def: "The amplitude (magnitude) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is altered compared to control. Changes in amplitude are often interpreted as alterations of postsynaptic responsiveness to the transmitter." [pmid:14735116, WB:WBPerson2021]
synonym: "endogenous synaptic amplitude abnormal" NARROW []
is_a: WBPhenotype:0001318 ! endogenous synaptic events variant

[Term]
id: WBPhenotype:0001321
name: presynaptic region morphology variant
def: "Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control." [GO:0042734, WB:WBPaper00000938, WB:WBPaper00027305, WB:WBPaper00028886, WB:WBPerson712]
synonym: "presynaptic region morphology abnormal" NARROW []
is_a: WBPhenotype:0000616 ! synapse morphology variant

[Term]
id: WBPhenotype:0001322
name: obsolete vesicle number reduced
def: "OBSOLETE. Total presynaptic vesicle number is reduced, possibly refecting a defect in the replenishment of synaptic vesicles compared to control." [pmid:16803962, WB:cab]
comment: Electron microscopic analysis.
is_obsolete: true
replaced_by: WBPhenotype:0001670

[Term]
id: WBPhenotype:0001323
name: vesicle morphology variant
def: "Animals display variations in the shape or size of their vesicles, which are spherical, membrane-bound fluid-filled organelles, compared to vesicles observed in control animals." [GO:0031982, pmid:16803962, WB:cab, WB:WBPaper00027612, WB:WBPaper00027711, WB:WBPerson712]
comment: Electron microscopic analysis.
synonym: "vesicle morphology abnormal" NARROW []
is_a: WBPhenotype:0001671 ! vesicle organization variant

[Term]
id: WBPhenotype:0001324
name: cell ionizing radiation response variant
def: "Cells exhibit variations in their response to ionizing radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "cell ionizing radiation response abnormal" NARROW []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0001325
name: backing not sustained
def: "Animals initiate but do not continue backward movement, similar to control animals." [WB:cab, WB:cgc914]
is_a: WBPhenotype:0001005 ! backward locomotion variant

[Term]
id: WBPhenotype:0001326
name: cell gamma ray response variant
def: "Cells exhibit variations in their response to gamma ray radiation compared to that observed in control animals." [WB:WBPerson557]
synonym: "cell gamma ray response abnormal" NARROW []
is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant

[Term]
id: WBPhenotype:0001327
name: cell gamma ray hypersensitive
def: "Cells respond to a lower dosage of gamma rays or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001326 ! cell gamma ray response variant

[Term]
id: WBPhenotype:0001328
name: posterior body dumpy
def: "The posterior part of the worm is shorter and stouter compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000793 ! posterior body morphology variant

[Term]
id: WBPhenotype:0001329
name: curly
def: "Animals exhibit a greater number of bends in their body compared to control. C. elegans posture assumes more than a single sine wave." [WB:cab, WB:cgc914]
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0001330
name: egg laying event infrequent
def: "The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate is reduced compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "egg laying event rare" RELATED []
is_a: WBPhenotype:0000006 ! egg laying defective
is_a: WBPhenotype:0000272 ! egg laying irregular

[Term]
id: WBPhenotype:0001331
name: motor neuron morphology variant
def: "Animals display variations in the structure or organization of components of the motor neuron, internal to the cell itself or in relation to the cellular environment compared to that observed in control animals. A motor neuron is a neuronal cell that synapses to an effector (muscle, gland etc.)." [WB:WBPerson712]
comment: WBbt:0005409.
synonym: "motor neuron morphology abnormal" NARROW []
is_a: WBPhenotype:0000905 ! neuron morphology variant

[Term]
id: WBPhenotype:0001332
name: vesicle number variant
def: "Animals display variations in the number of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "vesicle number abnormal" NARROW []
is_a: WBPhenotype:0001671 ! vesicle organization variant

[Term]
id: WBPhenotype:0001333
name: neuron cell body absent misplaced
def: "The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced." [WB:WBPaper00000502, WB:WBPaper00000635, WB:WBPerson712]
is_a: WBPhenotype:0000816 ! neuron development variant

[Term]
id: WBPhenotype:0001334
name: hermaphrodite sex muscle morphology variant
def: "Any variation in the form, structure or composition of the muscles of the adult hermaphrodite reproductive system compared to control. In C. elegans hermaphrodites these muscles include the vulval and uterine muscles, located near the vulva in the midbody, which all derive from the M myoblast (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hermaphrodite sex muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0001335 ! hermaphrodite reproductive system morphology variant

[Term]
id: WBPhenotype:0001335
name: hermaphrodite reproductive system morphology variant
def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the hermaphrodite reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hermaphrodite reproductive system morphology abnormal" NARROW []
is_a: WBPhenotype:0000605 ! reproductive system morphology variant

[Term]
id: WBPhenotype:0001336
name: male mating efficiency eliminated
def: "Males sire no cross progeny." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557]
synonym: "no male progeny" EXACT []
is_a: WBPhenotype:0000843 ! male mating efficiency reduced

[Term]
id: WBPhenotype:0001337
name: adrenergic receptor antagonist response variant
def: "Animals exhibit variations in their response to a specific adrenergic receptor antagonist compared to that observed in control animals." [WB:WBPerson557]
synonym: "adrenergic receptor antagonist response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001338
name: phentolamine resistant
def: "Animals fail to respond to the concentration of phentolamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001337 ! adrenergic receptor antagonist response variant

[Term]
id: WBPhenotype:0001339
name: egg laying levamisole resistant
def: "Animals are not induced to lay eggs in reponse to exogenous levamisole. In C. elegans, levamisole stimulates egg-laying." [WB:WBPaper00000635, WB:WBPerson712]
is_a: WBPhenotype:0000421 ! levamisole resistant
is_a: WBPhenotype:0001101 ! egg laying response to drug variant

[Term]
id: WBPhenotype:0001340
name: egg laying imipramine resistant
def: "Animals are not induced to lay eggs in reponse to exogenous imipramine. In C. elegans, imipramine stimulates egg-laying." [WB:WBPaper00000635, WB:WBPaper00001133, WB:WBPaper00031293, WB:WBPerson712]
is_a: WBPhenotype:0000340 ! imipramine resistant
is_a: WBPhenotype:0001101 ! egg laying response to drug variant

[Term]
id: WBPhenotype:0001341
name: egg laying phentolamine resistant
def: "Animals are not induced to lay eggs in reponse to exogenous phentolamine. In C. elegans, phentolamine stimulates egg-laying." [WB:WBPaper00000635, WB:WBPerson712]
is_a: WBPhenotype:0001101 ! egg laying response to drug variant
is_a: WBPhenotype:0001338 ! phentolamine resistant

[Term]
id: WBPhenotype:0001342
name: egg laying imipramine hypersensitive
def: "Animals respond to exogenous imipramine at a lower concentration or within a shorter time period than control animals under the same conditions." [WB:WBPaper00000635, WB:WBPerson712]
is_a: WBPhenotype:0001101 ! egg laying response to drug variant

[Term]
id: WBPhenotype:0001343
name: meiotic spindle defective early emb
def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a meiotic cell cycle." [GO:0000212, WB:WBPerson2021]
comment: Possible XP.
is_a: WBPhenotype:0000759 ! spindle defective early emb
is_a: WBPhenotype:0001868 ! meiotic spindle defective

[Term]
id: WBPhenotype:0001344
name: organelle organization biogenesis variant
def: "Intracellular membrane bound compartments vary in shape or size from that observed in control animals." [WB:WBPaper00032168, WB:WBPerson712]
synonym: "organelle organization biogenesis abnormal" NARROW []
is_a: WBPhenotype:0010002 ! cell organization biogenesis variant

[Term]
id: WBPhenotype:0001345
name: cytoskeleton organization biogenesis variant
def: "Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GO:0005856, WB:WBPerson2021, WB:WBPerson557]
synonym: "cytoskeleton organization biogenesis abnormal" NARROW []
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0001346
name: actin cytoskeleton dynamics phenotype
def: "Any variation in the dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins compared to control." [GO:0031532, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "actin cytoskeleton dynamic abnormal" NARROW []
synonym: "actin cytoskeleton dynamics variant" EXACT []
is_a: WBPhenotype:0001587 ! actin organization biogenesis phenotype

[Term]
id: WBPhenotype:0001347
name: intestinal calcium signaling variant
def: "Any variation in the series of molecular signals in which an intestinal cell uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "intestinal calcium signaling abnormal" NARROW []
is_a: WBPhenotype:0001093 ! intestinal physiology variant
is_a: WBPhenotype:0002170 ! calcium mediated signaling variant

[Term]
id: WBPhenotype:0001348
name: chromosome morphology variant
def: "Variations in the form or composition of a structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements compared to control. In C. elegans the normal cell contains 5 pairs of 'autosomes' and one or two X chromosomes (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "chromosome morphology abnormal" NARROW []
is_a: WBPhenotype:0001028 ! nuclear appearance variant

[Term]
id: WBPhenotype:0001349
name: protein phosphorylation variant
def: "Variations in the processes that incorporate phosphate groups to one or more amino acids within a protein, compared to control." [GO:0006468, WB:WBPerson2021]
synonym: "protein phosphorylation abnormal" NARROW []
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0001350
name: protein phosphorylation increased
def: "Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001349 ! protein phosphorylation variant

[Term]
id: WBPhenotype:0001351
name: protein phosphorylation reduced
def: "Animals exhibit decreased levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001349 ! protein phosphorylation variant

[Term]
id: WBPhenotype:0001352
name: endoplasmic reticulum metabolism variant
def: "Variations in the chemical reactions and pathways of the endoplasmic reticulum compared to control." [WB:WBPerson2021]
synonym: "endoplasmic reticulum metabolism abnormal" NARROW []
synonym: "er metabolism abnormal" RELATED []
is_a: WBPhenotype:0001283 ! organelle metabolism variant

[Term]
id: WBPhenotype:0001353
name: centration defective early emb
def: "The coordinated movement during prophase of the two centrosomes and the two pronuclei towards the center of the one cell embryo is abolished." [WB:WBPaper00027230, WB:WBPerson2021, WB:WBPerson557]
synonym: "centration abnormal" NARROW []
is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb

[Term]
id: WBPhenotype:0001354
name: actin cytoskeleton filament morphology phenotype
def: "Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "actin cytoskeleton filament morphology abnormal" EXACT []
synonym: "actin cytoskeleton filament morphology variant" EXACT []
is_a: WBPhenotype:0001587 ! actin organization biogenesis phenotype

[Term]
id: WBPhenotype:0001355
name: gonad morphology variant
def: "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "gonad morphology abnormal" NARROW []
is_a: WBPhenotype:0000605 ! reproductive system morphology variant

[Term]
id: WBPhenotype:0001356
name: male sex muscle morphology variant
def: "Any variation in the form, structure or composition of the muscles of the adult male reproductive system compared to control. In C. elegans males, the M myoblast gives rise to a much larger set of specialized muscles, compared to hermaphrodites, which differentiate within the tail region (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male sex muscle morphology abnormal" NARROW []
is_a: WBPhenotype:0001024 ! male morphology variant

[Term]
id: WBPhenotype:0001357
name: male gonad morphology variant
def: "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male gonad morphology abnormal" NARROW []
is_a: WBPhenotype:0001024 ! male morphology variant

[Term]
id: WBPhenotype:0001358
name: male nervous system morphology variant
def: "Male animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male nervous system morphology abnormal" NARROW []
is_a: WBPhenotype:0001024 ! male morphology variant

[Term]
id: WBPhenotype:0001359
name: proctodeum morphology variant
def: "Animals exhibit variations in the structure and organization of the chamber in the male tail that extends from the termination of four canals (vas deferens, gut, and left and right spicule channels) to just before the cloaca, from that observed in control animals." [WB:WBPaper00027278, WB:WBPerson712]
synonym: "proctodeum morphology abnormal" NARROW []
is_a: WBPhenotype:0000070 ! male tail morphology variant

[Term]
id: WBPhenotype:0001360
name: hermaphrodite self sterile
def: "Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males." [WB:WBPaper00001075, WB:WBPerson2021]
is_a: WBPhenotype:0000694 ! hermaphrodite sterile

[Term]
id: WBPhenotype:0001361
name: chromosome condensation variant
def: "Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557]
synonym: "chromosome condensation abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001362
name: chromosome condensation failure
def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis in eukaryotic cells is abolished." [GO:0030261, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001361 ! chromosome condensation variant

[Term]
id: WBPhenotype:0001363
name: head cavity
def: "The head contains cavities, possibly indicative of inappropriate cell death." [WB:cab]
synonym: "head vacuole" RELATED []
is_a: WBPhenotype:0000071 ! head morphology variant

[Term]
id: WBPhenotype:0001364
name: male fan morphology variant
def: "Any variation in the form, structure or composition of the flattened structure extending laterally at the extreme tip of the adult male consisting of nine pairs of sensory rays that lie within a web-like cuticle compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male fan morphology abnormal" NARROW []
is_a: WBPhenotype:0000070 ! male tail morphology variant

[Term]
id: WBPhenotype:0001365
name: male bursa development variant
def: "Any variation in the process whose specific outcome is the progression of the male bursa over time, from its formation to the mature structure, compared to control. The male bursa consists of the lateral fan and rays (WormAtlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "male bursa development abnormal" NARROW []
is_a: WBPhenotype:0001297 ! male tail development variant

[Term]
id: WBPhenotype:0001366
name: male fan development variant
def: "Any variation in the process whose specific outcome is the progression of the male fan over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021]
synonym: "male fan development abnormal" NARROW []
is_a: WBPhenotype:0001365 ! male bursa development variant

[Term]
id: WBPhenotype:0001367
name: proctodeum development variant
def: "Any variation in the process whose specific outcome is the progression of the male proctodeum over time, from its formation to the mature structure, compared to control. The union of the vas deferens and the intestine give rise to the proctodeum which contains copulatory spicules." [WB:WBPerson2021]
synonym: "proctodeum development abnormal" NARROW []
is_a: WBPhenotype:0001297 ! male tail development variant

[Term]
id: WBPhenotype:0001368
name: spermatheca absent
def: "Animals lack the somatic gonad structure that connects the distal gonad arm to the uterus." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001662 ! spermatheca development variant

[Term]
id: WBPhenotype:0001369
name: protein interaction variant
def: "Variations in the selective and non-covalent physical association between two or more proteins, or a protein and nucleic acid/macromolecular complex, compared to control." [GO:0005515, WB:WBPerson2021]
synonym: "protein interaction abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001370
name: protein protein interaction variant
def: "Variations in the selective and non-covalent physical association between two or more proteins, compared to control." [WB:WBPerson2021]
synonym: "protein protein interaction abnormal" NARROW []
is_a: WBPhenotype:0001369 ! protein interaction variant

[Term]
id: WBPhenotype:0001371
name: protein RNA interaction variant
def: "Variations in the selective and non-covalent physical association between a protein and a specific RNA sequence, compared to control." [WB:WBPerson2021]
synonym: "protein RNA interaction abnormal" NARROW []
is_a: WBPhenotype:0001369 ! protein interaction variant

[Term]
id: WBPhenotype:0001372
name: protein DNA interaction variant
def: "Variations in the selective and non-covalent physical association between a protein and a specific DNA sequence, compared to control." [WB:WBPerson2021]
synonym: "protein DNA interaction abnormal" NARROW []
is_a: WBPhenotype:0001369 ! protein interaction variant

[Term]
id: WBPhenotype:0001373
name: protein RNA interaction abolished
def: "Animals lack a specific protein-RNA interaction observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001371 ! protein RNA interaction variant

[Term]
id: WBPhenotype:0001374
name: pronuclear nuclear appearance variant emb
def: "The shape and size of nuclei as well as the distribution of nucleoporins are strongly affected." [WB:cab, WB:WBPaper00028895]
synonym: "Pna" RELATED []
synonym: "pronuclear nuclear appearance abnormal" NARROW []
is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant

[Term]
id: WBPhenotype:0001375
name: transgene expression undetectable
def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection." [WB:WBPerson557]
is_a: WBPhenotype:0001278 ! transgene expression reduced

[Term]
id: WBPhenotype:0001376
name: transgene expression undetectable cell specific
def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection in specific cells." [WB:WBPerson557]
is_a: WBPhenotype:0001375 ! transgene expression undetectable

[Term]
id: WBPhenotype:0001377
name: break induced focus formation variant
def: "Variations in the generation of foci that mark crossover recombination events, compared to control. These foci mark the boundary of asymmetric synaptonemal complex disassembly." [WB:WBPaper00032296, WB:WBPerson2021, WB:WBPerson557]
synonym: "break induced focus formation abnormal" NARROW []
is_a: WBPhenotype:0001256 ! DNA damage induced focus formation variant
is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant

[Term]
id: WBPhenotype:0001378
name: mitotic chromosome segregation variant
def: "Any variation in the cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle compared to control animals." [GO:0000070, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "mitotic chromosome segregation abnormal" NARROW []
is_a: WBPhenotype:0000773 ! chromosome segregation variant

[Term]
id: WBPhenotype:0001379
name: organism toxic chemical response variant
def: "Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism toxic chemical response abnormal" NARROW []
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0001380
name: anoxia hypersensitive
def: "Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021]
is_a: WBPhenotype:0002424 ! anoxia response variant

[Term]
id: WBPhenotype:0001381
name: anoxia resistant
def: "Animals fail to respond to trace amounts of oxygen that elicit a response in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0002424 ! anoxia response variant

[Term]
id: WBPhenotype:0001382
name: protein modification variant
def: "Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021]
synonym: "protein modification abnormal" NARROW []
is_a: WBPhenotype:0000112 ! protein expression variant

[Term]
id: WBPhenotype:0001383
name: protein methylation variant
def: "Variations in the processes that incorporate methyl groups to one or more amino acids within a protein, compared to control." [GO:0006479, WB:WBPerson2021]
synonym: "protein methylation abnormal" NARROW []
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0001384
name: fertility reduced
def: "Animals exhibit a reduction in the production of new individuals that contain some portion of their genetic material inherited from that organism as a result of defective gametes." [GO:0000003, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000145 ! fertility phenotype

[Term]
id: WBPhenotype:0001385
name: precocious oogenesis
def: "Relatively unspecialized germ cells prematurely acquire the specialized properties of mature oocytes." [WB:WBPaper00001475, WB:WBPaper00028819, WB:WBPerson2021]
is_a: WBPhenotype:0000186 ! oogenesis variant
is_a: WBPhenotype:0000439 ! precocious heterochronic variations

[Term]
id: WBPhenotype:0001386
name: fertilization defective hermaphrodite
def: "Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) in adult hermaphrodites during sexual reproduction." [WB:WBPerson2021]
is_a: WBPhenotype:0000983 ! fertilization defective

[Term]
id: WBPhenotype:0001387
name: fertilization defect male
def: "Failure of male-derived sperm to fuse with an oocyte during sexual reproduction." [WB:WBPaper00033007, WB:WBPerson2021]
is_a: WBPhenotype:0000983 ! fertilization defective

[Term]
id: WBPhenotype:0001388
name: organism hypersensitive gamma irradiation
def: "Organisms respond to a lower dosage of gamma rays or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000497 ! organism gamma ray response variant
is_a: WBPhenotype:0000711 ! organism hypersensitive ionizing radiation

[Term]
id: WBPhenotype:0001389
name: cell gamma ray resistant
def: "Cells fail to respond to the dosage of gamma irradiation that elicits a response in control animals. Alternatively, cells require longer exposure times to gamma irradiation to mimic the response observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001326 ! cell gamma ray response variant

[Term]
id: WBPhenotype:0001390
name: cell UV hypersensitive
def: "Cells respond to a lower dosage of UV or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000100 ! cell UV response variant

[Term]
id: WBPhenotype:0001391
name: gamma ray induced apoptosis increased
def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0000183 ! apoptosis increased
is_a: WBPhenotype:0001326 ! cell gamma ray response variant

[Term]
id: WBPhenotype:0001392
name: cell cycle arrest
def: "Cells of the animals cease during one of its replicative phases (G1, S, G2, M)." [GO:0051726, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0001995 ! cell cycle progression variant

[Term]
id: WBPhenotype:0001393
name: cell acidification variant
def: "Variations in the processes that reduce the internal pH of a cell (measured by the concentration of the hydrogen ion), compared to control." [GO:0045851, WB:WBPerson2021]
synonym: "cell acidification abnormal" NARROW []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0001394
name: cell acidification defective
def: "Animals lack the capacity to reduce the internal pH of a cell." [GO:0045851, WB:WBPerson2021]
synonym: "no pumping" RELATED []
is_a: WBPhenotype:0001393 ! cell acidification variant

[Term]
id: WBPhenotype:0001395
name: body vacuole
def: "Vacuoles accumulate in the body. A vacuole is a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GO:0005776, WB:WBPerson557]
is_a: WBPhenotype:0000072 ! body morphology variant
is_a: WBPhenotype:0002615 ! abnormal accumulation of vacuoles

[Term]
id: WBPhenotype:0001396
name: pumping absent
def: "Animals completely lack any pharyngeal pumping motion." [WB:WBPaper00001894, WB:WBPerson2021]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0001397
name: necrotic cell death increased
def: "Animals exhibit an increase in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control." [GO:0070265, WB:WBPerson712]
is_a: WBPhenotype:0000415 ! necrotic cell death variant

[Term]
id: WBPhenotype:0001398
name: neurite morphology variant
def: "Animals display variations in the structure, organization of components, or spatial pattern of any projection stemming from a neuronal cell, compared to that observed in control animals." [GO:0043005, WB:WBPaper00028886, WB:WBPerson712]
synonym: "neurite morphology abnormal" NARROW []
is_a: WBPhenotype:0000905 ! neuron morphology variant

[Term]
id: WBPhenotype:0001399
name: cell membrane morphology variant
def: "Any variation in the structure, form or composition of the semipermeable lipid bilayer that creates a boundary between the interior and exterior environment for cells, cellular organelles and tissues, within an organism compared to control." [GO:0005886, WB:WBPerson2021, WB:WBPerson557]
synonym: "cell membrane morphology abnormal" NARROW []
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0001400
name: level of protein expression variant
def: "Animals exhibit variations in the measured expression of a protein compared to that observed in control animals." [WB:WBPerson2021]
synonym: "level of protein expression abnormal" NARROW []
is_a: WBPhenotype:0000112 ! protein expression variant

[Term]
id: WBPhenotype:0001401
name: mitochondria morphology variant
def: "The morphological appearance of mitochondria is varied compared to control animals." [WB:cab]
synonym: "mitochondria morphology abnormal" EXACT []
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0001402
name: connected mitochondria
def: "Mitochondria are interconnected by thin tubules of mitochondrial inner or outer membrane." [GO:0007006, WB:WBPaper00032231, WB:WBPerson712]
synonym: "connected mitochodria muscle" NARROW []
synonym: "connected mitochondria epithelial" NARROW []
is_a: WBPhenotype:0001401 ! mitochondria morphology variant

[Term]
id: WBPhenotype:0001403
name: antibody subcellular localization variant
def: "Any variation in the placement of a protein, as detected by antibody staining, within in a cell or cellular compartment compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "antibody subcellular localization abnormal" NARROW []
is_a: WBPhenotype:0000424 ! antibody staining variant

[Term]
id: WBPhenotype:0001404
name: ectopic expression antibody
def: "Any variation that results in the detection of protein expression in cells/tissues through antibody staining, that is otherwise not observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000424 ! antibody staining variant

[Term]
id: WBPhenotype:0001405
name: protein aggregation variant
def: "Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
synonym: "protein aggregation abnormal" NARROW []
is_a: WBPhenotype:0001370 ! protein protein interaction variant

[Term]
id: WBPhenotype:0001406
name: protein expression reduced male
def: "Variations that result in a decrease in protein expression in male animals compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0000120 ! protein expression reduced

[Term]
id: WBPhenotype:0001407
name: protein expression reduced cell specific
def: "Variations that result in a decrease in protein expression in specific cells compared to that observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0000120 ! protein expression reduced

[Term]
id: WBPhenotype:0001408
name: pattern protein expression variant
def: "Any variation in the cellular or subcellular distribution of a protein compared to that observed in control animals." [WB:WBPerson2021]
synonym: "pattern protein expression abnormal" NARROW []
is_a: WBPhenotype:0000112 ! protein expression variant

[Term]
id: WBPhenotype:0001409
name: protein expression ectopic
def: "Any variation that results in the cellular expression of a protein in cells/tissues, that is otherwise not observed in control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001408 ! pattern protein expression variant

[Term]
id: WBPhenotype:0001410
name: protein expression absent
def: "Animals fail to express a given protein or class of proteins." [WB:WBPerson2021]
is_a: WBPhenotype:0000120 ! protein expression reduced

[Term]
id: WBPhenotype:0001411
name: cuticle carbohydrate surface variant
def: "Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals." [WB:WBPaper00001576, WB:WBPerson712]
synonym: "cuticle carbohydrate surface abnormal" NARROW []
synonym: "ectopic lectin binding" RELATED []
synonym: "Srf" NARROW []
is_a: WBPhenotype:0001210 ! pericellular component physiology phenotype

[Term]
id: WBPhenotype:0001412
name: alae morphology variant
def: "Animals exhibit variations in the organization of the longitudinal ridges on the cuticle along the length of the animal, from that observed for control animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712]
synonym: "alae morphology abnormal" NARROW []
is_a: WBPhenotype:0000948 ! cuticle morphology variant

[Term]
id: WBPhenotype:0001413
name: bacterially unswollen
def: "Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control." [WB:cab, WB:WBPaper00026735]
synonym: "Bus" BROAD []
is_a: WBPhenotype:0000073 ! tail morphology variant
is_a: WBPhenotype:0001014 ! pathogen resistance increased
is_a: WBPhenotype:0002545 ! response to bacteria variant

[Term]
id: WBPhenotype:0001414
name: male mating defective
def: "Males exhibit defects in the specific actions or reactions that are associated with reproduction." [GO:0060179, WB:WBPerson2021, WB:WBPerson557]
synonym: "Cod" BROAD []
is_a: WBPhenotype:0000648 ! male mating variant

[Term]
id: WBPhenotype:0001415
name: pathogen adherence variant
def: "Animals exhibit variations that result in variations in the ability of or extent to which pathogens adhere to the surface of animals, compared to control." [WB:cab, WB:WBPaper00026735, WB:WBPerson2987]
synonym: "pathogen adherence abnormal" NARROW []
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0001416
name: pathogen adherence defect
def: "Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host." [WB:WBPaper00028877, WB:WBPerson2021]
is_a: WBPhenotype:0001014 ! pathogen resistance increased
is_a: WBPhenotype:0002461 ! pathogen adherence decreased

[Term]
id: WBPhenotype:0001417
name: organism desiccation response variant
def: "Any variation in the state or activity of an organism in response to extreme dryness or drought-like conditions, compared to control ." [GO:0009819, WB:WBPerson2021]
synonym: "organism desication response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0001418
name: organism hypersensitive desiccation
def: "Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001417 ! organism desiccation response variant

[Term]
id: WBPhenotype:0001419
name: emetine hypersensitive
def: "Animals respond to emetine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0001420
name: biofilm absent head
def: "Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238]
synonym: "Bah" BROAD []
is_a: WBPhenotype:0001415 ! pathogen adherence variant

[Term]
id: WBPhenotype:0001421
name: endocytic transport variant
def: "Animals exhibit variations in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling compared to control." [GO:0016197, WB:WBPaper00031894, WB:WBPerson712]
synonym: "endocytic transport abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001422
name: endocytic transport defect
def: "Animals exhibit defects in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling." [GO:0016197, WB:WBPerson557]
is_a: WBPhenotype:0001421 ! endocytic transport variant

[Term]
id: WBPhenotype:0001423
name: coelomocyte physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the coelomocyte to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "coelomocyte physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001424
name: oocyte physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the oocyte to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712]
synonym: "oocyte physiology abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001425
name: receptor mediated endocytosis defective
def: "Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes." [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021]
comment: Possible XP = GO:0006898.
synonym: "Rme" RELATED []
is_a: WBPhenotype:0001422 ! endocytic transport defect
is_a: WBPhenotype:0001424 ! oocyte physiology variant

[Term]
id: WBPhenotype:0001426
name: coelomocyte endocytosis defective
def: "Fluid-phase endocytosis by coelomocytes is less frequent or efficient compared to control." [pmid:16042554, WB:cab]
synonym: "Cup" RELATED []
is_a: WBPhenotype:0001422 ! endocytic transport defect
is_a: WBPhenotype:0001423 ! coelomocyte physiology variant

[Term]
id: WBPhenotype:0001427
name: cytoplasmic appearance variant
def: "Animals exhibit variations in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "cytoplasmic appearance abnormal" NARROW []
is_a: WBPhenotype:0010002 ! cell organization biogenesis variant

[Term]
id: WBPhenotype:0001428
name: intestinal vacuole
def: "Vacuoles accumulate in the intestine." [WB:WBPaper00004718, WB:WBPaper00031894, WB:WBPerson712]
is_a: WBPhenotype:0000710 ! intestinal morphology variant
is_a: WBPhenotype:0002615 ! abnormal accumulation of vacuoles

[Term]
id: WBPhenotype:0001429
name: granules cytoplasm
def: "Animals accumulate an excess of vesicle-like structures in cells." [pmid:17203072, WB:cab]
is_a: WBPhenotype:0001427 ! cytoplasmic appearance variant

[Term]
id: WBPhenotype:0001430
name: lysosome organization biogenesis variant
def: "Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome, compared to control." [GO:0007040, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "lysosome organization biogenesis abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001431
name: pointed tail tip male
def: "Male tails fail to undergo tip retraction thereby forming a 'leptoderan' or 'pointed' adult tail." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Lep" BROAD []
synonym: "leptoderan tail" RELATED []
synonym: "male tail spike" EXACT []
is_a: WBPhenotype:0000070 ! male tail morphology variant

[Term]
id: WBPhenotype:0001432
name: over retracted male tail
def: "Adult males exhibit a truncated tail, often without a fan or have well-developed fans but squarish, truncated back ends compared to control. In C. elegans this is due to precocious male tail tip retraction beginning in the early L3 stage (normally retraction begins in the L4 stage). Condition can be lethal if the function of the anus is affected." [pmid:16806150, WB:cab]
synonym: "Ore" BROAD []
is_a: WBPhenotype:0000070 ! male tail morphology variant
is_a: WBPhenotype:0001297 ! male tail development variant

[Term]
id: WBPhenotype:0001433
name: precocious cell fusion
def: "Two or more individual cells form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes at an earlier stage of development compared to comparable cells in control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000165 ! cell fusion variant
is_a: WBPhenotype:0000439 ! precocious heterochronic variations

[Term]
id: WBPhenotype:0001434
name: chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific chemical concentration gradient compared to control. Directed movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GO:0006935, WB:cab]
synonym: "Che" RELATED []
synonym: "chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001040 ! chemosensory response variant

[Term]
id: WBPhenotype:0001435
name: ammonium chloride chemotaxis defective
def: "Failure in directed movement in response to ammonium chloride compared to control. In C. elegans, NH4Cl is an attractant. NH4Cl has also subsequently been used to assay for Cl- attraction in C. elegans." [WB:WBPaper00002087, WB:WBPaper00004609, WB:WBPaper00026812]
synonym: "chloride chemotaxis defective" RELATED [WB:WBPerson2021]
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective
is_a: WBPhenotype:0001460 ! ammonium chloride chemotaxis variant

[Term]
id: WBPhenotype:0001436
name: nose touch hypersensitive
def: "Animals tend to initiate a response more often, compared to control, after nose-on collisions with an object. In C. elegans, animals initiate backwards movement in response to nose touch." [WB:WBPaper00028963, WB:WBPerson557]
is_a: WBPhenotype:0004026 ! nose touch variant

[Term]
id: WBPhenotype:0001437
name: octanol chemotaxis hypersensitive
def: "Animals execute a response, via directed movement to octanol at a lower concentration or shorter exposure time compared to control. In C. elegans, animals avoid octanol." [WB:WBPaper00028963]
is_a: WBPhenotype:0001452 ! octanol chemotaxis variant

[Term]
id: WBPhenotype:0001438
name: odorant positive chemotaxis defective
def: "Animals fail to move towards attractive volatile organic molecules. In C. elegans, these compounds are sensed by the AWA and AWC neurons." [WB:WBPerson2021]
is_a: WBPhenotype:0000015 ! positive chemotaxis defective
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001439
name: anion positive chemotaxis defective
def: "Animals fail to move towards attractive anions." [WB:WBPaper00002033, WB:WBPaper00028386]
is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective

[Term]
id: WBPhenotype:0001440
name: cation positive chemotaxis defective
def: "Animals fail to move towards attractive cations." [WB:WBPaper00004609]
is_a: WBPhenotype:0001051 ! cation positive chemotaxis variant
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective

[Term]
id: WBPhenotype:0001441
name: aqueous positive chemotaxis defective
def: "Animals fail to move towards attractive water-soluble chemicals." [WB:WBPerson2021]
synonym: "water soluble positive chemotaxis abnormal" RELATED []
is_a: WBPhenotype:0000015 ! positive chemotaxis defective
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001442
name: sodium acetate chemotaxis defective
def: "Failure in directed movement in response to sodium acetate. In C. elegans, sodium acetate is an attractant. Sodium acetate has also subsequently been used to assay for Na+ attraction in C. elegans." [WB:WBPaper00000650, WB:WBPaper00004609, WB:WBPaper00006394]
synonym: "sodium chemotaxis defective" RELATED [WB:WBPerson2021]
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective
is_a: WBPhenotype:0001461 ! sodium acetate chemotaxis variant

[Term]
id: WBPhenotype:0001443
name: aqueous chemosensory response variant
def: "Animals exhibit variations in response to water-soluble chemicals, compared to control." [WB:cab]
synonym: "aqueous chemosensory response abnormal" NARROW []
synonym: "water soluble chemosensory response abnormal" RELATED []
is_a: WBPhenotype:0001040 ! chemosensory response variant

[Term]
id: WBPhenotype:0001444
name: aqueous adaptation defective
def: "Animals do not exhibit characteristic desensitization to a water-soluble chemo-attractive signal in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150]
synonym: "aqueous adaptation abnormal" NARROW []
synonym: "gustatory plasticity abnormal" RELATED []
synonym: "water soluble adaptation abnormal" RELATED []
is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant

[Term]
id: WBPhenotype:0001445
name: sodium acetate adaptation defective
def: "Animals do not exhibit characteristic chemoattractive desensitization to sodium acetate in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150]
synonym: "sodium acetate adaptation abnormal" NARROW []
is_a: WBPhenotype:0001444 ! aqueous adaptation defective

[Term]
id: WBPhenotype:0001446
name: sodium chloride adaptation defective
def: "Animals do not exhibit characteristic chemoattractive desensitization to sodium chloride in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150]
synonym: "sodium chloride adaptation abnormal" NARROW []
is_a: WBPhenotype:0001444 ! aqueous adaptation defective

[Term]
id: WBPhenotype:0001447
name: ammonium chloride adaptation defective
def: "Animals do not exhibit characteristic chemoattractive desensitization to ammonium chloride in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150]
synonym: "ammonium chloride adaptation abnormal" NARROW []
is_a: WBPhenotype:0001444 ! aqueous adaptation defective

[Term]
id: WBPhenotype:0001448
name: odorant negative chemotaxis defective
def: "Animals fail to move away from repellant volatile organic chemicals." [WB:WBPerson2021]
synonym: "volatile negative chemotaxis defective" RELATED []
is_a: WBPhenotype:0001455 ! odorant negative chemotaxis variant

[Term]
id: WBPhenotype:0001449
name: aqueous negative chemotaxis defective
def: "Animals fail to move away from repellent water soluble chemicals." [WB:WBPerson2021]
synonym: "water soluble chemotaxis defective" RELATED []
is_a: WBPhenotype:0001450 ! aqueous negative chemotaxis variant

[Term]
id: WBPhenotype:0001450
name: aqueous negative chemotaxis variant
def: "Animals exhibit variations through directed movement, in response to repellant water soluble chemicals, compared to control." [WB:WBPaper00006481]
synonym: "aqueous negative chemotaxis abnormal" NARROW []
synonym: "water soluble chemotaxis abnormal" RELATED []
is_a: WBPhenotype:0000481 ! negative chemotaxis variant
is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant

[Term]
id: WBPhenotype:0001451
name: garlic chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of garlic compared to control. In C. elegans, garlic is typically a repellant." [WB:WBPaper00002135, WB:WBPaper00006481, WB:WBPerson557]
synonym: "garlic chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001450 ! aqueous negative chemotaxis variant

[Term]
id: WBPhenotype:0001452
name: octanol chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of octanol. In C. elegans, octanol is typically a repellant." [WB:WBPerson557]
synonym: "octanol chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001455 ! odorant negative chemotaxis variant

[Term]
id: WBPhenotype:0001453
name: high sodium chloride concentration osmotic avoidance variant
def: "Animals exhibit variations in their avoidance response to high concentrations of sodium chloride solution compared to control." [WB:WBPerson2021]
synonym: "high sodium chloride concentration osmotic avoidance abnormal" NARROW []
is_a: WBPhenotype:0000663 ! osmotic avoidance variant

[Term]
id: WBPhenotype:0001454
name: quinine chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of the bitter tastant quinine, a water soluble molecule. In C. elegans, quinine is typically a repellant." [WB:WBPaper00002135, WB:WBPaper00027118, WB:WBPaper00035961, WB:WBPerson557, WB:WBPerson712]
synonym: "quinine chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001939 ! bitter tastant response variant

[Term]
id: WBPhenotype:0001455
name: odorant negative chemotaxis variant
def: "Animals exhibit variations through directed movement, in response to repellant volatile organic chemicals, compared to control." [WB:WBPaper00001786]
synonym: "odorant negative chemotaxis abnormal" NARROW []
synonym: "volatile negative chemotaxis abnormal" RELATED []
is_a: WBPhenotype:0000481 ! negative chemotaxis variant
is_a: WBPhenotype:0001048 ! odorant chemosensory response variant

[Term]
id: WBPhenotype:0001456
name: nonanone chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of nonanone. In C. elegans, nonanone is typically a repellant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "nonanone chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001455 ! odorant negative chemotaxis variant

[Term]
id: WBPhenotype:0001457
name: bromide chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of bromide. In C. elegans, bromide is typically an attractant." [WB:WBPaper00000387, WB:WBPerson557]
synonym: "bromide chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant

[Term]
id: WBPhenotype:0001458
name: chloride chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of chloride." [WB:WBPaper00000387]
synonym: "ammonium chloride chemotaxis abnormal" RELATED [WB:WBPerson2021]
synonym: "chloride chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant

[Term]
id: WBPhenotype:0001459
name: iodide chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of iodide." [WB:WBPaper00000387]
synonym: "iodide chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant

[Term]
id: WBPhenotype:0001460
name: ammonium chloride chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of ammonium chloride. In C. elegans, at specific concentrations, ammonium chloride is an attractant. NH4Cl has also been used to assay for Cl- attraction." [WB:WBPaper00000387, WB:WBPaper00004609, WB:WBPaper00026812]
synonym: "ammonium chloride chemotaxis abnormal" NARROW []
synonym: "chloride chemotaxis abnormal" RELATED [WB:WBPerson2021]
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001461
name: sodium acetate chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium acetate. In C. elegans, at specific concentrations, sodium acetate is an attractant. Sodium acetate has also been used to assay for Na+ attraction." [WB:WBPaper00000387, WB:WBPaper00000650, WB:WBPaper00004609)]
synonym: "sodium acetate chemotaxis abnormal" NARROW []
synonym: "sodium chemotaxis abnormal" RELATED [WB:WBPerson2021]
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001462
name: sodium chloride chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium chloride. In C. elegans, at specific concentrations, sodium chloride is an attractant." [WB:WBPaper00000387]
synonym: "sodium chloride chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0001463
name: cAMP chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of cAMP." [GO:0043327, WB:WBPaper00000387]
synonym: "cAMP chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001053 ! cyclic nucleotide positive chemotaxis variant

[Term]
id: WBPhenotype:0001464
name: cGMP chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of cGMP." [WB:WBPaper00000387]
synonym: "cGMP chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001053 ! cyclic nucleotide positive chemotaxis variant

[Term]
id: WBPhenotype:0001465
name: acetone chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of acetone. In C. elegans, at specific concentrations, acetone is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "acetone chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001466
name: AWA odorant chemotaxis variant
def: "Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWA sensory neuron in control animals." [WB:WBPerson2021]
synonym: "AWA odorant chemotaxis abnormal" NARROW []
synonym: "AWA volatile chemotaxis abnormal" RELATED []
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001467
name: AWC odorant chemotaxis variant
def: "Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWC sensory neuron in control animals." [WB:WBPerson2021]
synonym: "AWC odorant chemotaxis abnormal" NARROW []
synonym: "AWC volatile chemotaxis abnormal" RELATED []
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001468
name: benzaldehyde chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of benzaldehyde. In C. elegans, at specific concentrations, benzaldehyde is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "benzaldehyde chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant

[Term]
id: WBPhenotype:0001469
name: butanone chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of butanone. In C. elegans, at specific concentrations, butanone is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "butanone chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant

[Term]
id: WBPhenotype:0001470
name: diacetyl chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of diacetyl. In C. elegans, at specific concentrations, diacetyl is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "diacetyl chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001466 ! AWA odorant chemotaxis variant

[Term]
id: WBPhenotype:0001471
name: hexanol chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of hexanol. In C. elegans, at specific concentrations, hexanol is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hexanol chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001472
name: isoamyl alcohol chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of isoamyl alcohol. In C. elegans, at specific concentrations, isoamyl alcohol is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "isoamyl alcohol chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant

[Term]
id: WBPhenotype:0001473
name: pentanol chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanol. In C. elegans, at specific concentrations, pentanol is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pentanol chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001474
name: pyrazine chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pyrazine. In C. elegans, at specific concentrations, pyrazine is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pyrazine chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001466 ! AWA odorant chemotaxis variant

[Term]
id: WBPhenotype:0001475
name: trimethylthiazole chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of trimethylthiazole. In C. elegans, at specific concentrations, trimethylthiazole is an attractant." [WB:WBPerson2021, WB:WBPerson557]
synonym: "trimethylthiazole chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant

[Term]
id: WBPhenotype:0001476
name: anterior body contraction variant
def: "Any variation in the defecation motor program that involves the contraction of the anterior body wall muscles compared to control." [WB:WBPaper00001937, WB:WBPerson2021, WB:WBPerson557]
synonym: "anterior body contraction abnormal" NARROW []
is_a: WBPhenotype:0000210 ! defecation contraction variant

[Term]
id: WBPhenotype:0001477
name: anterograde transport variant
def: "Any variation in the directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons, compared to control." [GO:0008089, WB:WBPerson2021, WB:WBPerson557]
synonym: "anterograde transport abnormal" NARROW []
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0001478
name: body elongation variant
def: "Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body elongation abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0001479
name: dauer pheromone sensation variant
def: "Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that induces dauer formation in control animals." [GO:0043695, WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer pheromone sensation abnormal" NARROW []
is_a: WBPhenotype:0000132 ! pheromone induced dauer formation variant
is_a: WBPhenotype:0000305 ! pheromone sensation variant
is_a: WBPhenotype:0001847 ! sterol induced dauer formation variant

[Term]
id: WBPhenotype:0001480
name: grinder relaxation variant
def: "Variations in the rhythmic relaxations of the a highly specialized cuticle region of the pharynx inside the lumen of the second bulb, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "grinder relaxation abnormal" NARROW []
is_a: WBPhenotype:0000336 ! terminal bulb relaxation variant

[Term]
id: WBPhenotype:0001481
name: thrashing increased
def: "The number of body thrashes within an aqueous environment in a given period of time is increased, compared with control worms." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001700 ! swimming variant

[Term]
id: WBPhenotype:0001482
name: frequency body bend reduced
alt_id: WBPhenotype:0002330
def: "Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712]
synonym: "bending frequency reduced" EXACT []
synonym: "frequency of sinusoidal movement reduced" EXACT []
synonym: "temporal frequency of sinusoidal movement decreased" EXACT []
is_a: WBPhenotype:0001213 ! locomotion reduced
is_a: WBPhenotype:0004023 ! frequency of body bend variant

[Term]
id: WBPhenotype:0001483
name: late stage egg laid
def: "The eggs being deposited by adults are of a later developmental stage, compared to control. In C. elegans, this is likely to be a consequence of delayed active egg-laying periods." [WB:WBPaper00004310, WB:WBPerson2021]
is_a: WBPhenotype:0000438 ! retarded heterochronic variations
is_a: WBPhenotype:0000545 ! egg retention

[Term]
id: WBPhenotype:0001484
name: ammonium acetate chemotaxis defective
def: "Animals fail to execute directed movement in response to ammonium acetate. In C. elegans, ammonium acetate is an attractant." [WB:WBPaper00004136]
is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective

[Term]
id: WBPhenotype:0001485
name: ER stress response variant
def: "Animals exhibit variations in their response to the presence of unfolded proteins in the endoplasmic reticulum (ER) or to other ER-related stressors compared to control." [GO:0030968]
synonym: "endoplasmic reticulum stress response abnormal" EXACT []
synonym: "ER stress response abnormal" EXACT []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0001486
name: unfolded protein accumulation
def: "Animals accumulate unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria." [WB:WBPerson557]
is_a: WBPhenotype:0000142 ! cell stress response variant
is_a: WBPhenotype:0001644 ! protein metabolism variant

[Term]
id: WBPhenotype:0001487
name: male spicule development variant
def: "Animals exhibit variations in the development of the male elongated sclerotized structures covered by a hardened layer of cuticle in the tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control." [WB:cab, WB:WBPerson363]
synonym: "male spicule development abnormal" NARROW []
is_a: WBPhenotype:0000430 ! male copulatory structure development variant

[Term]
id: WBPhenotype:0001488
name: gubernaculum development variant
def: "Animals exhibit variations in the development of the sclerotic cuticle that forms the roof of the proctodeum (gubernaculum) compared to control." [WB:cab, WB:WBPerson363]
synonym: "gubernaculum development abnormal" NARROW []
is_a: WBPhenotype:0001367 ! proctodeum development variant

[Term]
id: WBPhenotype:0001489
name: gubernaculum morphology variant
def: "Animals exhibit variations in the structure or composition of the sclerotic cuticle that forms the roof of the proctodeum, from that observed in control animals." [WB:cab, WB:WBPaper00027278, WB:WBPerson363, WB:WBPerson712]
synonym: "gubernaculum morphology abnormal" NARROW []
is_a: WBPhenotype:0001359 ! proctodeum morphology variant

[Term]
id: WBPhenotype:0001490
name: obsolete posterior region morphology abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000793

[Term]
id: WBPhenotype:0001491
name: obsolete anterior region morphology abnormal
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000792

[Term]
id: WBPhenotype:0001492
name: no back end
def: "Animals lack a properly developed posterior region compared to control. In C. elegans, mutants exhibit a severely deformed posterior region with a variable knob-like shape; accompanied by arrest at about the time of hatching with fairly normal pharyngeal and anterior development. Most mutants arrest as L1 larvae, and 5% do not hatch." [WB:cab, WB:cgc4499]
synonym: "Nob" BROAD []
is_a: WBPhenotype:0000081 ! L1 arrest
is_a: WBPhenotype:0000793 ! posterior body morphology variant
is_a: WBPhenotype:0000800 ! posterior region development variant
is_a: WBPhenotype:0000867 ! embryonic arrest

[Term]
id: WBPhenotype:0001493
name: VPC cell division precocious
def: "VPCs (vulval precursor cells) divide at an earlier stage of development compared to control animals; in C. elegans, VPCs divide in the mid-L3 stage to generate the 22 cells that comprise the vulva." [pmid:16300753, WB:cab]
is_a: WBPhenotype:0000345 ! VPC cell division variant
is_a: WBPhenotype:0001495 ! cell division precocious

[Term]
id: WBPhenotype:0001494
name: distal tip cell migration precocious
def: "DTCs migrate at an earlier stage of development, compared to control." [pmid:16300753, WB:cab]
is_a: WBPhenotype:0000195 ! distal tip cell migration variant
is_a: WBPhenotype:0000439 ! precocious heterochronic variations

[Term]
id: WBPhenotype:0001495
name: cell division precocious
def: "Cells divide at an earlier stage of development compared to control animals." [WB:cab]
is_a: WBPhenotype:0000439 ! precocious heterochronic variations
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0001496
name: metaphase to anaphase transition defect
alt_id: WBPhenotype:0001214
def: "Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [GO:0007091, WB:WBPerson712]
synonym: "Mat" RELATED []
synonym: "metaphase to anaphase transition fails" EXACT []
is_a: WBPhenotype:0000740 ! cell cycle variant

[Term]
id: WBPhenotype:0001497
name: mitotic metaphase to anaphase transition defect
def: "Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids separate and migrate towards the poles of the spindle." [GO:0007091, WB:WBPerson712]
is_a: WBPhenotype:0001496 ! metaphase to anaphase transition defect

[Term]
id: WBPhenotype:0001498
name: sperm pseudopod physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the pseudopod of the sperm to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557]
synonym: "sperm pseudopod physiology abnormal" NARROW []
is_a: WBPhenotype:0000987 ! germ cell physiology variant

[Term]
id: WBPhenotype:0001499
name: meiotic chromosome segregation variant
def: "Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control." [GO:0045132, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "meiotic chromosome segregation abnormal" NARROW []
is_a: WBPhenotype:0000773 ! chromosome segregation variant

[Term]
id: WBPhenotype:0001500
name: pentanedione chemotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanedione." [WB:cab, WB:cgc2931]
synonym: "pentanedione chemotaxis abnormal" NARROW []
is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant

[Term]
id: WBPhenotype:0001501
name: odorant discrimination defective
def: "Animals fail to discriminate between distinct odorants." [WB:cab]
synonym: "odorant discrimination abnormal" NARROW []
is_a: WBPhenotype:0001048 ! odorant chemosensory response variant

[Term]
id: WBPhenotype:0001502
name: chemical resistant
def: "Animals fail to respond to the concentration of a specific chemical that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0001503
name: ventral nerve cord maintenance variant
def: "Any variation in the mechanisms used to ensure that axons in the ventral nerve cord maintain their correct positioning after termination of axonal outgrowth and target recognition compared to control." [WB:WBPaper00005064, WB:WBPerson557]
synonym: "ventral nerve cord maintenance abnormal" NARROW []
is_a: WBPhenotype:0000515 ! ventral nerve cord development variant

[Term]
id: WBPhenotype:0001504
name: maternal effect sterile
def: "Sterility caused by aberrant maternal components required for normal postembryonic development and/or function of the germ line." [WB:WBPaper00001477]
synonym: "Mes" BROAD []
is_a: WBPhenotype:0001037 ! sterile progeny

[Term]
id: WBPhenotype:0001505
name: spontaneous reversal variant
def: "Any variation in the processes that govern spontaneous backward locomotion compared to control." [WB:WBPaper00001311, WB:WBPerson557]
synonym: "spontaneous reversal abnormal" NARROW []
is_a: WBPhenotype:0002320 ! reversal variant

[Term]
id: WBPhenotype:0001506
name: spontaneous reversal rate variant
def: "Any variation in the processes that govern the rate at which spontaneous backward locomotion is initiated compared to control." [WB:WBPaper00001311, WB:WBPaper00026650, WB:WBPerson557]
synonym: "spontaneous reversal rate abnormal" NARROW []
is_a: WBPhenotype:0001505 ! spontaneous reversal variant

[Term]
id: WBPhenotype:0001507
name: Bacillus thuringiensis toxin resistant
def: "Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0009410, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0001508
name: anchor cell fusion defective
def: "Any perturbation that disrupts the fusion between the anchor cell and the surrounding utse syncytium. Such variations result in the loss of uterine-vulval connectivity and continuity." [WB:WBPaper00029363, WB:WBPerson2021]
synonym: "anchor cell fusion abnormal" NARROW []
is_a: WBPhenotype:0000165 ! cell fusion variant
is_a: WBPhenotype:0000283 ! vulva uterus connection defective

[Term]
id: WBPhenotype:0001509
name: rays missing
alt_id: WBPhenotype:0000407
def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are absent." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ray loss" EXACT []
is_a: WBPhenotype:0000199 ! male tail sensory ray development variant
is_a: WBPhenotype:0000505 ! male ray morphology variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001510
name: neuronal cell fate specification variant
def: "Any variation in the processes that govern acquisition of neuronal cell fates compared to control." [WB:WBPerson2021]
synonym: "neuronal cell fate specification abnormal" NARROW []
is_a: WBPhenotype:0000216 ! cell fate specification variant
is_a: WBPhenotype:0000816 ! neuron development variant

[Term]
id: WBPhenotype:0001511
name: linker cell migration variant
def: "Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control." [WB:WBPaper00028966, WB:WBPerson2021]
synonym: "linker cell migration abnormal" NARROW []
is_a: WBPhenotype:0000594 ! cell migration variant

[Term]
id: WBPhenotype:0001512
name: loss of left right asymmetry
def: "Bilaterally symmetric cell fail to acquire specific left-right asymmetric properties such as L/R specific cell position, cell death or gene expression." [WB:WBPaper00037739, WB:WBPerson2021]
synonym: "Lsy" BROAD []
is_a: WBPhenotype:0000216 ! cell fate specification variant

[Term]
id: WBPhenotype:0001513
name: dense core vesicle exocytosis variant
def: "Variations in the process of secretion of a class of membrane-bound vesicles found inside neurons, gland cells, and some epithelial cells in which the central core appears darkly stained when viewed in thin section by electron microscopy, compared to control. Exocytosis occurs via the fusion of the vesicle with the plasma membrane of a cell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dense core vesicle exocytosis abnormal" NARROW []
is_a: WBPhenotype:0000728 ! exocytosis variant

[Term]
id: WBPhenotype:0001514
name: synaptic vesicle endocytosis variant
def: "Variations in the uptake of a small membrane-bound organelle, filled with neurotransmitter(s) and/or neuropeptides, by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle compared to control(Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "synaptic vesicle endocytosis abnormal" NARROW []
is_a: WBPhenotype:0001422 ! endocytic transport defect
is_a: WBPhenotype:0001684 ! synaptic vesicle homeostasis variant

[Term]
id: WBPhenotype:0001515
name: struts variant
def: "Animals exhibit variations in the quantity or patterning of electron-dense columnar structures that join the basal and cortical cuticle layers, from that observed in control animals." [WB:WBPaper00000465, WB:WBPerson712]
synonym: "struts abnormal" NARROW []
is_a: WBPhenotype:0000948 ! cuticle morphology variant

[Term]
id: WBPhenotype:0001516
name: helical cuticle
def: "Animals exhibit a helically twisted cuticle. In practice the degree of twisting is measured as the number of helical twists the alae make about anterior/posterior axis of the animal." [WB:WBPaper00000465, WB:WBPerson712]
synonym: "cuticle helicity abnormal" NARROW []
is_a: WBPhenotype:0000948 ! cuticle morphology variant

[Term]
id: WBPhenotype:0001517
name: annulae morphology variant
def: "Animals exhibit variations in the circumferential pattern of ridges in the outer cortical layer of the cuticle, compared to that observed in control animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712]
synonym: "annulae morphology abnormal" NARROW []
is_a: WBPhenotype:0000948 ! cuticle morphology variant

[Term]
id: WBPhenotype:0001518
name: biogenic amine physiology variant
def: "Any variation in the levels and/or localization of biogenic amines compared to control animals." [WB:WBPaper00000365]
synonym: "biogenic amine physiology abnormal" NARROW []
synonym: "FIF" BROAD []
synonym: "Formaldehyde induced fluorescence abnormal" RELATED []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001519
name: posterior cell migration variant
def: "Any variation in the orderly movement of cells along the posterior axis of the animal (abolished, misdirected or incomplete) compared to control." [WB:WBPerson2021]
synonym: "abnormal posterior cell migration" NARROW []
is_a: WBPhenotype:0000594 ! cell migration variant

[Term]
id: WBPhenotype:0001520
name: posterior neuron migration variant
def: "Any variation in the orderly movement of neurons along the posterior axis of the animal(abolished, misdirected or incomplete) compared to control." [WB:WBPerson2021]
synonym: "abnormal posterior neuron migration" NARROW []
is_a: WBPhenotype:0001140 ! neuron migration variant

[Term]
id: WBPhenotype:0001521
name: body elongation retracted
def: "Embryos retract after the embryonic elongation process." [WB:WBPerson557]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0001522
name: spicules protrude
def: "The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) constitutively extend into the external environment through the cloacal opening. In C. elegans males there are two copulatory spicules." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000908 ! cloacal morphology variant

[Term]
id: WBPhenotype:0001523
name: extracellular matrix variant
def: "Any variation in the makeup, density or area of the ECM compared to control." [WB:WBPerson712]
synonym: "extracellular matrix abnormal" NARROW []
is_a: WBPhenotype:0000912 ! pericellular component morphology variant

[Term]
id: WBPhenotype:0001524
name: quiescence variant
def: "Exhibition of quiescent behavior under inappropriate conditions and improper recovery from quiescent state. Quiescent behavior is normally coupled with lethargus." [WB:WBPerson2021]
synonym: "narcoleptic" RELATED []
synonym: "quiescence abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001525
name: terminal bulb morphology variant
def: "Animals exhibit variations in the structure or organization of the posterior region of the pharynx compared to control." [WB:WBPerson2021]
synonym: "terminal bulb morphology abnormal" NARROW []
is_a: WBPhenotype:0000709 ! pharyngeal morphology variant

[Term]
id: WBPhenotype:0001526
name: ciliated neuron morphology variant
def: "Animals exhibit variations in the structure or organization of any one of the specialized sensory receptor cells of the nervous system that compared to control animals. In C. elegans, these specialized cells are characterized as having axoneme containing dendritic projections emanating from their cell body." [WB:WBPaper00000503, WB:WBPaper00029016, WB:WBPerson712]
comment: WBbt:0006816.
synonym: "ciliated neuron morphology abnormal" NARROW []
is_a: WBPhenotype:0000299 ! sensillum morphology variant

[Term]
id: WBPhenotype:0001527
name: amphid phasmid sensillum morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head or along the tail, compared to that observed in control animals." [WB:WBPerson712]
comment: WBbt:0005391.
synonym: "amphid phasmid sensillum morphology abnormal" NARROW []
is_a: WBPhenotype:0000299 ! sensillum morphology variant

[Term]
id: WBPhenotype:0001528
name: sensillum accessory cell morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of any component of the sensillum channel including the sheath and or socket cells, their junctions with each other, channel neurons or surrounding epithelia compared to control." [WB:WBPaper00000932, WB:WBPerson712]
synonym: "sensillum accessory cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000299 ! sensillum morphology variant

[Term]
id: WBPhenotype:0001529
name: obsolete sensilium sheath cell variant
def: "OBSOLETE: Any variation in the form, structure or composition of an interfacial epithelial cell which forms a specialized environment surrounding the ciliated sensory ending(s) of one or more neurons and is often accompanied by a more distal socket cell compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0000972

[Term]
id: WBPhenotype:0001530
name: cephalic sensillum morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000932, WB:WBPerson712]
comment: WBbt:0006920.
synonym: "cephalic sensillum morphology abnormal" NARROW []
is_a: WBPhenotype:0000299 ! sensillum morphology variant

[Term]
id: WBPhenotype:0001531
name: labial sensillum morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712]
synonym: "labial sensillum morphology abnormal" NARROW []
is_a: WBPhenotype:0000299 ! sensillum morphology variant

[Term]
id: WBPhenotype:0001532
name: inner labial morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2." [WB:WBPaper00000938, WB:WBPerson712]
synonym: "inner labial morphology abnormal" NARROW []
is_a: WBPhenotype:0001531 ! labial sensillum morphology variant

[Term]
id: WBPhenotype:0001533
name: outer labial morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum." [WB:WBPaper00000938, WB:WBPerson712]
synonym: "outer labial morphology abnormal" NARROW []
is_a: WBPhenotype:0001531 ! labial sensillum morphology variant

[Term]
id: WBPhenotype:0001534
name: neuronal ECM variant
def: "Any variation in makeup, density or area of the ECM lending structure to neurons compared to control animals. In C. elegans, the neuronal ECM is sometimes referred to as a mantle." [WB:WBPaper00000502, WB:WBPerson712]
synonym: "neuronal ECM abnormal" NARROW []
is_a: WBPhenotype:0001523 ! extracellular matrix variant

[Term]
id: WBPhenotype:0001535
name: deirid sensillum morphology variant
def: "Animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPaper00000938, WB:WBPaper00029016, WB:WBPerson712]
synonym: "deirid sensillum morphology abnormal" NARROW []
is_a: WBPhenotype:0000299 ! sensillum morphology variant

[Term]
id: WBPhenotype:0001536
name: embryonic cell patterning variant
def: "Embryos exhibit variations in the patterning of differentiated cell types, compared to control." [WB:WBPerson557]
synonym: "embryonic cell patterning abnormal" NARROW []
is_a: WBPhenotype:0000050 ! embryonic lethal

[Term]
id: WBPhenotype:0001537
name: mRNA surveillance variant
def: "Any variation in the ability of cells to monitor the quality of their mRNAs and degrade any transcripts that are poorly or incompletely translated compared to control." [WB:WBPaper00004926]
synonym: "mRNA turnover abnormal" NARROW []
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0001538
name: mRNA surveillance defective
def: "Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926]
synonym: "Smg" NARROW []
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0001539
name: dauer induction variant
def: "Animals exhibit variations in the entry into the dauer stage when exposed to conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer induction abnormal" NARROW []
is_a: WBPhenotype:0000308 ! dauer development phenotype

[Term]
id: WBPhenotype:0001540
name: dauer lifespan variant
def: "The life span of dauer-staged animals is either longer or shorter than that observed in control dauer animals." [WB:WBPerson2021]
synonym: "dauer lifespan abnormal" NARROW []
is_a: WBPhenotype:0001547 ! dauer metabolism phenotype

[Term]
id: WBPhenotype:0001541
name: dauer gonad arrest variant
def: "Variations in the execution of the developmentally-regulated cell cycle arrest in the gonad during the dauer stage, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer gonad arrest abnormal" NARROW []
is_a: WBPhenotype:0000637 ! dauer formation variant

[Term]
id: WBPhenotype:0001542
name: dauer feeding suppressed variant
def: "Any variation in the inhibition of feeding which is induced/occurs during the dauer stage compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer feeding suppressed abnormal" NARROW []
is_a: WBPhenotype:0001001 ! dauer behavior variant

[Term]
id: WBPhenotype:0001543
name: dauer reduced locomotion variant
def: "Dauer stage animals exhibit a decrease in self-propelled movement on a solid medium compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer reduced locomotion abnormal" NARROW []
is_a: WBPhenotype:0001001 ! dauer behavior variant

[Term]
id: WBPhenotype:0001544
name: dauer sensory response variant
def: "Variations in the state or activity of a dauer stage organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer sensory response abnormal" NARROW []
is_a: WBPhenotype:0001001 ! dauer behavior variant

[Term]
id: WBPhenotype:0001545
name: dauer body morphology variant
def: "Any variation in the overall structure or appearance of an animal progressing through an alternative larval stage in response to environmental stresses compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer body morphology abnormal" NARROW []
is_a: WBPhenotype:0000934 ! developmental morphology variant

[Term]
id: WBPhenotype:0001546
name: dauer resistance to harsh conditions variant
def: "Variations which lead to the decreased ability of dauer larva to survive at extreme conditions, such as high or low temperatures, the presence of dilute acids, detergents, anesthetics, or even fixatives, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer resistance to harsh conditions abnormal" NARROW []
is_a: WBPhenotype:0002527 ! dauer larva physiology variant

[Term]
id: WBPhenotype:0001547
name: dauer metabolism phenotype
def: "Animals exhibit variations in the chemical reactions and pathways that occur during the dauer life stage, compared to control." [WB:WBPerson2021]
synonym: "dauer metabolism abnormal" EXACT []
synonym: "dauer metabolism variant" EXACT []
is_a: WBPhenotype:0002527 ! dauer larva physiology variant

[Term]
id: WBPhenotype:0001548
name: dauer axial ratio variant
def: "Any variation in the ratio of the body length to body width in a dauer stage animal, compared to control. Long thin animals will have a high axial ratio." [WB:WBPerson557]
synonym: "dauer axial ratio abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001549
name: dauer gut variant
def: "Dauer stage animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer gut abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001550
name: dauer buccal cavity morphology variant
def: "Variations in the form or composition of the cuticle-lined lumenal region which lies just behind the lips at the entrance to the pharyngeal lumen in dauer stage animals compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer buccal cavity morphology abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001551
name: dauer cuticle variant
def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) during the dauer larva stage, compared to control animals (Wormatlas). The dauer larval stage is a developmentally arrested larval stage that is specialized for survival under harsh, or otherwise unfavorable environmental conditions." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer cuticle abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001552
name: dauer pharynx morphology variant
def: "Variations in the form or composition of the mouthparts at the anterior end of the digestive tract during the dauer stage, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer pharynx morphology abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001553
name: dauer excretory gland variant
def: "Dauer stage animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer excretory gland abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001554
name: dauer nose morphology variant
def: "Dauer stage animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer nose morphology abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001555
name: dauer sensory system morphology variant
def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the dauer sensory system, compared to control. The dauer sensory system is used to perceive the physical and chemical environment during the dauer larval stage." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer sensory system morphology abnormal" NARROW []
is_a: WBPhenotype:0001545 ! dauer body morphology variant

[Term]
id: WBPhenotype:0001556
name: dauer sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer sensillum abnormal" NARROW []
is_a: WBPhenotype:0001555 ! dauer sensory system morphology variant

[Term]
id: WBPhenotype:0001557
name: dauer labial sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer labial sensillum abnormal" NARROW []
is_a: WBPhenotype:0001556 ! dauer sensillum variant

[Term]
id: WBPhenotype:0001558
name: dauer amphid sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer amphid sensillum abnormal" NARROW []
is_a: WBPhenotype:0001556 ! dauer sensillum variant

[Term]
id: WBPhenotype:0001559
name: dauer deirid sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer deirid sensillum abnormal" NARROW []
is_a: WBPhenotype:0001556 ! dauer sensillum variant

[Term]
id: WBPhenotype:0001560
name: obsolete dauer sensory system plug variant
def: "OBSOLETE." [WB:WBPerson557]
synonym: "dauer sensory system plug abnormal" NARROW []
is_obsolete: true
consider: WBPhenotype:0001550

[Term]
id: WBPhenotype:0001561
name: dauer inner labial sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer inner labial sensillum abnormal" NARROW []
is_a: WBPhenotype:0001557 ! dauer labial sensillum variant

[Term]
id: WBPhenotype:0001562
name: dauer outer labial sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer outer labial sensillum abnormal" NARROW []
is_a: WBPhenotype:0001557 ! dauer labial sensillum variant

[Term]
id: WBPhenotype:0001563
name: dauer cephalic sensillum variant
def: "Dauer stage animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake." [WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer cephalic sensillum abnormal" NARROW []
is_a: WBPhenotype:0001556 ! dauer sensillum variant

[Term]
id: WBPhenotype:0001564
name: duration of self fertility variant
def: "The window of production of self-fertilized eggs exceeds or does not extend to the same length as control." [WB:WBPaper00002419, WB:WBPerson712]
synonym: "duration of self fertility abnormal" NARROW []
is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant

[Term]
id: WBPhenotype:0001565
name: lysine chemotaxis defective
def: "Failure to execute characteristic response to lysine as defined by control animals. In C. elegans, lysine is an attractant." [WB:WBPaper00001481, WB:WBPaper00001786, WB:WBPerson2021]
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective

[Term]
id: WBPhenotype:0001566
name: ventral enclosure variant
def: "Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control." [WB:WBPaper00027244, WB:WBPerson2021]
synonym: "ventral enclosure abnormal" NARROW []
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0001567
name: nuclei enlarged
def: "Nuclei of specific cells are larger compared to control animals." [WB:WBPerson557]
synonym: "nuclear size increased" EXACT []
is_a: WBPhenotype:0002607 ! nuclear size abnormal

[Term]
id: WBPhenotype:0001568
name: mRNA export variant
def: "Any variation in the export of mRNA from the cell nucleus compared to control." [WB:WBPaper00005960]
synonym: "mRNA export abnormal" NARROW []
is_a: WBPhenotype:0000114 ! mRNA expression variant
is_a: WBPhenotype:0001706 ! nuclear export defective

[Term]
id: WBPhenotype:0001569
name: body wall muscle myosin organization defective
def: "The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021]
synonym: "body wall muscle myosin organization abnormal" NARROW []
synonym: "body wall muscle thick myofilament organization abnormal" RELATED [WB:WBPerson2021]
synonym: "Dim" RELATED []
is_a: WBPhenotype:0000782 ! body wall muscle thick filament variant

[Term]
id: WBPhenotype:0001570
name: body wall muscle actin organization defective
def: "The characteristic organization of actin filaments into I-bands is disrupted. In C. elegans, actin filaments no longer appear as thin continuous longitudinal stripes along the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021]
synonym: "body wall muscle actin organization abnormal" NARROW []
synonym: "body wall muscle thin myofilament organization abnormal" RELATED [WB:WBPerson2021]
is_a: WBPhenotype:0000781 ! body wall muscle thin filament variant

[Term]
id: WBPhenotype:0001571
name: body wall muscle cell polarization variant
def: "Variations in the accumulation of muscle proteins at membranes where adjacent muscle cells contact each other and the hypodermis compared to control. In C. elegans, during early embryonic body wall muscle development, muscle, basement membrane, and hypodermal components are all colocalized in a continuous linear structure at the site of muscle-hypodermal contact." [WB:WBPaper00001895]
synonym: "body wall muscle cell polarization abnormal" NARROW []
is_a: WBPhenotype:0000926 ! body wall muscle morphology variant

[Term]
id: WBPhenotype:0001572
name: masculinized
def: "Animals that are not ordinarily male, exhibit male-specific attributes. In C. elegans, XX animals exhibit male-specific attributes." [WB:WBPaper00000178, WB:WBPaper00001206, WB:WBPerson712]
is_a: WBPhenotype:0001022 ! hermaphrodite sexual development variant

[Term]
id: WBPhenotype:0001573
name: nicotine response variant
def: "Animals exhibit variations in the response to the addition of nicotine compared to that observed in control animals. Nicotine is a cholinergic agonist." [WB:WBPerson557]
synonym: "nicotine response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001574
name: ATP levels variant
def: "Animals exhibit variations in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPerson2021, WB:WBPerson557]
synonym: "ATP levels abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001575
name: ATP levels reduced
def: "Animals exhibit a decrease in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001574 ! ATP levels variant

[Term]
id: WBPhenotype:0001576
name: mitochondria spacing variant
def: "Variations in the spatial distribution of the mitochondria within the cell compared to control." [GO:0048311, WB:WBPerson2021, WB:WBPerson557]
synonym: "mitochondria spacing abnormal" NARROW []
is_a: WBPhenotype:0001401 ! mitochondria morphology variant
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0001577
name: mitochondria alignment variant
def: "Animals exhibit variations in the parallel arrangement of mitochondria within a cell compared to control." [WB:WBPaper00028954]
synonym: "mitochondria alignment abnormal" NARROW []
is_a: WBPhenotype:0001401 ! mitochondria morphology variant
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0001578
name: cholinergic agonist resistant
def: "Animals fail to respond to the concentration of cholinergic agonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0001579
name: cholinergic agonist hypersensitive
def: "Animals respond to a cholinergic agonist at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0001580
name: nuclear envelope breakdown variant
def: "Any variation in the progression of the controlled breakdown of the nuclear envelope, compared to control." [GO:0051081, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "nuclear envelope breakdown abnormal" NARROW []
is_a: WBPhenotype:0002037 ! nuclear envelope organization variant

[Term]
id: WBPhenotype:0001581
name: X linked gene expression enhanced
def: "Levels of transcripts associated with genes on the X chromosome are increased compared to control." [WB:WBPaper00001011, WB:WBPerson712]
is_a: WBPhenotype:0000718 ! dosage compensation variant

[Term]
id: WBPhenotype:0001582
name: X linked gene expression reduced
def: "Levels of transcripts associated with genes on the X chromosome are decreased compared to control." [WB:WBPaper00001011, WB:WBPerson712]
is_a: WBPhenotype:0000718 ! dosage compensation variant

[Term]
id: WBPhenotype:0001583
name: XXX progeny
def: "Animals segregate progeny with 3 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712]
is_a: WBPhenotype:0001664 ! X chromosome nondisjunction

[Term]
id: WBPhenotype:0001584
name: chromosome alignment variant
def: "Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals." [GO:0051310, WB:WBPerson557]
synonym: "chromosome alignment at metaphase plate abnormal" NARROW []
synonym: "chromosome alignment at metaphase plate variant" NARROW []
synonym: "chromosome congression" RELATED []
is_a: WBPhenotype:0000773 ! chromosome segregation variant

[Term]
id: WBPhenotype:0001585
name: asymmetric cell division variant
def: "Any variation in a cell's ability to divide asymmetrically to produce two daughter cells with different developmental potentials compared to control." [GO:0008356, WB:WBPerson2021, WB:WBPerson557]
synonym: "asymmetric cell division abnormal" NARROW []
is_a: WBPhenotype:0001235 ! cell division polarity variant

[Term]
id: WBPhenotype:0001586
name: multiple anchor cells
def: "Animals contain more than one anchor cell. In C. elegans, presumptive ventral uterine cells undergo fate transformation and instead acquire the properties of an anchor cell (often due to defects in lateral signaling)." [WB:WBPaper00001423, WB:WBPerson2021]
synonym: "double anchor cell" NARROW []
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001587
name: actin organization biogenesis phenotype
def: "Animals exhibit variations in the formation and/or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [GO:0030036, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "actin organization biogenesis abnormal" NARROW []
synonym: "actin organization biogenesis variant" EXACT []
is_a: WBPhenotype:0001345 ! cytoskeleton organization biogenesis variant

[Term]
id: WBPhenotype:0001588
name: microtubule organization biogenesis variant
def: "Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas)." [GO:0000226, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
synonym: "microtubule organization biogenesis abnormal" NARROW []
is_a: WBPhenotype:0001345 ! cytoskeleton organization biogenesis variant

[Term]
id: WBPhenotype:0001589
name: microtubule nucleation variant
def: "Any variation that alters the characteristic de novo formation of a microtubule compared to control." [GO:0007020]
synonym: "microtubule nucleation abnormal" NARROW []
is_a: WBPhenotype:0001588 ! microtubule organization biogenesis variant

[Term]
id: WBPhenotype:0001590
name: microtubule depolymerization variant
def: "Any variation that alters the characteristic removal of tubulin heterodimers from one or both ends of a microtubule compared to control." [GO:0007019]
synonym: "microtubule depolymerization abnormal" NARROW []
is_a: WBPhenotype:0001588 ! microtubule organization biogenesis variant

[Term]
id: WBPhenotype:0001591
name: microtubule polymerization variant
def: "Any variation that alters the characteristic addition of tubulin heterodimers to one or both ends of a microtubule compared to control." [GO:0046785]
synonym: "microtubule polymerization abnormal" NARROW []
is_a: WBPhenotype:0001588 ! microtubule organization biogenesis variant

[Term]
id: WBPhenotype:0001592
name: fainter
def: "Alternating periods of stopping and moving; Motion is interrupted by periods of inactivity lasting several seconds." [WB:WBPaper00031286]
is_a: WBPhenotype:0002308 ! pausing variant

[Term]
id: WBPhenotype:0001593
name: transgene silencing variant
def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. In C. elegans this silencing occurs only in the germline." [WB:WBPaper00005399, WB:WBPerson2021, WB:WBPerson557]
synonym: "transgene silencing abnormal" NARROW []
is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant

[Term]
id: WBPhenotype:0001594
name: germline transgene silencing variant
def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the germline, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "germline transgene silencing abnormal" NARROW []
is_a: WBPhenotype:0001593 ! transgene silencing variant

[Term]
id: WBPhenotype:0001595
name: somatic transgene silencing variant
def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the soma, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "somatic transgene silencing abnormal" NARROW []
is_a: WBPhenotype:0001593 ! transgene silencing variant

[Term]
id: WBPhenotype:0001596
name: tail bobbed
def: "Swelling of the tail hypodermis resulting in a prematurely-truncated and thickened appearance of the tail. In C. elegans, this is usually applies to hermaphrodites." [WB:WBPaper00024194, WB:WBPerson712]
is_a: WBPhenotype:0000073 ! tail morphology variant

[Term]
id: WBPhenotype:0001597
name: muscle missing
def: "Any variation that results in a fewer than control number of muscle cells." [WB:WBPaper00001423, WB:WBPaper00002946, WB:WBPerson2021]
is_a: WBPhenotype:0000622 ! muscle system development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001598
name: inhibitor of serotonin uptake variant
def: "Treatment with inhibitors of serotonin reuptake does not elicit the same response as observed for control animals." [WB:WBPerson712]
synonym: "inhibitor of serotonin uptake abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001599
name: ouabain resistant
def: "Animals fail to respond to the concentration of ouabain that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, resistance to ouabain is often assayed via body contraction response." [WB:WBPaper00000484, WB:WBPerson2021]
is_a: WBPhenotype:0000331 ! inhibitors of na k atpase resistant

[Term]
id: WBPhenotype:0001600
name: contraction response to ouabain resistant
def: "Animals require increased concentration or longer exposure to ouabain to elicit the rapid muscular contractions seen in control animals." [WB:WBPaper00000484]
is_a: WBPhenotype:0001599 ! ouabain resistant

[Term]
id: WBPhenotype:0001601
name: biogenic amine receptor antagonist resistant
def: "Animals fail to respond to the concentration of biogenic amine receptor antagonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson712]
synonym: "serotonin receptor antagonist" NARROW []
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0001602
name: methiothepin resistant
def: "Animals fail to respond to the concentration of methiothepin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721]
is_a: WBPhenotype:0001601 ! biogenic amine receptor antagonist resistant

[Term]
id: WBPhenotype:0001603
name: cyproheptadine resistant
def: "Animals fail to respond to the concentration of cyproheptadine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721]
is_a: WBPhenotype:0001601 ! biogenic amine receptor antagonist resistant

[Term]
id: WBPhenotype:0001604
name: mianserin resistant
def: "Animals fail to respond to the concentration of mianserin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721]
synonym: "dibenzazepine resistant" RELATED []
is_a: WBPhenotype:0001601 ! biogenic amine receptor antagonist resistant

[Term]
id: WBPhenotype:0001605
name: extended life span response to mianserin resistant
def: "Animals do not live longer in response to mianserin compared to control." [WB:WBPaper00031241, WB:WBPerson721]
is_a: WBPhenotype:0001604 ! mianserin resistant

[Term]
id: WBPhenotype:0001606
name: ethanol hypersensitive
def: "Animals respond to ethanol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002358, WB:WBPerson712]
synonym: "alcohol sensitive" BROAD []
is_a: WBPhenotype:0000008 ! anesthetic hypersensitive

[Term]
id: WBPhenotype:0001607
name: paralysis response to ethanol hypersensitive
def: "Animals become paralyzed in response to ethanol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002358, WB:WBPerson712]
is_a: WBPhenotype:0001606 ! ethanol hypersensitive

[Term]
id: WBPhenotype:0001608
name: enflurane hypersensitive
def: "Animals respond to the anesthetic enflurane at lower concentrations or shorter exposure times than control animals." [WB:WBPaper00002037, WB:WBPerson721]
synonym: "ether hypersensitive" RELATED []
is_a: WBPhenotype:0000008 ! anesthetic hypersensitive

[Term]
id: WBPhenotype:0001609
name: isoflurane hypersensitive
def: "Animals respond to the anesthetic isoflurane at lower concentrations or shorter response times than control animals." [WB:WBPaper00002037, WB:WBPerson721]
synonym: "ether hypersensitive" RELATED []
is_a: WBPhenotype:0000008 ! anesthetic hypersensitive

[Term]
id: WBPhenotype:0001610
name: diethyl ether hypersensitive
def: "Animals respond to the anesthetic ether at lower concentrations or shorter response times than control animals." [WB:WBPaper00001063, WB:WBPaper00002037, WB:WBPerson721]
synonym: "ether hypersensitive" RELATED []
is_a: WBPhenotype:0000008 ! anesthetic hypersensitive

[Term]
id: WBPhenotype:0001611
name: halothane hypersensitive
def: "Animals respond to the lipid-soluble anesthetic halothane at lower concentrations or shorter response times compared to control animals." [WB:WBPaper00000958, WB:WBPaper00031286, WB:WBPerson721]
is_a: WBPhenotype:0000008 ! anesthetic hypersensitive

[Term]
id: WBPhenotype:0001612
name: ethanol resistant
def: "Animals fail to respond to the concentration of ethanol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to ethanol to elicit the response compared to control animals. In C.elegans the phenotype designation Jud is short for JUDang, which is Korean for resistant to alcohol." [WB:WBPaper00002358, WB:WBPaper00031371, WB:WBPerson557, WB:WBPerson712]
synonym: "alcohol resistant" BROAD []
synonym: "Jud" BROAD []
is_a: WBPhenotype:0000009 ! anesthetic resistant

[Term]
id: WBPhenotype:0001613
name: paralysis response to ethanol resistant
def: "Animals in the presence of ethanol continue to respond to touch under conditions when control worms have stopped responding to stimuli." [WB:WBPaper00031371, WB:WBPerson712]
is_a: WBPhenotype:0001612 ! ethanol resistant

[Term]
id: WBPhenotype:0001614
name: anticonvulsant response variant
def: "Animals exhibit variations in their response to a specific anticonvulsant compared to that observed in control animals." [WB:WBPerson557]
synonym: "anticonvulsant response abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001615
name: anticonvulsant resistant
def: "Animals fail to respond to the concentration of compounds that act as anticonvulsants that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00024698, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0001614 ! anticonvulsant response variant

[Term]
id: WBPhenotype:0001616
name: trimethadione resistant
def: "Animals fail to respond to the concentration of trimethadione, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00024698, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0001615 ! anticonvulsant resistant

[Term]
id: WBPhenotype:0001617
name: ethosuximide resistant
def: "Animals fail to respond to the concentration of ethosuximide, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson712]
is_a: WBPhenotype:0001615 ! anticonvulsant resistant

[Term]
id: WBPhenotype:0001618
name: halothane resistant
def: "Animals fail to respond to the concentration of the anesthetic halothane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00004721, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000009 ! anesthetic resistant

[Term]
id: WBPhenotype:0001619
name: isoflurane resistant
def: "Animals fail to respond to the concentration of the volatile anesthetic isoflurane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00004721, WB:WBPerson712]
is_a: WBPhenotype:0000009 ! anesthetic resistant

[Term]
id: WBPhenotype:0001620
name: organism oxidative stress response variant
def: "Animals exhibit variations in their response to oxidative stress compared to that observed in control animals." [WB:WBPerson557]
synonym: "organism oxidative stress response abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0001621
name: organism oxidative stress response hypersensitive
def: "Animals respond to a lower concentration of reactive oxygen species or a shorter exposure compared to control animals." [WB:WBPerson2021]
is_a: WBPhenotype:0001620 ! organism oxidative stress response variant

[Term]
id: WBPhenotype:0001622
name: egg laying serotonin hypersensitive
def: "Animals lay eggs at a greater rate in response to exogenous serotonin compared to control animals." [WB:WBPaper00002487, WB:WBPerson712]
is_a: WBPhenotype:0000023 ! serotonin hypersensitive
is_a: WBPhenotype:0001629 ! egg laying serotonin variant

[Term]
id: WBPhenotype:0001623
name: male tail curling serotonin variant
def: "Any variation in the posture of the male tail after application of exogenous serotonin compared to control. In C. elegans, males respond with a tight ventral curling of the male tail in response to serotonin." [WB:WBPaper00001861, WB:WBPerson557]
synonym: "male tail curling serotonin abnormal" NARROW []
is_a: WBPhenotype:0001232 ! serotonin response variant

[Term]
id: WBPhenotype:0001624
name: male tail curling serotonin resistant
def: "Animals fail to respond to the concentration of serotonin that elicits a male tail curling response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body." [WB:WBPaper00001861, WB:WBPerson557]
is_a: WBPhenotype:0000024 ! serotonin resistant
is_a: WBPhenotype:0001623 ! male tail curling serotonin variant

[Term]
id: WBPhenotype:0001625
name: male tail curling serotonin hypersensitive
def: "Males respond to serotonin by curling their tails at a lower concentration or a shorter exposure compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body." [WB:WBPaper00001861, WB:WBPaper00028762, WB:WBPerson557]
is_a: WBPhenotype:0000023 ! serotonin hypersensitive
is_a: WBPhenotype:0001623 ! male tail curling serotonin variant

[Term]
id: WBPhenotype:0001626
name: locomotion rate serotonin variant
def: "Any variation in the locomotion rate after application of exogenous serotonin compared to control." [WB:WBPaper00002141]
synonym: "locomotion rate serotonin abnormal" NARROW []
is_a: WBPhenotype:0001232 ! serotonin response variant

[Term]
id: WBPhenotype:0001627
name: locomotion rate serotonin hypersensitive
def: "The decrease in locomotion rate in the presence of serotonin is greater than control animals." [WB:WBPaper00002141]
synonym: "locomotion rate serotonin reduced" RELATED []
is_a: WBPhenotype:0000023 ! serotonin hypersensitive
is_a: WBPhenotype:0001626 ! locomotion rate serotonin variant

[Term]
id: WBPhenotype:0001628
name: locomotion rate serotonin resistant
def: "Animals fail to decrease their locomotion rate in response the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00002141]
synonym: "locomotion rate serotonin increased" RELATED []
is_a: WBPhenotype:0000024 ! serotonin resistant
is_a: WBPhenotype:0001626 ! locomotion rate serotonin variant

[Term]
id: WBPhenotype:0001629
name: egg laying serotonin variant
def: "Any variation in egg laying behavior after application of exogenous serotonin compared to control. In C. elegans, serotonin induces egg laying." [WB:WBPaper00000635, WB:WBPerson712]
synonym: "egg laying serotonin abnormal" NARROW []
is_a: WBPhenotype:0001101 ! egg laying response to drug variant
is_a: WBPhenotype:0001232 ! serotonin response variant

[Term]
id: WBPhenotype:0001630
name: gut obstructed
def: "Any variation in the developmental progression of the intestine that leads to a blockage in the alimentary canal." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Gob" BROAD []
is_a: WBPhenotype:0000708 ! intestinal development variant

[Term]
id: WBPhenotype:0001631
name: nullo X gamete
def: "Animals produce ova/sperm that contain no X chromosome in a nonmendelian segregation pattern." [WB:WBPaper00000179, WB:WBPerson712]
synonym: "nullo X gamete abnormal" NARROW []
is_a: WBPhenotype:0001664 ! X chromosome nondisjunction

[Term]
id: WBPhenotype:0001632
name: diplo X gamete
def: "Animals produce ova/sperm that contain 2 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712]
is_a: WBPhenotype:0001664 ! X chromosome nondisjunction

[Term]
id: WBPhenotype:0001633
name: lethal gamete
def: "Animals produce ova/sperm that contain lethal factors as a result of chromosomal disjunction defects." [WB:WBPaper00000179, WB:WBPerson712]
is_a: WBPhenotype:0001174 ! chromosome disjunction defective

[Term]
id: WBPhenotype:0001634
name: organism electrophilic stress hypersensitive
def: "Animals respond to compounds that elicit electrophilic stress at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0001635
name: excess pharyngeal cells
def: "Animals contain an excess number of pharyngeal cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate." [WB:WBPaper00001584, WB:WBPaper00002922, WB:WBperson2021]
is_a: WBPhenotype:0000707 ! pharyngeal development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001636
name: excess intestinal cells
def: "Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate or excess cell proliferation in the E lineage." [WB:WBPaper00001584, WB:WBPaper00002330, WB:WBperson2021]
is_a: WBPhenotype:0000708 ! intestinal development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001637
name: no Intestine
def: "Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells." [WB:WBPaper00002946, WB:WBperson2021]
is_a: WBPhenotype:0000708 ! intestinal development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001638
name: obsolete endosome fusion defective
def: "OBSOLETE: Animals are deficient in the formation or disassembly of lysosomes." [GO:0034058, WB:WBPaper00029049, WB:WBPerson712]
is_obsolete: true
replaced_by: WBPhenotype:0002561

[Term]
id: WBPhenotype:0001639
name: roaming reduced
def: "Animals exhibit a decrease in their high-speed movement in the forward direction with brief backward movement compared to control. In C. elegans, Animals do not move more than a few body lengths from their starting position and searches occur locally with pivoting behavior." [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson712]
synonym: "lurcher" RELATED []
synonym: "path range decreased" RELATED []
is_a: WBPhenotype:0000238 ! foraging reduced
is_a: WBPhenotype:0001213 ! locomotion reduced
is_a: WBPhenotype:0002315 ! roaming variant

[Term]
id: WBPhenotype:0001640
name: acidification level defective
def: "Animals are unable to acidify compartments to the same level as that observed in control animals given the same stimulus." [WB:WBPaper00031246, WB:WBPerson712]
synonym: "acidification level abnormal" NARROW []
is_a: WBPhenotype:0000607 ! coelomic system physiology variant

[Term]
id: WBPhenotype:0001641
name: posterior body wall contraction defective
def: "Animals lack or exhibit defects in the posterior body muscle contractions during the defecation cycle." [WB:WBPaper00031426, WB:WBPerson712]
synonym: "pBoc" RELATED []
is_a: WBPhenotype:0000157 ! posterior body wall contraction defecation cycle variant

[Term]
id: WBPhenotype:0001642
name: cell cleavage variant emb
def: "Variations that disrupt stereotypical embryonic cleavage patterns (such as cleavage rate, division axes or asymmetric division)." [GO:0040016, WB:WBPaper00001032, WB:WBPerson2021]
is_a: WBPhenotype:0000266 ! cell cleavage variant

[Term]
id: WBPhenotype:0001643
name: excess hypodermal cells
def: "Embryos generate an excess number of hypodermal cells compared to control." [WB:WBPerson2021]
synonym: "Skn" BROAD []
is_a: WBPhenotype:0002175 ! cell number increased
is_a: WBPhenotype:0002569 ! hypodermis development variant

[Term]
id: WBPhenotype:0001644
name: protein metabolism variant
def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of proteins in the organism compared to control." [WB:WBPerson557]
synonym: "protein metabolism abnormal" NARROW []
is_a: WBPhenotype:0000463 ! metabolic pathway variant
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0001645
name: protein degradation variant
def: "Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control." [GO:0030163, WB:WBPerson2021]
synonym: "protein degradation abnormal" NARROW []
is_a: WBPhenotype:0001644 ! protein metabolism variant

[Term]
id: WBPhenotype:0001646
name: no pharynx
def: "Embryos fail to generate cells that exhibit pharyngeal specification." [WB:WBPaper00001521, WB:WBPerson2021]
synonym: "Pha" BROAD []
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0001647
name: posterior pharynx variant
def: "Any variation in the progression of the posterior portion of the pharynx over time compared to control. In C. elegans the posterior region includes the isthmus and terminal bulb (second bulb)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "posterior pharynx abnormal" NARROW []
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0001648
name: no posterior pharynx
def: "Embryos fail to generate cells that give rise to the posterior portion of the pharynx. In C. elegans, the MS blastomere- derived pharyngeal cells constitute the posterior portion of the pharynx." [WB:WBPaper00002330, WB:WBPerson2021]
is_a: WBPhenotype:0001646 ! no pharynx
is_a: WBPhenotype:0001647 ! posterior pharynx variant

[Term]
id: WBPhenotype:0001649
name: Fluorouracil resistant
def: "Animals fail to respond to the concentration of Fluorouracil (5-FU) that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. Elegans Fluorouracil induces germ cell death, inhibits embryogenesis and inhibits larval growth (depending on dose) in control animals." [WB:WBPaper00031571, WB:WBPerson721]
synonym: "5 FU resistant" EXACT []
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0001650
name: germ cell death response to 5 FU resistant
def: "Germ cell death fails in response to the concentration of 5-FU that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, in addition to cell death, 5-FU exposed animals exhibit condensed germ cell nuclei or unhealthy nuclei." [WB:WBPaper00031571, WB:WBPerson721]
is_a: WBPhenotype:0001649 ! Fluorouracil resistant

[Term]
id: WBPhenotype:0001651
name: growth arrest response to 5 FU resistant
def: "Animals grow well during or after exposure to 5-FU under conditions where control animals are growth inhibited." [WB:WBPaper00031571, WB:WBPerson721]
is_a: WBPhenotype:0001649 ! Fluorouracil resistant

[Term]
id: WBPhenotype:0001652
name: anchor cell invasion variant
def: "Any variation in the process by which the gonad anchor cell makes contact with vulval cells in order to create a uterine-vulval connection. In C. elegans, this includes the loss of the basement membranes between these cells and the crossing of the basolateral portion of the anchor cell through this gap." [WB:WBPaper00005989]
synonym: "anchor cell invasion abnormal" NARROW []
is_a: WBPhenotype:0000283 ! vulva uterus connection defective

[Term]
id: WBPhenotype:0001653
name: cadmium response variant
def: "Animals exhibit variations in their response to cadmium compared to that observed in control animals." [WB:WBPerson557]
synonym: "cadmium response abnormal" NARROW []
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0001654
name: cadmium resistant
def: "Animals fail to respond to the concentration of cadmium that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to cadmium to elicit the response compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001653 ! cadmium response variant

[Term]
id: WBPhenotype:0001655
name: cadmium hypersensitive
def: "Animals respond to cadmium at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001653 ! cadmium response variant

[Term]
id: WBPhenotype:0001656
name: distal tip cell development variant
def: "Any variation in the progression of the leader cell that guides and shapes the outgrowth of the gonad while crawling along the body wall to force the germline to extend into a long tubular shape over time from its formation to its mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "distal tip cell development abnormal" NARROW []
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0001657
name: cell junction variant
def: "Animals exhibit variations in the specialized region of connection between two cells or between a cell and the extracellular matrix compared to control." [GO:0030054, WB:WBPaper00031590, WB:WBPerson712]
synonym: "cell junction abnormal" NARROW []
is_a: WBPhenotype:0001399 ! cell membrane morphology variant

[Term]
id: WBPhenotype:0001658
name: intercellular junction variant
def: "Animals exhibit variations in the specialized region of connection between two cells compared to control." [GO:0005911, WB:WBPaper00031590, WB:WBPerson712]
synonym: "cell cell junction abnormal" RELATED []
synonym: "intercellular junction abnormal" NARROW []
is_a: WBPhenotype:0001657 ! cell junction variant

[Term]
id: WBPhenotype:0001659
name: spermatheca morphology variant
def: "Any variation in the form, structure or composition of the somatic gonad structure that connects the distal gonad arm to the uterus compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "spermatheca morphology abnormal" NARROW []
is_a: WBPhenotype:0000977 ! somatic gonad morphology variant

[Term]
id: WBPhenotype:0001660
name: loss of asymmetry ASE
def: "The two morphologically bilaterally symmetric gustatory neurons ASE left (ASEL) and ASE right (ASER) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00030973, WB:WBPerson2021]
synonym: "2ASEL" NARROW []
synonym: "2ASER" NARROW []
is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant
is_a: WBPhenotype:0001512 ! loss of left right asymmetry

[Term]
id: WBPhenotype:0001661
name: loss of asymmetry AWC
def: "The two morphologically bilaterally symmetric olfactory neurons AWC left (AWCL) and AWC right (AWCR) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00003760, WB:WBPerson2021]
synonym: "2 AWC off" NARROW []
synonym: "2 AWC on" NARROW []
is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant
is_a: WBPhenotype:0001512 ! loss of left right asymmetry

[Term]
id: WBPhenotype:0001662
name: spermatheca development variant
def: "Any variation in the progression of the somatic gonad structure that connects the distal gonad arm to the uterus over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "spermatheca development abnormal" NARROW []
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0001663
name: organism oxidative stress resistant
def: "Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals." [WB:WBPerson2021]
synonym: "Oxr" BROAD []
is_a: WBPhenotype:0001620 ! organism oxidative stress response variant

[Term]
id: WBPhenotype:0001664
name: X chromosome nondisjunction
def: "The frequency of sex chromosome segregation is perturbed, resulting in the production of exceptional gametes (e.g. ova or sperm) and populations with a sex ratio altered from the rate of 1:500 as observed for control populations." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712]
is_a: WBPhenotype:0001174 ! chromosome disjunction defective

[Term]
id: WBPhenotype:0001665
name: low incidence male progeny
def: "Lower numbers of male progeny occur in the population compared to control populations. In C. elegans, the low incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an decrease in X chromosome nondisjunction." [WB:WBPaper00000565, WB:WBPerson712]
is_a: WBPhenotype:0001664 ! X chromosome nondisjunction

[Term]
id: WBPhenotype:0001666
name: organism hypersensitive X ray irradiation
def: "Animals respond to iononizing radiation at a lower dose or a shorter exposure compared to control animals. Iononizing radiation has a wavelength in the 10 to 0.01 nanometer range. In C. elegans, increased sensitivity to X-ray irradiation is often observed as a decrease in survival upon exposure compared to control animals given the same treatment." [WB:WBPaper00000565, WB:WBPaper00003886, WB:WBPerson712]
is_a: WBPhenotype:0000276 ! organism X ray response variant
is_a: WBPhenotype:0000711 ! organism hypersensitive ionizing radiation

[Term]
id: WBPhenotype:0001667
name: methyl methanesulfonate hypersensitive
def: "Animals respond to the chemical mutagen methyl methanesulfonate (MMS) a methanesulfonate ester and alkylating agent at a lower concentration or a shorter exposure compared to control animals. In C. elegans, increased sensitivity to MMS can be observed as a decrease in egg hatch upon acute exposure or inhibition of growth after chronic exposure compared to control animals given the same treatment." [WB:WBPaper00000565, WB:WBPerson712]
synonym: "MMS hypersensitive" EXACT []
is_a: WBPhenotype:0000498 ! methyl methanesulfonate response variant

[Term]
id: WBPhenotype:0001668
name: oocyte accumulation
def: "An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control." [WB:WBPaper00006281, WB:WBPaper00030855]
synonym: "oocyte number increased" RELATED []
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0001669
name: presynaptic vesicle number variant
def: "Animals exhibit a variation in the ratio of synaptic vesicles per synapse of a neuron, compared to control animals." [WB:WBPaper00027305, WB:WBPerson712]
synonym: "presynaptic vesicle number abnormal" NARROW []
synonym: "synaptic vesicle number abnormal" RELATED []
is_a: WBPhenotype:0001321 ! presynaptic region morphology variant

[Term]
id: WBPhenotype:0001670
name: presynaptic vesicle number reduced
alt_id: WBPhenotype:0001322
def: "Animals exhibit an overall decrease in the quantity of synaptic vesicles at the synapse compared to control animals." [WB:WBPaper00027305, WB:WBPerson712]
synonym: "synaptic vesicle number reduced" RELATED []
is_a: WBPhenotype:0001669 ! presynaptic vesicle number variant

[Term]
id: WBPhenotype:0001671
name: vesicle organization variant
def: "Animals display variations in the distribution of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "vesicle organization abnormal" NARROW []
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0001672
name: commisure growth variant
def: "Animals exhibit variations in the extension of the part of the axon that forms a bridge between body regions, compared to control animals." [WB:WBPerson2021, WB:WBPerson712]
synonym: "commisure growth abnormal" NARROW []
is_a: WBPhenotype:0001224 ! axon outgrowth variant

[Term]
id: WBPhenotype:0001673
name: telomere homeostasis variant
def: "Animals exhibit variations in the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA, which allow the chromosome to persist from generation to generation, compared to control." [GO:0032204, WB:WBPaper00031585, WB:WBPerson712]
synonym: "telomere homeostasis abnormal" NARROW []
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0001674
name: telomere morphology variant
def: "Animals exhibit variations in the sequence or organization of the components of the terminal region of its chromosome, (i.e. telomere, which serves to stabilize the chromosome) compared to control." [GO:0000781, WB:WBPaper00003886, WB:WBPerson712]
synonym: "telomere morphology abnormal" NARROW []
is_a: WBPhenotype:0001348 ! chromosome morphology variant

[Term]
id: WBPhenotype:0001675
name: male gonad development variant
def: "Males exhibit variations in the reproductive system, from its formation to the mature structure compared to control." [WB:WBPerson712]
synonym: "male gonad development abnormal" NARROW []
is_a: WBPhenotype:0000691 ! gonad development variant

[Term]
id: WBPhenotype:0001676
name: touch receptor cell morphology variant
def: "Animals exhibit variations in the structure or composition of any neuron within the class of sensory neurons responsible for relaying mechanical stimuli to the animal compared to control." [WB:WBPaper00000550, WB:WBPerson712]
synonym: "mechanosensory neuron abnormal" RELATED []
synonym: "microtubule cell morphology abnormal" RELATED []
synonym: "touch receptor cell morphology abnormal" NARROW []
is_a: WBPhenotype:0000905 ! neuron morphology variant

[Term]
id: WBPhenotype:0001677
name: stage specific cuticle antigenicity variant
def: "Animals display cuticle components displayed by animals of a different developmental stage, compared to control." [WB:WBPaper00002589, WB:WBPerson712]
synonym: "Srf" NARROW []
synonym: "stage specific cuticle antigenicity abnormal" NARROW []
is_a: WBPhenotype:0001687 ! surface antigenicity variant

[Term]
id: WBPhenotype:0001678
name: cuticle physiology variant
def: "Animals produce cuticles that vary in components such as proteins or carbohydrates, observed in control animals of the same developmental stage and raised under the same conditions." [WB:WBPaper00001576, WB:WBPerson712]
synonym: "cuticle physiology abnormal" NARROW []
is_a: WBPhenotype:0001210 ! pericellular component physiology phenotype

[Term]
id: WBPhenotype:0001679
name: multipolar neuron
def: "Neurons have more than one process extending from the cell body." [WB:WBPaper00031901, WB:WBPerson712]
is_a: WBPhenotype:0000905 ! neuron morphology variant

[Term]
id: WBPhenotype:0001680
name: adoption of fused vulval cell fate
def: "Vulval precursor cells forgo further cell division and fuse to the hypodermis instead of adopting their intended fate (becoming primary, secondary or tertiary vulval cells)." [WB:WBPerson2021, WB:WBPerson712]
synonym: "F fate abnormal" RELATED []
synonym: "VPC fused fate abnormal" RELATED []
is_a: WBPhenotype:0001272 ! vulval cell induction variant

[Term]
id: WBPhenotype:0001681
name: spindle orientation variant
def: "The alignment of the spindle relative to other cellular structures varies from that observed in control animals." [GO:0051294, WB:WBPaper00031898, WB:WBPerson712]
synonym: "spindle orientation abnormal" NARROW []
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0001682
name: organism UV resistant
def: "Organisms respond to UV at a higer dose or a longer exposure compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000143 ! organism UV response variant

[Term]
id: WBPhenotype:0001683
name: spermatogenesis defective hermaphrodite
def: "Variations that specifically disrupt sperm production in XX hermaphrodites. By contrast, spermatogenesis in XO males remains unaffected." [WB:WBPaper00002113, WB:WBPaper00002631]
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0001684
name: synaptic vesicle homeostasis variant
def: "The rates of synaptic vesicle exocytosis and endocytosis vary from that observed in control animals." [WB:WBPaper00031872, WB:WBPerson712]
synonym: "synaptic vesicle homeostasis abnormal" NARROW []
is_a: WBPhenotype:0000846 ! presynaptic region physiology variant

[Term]
id: WBPhenotype:0001685
name: postsynaptic region morphology variant
def: "The region opposite to the presynaptic region deviates in the structure, configuration or ratio of its components specific for receiving signals from the other side of the synapse compared to control." [WB:WBPaper00031872, WB:WBPerson712]
synonym: "postsynaptic region morphology abnormal" NARROW []
is_a: WBPhenotype:0000616 ! synapse morphology variant

[Term]
id: WBPhenotype:0001686
name: postsynaptic region physiology variant
def: "Animals exhibit variations in any physical or chemical process in the region, opposite to the presynaptic region, which is required for receiving signals from the other side of the synapse compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "postsynaptic region physiology abnormal" NARROW []
is_a: WBPhenotype:0000584 ! synaptic transmission variant

[Term]
id: WBPhenotype:0001687
name: surface antigenicity variant
def: "Cuticles of animals or cuticular extracts exhibit an altered pattern of antibody binding compared to Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712]
synonym: "Srf" BROAD []
synonym: "surface antigenicity abnormal" NARROW []
is_a: WBPhenotype:0001688 ! surface coat variant

[Term]
id: WBPhenotype:0001688
name: surface coat variant
def: "The electron dense, amorphous envelope that comprises the outermost layer of the cuticle varies in composition from that observed in control animals of the same developmental stage. The integrity of the surface coat is often revealed by an altered antigenicity or biochemical make up." [GO:0060104]
synonym: "Srf" BROAD []
synonym: "surface coat abnormal" NARROW []
is_a: WBPhenotype:0000201 ! cuticle development variant
is_a: WBPhenotype:0001678 ! cuticle physiology variant

[Term]
id: WBPhenotype:0001689
name: surface antigen negative
def: "Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712]
synonym: "Srf" NARROW []
is_a: WBPhenotype:0001687 ! surface antigenicity variant

[Term]
id: WBPhenotype:0001690
name: constitutive larval display
def: "Animals display surface antigens throughout all larval stages, unlike Bristol N2 worms, which display the antigens only during one larval stage." [WB:WBPaper00002589, WB:WBPerson712]
synonym: "Cld" BROAD []
is_a: WBPhenotype:0001677 ! stage specific cuticle antigenicity variant

[Term]
id: WBPhenotype:0001691
name: germ nuclei rachis
def: "Germ nuclei are misplaced in the gonad and are observed in the rachis. Sheath cells are observed protruding between these nuclei. Meiotic or mitotic specification of germ nuclei is not affected." [WB:WBPaper00031889, WB:WBPerson712]
synonym: "germ line morphogenesis(Glm)" NARROW []
is_a: WBPhenotype:0001940 ! rachis morphology variant

[Term]
id: WBPhenotype:0001692
name: pheromone induced larval display defective
def: "Animals are not induced to display surface antigens by exposure to pheromone as observed for Bristol N2 animals." [WB:WBPaper00002589, WB:WBPerson712]
synonym: "ILD abnormal" EXACT []
synonym: "induced larval display abnormal" RELATED []
synonym: "pheromone induced larval display abnormal" NARROW []
is_a: WBPhenotype:0001687 ! surface antigenicity variant

[Term]
id: WBPhenotype:0001693
name: male posterior alae
def: "Males have alae that extend into the tail region. Alae are small linear ridges running along the lateral lines of the cuticle. In C. elegans alae do not extend into the tail region (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Pal" BROAD []
is_a: WBPhenotype:0000202 ! alae variant
is_a: WBPhenotype:0001240 ! male tail sensory ray differentiation variant

[Term]
id: WBPhenotype:0001694
name: spermatogenesis to oogenesis switch defective
def: "Hermaphrodites continue to produce sperm past the time at which the transition to oogenesis normally occurs. Thus, germ cells that would normally become oocytes are transformed into sperm instead." [WB:WBPaper00001883, WB:WBPaper00002113, WB:WBPerson2021]
synonym: "spermatogenesis to oogenesis switch abnormal" NARROW []
is_a: WBPhenotype:0001572 ! masculinized

[Term]
id: WBPhenotype:0001695
name: glycosyltransferase activity variant
def: "Animals exhibit variations in their catalytic ability the transfer glycolsyl groups from one compound (donor) to another (acceptor) often measured by a reduction in the amount of glycosylated products compared to that observed in control animals of the same developmental stage." [GO:0016757, WB:WBPerson712]
synonym: "glycosyltransferase activity abnormal" NARROW []
is_a: WBPhenotype:0000733 ! catalysis variant

[Term]
id: WBPhenotype:0001696
name: biosynthesis variant
def: "Animals exhibit variations in the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones compared to control." [GO:0009058, WB:WBPaper00029024, WB:WBPerson712]
synonym: "biosynthesis abnormal" NARROW []
is_a: WBPhenotype:0000463 ! metabolic pathway variant

[Term]
id: WBPhenotype:0001697
name: chondroitin biosynthesis variant
def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712]
synonym: "chondroitin biosynthesis abnormal" NARROW []
is_a: WBPhenotype:0001696 ! biosynthesis variant

[Term]
id: WBPhenotype:0001698
name: heparan sulfate biosynthesis variant
def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712]
synonym: "heparan sulfate biosynthesis abnormal" NARROW []
is_a: WBPhenotype:0001696 ! biosynthesis variant

[Term]
id: WBPhenotype:0001699
name: localized movement variant
def: "Specific body regions of an animal display variations in movement compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "localized movement abnormal" NARROW []
is_a: WBPhenotype:0001206 ! movement variant

[Term]
id: WBPhenotype:0001700
name: swimming variant
def: "Animals exhibit variations in movement in liquid from that observed for control animals." [WB:WBPaper00031835, WB:WBPerson712]
synonym: "movement in liquid abnormal" RELATED []
synonym: "swimming abnormal" NARROW []
synonym: "thrashing abnormal" RELATED []
is_a: WBPhenotype:0001206 ! movement variant

[Term]
id: WBPhenotype:0001701
name: spastic locomotion
def: "Animals exhibit uncharacteristic muscle contractions during the process by which they travel from one location to another." [WB:WBPerson2021, WB:WBPerson557]
synonym: "convulsive" RELATED []
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0001702
name: directionality variant
def: "Animals exhibit variations in the directional changes that separate consecutive runs, from that observed for control animals. In C. elegans, these aberrations include variations in the form or extent of omega turns or reversals (shifts from forward to backward movements)." [WB:WBPaper00000075, WB:WBPaper00003740, WB:WBPaper00031656, WB:WBPerson712]
synonym: "directionality abnormal" NARROW []
synonym: "reversal abnormal" RELATED []
synonym: "turning abnormal" RELATED []
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0001703
name: body bend variant
def: "Any variation in the maximum ventral and dorsal flex of the animal compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "body bend abnormal" NARROW []
is_a: WBPhenotype:0004018 ! sinusoidal movement variant

[Term]
id: WBPhenotype:0001704
name: multiple alae
def: "Alae contain more cuticular ridges than control animals. In C. elegans alae are composed of three cuticular ridges." [WB:WBPaper00026841, WB:WBPerson557]
is_a: WBPhenotype:0001412 ! alae morphology variant

[Term]
id: WBPhenotype:0001705
name: nucleocytoplasmic transport defective
def: "The directed movement of molecules between the nucleus and the cytoplasm is impaired." [GO:0006913, WB:WBPerson557]
synonym: "nucleocytoplasmic transport abnormal" NARROW []
is_a: WBPhenotype:0001283 ! organelle metabolism variant

[Term]
id: WBPhenotype:0001706
name: nuclear export defective
def: "The directed movement of substances out of the nucleus is impaired." [GO:0051168, WB:WBPerson557]
synonym: "nuclear export abnormal" NARROW []
is_a: WBPhenotype:0001705 ! nucleocytoplasmic transport defective

[Term]
id: WBPhenotype:0001707
name: nuclear import defective
def: "The directed movement of substances into the nucleus is impaired." [GO:0051170, WB:WBPerson557]
synonym: "nuclear import abnormal" NARROW []
is_a: WBPhenotype:0001705 ! nucleocytoplasmic transport defective

[Term]
id: WBPhenotype:0001708
name: protein export from nucleus defective
def: "The directed movement of a protein from the nucleus into the cytoplasm is impaired." [GO:0006611, WB:WBPerson557]
synonym: "protein export from nucleus abnormal" NARROW []
is_a: WBPhenotype:0001706 ! nuclear export defective

[Term]
id: WBPhenotype:0001709
name: rhythmic tolerance to stress variant
def: "Animals exhibit variations in light/dark cycle recurrence of reactions to stress conditions compared to that observed for control animals." [WB:WBPaper00032037, WB:WBPerson712]
synonym: "circadian variation in stress tolerance abnormal" RELATED []
synonym: "rhythmic tolerance to stress abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant
is_a: WBPhenotype:0001711 ! rhythmic behavior variant

[Term]
id: WBPhenotype:0001710
name: rhythmic tolerance to osmotic stress variant
def: "Animals exhibit variations in light/dark cycle recurrence of reactions to osmotic stress compared to that observed for control animals." [WB:WBPaper00032037, WB:WBPerson712]
synonym: "rhythmic tolerance to osmotic stress abnormal" NARROW []
is_a: WBPhenotype:0001709 ! rhythmic tolerance to stress variant

[Term]
id: WBPhenotype:0001711
name: rhythmic behavior variant
def: "Animals exhibit variations in actions or responses that occur with measurable periodicity, from that observed for control animals." [GO:0007622, WB:WBPerson712]
synonym: "rhythmic behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001712
name: circadian rhythm behavior variant
def: "Animals exhibit variations in the actions or reactions that recur with a periodicity associated with light/dark cycles, compared to control." [GO:0048512, WB:WBPaper00032037, WB:WBPerson712]
synonym: "circadian rhythm behavior abnormal" NARROW []
is_a: WBPhenotype:0001711 ! rhythmic behavior variant

[Term]
id: WBPhenotype:0001713
name: locomotory rhythm variant
def: "Animals exhibit variations in locomotor activity during its light/dark cycle from that observed in control animals." [GO:0045475, WB:WBPaper00031656, WB:WBPerson712]
synonym: "locomotory rhythm abnormal" NARROW []
is_a: WBPhenotype:0001711 ! rhythmic behavior variant

[Term]
id: WBPhenotype:0001714
name: pirouette variant
def: "Animals exhibit variations in turning bouts, consisting of one or more sharp turning events separating consecutive runs, which serve to orient the animal within a gradient, compared to control." [WB:WBPaper00003740, WB:WBPaper00026967, WB:WBPerson712]
synonym: "pirouette abnormal" NARROW []
is_a: WBPhenotype:0002311 ! turning variant

[Term]
id: WBPhenotype:0001715
name: pirouette frequency variant
def: "Animals exhibit variations in the number of directional changes over time from that observed for control animals." [WB:WBPaper00031656, WB:WBPerson712]
synonym: "frequency of directionality abnormal" NARROW []
synonym: "pirouette frequency abnormal" NARROW []
is_a: WBPhenotype:0001714 ! pirouette variant

[Term]
id: WBPhenotype:0001716
name: forward point velocity variant
def: "Animals exhibit variations in the velocity of forward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00024949, WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson712]
synonym: "forward point velocity abnormal" NARROW []
is_a: WBPhenotype:0004025 ! velocity of movement variant

[Term]
id: WBPhenotype:0001717
name: centroid velocity variant
def: "Animals exhibit variations in the translocation of the mean position of the rear two-thirds (centroid position) of the animal over time, from that observed for control animals." [WB:WBPaper00024949, WB:WBPaper00031656, WB:WBPerson712]
synonym: "centroid velocity abnormal" NARROW []
is_a: WBPhenotype:0004025 ! velocity of movement variant

[Term]
id: WBPhenotype:0001718
name: instantaneous velocity variant
def: "Animals exhibit variations in the mean translocation of the points along the animal's track compared to control." [WB:WBPaper00024949, WB:WBPerson712]
synonym: "instantaneous velocity abnormal" NARROW []
is_a: WBPhenotype:0004025 ! velocity of movement variant

[Term]
id: WBPhenotype:0001719
name: unfolded protein response variant
def: "Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones." [GO:0030968, WB:WBPaper00030877, WB:WBPaper00032003, WB:WBPerson557, WB:WBPerson712]
synonym: "ER unfolded protein response abnormal" RELATED []
synonym: "unfolded protein response" RELATED []
synonym: "unfolded protein response abnormal" NARROW []
synonym: "UPR" RELATED []
is_a: WBPhenotype:0000142 ! cell stress response variant
is_a: WBPhenotype:0001644 ! protein metabolism variant

[Term]
id: WBPhenotype:0001720
name: spermatozoa retro location defective
def: "Spermatozoa do not crawl back into the spermatheca after being swept into the uterus by passing oocytes." [WB:WBPaper00032030, WB:WBPerson712]
synonym: "spermatheca homing abnormal" RELATED []
synonym: "spermatozoa retro location abnormal" NARROW []
is_a: WBPhenotype:0000389 ! hermaphrodite sperm fertilization defective
is_a: WBPhenotype:0001386 ! fertilization defective hermaphrodite

[Term]
id: WBPhenotype:0001721
name: pathogen infected pharynx variant
def: "Animals exhibit variations in the extent of pathogen invasion into the pharynx compared to control. This is often measured as the percentage of animals exhibiting a pathogen-invaded pharynx within a given population." [WB:WBPaper00032003, WB:WBPerson712]
synonym: "pathogen infected pharynx abnormal" NARROW []
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0001722
name: pathogen infected pharynx increase
def: "Animals exhibit a greater extent of pathogen invasion into the pharynx compared to control." [WB:WBPaper00032003, WB:WBPerson712]
is_a: WBPhenotype:0001721 ! pathogen infected pharynx variant

[Term]
id: WBPhenotype:0001723
name: pathogen infected pharynx decrease
def: "Animals exhibit a lesser extent of pathogen invasion into the pharynx compared to control." [WB:WBPaper00032003, WB:WBPerson712]
is_a: WBPhenotype:0001721 ! pathogen infected pharynx variant

[Term]
id: WBPhenotype:0001724
name: tunicamycin hypersensitive
def: "Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557]
is_a: WBPhenotype:0000359 ! tunicamycin response variant

[Term]
id: WBPhenotype:0001725
name: cellular osmotic stress response variant
def: "Cells exhibit variations in the response to osmotic stress compared to control. In C. elegans, exposure to stress-inducing osmotic conditions invokes cellular changes, including transcriptional up or down-regulation of genes." [WB:WBPaper00032031, WB:WBPerson712]
synonym: "osmotic stress response abnormal" NARROW []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0001726
name: body length variant
def: "Animals vary in the distance between anterior and posterior ends of the animal from that observed in control animals." [WB:WBPerson712]
synonym: "body length abnormal" NARROW []
is_a: WBPhenotype:0000231 ! body size variant

[Term]
id: WBPhenotype:0001727
name: body width variant
def: "Animals vary in the distance between dorsal and ventral sides when measured across the body at right angles to the length, from that observed in control animals." [WB:WBPerson712]
synonym: "body width abnormal" NARROW []
is_a: WBPhenotype:0000231 ! body size variant

[Term]
id: WBPhenotype:0001728
name: mating plug production variant
def: "Males differ from control animals in their ability to form copulatory plugs or their placement of these plugs. In C. elegans, males of the Hawaiian strain (CB4856) typically form mating plugs." [WB:WBPaper00032027, WB:WBPerson712]
synonym: "mating plug production abnormal" NARROW []
is_a: WBPhenotype:0000928 ! male physiology variant

[Term]
id: WBPhenotype:0001729
name: mating plug produced
def: "Males form copulatory mating plugs." [WB:WBPaper00002770, WB:WBPerson712]
synonym: "mating plug plus" RELATED []
synonym: "plug plus" RELATED []
is_a: WBPhenotype:0001728 ! mating plug production variant

[Term]
id: WBPhenotype:0001730
name: mating plug deficient
def: "Males do not form copulatory mating plug." [WB:WBPaper00002770, WB:WBPerson712]
synonym: "mating plug minus" RELATED []
synonym: "plug minus" RELATED []
is_a: WBPhenotype:0001728 ! mating plug production variant

[Term]
id: WBPhenotype:0001731
name: thermal bias in tracking variant
def: "Animals exhibit variations in the duration of the trajectory of the forward track in a thermal gradient compared to control." [WB:WBPaper00032070, WB:WBPerson712]
synonym: "cryophilic bias" RELATED []
synonym: "thermal bias in tracking abnormal" NARROW []
is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant

[Term]
id: WBPhenotype:0001732
name: organism response to pH variant
def: "Animals exhibit variations in their response and ability to survive over a range of pH conditions compared to control." [WB:WBPaper00032033, WB:WBPerson712]
synonym: "organism response to pH abnormal" NARROW []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0001733
name: pheromone suppressed pumping defective
def: "Animals treated with pheromone do not exhibit a decrease in pumping rate similar to that observed for control animals." [WB:WBPaper00032082, WB:WBPerson712]
synonym: "pheromone suppressed pumping abnormal" NARROW []
is_a: WBPhenotype:0001287 ! suppressed pharyngeal pumping defective

[Term]
id: WBPhenotype:0001734
name: starvation suppressed pumping defective
def: "Animals deprived of food do not exhibit a decrease in pumping rate similar to that observed for control animals." [WB:WBPaper00032082, WB:WBPerson712]
synonym: "food deprived suppression of pumping abnormal" RELATED []
synonym: "starvation suppressed pumping abnormal" NARROW []
is_a: WBPhenotype:0001287 ! suppressed pharyngeal pumping defective

[Term]
id: WBPhenotype:0001735
name: muscle cell activity variant
def: "Animals exhibit variations in the frequency, rate or extent of muscle contraction compared to control animals." [GO:0006937, WB:WBPaper00032000, WB:WBPerson712]
synonym: "muscle cell activity abnormal" NARROW []
is_a: WBPhenotype:0000990 ! muscle cell physiology variant

[Term]
id: WBPhenotype:0001736
name: acetate chemotaxis defective
def: "Failure to execute the characteristic response to acetate compared to control animals." [WB:WBPaper00031959, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000015 ! positive chemotaxis defective

[Term]
id: WBPhenotype:0001737
name: aqueous compound discrimination defective
def: "Animals are unable to locate the gradient peak of a water soluble compound, which was generated on a uniform concentration of another compound." [WB:WBPaper00031959, WB:WBPerson712]
synonym: "aqueous compound discrimination abnormal" NARROW []
is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant

[Term]
id: WBPhenotype:0001738
name: ammonium chemotaxis defective
def: "Failure to execute the characteristic response to ammonium compared to control animals." [WB:WBPaper00031959, WB:WBPerson712]
is_a: WBPhenotype:0000015 ! positive chemotaxis defective

[Term]
id: WBPhenotype:0001739
name: aging variant
def: "Any variation in an organism's decline over time from its optimal fertility and viability compared to control animals." [WB:WBPaper00032067, WB:WBPerson712]
synonym: "aging abnormal" NARROW []
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0001740
name: organ senescence variant
def: "Any variation in the preprogrammed process that occurs in an organism that is associated with the dismantling of an organ and an overall decline in metabolic function compared to control animals. This may include variations in the rate or extent of morphological disarray and of the breakdown or organelles, membranes and other cellular components." [GO:0010260, WB:WBPaper00032067, WB:WBPerson712]
synonym: "organ senescence abnormal" NARROW []
is_a: WBPhenotype:0000530 ! organ system development variant
is_a: WBPhenotype:0000534 ! organ system morphology variant
is_a: WBPhenotype:0000575 ! organ system physiology phenotype
is_a: WBPhenotype:0001739 ! aging variant

[Term]
id: WBPhenotype:0001741
name: spontaneous spicule protraction
def: "Males exhibit spicule-muscle seizures leading to inappropriately timed protraction compared to control." [WB:WBPaper00032000, WB:WBPerson712]
synonym: "Prc" BROAD []
synonym: "precocious spicule protraction" RELATED []
synonym: "protraction constitutive" RELATED []
is_a: WBPhenotype:0002443 ! spicule protraction variant

[Term]
id: WBPhenotype:0001742
name: lipid synthesis increased
def: "The endogenous anabolism of any lipid species has been increased compared to that observed in control animals." [WB:WBPaper00032082, WB:WBPerson712]
is_a: WBPhenotype:0000725 ! lipid metabolism variant

[Term]
id: WBPhenotype:0001743
name: mitosis variant
def: "Any variation in the division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the identical chromosome complement of their mother compared to control." [GO:0000278, WB:WBPerson557]
synonym: "mitosis abnormal" NARROW []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0001744
name: cell adhesion variant
def: "Any variation in the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix compared to control." [GO:0007155, WB:WBPerson557]
synonym: "cell adhesion abnormal" NARROW []
is_a: WBPhenotype:0001657 ! cell junction variant

[Term]
id: WBPhenotype:0001745
name: adherens junction variant
def: "Any variation in a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control." [GO:0005912, WB:WBPerson557]
synonym: "adherens junction abnormal" NARROW []
is_a: WBPhenotype:0001658 ! intercellular junction variant

[Term]
id: WBPhenotype:0001746
name: tight junction defective
def: "Any perturbation in the belt-like region of very close contact between the plasma membranes of adjacent cells that results in the complete occlusion of the intercellular space." [GO:0005923, WB:WBPerson557]
synonym: "tight junction abnormal" NARROW []
synonym: "zonula occludens abnormal" EXACT []
is_a: WBPhenotype:0001658 ! intercellular junction variant

[Term]
id: WBPhenotype:0001747
name: zinc response variant
def: "Animals exhibit variations in the change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus compared to control." [GO:0010043, WB:WBPerson712]
synonym: "zinc response abnormal" NARROW []
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0001748
name: pharynx unattached
def: "The pharynx or pharyngeal muscle does not form a functional connection to the mouth or buccal cavity." [WB:WBPaper00031910, WB:WBPerson712]
synonym: "Pun" EXACT []
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0001749
name: zinc toxicity hypersensitive
def: "The toxic response to zinc occurs at a lower concentration or a shorter exposure compared to control animals. In C. elegans hypersensitive animals exhibit delayed development or lethality at concentrations of zinc (e.g. ZnSO4), which has little or no effect on control worms." [WB:WBPaper00031911, WB:WBPerson712]
is_a: WBPhenotype:0001747 ! zinc response variant

[Term]
id: WBPhenotype:0001750
name: zinc toxicity resistant
def: "Animals fail to exhibit toxicity to the concentration of zinc that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to zinc include delayed development or lethality." [WB:WBPaper00031911, WB:WBPerson712]
is_a: WBPhenotype:0001747 ! zinc response variant

[Term]
id: WBPhenotype:0001751
name: organism hypertonic lethality increased
def: "Animals exhibit increased lethality as a result of exposure to environments with a higher solute concentration than their own internal environment, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "Hos" RELATED []
synonym: "hypertonic sensitive" RELATED []
is_a: WBPhenotype:0000141 ! stress induced lethality increased
is_a: WBPhenotype:0000876 ! organism osmotic stress response variant

[Term]
id: WBPhenotype:0001752
name: vesicle trafficking variant
def: "Animals exhibit variations in vesicle-based directed movement of substances into, out of, or within a cell compared to control." [GO:0016192, WB:WBPerson712]
synonym: "vesicle trafficking abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001753
name: coelomocyte uptake increased
def: "Animals exhibit intensified accumulation of fluids or fluorescent markers etc. within their coelomocytes compared to control animals." [WB:WBPaper00004883, WB:WBPerson712]
is_a: WBPhenotype:0001423 ! coelomocyte physiology variant

[Term]
id: WBPhenotype:0001754
name: endosome to lysosome trafficking defective
def: "Contents of endosomes fail to be transported to lysosomal compartments." [WB:WBPaper00029049, WB:WBPerson712]
is_a: WBPhenotype:0001421 ! endocytic transport variant

[Term]
id: WBPhenotype:0001755
name: UV induced mitotic germ cell arrest defective
def: "Animals do not arrest mitotic germ cell division, as control animals, when treated with UV radiation." [WB:WBPaper00028948, WB:WBPerson557]
is_a: WBPhenotype:0000100 ! cell UV response variant

[Term]
id: WBPhenotype:0001756
name: UV induced apoptosis decreased
def: "Programmed cell death caused by UV radiation is reduced compared to control animals. In C. elegans, this is often measured in the pachytene region of the gonad." [WB:WBPaper00028948, WB:WBPerson557]
is_a: WBPhenotype:0000100 ! cell UV response variant

[Term]
id: WBPhenotype:0001757
name: neuropeptide metabolism variant
def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of signalling peptides in the organism compared to control." [WB:WBPerson712]
synonym: "neuropeptide metabolism abnormal" NARROW []
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001758
name: neuropeptide processing variant
def: "Variations in the chemical reactions and pathways involved in the formation and maturation of specialized peptidergic neurotransmitters encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
synonym: "neuropeptide processing abnormal" NARROW []
is_a: WBPhenotype:0000122 ! post translational processing variant
is_a: WBPhenotype:0001757 ! neuropeptide metabolism variant

[Term]
id: WBPhenotype:0001759
name: 21U RNA expression variant
def: "Variations in the biogenesis or stability of the 21U-RNA class of molecules compared to control. Molecules are classified as 21U-RNA based on the presence of a 5'U and a conserved upstream motif, which may specify the production of these molecules, in addition these molecules are typically 21nt in length." [GO:0016070, WB:WBPaper00028915, WB:WBPaper00031962, WB:WBPerson712]
synonym: "21U RNA expression abnormal" NARROW []
synonym: "piRNA expression abnormal" RELATED []
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0001760
name: G tract instability
def: "Animals exhibit an increase in the rate of deletion events in mono-G or G-rich tracts within the genome compared to control." [WB:WBPaper00031945, WB:WBPerson712]
is_a: WBPhenotype:0000000 ! chromosome instability

[Term]
id: WBPhenotype:0001761
name: axon midline crossing variant
def: "Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control." [GO:0016199, WB:WBPaper00032007, WB:WBPerson712]
synonym: "axon midline crossing abnormal" NARROW []
is_a: WBPhenotype:0000384 ! axon guidance variant

[Term]
id: WBPhenotype:0001762
name: uptake of yolk defective
def: "Yolk is not taken up by oocytes in the same manner or to the same degree as observed for control animals. This often leads to an accumulation of yolk in the pseudocoelom." [WB:WBPaper00003831, WB:WBPerson712]
is_a: WBPhenotype:0001422 ! endocytic transport defect
is_a: WBPhenotype:0001424 ! oocyte physiology variant

[Term]
id: WBPhenotype:0001763
name: uptake by intestinal cell defective
def: "Uptake of subtances from the intestine is altered from that observed in control animals." [WB:WBPaper00004883, WB:WBPerson712]
is_a: WBPhenotype:0000986 ! epithelial cell physiology variant

[Term]
id: WBPhenotype:0001764
name: carbon dioxide response variant
def: "Animals exhibit variations in their response to carbon dioxide compared to control." [WB:WBPerson712]
synonym: "carbon dioxide response abnormal" NARROW []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0001765
name: carbon dioxide avoidance variant
def: "Variations in the characteristic movement away from specific CO2 levels compared to control. C. elegans avoids high levels of CO2." [WB:WBPaper00031935, WB:WBPerson557, WB:WBPerson712]
synonym: "carbon dioxide avoidance abnormal" NARROW []
synonym: "Cdad" RELATED []
synonym: "CO2 avoidance abnormal" RELATED []
is_a: WBPhenotype:0001764 ! carbon dioxide response variant

[Term]
id: WBPhenotype:0001766
name: cholesterol depletion hypersensitive
def: "Animals are more sensitive to the reduction of cholesterol in the environment compared to control animals." [GO:0042632, WB:WBPaper00026641, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000725 ! lipid metabolism variant
is_a: WBPhenotype:0002525 ! diet response variant

[Term]
id: WBPhenotype:0001767
name: commissure handedness defective
def: "Outgrowth of the commissure occurs on the side of the body different from that observed in control animals." [WB:WBPaper00032007, WB:WBPerson712]
is_a: WBPhenotype:0000181 ! axon trajectory variant
is_a: WBPhenotype:0000384 ! axon guidance variant

[Term]
id: WBPhenotype:0001768
name: commissure number variant
def: "Variations in the quantity of circumferential axonal tracts from the number observed in control animals." [WB:WBPaper00032007, WB:WBPerson712]
synonym: "commissure number abnormal" NARROW []
is_a: WBPhenotype:0001226 ! commissure variant

[Term]
id: WBPhenotype:0001769
name: cytoplasmic RNAi defective
def: "Animals fail to silence cytoplasmic-localized RNAs. Nuclear-localized RNAs may still be sensitive to RNAi." [WB:WBPaper00032049, WB:WBPerson712]
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001770
name: endo siRNA binding variant
def: "Animals exhibit variations in their selective interactions with small interfering RNA molecules compared to control." [GO:0035197, WB:WBPaper00032049, WB:WBPerson712]
synonym: "endo siRNA binding abnormal" NARROW []
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001771
name: endo siRNA production variant
def: "Animals exhibit variations in the length or amount of any endogenous small interfering RNA molecule populations compared to control." [WB:WBPaper00031932, WB:WBPaper00032049, WB:WBPerson712]
synonym: "endo siRNA production abnormal" NARROW []
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001772
name: endogenous transposase levels increased
def: "Animals exhibit an increase in the levels of transposase mRNA, from endogenous transposons, over that measured in control animals." [WB:WBPaper00031962, WB:WBPerson712]
is_a: WBPhenotype:0000745 ! transposon silencing variant

[Term]
id: WBPhenotype:0001773
name: enhanced locomotion defective
def: "Animals do not exhibit an increase in speed when placed in an environment that relies on a combination of swimming and crawling behaviors compared to control." [WB:WBPaper00031965, WB:WBPerson712]
is_a: WBPhenotype:0001206 ! movement variant

[Term]
id: WBPhenotype:0001774
name: gut on the exterior
def: "An epidermal enclosure defect that results in internal organs lying on the outside of the embryo." [WB:WBPaper00005123, WB:WBPaper00032090, WB:WBPerson712]
synonym: "Gex" EXACT []
is_a: WBPhenotype:0000047 ! gastrulation variant

[Term]
id: WBPhenotype:0001775
name: hormetic temperature induced life span extension defective
def: "Pre-treatment with stress-inducing temperatures does not result in a life-span extension as it does in control animals." [WB:WBPaper00028750, WB:WBPaper00031942, WB:WBPerson712]
is_a: WBPhenotype:0000039 ! life span phenotype
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0001776
name: siRNA expression variant
def: "Variations in the biogenesis and stability of the small interfering class of RNA molecules compared to control. In C. elegans these molecules are antisense to mRNA's and may be processed from long double-stranded RNA." [GO:0016070, WB:WBPaper00028915, WB:WBPaper00031962, WB:WBPerson712]
synonym: "siRNA expression abnormal" NARROW []
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0001777
name: pre mRNA levels increased
def: "Animals exhibit an increase in the levels of nuclear mRNA species compared to control." [WB:WBPaper00032049, WB:WBPerson712]
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0001778
name: nuclear RNAi defective
def: "Animals fail to silence nuclear-localized RNAs. Animals still retain sensitivity to RNAi for those RNAs located outside of the nucleus." [WB:WBPaper00032049, WB:WBPerson712]
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001779
name: miRNA expression variant
def: "Variations in the biogenesis or stability of the microRNA class of molecules compared to control. In C. elegans these molecules are endogenous single-stranded regulatory molecules, 19-25 nucleotides long, with the potential to arise from hairpin, foldback, structures from their primary transcripts." [GO:0035196, WB:WBPaper00028915, WB:WBPaper00029181, WB:WBPaper00030747, WB:WBPaper00031962, WB:WBPerson712]
synonym: "miRNA expression abnormal" NARROW []
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0001780
name: associative learning variant
def: "Variations in the behavioral plasticity induced by the integration of two sensory signals compared to control. In C. elegans animals exhibit enhancement of butanone chemotaxis by preexposure to butanone and food." [WB:WBPaper00029060, WB:WBPerson2021]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0001781
name: hypersensitivity to mutagen
def: "Animals are more susceptible than control animals to the effects of a nucleic acid damaging agent. This increased susceptibility is often measured by an increase in the rate of spontaneous mutations or an increased lethality." [WB:WBPaper00031945, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0001782
name: anoxia response attenuated
def: "Response to trace levels of oxygen is reduced or weakened compared to the response of control animals." [WB:WBPaper00031981, WB:WBPerson712]
is_a: WBPhenotype:0002424 ! anoxia response variant

[Term]
id: WBPhenotype:0001783
name: ligand gated channel activity variant
def: "Animals exhibit variations in the actions of a channel that catalyses the transmembrane transfer of a cation when acetylcholine has been bound by the channel complex or one of its constituent parts compared to control animals." [GO:0022834, WB:WBPaper00031930, WB:WBPerson712]
synonym: "ligand gated channel activity abnormal" NARROW []
is_a: WBPhenotype:0000631 ! drug response variant
is_a: WBPhenotype:0000656 ! acetylcholine synaptic transmission variant
is_a: WBPhenotype:0001833 ! membrane trafficking variant

[Term]
id: WBPhenotype:0001784
name: obsolete lysosome homeostasis deficient
def: "OBSOLETE: Animals are deficient in the formation or disassembly of lysosomes." [GO:0007040, WB:WBPaper00029049, WB:WBPerson712]
is_obsolete: true
replaced_by: WBPhenotype:0002562

[Term]
id: WBPhenotype:0001785
name: associative memory defective
def: "Animals are deficient in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms." [WB:WBPaper00031974, WB:WBPerson712]
is_a: WBPhenotype:0002564 ! associative memory phenotype

[Term]
id: WBPhenotype:0001786
name: neuronal ion channel clustering defective
def: "Animals exhibit variations in the targeting, clustering and or maintenance of ion channels in distinct subcellular domains of the neuron compared to control animals." [GO:0045161, WB:WBPaper00031930, WB:WBPerson712]
is_a: WBPhenotype:0000612 ! nervous system physiology variant
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0001787
name: phototaxis defective
def: "Animals do not respond via directed movement to light stimuli in the same manner as control animals. In C. elegans, animals move away from light." [WB:WBPaper00031999, WB:WBPerson712]
is_a: WBPhenotype:0001897 ! light response variant

[Term]
id: WBPhenotype:0001788
name: resistant to mutagens
def: "Animals survive longer than control animals after or during exposure to DNA damaging agents." [WB:WBPaper00031934, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant
is_a: WBPhenotype:0000739 ! DNA damage response variant

[Term]
id: WBPhenotype:0001789
name: temperature influenced life span variant
def: "Life span of the animal is not influenced by changes in temperature in the same manner as control animals." [WB:WBPaper00031942, WB:WBPerson712]
synonym: "temperature independent life span" NARROW []
synonym: "temperature influenced life span abnormal" NARROW []
is_a: WBPhenotype:0000039 ! life span phenotype
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0001790
name: thermoreceptor currents absent
def: "Cooling or warming evoked changes in membrane currents are not observed." [WB:WBPaper00032060, WB:WBPerson712]
synonym: "ThRC absent" RELATED []
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0001791
name: defecation cycle temperature compensation variant
def: "Animals exhibit variations in temperature dependent differences in the length of their defecation cycle. In C. elegans the length of the cycle is the same at different temperatures, showing temperature compensation." [WB:WBPaper00002315, WB:WBPerson712]
synonym: "defecation cycle temperature compensation abnormal" NARROW []
is_a: WBPhenotype:0000207 ! defecation cycle variant

[Term]
id: WBPhenotype:0001792
name: nuclei small
def: "Nuclei of specific cells are smaller compared to control animals." [WB:WBPerson557]
synonym: "nuclear size decreased" EXACT []
is_a: WBPhenotype:0002607 ! nuclear size abnormal

[Term]
id: WBPhenotype:0001793
name: aboc expulsion missing
def: "The anterior body contraction and expulsion steps of the defecation cycle are absent; posterior body contractions are still present." [WB:WBPaper00002776, WB:WBPerson712]
synonym: "Aex" RELATED []
is_a: WBPhenotype:0000391 ! defecation missing motor steps

[Term]
id: WBPhenotype:0001794
name: cytoplasmic processing body variant
def: "Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control." [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712]
synonym: "cytoplasmic processing body abnormal" NARROW []
synonym: "P body abnormal" RELATED []
is_a: WBPhenotype:0001300 ! germ cell cytoplasmic morphology variant

[Term]
id: WBPhenotype:0001795
name: microsatellite instability
def: "Animals exhibit variations in repeat lengths of microsatellite genomic sequences compared to control." [WB:WBPaper00031859, WB:WBPerson712]
is_a: WBPhenotype:0000000 ! chromosome instability

[Term]
id: WBPhenotype:0001796
name: organism hypersensitive interstrand cross link agents
def: "Animals exhibit increased sensitivity to interstrand cross-linking agents, such as HN2 (nitrogen mustard) and CDDP (cisplatin) compared to control. In C. elegans, increased sensitivity to these agents is often observed as a decrease in survival compared to control animals after exposure to the agent." [WB:WBPaper00031868, WB:WBPerson712]
synonym: "interstrand cross link agent hypersensitive" RELATED []
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0001797
name: pachytene arrested germline nuclei
def: "Germline nuclei do not progress through pachytene to diplotene." [WB:WBPaper00031914, WB:WBPerson712]
is_a: WBPhenotype:0001946 ! pachytene progression during oogenesis variant

[Term]
id: WBPhenotype:0001798
name: inhibition of synaptogenesis defective
def: "The processes that inhibit the location or frequency of formation of synapses are downregulated resulting in the formation of synapses or synapse-like structures in areas of the neuron that are typically devoid of synapses in control animals." [GO:0051964, WB:WBPaper00032163, WB:WBPerson712]
is_a: WBPhenotype:0000625 ! synaptogenesis variant
is_a: WBPhenotype:0000944 ! neurite development variant

[Term]
id: WBPhenotype:0001799
name: inhibition of synaptogenesis hyperactive
def: "The processes that inhibit the location or frequency of formation of synapses are upregulated compared to control." [GO:0051964, WB:WBPaper00032163, WB:WBPerson712]
is_a: WBPhenotype:0000944 ! neurite development variant

[Term]
id: WBPhenotype:0001800
name: pathogen induced antimicrobial gene expression variant
def: "Changes in the levels of innate immune gene products in response to pathogen exposure are significantly different from that observed in control animals." [WB:WBPaper00031865, WB:WBPerson712]
synonym: "antimicrobial gene expression abnormal" NARROW []
is_a: WBPhenotype:0001857 ! pathogen induced gene expression variant
is_a: WBPhenotype:0002164 ! innate immune response variant
is_a: WBPhenotype:0002534 ! antimicrobial gene expression variant

[Term]
id: WBPhenotype:0001801
name: axodendritic polarity variant
def: "Animals fail to establish or maintain characteristics that delineate the dendrite from the axon. The exclusion of presynaptic components from the dendrite is one indication of axodendritic polarity." [WB:WBPaper00032163, WB:WBPerson712]
synonym: "axodendritic polarity abnormal" NARROW []
is_a: WBPhenotype:0000944 ! neurite development variant

[Term]
id: WBPhenotype:0001802
name: body wall muscle relaxation defective
def: "Animals fail to relax their body wall muscles to the same extent as muscles in control animals." [WB:WBPaper00032190, WB:WBPerson712]
is_a: WBPhenotype:0000596 ! body behavior variant

[Term]
id: WBPhenotype:0001803
name: endosome biogenesis variant
def: "Animals exhibit variations in the formation or disassembly of membrane bound organelles that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00032168, WB:WBPerson712]
synonym: "endosome biogenesis abnormal" NARROW []
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0001804
name: fat associated bodies reduced
def: "Animals exhibit a decrease in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by decreases in the number of Nile Red or BODIPY 493/503 staining bodies." [WB:WBPaper00032168, WB:WBPerson712]
synonym: "lipid body number reduced" RELATED []
is_a: WBPhenotype:0001901 ! fat associated bodies variant

[Term]
id: WBPhenotype:0001805
name: mitochondria vesiculated
def: "Inner membrane of mitochondria are disconnected and form vesicular bodies." [GO:0007005, WB:WBPaper00032231, WB:WBPerson712]
is_a: WBPhenotype:0001401 ! mitochondria morphology variant

[Term]
id: WBPhenotype:0001806
name: protein stabilization variant
def: "Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control." [WB:WBPaper00029085, WB:WBPerson2021]
synonym: "protein stabilization abnormal" NARROW []
is_a: WBPhenotype:0001644 ! protein metabolism variant

[Term]
id: WBPhenotype:0001807
name: alternative splicing variant
def: "Any variation in the process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition compared to control." [GO:0000380, WB:WBPerson557]
synonym: "alternative splicing abnormal" NARROW []
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0001808
name: cell corpse digestion variant
def: "The degradation of genomic and or cellular material of the corpse does not occur at the same rate or under the same conditions as observed in control animals undergoing cell death." [WB:WBPaper00032272, WB:WBPerson712]
synonym: "cell corpse digestion abnormal" NARROW []
is_a: WBPhenotype:0000885 ! engulfment variant

[Term]
id: WBPhenotype:0001809
name: organelle fusion defective
def: "The formation of mature intracellular compartments via membrane fusion is disrupted." [WB:WBPaper00032272, WB:WBPerson712]
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0001810
name: oocyte septum formation variant
def: "Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947]
synonym: "oocyte cellularization defective" RELATED []
synonym: "oocyte partition variant" RELATED []
synonym: "oocyte septum formation abnormal" NARROW []
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0001811
name: serotonin induced fat reduction variant
def: "Animals retain a significantly greater proportion of their fat upon serotonin treatment, compared to control." [WB:WBPaper00031915, WB:WBPerson2021]
synonym: "serotonin induced fat reduction abnormal" NARROW []
synonym: "serotonin induced fat regulation" RELATED []
is_a: WBPhenotype:0000024 ! serotonin resistant
is_a: WBPhenotype:0001232 ! serotonin response variant

[Term]
id: WBPhenotype:0001812
name: embryonic rupture
def: "During development of the embryo, the epidermis loses integrity and the contents of the embryo are expelled." [WB:WBPerson557]
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0001813
name: synapsis defective
def: "Animals exhibit defects in the stabilization of homologue pairing, which occurs through the initiation and formation of the synaptonemal complex, during meiosis." [WB:WBPaper00032296, WB:WBPerson712]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0001814
name: crossover defective
def: "Animals exhibit defects in the number or extent of connections between chromatids that occur during the process of genetic material exchange between homologous segments of non-sister chromatids." [GO:0051026, WB:WBPaper00032296, WB:WBPerson712]
synonym: "chiasma defective" RELATED []
synonym: "homologous recombination foci variant" RELATED []
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0001815
name: desynapsis defective
def: "Animals exhibit defects in the asymmetric diassembly of the synaptonemal complex during progression through meiosis." [WB:WBPaper00032296, WB:WBPerson712]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0001816
name: egg laying circuit variant
def: "Neuromuscular signaling between neurons and egg laying musculature varies from that observed for control animals." [WB:WBPaper00032221, WB:WBPerson712]
synonym: "egg laying circuit abnormal" NARROW []
is_a: WBPhenotype:0000929 ! hermaphrodite physiology variant

[Term]
id: WBPhenotype:0001817
name: enhanced taste aversion defective
def: "The conditioned aversion to a specific chemical compound as a result of that compound being coupled with an unfavorable condition, such as starvation, does not increase to the same extent as observed for control animals." [WB:WBPaper00032335, WB:WBPerson712]
synonym: "enhanced gustatory plasticity defective" RELATED []
synonym: "enhanced taste aversion defective" RELATED []
synonym: "starvation enhanced taste aversion defective" RELATED []
is_a: WBPhenotype:0000147 ! organism starvation response variant
is_a: WBPhenotype:0001444 ! aqueous adaptation defective

[Term]
id: WBPhenotype:0001818
name: neuron activation variant
def: "Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes." [WB:WBPaper00032221, WB:WBPerson712]
synonym: "neuron activation abnormal" NARROW []
synonym: "neuron activity abnormal" RELATED []
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0001819
name: pathogen load variant
def: "The number of pathogens associated with the animal vary from that associated with control animals." [WB:WBPaper00032196, WB:WBPerson712]
synonym: "bacterial load variant" NARROW []
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0001820
name: bordering
def: "Animals tend to accumulate at the thickest part of the bacterial lawn." [WB:WBPaper00003187, WB:WBPaper00032342, WB:WBPerson712]
synonym: "bordering increased" RELATED []
is_a: WBPhenotype:0000662 ! foraging behavior variant
is_a: WBPhenotype:0001291 ! social behavior variant

[Term]
id: WBPhenotype:0001821
name: non bordering
def: "Animals do not accumulate at the thickest part of the bacterial lawn. Animals do not preferentially deplete bacterial food at the thicker parts of the lawn." [WB:WBPaper00032342, WB:WBPerson712]
is_a: WBPhenotype:0000662 ! foraging behavior variant
is_a: WBPhenotype:0001291 ! social behavior variant

[Term]
id: WBPhenotype:0001822
name: dauer pheromone secretion variant
def: "Animals produce pheromone but it does not undergo controlled release into the environment." [WB:WBPaper00032517, WB:WBPerson712]
is_a: WBPhenotype:0000258 ! cell secretion variant
is_a: WBPhenotype:0000609 ! excretory secretory system physiology variant

[Term]
id: WBPhenotype:0001823
name: sperm recruitment variant
def: "Any variation in the mechanism by which sperm find their correct target destinations (spermatheca)." [WB:WBPaper00028527, WB:WBPerson2021]
is_a: WBPhenotype:0001424 ! oocyte physiology variant

[Term]
id: WBPhenotype:0001824
name: meiotic progression prophase variant
def: "Animals exhibit variations in any process necessary for the progression through prophase during meiosis compared to control animals." [WB:WBPaper00005486, WB:WBPerson557]
is_a: WBPhenotype:0000313 ! meiotic progression during oogenesis variant
is_a: WBPhenotype:0000775 ! meiosis variant

[Term]
id: WBPhenotype:0001825
name: rudimentary gonad
def: "Animals have very few or no germline nuclei and gonad arms that are very small or missing." [WB:WBPaper00005486, WB:WBPerson557]
is_a: WBPhenotype:0001355 ! gonad morphology variant

[Term]
id: WBPhenotype:0001826
name: RNA degradation variant
def: "Variations in the regulated breakdown of RNA species via the action of cellular enzymes (RNases) compared to control." [WB:WBPaper00032091, WB:WBPerson2021]
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0001827
name: RNA metabolism variant
def: "Variations in any process that involves the maintenance, biosynthesis or accumulation of RNA in the organism compared to control." [WB:WBPaper00004325, WB:WBPerson2021]
is_a: WBPhenotype:0000463 ! metabolic pathway variant
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0001828
name: RNAi persistence variant
def: "Variations in the persistence of an RNAi induced phenotype compared to control." [WB:WBPaper00004325, WB:WBPerson2021]
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0001829
name: premature spermatid activation
def: "Any variation that results in the premature differentiation of spermatids into motile spermatozoa compared to control." [WB:WBPaper00033007, WB:WBPerson2021]
is_a: WBPhenotype:0000670 ! spermatogenesis variant

[Term]
id: WBPhenotype:0001830
name: response to multiple stressors variant
def: "Any variation in an animal's response to exposure to multiple stressors occuring simultaneously or during an overlapping temporal window compared to control." [WB:WBPaper00031874, WB:WBPerson2021]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0001831
name: intestinal microvilli variant
def: "Any variation in the formation of intestinal microvilli. Microvilli are actin-based cellular structures that form plasma membrane projections into the extracellular space and whose specialized shape provides increased cellular surface area. Microvilli are a crucial component of the terminal differentiation process for many epithelial cell types, usually ones that play an absorptive or filtering role." [WB:WBPaper00025171, WB:WBPerson557]
is_a: WBPhenotype:0000705 ! intestinal cell development variant

[Term]
id: WBPhenotype:0001832
name: nuclear pore variant
def: "Any variation that disrupts the assembly, distribution, localization or organization of any of the numerous similar discrete openings in the nuclear envelope, where the inner and outer nuclear membranes are joined." [GO:0005643, WB:WBPerson557]
is_a: WBPhenotype:0002037 ! nuclear envelope organization variant

[Term]
id: WBPhenotype:0001833
name: membrane trafficking variant
def: "Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control." [GO:0005215, WB:WBPaper00025137, WB:WBPerson2021]
synonym: "membrane transport variant" RELATED []
synonym: "transporter activity variant" RELATED []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001834
name: mRNA splicing variant
def: "Variations in the processes regulating the excision of intervening introns from the primary mRNA transcript, compared to control." [GO:0008380, WB:WBPaper00032287, WB:WBPerson2021]
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0001835
name: energy expenditure variant
def: "Variations in the amount of energy consumed by an organism compared to control. Energy expenditure is often determined by assaying oxygen consumption." [WB:WBPaper00032936, WB:WBPerson2021]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001836
name: eggshell morphology variant
def: "Any variation in the overall structure or appearance of the protective barrier which isolates the embryo from the external environment, compared to control ." [WB:WBPaper00033072, WB:WBPerson2021]
is_a: WBPhenotype:0000037 ! egg morphology variant

[Term]
id: WBPhenotype:0001837
name: diet induced life span variant
def: "Life span of the animal is not influenced by changes in diet in the same manner as control animals." [WB:WBPaper00032936, WB:WBPerson2021]
is_a: WBPhenotype:0000039 ! life span phenotype
is_a: WBPhenotype:0002525 ! diet response variant

[Term]
id: WBPhenotype:0001838
name: drug induced gene expression variant
def: "Gene expression of an animal is not influenced by drug treatment in the same manner as control animals." [WB:WBPaper00033094, WB:WBPerson2021]
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0001839
name: phorbol ester resistant
def: "Animals fail to respond to the concentration of phorbol esters that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Phorbol esters such as PMA act as DAG mimetics." [WB:WBPaper00033094, WB:WBPerson2021]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0001840
name: response to injury variant
def: "Variations in the processes that restore integrity to a damaged tissue following an injury, compared to control." [GO:0042060, WB:WBPaper00033094, WB:WBPerson2021]
synonym: "wound healing variant" RELATED []
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0001841
name: second messenger mediated signaling variant
def: "Any variation in a series of molecular signals that help relay a receptor mediated signal within the cell, compared to control. Second messengers often comprise of ions (eg: Ca2+) or small molecules (cGMP, cAMP etc) that are formed or released into the cytosol." [GO:0019932, WB:WBPaper00033456, WB:WBPerson2021]
is_a: WBPhenotype:0000463 ! metabolic pathway variant

[Term]
id: WBPhenotype:0001842
name: drug withdrawal response variant
def: "Any variation in the state or activity of an organism as a result of abrupt discontinuation or decreased dosage of a drug, compared to control." [WB:WBPaper00033168, WB:WBPerson2021]
synonym: "rebound response defective" RELATED []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001843
name: hormone metabolism variant
def: "Animals exhibit variations in any process that involves the degradation, biosynthesis or accumulation of hormones within the organism compared to control. Hormones are naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GO:0042445, WB:WBPaper00034639, WB:WBPerson2021]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001844
name: lipid hydrolysis regulation variant
def: "Variations in the process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids, compared to control." [GO:0050994, WB:WBPaper00033126, WB:WBPerson2021]
synonym: "fat granule regulated breakdown variant" RELATED []
synonym: "fat granule regulated hydrolysis variant" RELATED []
synonym: "lipid lysis regulation variant" RELATED []
synonym: "regulation of lipid catabolic process variant" RELATED []
is_a: WBPhenotype:0000725 ! lipid metabolism variant

[Term]
id: WBPhenotype:0001845
name: lipid modification variant
def: "Variations in the covalent alteration of one or more components (eg: fatty acids, sterols etc.) in a lipid, resulting in a change in the properties of the lipid, compared to control." [GO:0030258, WB:WBPaper00034639, WB:WBPerson2021]
is_a: WBPhenotype:0000725 ! lipid metabolism variant

[Term]
id: WBPhenotype:0001846
name: phagosome maturation defective
def: "Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes." [GO:0001845, WB:WBPaper00031805, WB:WBPerson2021]
is_a: WBPhenotype:0000885 ! engulfment variant

[Term]
id: WBPhenotype:0001847
name: sterol induced dauer formation variant
def: "Variations in the processes that facilitate/permit dauer entry when exposed to specific sterol molecules, compared to control." [WB:WBPaper00034639, WB:WBPerson2021]
is_a: WBPhenotype:0001539 ! dauer induction variant

[Term]
id: WBPhenotype:0001848
name: tube morphogenesis variant
def: "Variations in the process by which the anatomical structures of a tube are generated and organized, compared to control. Morphogenesis pertains to the creation of form or shape." [GO:0035239, WB:WBPaper00033081, WB:WBPerson2021]
synonym: "tubulogenesis variant" RELATED []
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0001849
name: zinc homeostasis variant
def: "Variations in the regulation of levels, transport, and metabolism of zinc ions within an organism compared to control." [GO:0006882, WB:WBPaper00033166, WB:WBPerson2021]
is_a: WBPhenotype:0002029 ! metal homeostasis variant

[Term]
id: WBPhenotype:0001850
name: radiation induced germ cell apoptosis variant
def: "Programmed cell death of germ cells caused by exposure to ionizing energy does not occur to the same extent as it does in control animals." [WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson712]
is_a: WBPhenotype:0000737 ! germ cell resistant ionizing radiation
is_a: WBPhenotype:0002152 ! mutagen induced apoptosis variant

[Term]
id: WBPhenotype:0001851
name: radiation induced reproductive cell death variant
def: "Animals exhibit variations in radiation induced non-apoptotic death of multipotential precursor cells or tissues (clonogens) compared to control. Elimination of clonogens results in normal tissue damage as well as solid-tumor eradication." [WB:WBPaper00027700, WB:WBPerson2021]
is_a: WBPhenotype:0001173 ! non apoptotic cell death variant
is_a: WBPhenotype:0001268 ! induced cell death variant

[Term]
id: WBPhenotype:0001852
name: antihelmintic response variant
def: "Animals exhibit variations in their response to an agent that destroys or causes the expulsion of parasitic intestinal worms compared to that observed in control animals." [WB:WBPaper00035074, WB:WBPerson2021]
is_a: WBPhenotype:0000459 ! pesticide response variant

[Term]
id: WBPhenotype:0001853
name: AAD response variant
def: "Animals exhibit variations in their response to the amino-acetonitrile derivatives (AADs) class of synthetic anthelmintics, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPerson2021]
is_a: WBPhenotype:0001852 ! antihelmintic response variant

[Term]
id: WBPhenotype:0001854
name: benomyl response variant
def: "Animals exhibit variations in their response to the microtubule-depolymerizing drug benomyl, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPerson2021]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001855
name: fluoride resistant
def: "Animals fail to respond to the concentration of fluoride ions that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to fluoride ions to elicit the response compared to control animals." [WB:WBPaper00035174, WB:WBPerson2021]
is_a: WBPhenotype:0001502 ! chemical resistant

[Term]
id: WBPhenotype:0001856
name: ivermectin response variant
def: "Animals exhibit variations in their response to ivermectin, an agonist of glutamate-gated chloride channels, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPaper00035194, WB:WBPerson2021]
is_a: WBPhenotype:0000631 ! drug response variant
is_a: WBPhenotype:0001852 ! antihelmintic response variant

[Term]
id: WBPhenotype:0001857
name: pathogen induced gene expression variant
def: "Gene expression of an animal is not influenced by the exposure to disease causing agents in the same manner as control animals." [WB:WBPaper00035315, WB:WBPerson2021]
is_a: WBPhenotype:0000717 ! gene expression variant
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0001858
name: suppression of head oscillations defective
def: "Animals fail to suppress head oscillations in response to anterior touch. In C. elegans, this behavior is a result of tyraminergic signaling." [WB:WBPaper00031692, WB:WBPaper00034683, WB:WBPerson2021]
synonym: "Sho" RELATED [WB:WBPaper00025096]
is_a: WBPhenotype:0000595 ! head behavior variant

[Term]
id: WBPhenotype:0001859
name: Dosage compensation complex assembly variant
def: "Any variation in the aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes, compared to control." [GO:0042714, WB:WBPaper00035328, WB:WBPerson2021]
comment: Possible xp.
synonym: "DCC localization variant" RELATED []
is_a: WBPhenotype:0000718 ! dosage compensation variant

[Term]
id: WBPhenotype:0001860
name: endocytic recycling defective
def: "Variations in the directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport, compared to control." [GO:0032456, WB:WBPaper00035466, WB:WBPerson2021]
is_a: WBPhenotype:0001422 ! endocytic transport defect

[Term]
id: WBPhenotype:0001861
name: environmental stimuli induced gene expression variant
def: "Gene expression of an animal is not influenced by environmental changes in the same manner as control animals." [WB:WBPaper00035435, WB:WBPerson2021]
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0001862
name: manganese homeostasis variant
def: "Variations in the regulation of levels, transport, and metabolism of manganese ions within an organism compared to control." [GO:0030026, WB:WBPaper00035485, WB:WBPerson2021]
comment: Possible XP.
is_a: WBPhenotype:0002029 ! metal homeostasis variant

[Term]
id: WBPhenotype:0001863
name: manganese response variant
def: "Animals exhibit variations in their response to manganese compared to that observed in control animals." [GO:0010042, WB:WBPaper00035485, WB:WBPerson2021]
comment: Possible XP.
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0001864
name: protein transport variant
def: "Any variation in the processes that modulate the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore compared to control." [GO:0051223, WB:WBPaper00035491, WB:WBPerson2021]
comment: Possible XP.
is_a: WBPhenotype:0001644 ! protein metabolism variant
is_a: WBPhenotype:0001833 ! membrane trafficking variant

[Term]
id: WBPhenotype:0001865
name: protein ubiquitination variant
def: "Variations in the process by which one or more ubiquitin moieties are added to a protein, compared to control." [GO:0016567, WB:WBPaper00035602, WB:WBPerson2021]
comment: Possible XP.
synonym: "protein ubiquitylation variant" RELATED []
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0001866
name: reduced pathogen accumulation
def: "Animals exhibit a reduction in pathogen accumulation, persistent colonization, and luminal distension of the intestine." [GO:0009617, GO:0045087, WB:WBPaper00035215, WB:WBPerson2987]
synonym: "Rpa" RELATED []
is_a: WBPhenotype:0001819 ! pathogen load variant

[Term]
id: WBPhenotype:0001867
name: mitotic spindle asters defective early emb
def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a mitotic cell cycle." [WB:WBPaper00032910, WB:WBPerson2987]
is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb
is_a: WBPhenotype:0001110 ! aster defective early emb

[Term]
id: WBPhenotype:0001868
name: meiotic spindle defective
def: "Cells undergoing meiosis exhibit defects in the overall function or activity of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987]
is_a: WBPhenotype:0000775 ! meiosis variant

[Term]
id: WBPhenotype:0001869
name: meiotic spindle positioning defective
def: "Cells undergoing meiosis exhibit defects in the positioning of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987]
is_a: WBPhenotype:0001868 ! meiotic spindle defective

[Term]
id: WBPhenotype:0001870
name: meiotic spindle rotation defective
def: "Cells undergoing meiosis exhibit defects in the rotation of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987]
is_a: WBPhenotype:0001868 ! meiotic spindle defective

[Term]
id: WBPhenotype:0001871
name: drug induced life span variant
def: "Life span of the animal is not influenced by drug exposure in the same manner as control animals." [WB:WBPaper00035656, WB:WBPerson2021]
is_a: WBPhenotype:0000039 ! life span phenotype
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001872
name: drug induced locomotion variant
def: "Locomotion of the animal is not influenced by drug exposure in the same manner as control animals." [WB:WBPaper00035656, WB:WBPerson2021]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001873
name: meiotic spindle assembly defective
def: "Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the meiotic spindle, the array of microtubules and associated molecules that serves to move duplicated and/or homologous chromosomes apart." [WB:WBPaper00032910, WB:WBPerson2987]
is_a: WBPhenotype:0001868 ! meiotic spindle defective

[Term]
id: WBPhenotype:0001874
name: protein neddylation variant
def: "Any variation in the conjugation of the ubiquitin-like protein Nedd8 to another protein compared to control." [GO:0045116, WB:WBPerson2021, WB:WBPerson557]
comment: Possible XP.
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0001875
name: anaphase bridging
def: "Chromosomal masses fail to fully separate and remained linked during anaphase." [WB:WBPerson2021, WB:WBPerson557]
synonym: "chromosome bridging" RELATED []
synonym: "lagging chromatin" RELATED []
is_a: WBPhenotype:0001378 ! mitotic chromosome segregation variant

[Term]
id: WBPhenotype:0001876
name: centriole biogenesis variant
def: "Any variation in the formation or disassembly of the cylindrical structures that are composed of groupings of microtubules found close to the nucleus (centrioles) compared to control. Centrioles are arranged perpendicularly and are surrounded by an amorphous mass of dense material (the pericentriolar material). The centrioles and the pericentriolar material constitute the compound structure known as the centrosome." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0001903 ! centrosome biogenesis variant

[Term]
id: WBPhenotype:0001877
name: nuclear membrane morphology variant
def: "Any variation in the structure, form or composition of the membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated, compared to control." [GO:0005634, WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0002037 ! nuclear envelope organization variant

[Term]
id: WBPhenotype:0001878
name: hydroxyurea response variant
def: "Animals exhibit variations in the response to the addition of hydroxyurea compared to that observed in control animals. Hydroxyurea stops DNA from being replicated." [WB:WBPerson2021, WB:WBPerson557]
synonym: "HU response variant" RELATED []
synonym: "hydroxycarbamide response variant" RELATED []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0001879
name: hydroxyurea hypersensitive
def: "Animals respond to hydroxyurea at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive
is_a: WBPhenotype:0001878 ! hydroxyurea response variant

[Term]
id: WBPhenotype:0001880
name: endoplasmic reticulum morphology variant
def: "Any variation in the form, structure or composition of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GO:0005783, WB:WBPaper00025163, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0001881
name: endoplasmic reticulum symmetry variant early emb
def: "Any variation in the normally asymmetric distribution of the endoplasmic reticulum during cell divisions of the early embryo. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [WB:WBPaper00025163, WB:WBPerson2987]
is_a: WBPhenotype:0001880 ! endoplasmic reticulum morphology variant

[Term]
id: WBPhenotype:0001882
name: aneuploidy
def: "Any variation in the number of chromosomes in a cell compared to control." [WB:WBPaper00032450, WB:WBPerson2987]
is_a: WBPhenotype:0000773 ! chromosome segregation variant

[Term]
id: WBPhenotype:0001885
name: cleavage furrow initiation defective early emb
def: "Embryos exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [WB:WBPaper00024200, WB:WBPerson2987]
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0001886
name: cleavage furrow termination defective early emb
def: "Embryos exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis." [WB:WBPaper00024200, WB:WBPerson2987]
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0001887
name: excess seam cells
def: "Animals execute supernumerary cell divisions during the development of the lateral, alae-producing epithelial cells, resulting in a larger number of these cells than control animals." [WB:WBPaper00032974, WB:WBPerson2987]
is_a: WBPhenotype:0002175 ! cell number increased
is_a: WBPhenotype:0002569 ! hypodermis development variant

[Term]
id: WBPhenotype:0001888
name: fat associated bodies increased
def: "Animals exhibit an increase in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by increases in the number of BODIPY 493/503 staining." [WB:WBPaper00035972, WB:WBPerson2021]
synonym: "lipid body number increased" RELATED []
synonym: "lipid droplet expansion" RELATED []
is_a: WBPhenotype:0001901 ! fat associated bodies variant

[Term]
id: WBPhenotype:0001889
name: body wall muscle sarcomere morphology variant
def: "Any variation in the form, structure or composition of the repeating units of a myofibrils in a muscle cell that are composed of an array of overlapping thick and thin filaments, compared to control." [GO:0030017, WB:WBPerson557]
is_a: WBPhenotype:0000926 ! body wall muscle morphology variant

[Term]
id: WBPhenotype:0001890
name: body wall muscle dense body variant
def: "Any variation in the attachment plaque for thin filaments onto the cell membrane. The dense body in body wall muscles is especially large, indenting far into the cytoplasm to border each sarcomere, thus providing a long row of coherent attachment sites at regular intervals (WormAtlas)." [WB:WBPerson557]
is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant

[Term]
id: WBPhenotype:0001891
name: M line variant
def: "Animals exhibit variations in the form, structure or composition of a planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas)." [WB:WBPerson557]
is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant

[Term]
id: WBPhenotype:0001892
name: glycogen levels variant
def: "Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls." [WB:WBPaper00033086, WB:WBPerson2987]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001893
name: mitochondrial membrane potential reduced
def: "Any reduction in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control." [WB:WBPaper00033162, WB:WBPerson2987]
is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant

[Term]
id: WBPhenotype:0001894
name: nuclear number variant
def: "Animals exhibit variations in the number of nuclei contained in a particular cell type compared to control." [WB:WBPaper00033438, WB:WBPerson2987]
is_a: WBPhenotype:0000504 ! nuclear division variant

[Term]
id: WBPhenotype:0001895
name: parental chromosome mixing defective
def: "Parental chromosomes fail to undergo appropriate mixing upon pronuclear fusion resulting in a zygotic nucleus in which parental genomes remain segregated." [GO:0007344, WB:WBPerson2987]
synonym: "pronuclear fusion defective" RELATED []
is_a: WBPhenotype:0001138 ! nucleus defective early emb

[Term]
id: WBPhenotype:0001896
name: gamma ray induced apoptosis decreased
def: "Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control." [WB:WBPaper00036343, WB:WBPerson2021]
is_a: WBPhenotype:0000182 ! apoptosis reduced
is_a: WBPhenotype:0001326 ! cell gamma ray response variant

[Term]
id: WBPhenotype:0001897
name: light response variant
def: "Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus (electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light) compared to control." [GO:0009416, WB:WBPaper00032087, WB:WBPerson2021]
synonym: "Lite" RELATED []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0001898
name: meiotic sister chromatid segregation variant
def: "Variations in the process by which sister chromatids, identical chromosomes resulting from DNA replication, are physically separated during the meiotic cell cycle, compared to control." [WB:WBPaper00034684, WB:WBPerson2987]
is_a: WBPhenotype:0001499 ! meiotic chromosome segregation variant

[Term]
id: WBPhenotype:0001899
name: glutathione levels variant
def: "Animals exhibit variations in the amount of glutathione compared to control animals at a defined stage. Glutathione, the tripeptide glutamylcysteinylglycine, acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GO:0006749, WB:WBPerson557]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0001900
name: reduced levels of reduced glutathione
def: "Animals exhibit a decrease in the cellular levels of reduced glutathione (GSH), compared to control. Reduced levels of GSH may be an indication of susceptibility to oxidative stress." [WB:WBPaper00034717, WB:WBPerson2987]
synonym: "reduced levels of GSH" RELATED []
is_a: WBPhenotype:0001899 ! glutathione levels variant

[Term]
id: WBPhenotype:0001901
name: fat associated bodies variant
def: "Animals exhibit variations in the formation or disassembly of fat containing organelles compared to control." [WB:WBPerson557]
synonym: "lipid body variant" RELATED []
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0001902
name: fat associated body size increased
def: "Animals exhibit an increase in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining." [WB:WBPaper00034742, WB:WBPerson2987]
synonym: "lipid body size increased" RELATED []
is_a: WBPhenotype:0001901 ! fat associated bodies variant

[Term]
id: WBPhenotype:0001903
name: centrosome biogenesis variant
def: "Animals exhibit variations in the formation, maturation or disassembly of the centrosome (a subcellular body consisting of two centrioles embedded in a protein matrix).  The centrosome serves as a microtubule organizing center as well as a regulator of cell-cycle progression." [WB:WBPerson557]
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0001904
name: manganese toxicity resistant
def: "Animals fail to exhibit toxicity to the concentration of manganese that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to manganese include dopamine (DA) neuron neurodegeneration." [WB:WBPaper00035259, WB:WBPerson557]
is_a: WBPhenotype:0001863 ! manganese response variant

[Term]
id: WBPhenotype:0001905
name: fewer eggs laid
def: "Animals lay fewer total number of eggs over the lifetime of the animal." [WB:WBPaper00035252, WB:WBPerson2987]
is_a: WBPhenotype:0000640 ! egg laying variant

[Term]
id: WBPhenotype:0001906
name: hypodermal cell elongation defective
def: "During epidermal morphogenesis, hypodermal cells do not properly undergo the characteristic cell shape changes necessary for the embryo to elongate." [WB:WBPaper00003991, WB:WBPerson712]
is_a: WBPhenotype:0002569 ! hypodermis development variant

[Term]
id: WBPhenotype:0001907
name: dorsal intercalation defective
def: "Animals exhibit defects in the generation of the dorsal epithelial sheet, which entails distinct cell shape changes and movements to affect the interdigitation of two rows of dorsal cells resulting in a single row of cells across the dorsal midline." [WB:WBPaper00003991, WB:WBPerson712]
is_a: WBPhenotype:0002569 ! hypodermis development variant

[Term]
id: WBPhenotype:0001908
name: ventral closure defective
def: "The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo." [WB:WBPaper00003991, WB:WBPerson712]
is_a: WBPhenotype:0001566 ! ventral enclosure variant

[Term]
id: WBPhenotype:0001909
name: obsolete translational repression variant
def: "OBSOLETE. Any variation in the prevention of mRNA translation that normally occurs in certain cells, compared to control." [WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0002157

[Term]
id: WBPhenotype:0001910
name: kinetochore organization variant
def: "Animals exhibit variations in the assembly, arrangement, orientation, or disassembly of the kinetochore, a multisubunit protein complex on chromosomes where the spindle fibers attach during cell division to pull the chromosomes apart." [GO:0051383, WB:WBPaper00035270, WB:WBPerson557]
comment: Possible XP.
is_a: WBPhenotype:0001348 ! chromosome morphology variant

[Term]
id: WBPhenotype:0001911
name: axon regeneration defective
def: "Animals do not regrow axons following axon loss or damage, to the same extent, or in the same manner as observed in control animals." [WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000880 ! axon development variant

[Term]
id: WBPhenotype:0001912
name: fewer coelomocytes
def: "The number of coelomocytes are reduced compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds." [WB:WBPaper00035290, WB:WBPerson2987]
is_a: WBPhenotype:0000618 ! coelomic system development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001913
name: excess coelomocytes
def: "The number of coelomocytes are increased compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds." [WB:WBPaper00035290, WB:WBPerson2987]
is_a: WBPhenotype:0000618 ! coelomic system development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001914
name: fewer pharyngeal cells
def: "Animals contain fewer pharyngeal cells compared to control animals.  In C. elegans, pharyngeal cells are derived from MS-blastomere." [WB:WBPaper00035290, WB:WBPerson2987]
is_a: WBPhenotype:0000707 ! pharyngeal development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001915
name: mRNA expression ectopic
def: "Any variation that results in the cellular expression of an mRNA in cells/tissues, that is otherwise not observed in control animals." [WB:WBPaper00035290, WB:WBPerson2987]
is_a: WBPhenotype:0000114 ! mRNA expression variant

[Term]
id: WBPhenotype:0001916
name: increased pathogen survival
def: "Pathogens internally associated with the animal exhibit an increase in survival compared to control animals." [WB:WBPaper00035289, WB:WBPerson2987]
is_a: WBPhenotype:0001819 ! pathogen load variant

[Term]
id: WBPhenotype:0001917
name: protein acetylation variant
def: "Variations in the processes that incorporate acetyl groups to one or more amino acids within a protein, compared to control. An acetyl group is CH3CO-." [GO:0006473, WB:WBPaper00025192, WB:WBPerson557]
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0001918
name: chemical hypersensitive
def: "Animals respond to a specific chemical at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0001919
name: gut granules enlarged
def: "Animals exhibit larger inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPaper00035924, WB:WBPerson2987]
is_a: WBPhenotype:0002240 ! gut granule morphology variant

[Term]
id: WBPhenotype:0001920
name: twisted pharynx
def: "The growth of pharyngeal components occurs in a radial fashion around the longitudinal axis of the worm as demonstrated by bent radial contractile arrays within the pharyngeal muscle cells. The defect is more pronounced as development progresses resulting in a more obvious twisting phenotype. Depending on the allele, the twist can be right-handed or left-handed" [WB:WBPaper00030736, WB:WBPerson712]
synonym: "pharynx twisted" RELATED []
synonym: "Twp" RELATED []
is_a: WBPhenotype:0000707 ! pharyngeal development variant

[Term]
id: WBPhenotype:0001921
name: meiotic DNA double strand break formation variant
def: "Any variation in the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination." [GO:0042138, WB:WBPerson557]
comment: Possible XP.
is_a: WBPhenotype:0000775 ! meiosis variant

[Term]
id: WBPhenotype:0001922
name: axonal transport variant
def: "Any variation in the directed movement of organelles or molecules along microtubules in nerve cell axons." [GO:0008088, WB:WBPerson557]
comment: Possible XP.
synonym: "axon cargo transport variant" RELATED []
synonym: "axon transport variant" EXACT []
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0001923
name: fewer seam cells
def: "The population of the lateral, alae-producing epithelial cells (seam cells) is reduced compared to control animals." [WB:WBPaper00034768]
is_a: WBPhenotype:0002174 ! cell number decreased
is_a: WBPhenotype:0002569 ! hypodermis development variant

[Term]
id: WBPhenotype:0001924
name: oocytes stacked
def: "Oocytes are found one on top of the other in the dorsal to ventral orientation in the gonad." [WB:WBPerson557]
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0001925
name: oocytes disorganized
def: "Oocytes are no longer arranged in the gonad in the same manner as control animals." [WB:WBPerson557]
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0001926
name: gonad sheath contraction rate increased
def: "Basal contraction rate and or peak contraction rate of the gonadal sheath is increased relative to control animals." [WB:WBPaper00027739, WB:WBPerson2987]
is_a: WBPhenotype:0001199 ! gonad sheath contractions variant

[Term]
id: WBPhenotype:0001927
name: extra distal tip cells
def: "Animals produce an excess number of distal tip cells compared to controls." [WB:WBPaper00033102, WB:WBPerson2987]
is_a: WBPhenotype:0001656 ! distal tip cell development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001928
name: extra gonad arms
def: "Animals produce an excess number of gonad arms compared to controls." [WB:WBPaper00033102, WB:WBPerson2987]
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0001929
name: linker cell absent
def: "The gonads of male animals do not produce the linker cell involved in guiding the developing male gonad to the sex organs in the male tail." [WB:WBPaper00033102, WB:WBPerson2987]
is_a: WBPhenotype:0001675 ! male gonad development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001930
name: muscle arm development defective
def: "Animals extend altered or fewer numbers of dorsal and or ventral muscle arms compared to control animals." [WB:WBPaper00032907, WB:WBPerson712]
synonym: "Madd" RELATED []
synonym: "muscle arm extension defective" RELATED []
is_a: WBPhenotype:0000540 ! muscle arm development variant

[Term]
id: WBPhenotype:0001931
name: muscle arm axon connection variant
def: "The morphology or number of connections between muscle arms and commissural motor axons varies from control animals." [WB:WBPaper00032907, WB:WBPerson712]
is_a: WBPhenotype:0000540 ! muscle arm development variant

[Term]
id: WBPhenotype:0001932
name: myopodia present
def: "Animals exhibit ectopic plasma membrane extensions from muscle, these extensions are random projections that are thinner than the typical muscle arm." [WB:WBPaper00032907, WB:WBPerson712]
is_a: WBPhenotype:0000904 ! muscle cell morphology variant

[Term]
id: WBPhenotype:0001933
name: synaptic vesicle tag abnormal in mechanosensory neurons
def: "The pattern of localization of presynaptic markers is disrupted compared to control animals." [WB:WBPaper00035070, WB:WBPerson712]
synonym: "Sam" RELATED []
is_a: WBPhenotype:0000847 ! presynaptic component localization variant

[Term]
id: WBPhenotype:0001934
name: vulval muscle extension variant
def: "Any variation in the extension of vulval muscles compared to control.  In C. elegans contralateral vulval muscles fail to meet at the midline." [WB:WBPaper00036485, WB:WBPerson712]
synonym: "Vme" RELATED []
is_a: WBPhenotype:0001314 ! vulval muscle variant

[Term]
id: WBPhenotype:0001935
name: protein aggregation induced paralysis
def: "Animals become paralyzed in response to aggregation of proteins like poly-glutamine or beta-amyloid." [WB:WBPaper00033115, WB:WBPerson2987]
is_a: WBPhenotype:0002425 ! protein aggregation induced behavior variant

[Term]
id: WBPhenotype:0001936
name: resistant to protein aggregation induced paralysis
def: "Animals fail to respond to the aggregation of proteins that elicits a paralysis response in control animals." [WB:WBPaper00033115, WB:WBPerson2987]
is_a: WBPhenotype:0001935 ! protein aggregation induced paralysis

[Term]
id: WBPhenotype:0001937
name: hypersensitive to protein aggregation induced paralysis
def: "Animals respond to protein aggregation at a lower concentration of aggregates or in less time compared to control animals." [WB:WBPaper00033115, WB:WBPerson2987]
is_a: WBPhenotype:0001935 ! protein aggregation induced paralysis

[Term]
id: WBPhenotype:0001938
name: DNA repair variant
def: "Any variation in the process of restoring DNA after damage.  DNA damage can be caused by a many chemical or physical agents, and this damage is repaired by a variety  of different DNA repair pathways." [GO:0006281, WB:WBPerson557]
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0001939
name: bitter tastant response variant
def: "Animals are not repelled by bitter tastants such as quinine, primaquine quinacrine etc., to the same extent as control animals." [WB:WBPaper00035961, WB:WBPerson712]
is_a: WBPhenotype:0001450 ! aqueous negative chemotaxis variant

[Term]
id: WBPhenotype:0001940
name: rachis morphology variant
def: "Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557]
synonym: "rachis morphology abnormal" RELATED []
is_a: WBPhenotype:0001355 ! gonad morphology variant

[Term]
id: WBPhenotype:0001941
name: rachis narrow
def: "The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001940 ! rachis morphology variant

[Term]
id: WBPhenotype:0001942
name: rachis absent
def: "The nucleus-free core of germline cytoplasm in the gonad is missing." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001940 ! rachis morphology variant

[Term]
id: WBPhenotype:0001943
name: rachis wide
def: "The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001940 ! rachis morphology variant

[Term]
id: WBPhenotype:0001944
name: oocyte number decreased
def: "A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557]
synonym: "fewer oocytes" RELATED []
is_a: WBPhenotype:0000186 ! oogenesis variant
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0001945
name: oocytes small
def: "The size of haploid female germ cells (oocytes) are significantly smaller compared to control." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0001946
name: pachytene progression during oogenesis variant
def: "Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GO:0000239, WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001824 ! meiotic progression prophase variant

[Term]
id: WBPhenotype:0001947
name: diplotene progression during oogenesis variant
def: "Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001824 ! meiotic progression prophase variant

[Term]
id: WBPhenotype:0001948
name: diakinesis progression during oogenesis variant
def: "Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GO:0000241, WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001824 ! meiotic progression prophase variant

[Term]
id: WBPhenotype:0001949
name: diakinesis region organization variant
def: "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001355 ! gonad morphology variant
is_a: WBPhenotype:0001948 ! diakinesis progression during oogenesis variant

[Term]
id: WBPhenotype:0001950
name: diplotene region organization variant
def: "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001355 ! gonad morphology variant
is_a: WBPhenotype:0001947 ! diplotene progression during oogenesis variant

[Term]
id: WBPhenotype:0001951
name: pachytene region organization variant
def: "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas)." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001355 ! gonad morphology variant
is_a: WBPhenotype:0001946 ! pachytene progression during oogenesis variant

[Term]
id: WBPhenotype:0001952
name: germline nuclear positioning variant
def: "Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
synonym: "germline nuclear migration variant" RELATED []
is_a: WBPhenotype:0000511 ! nuclear positioning variant

[Term]
id: WBPhenotype:0001953
name: nuclear fallout
def: "Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001952 ! germline nuclear positioning variant

[Term]
id: WBPhenotype:0001954
name: diplotene absent during oogenesis
def: "The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001947 ! diplotene progression during oogenesis variant

[Term]
id: WBPhenotype:0001955
name: multiple nuclei oocyte
def: "Haploid female germ cells (oocytes) contain more than one nucleus." [WB:WBPaper00038381, WB:WBPerson557]
synonym: "multinucleate oocyte" RELATED []
is_a: WBPhenotype:0000186 ! oogenesis variant
is_a: WBPhenotype:0001260 ! oocyte morphology variant
is_a: WBPhenotype:0002413 ! multiple nuclei

[Term]
id: WBPhenotype:0001956
name: oocytes lack nucleus
def: "Haploid female germ cells (oocytes) lack a nucleus." [WB:WBPaper00038381, WB:WBPerson557]
synonym: "anucleate oocytes" RELATED []
is_a: WBPhenotype:0000186 ! oogenesis variant
is_a: WBPhenotype:0001260 ! oocyte morphology variant

[Term]
id: WBPhenotype:0001957
name: gonad small
def: "A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001355 ! gonad morphology variant

[Term]
id: WBPhenotype:0001958
name: gonad degenerate
def: "Animals contain a gonad that initially functioned, but subsequently stopped.  In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus." [WB:WBPaper00038381, WB:WBPerson557]
synonym: "degenerate gonad" RELATED []
is_a: WBPhenotype:0001355 ! gonad morphology variant

[Term]
id: WBPhenotype:0001959
name: spindle pole pulling force variant
def: "Pulling forces on the astral microtubules at the spindle poles vary from that observed for control spindles." [WB:WBPaper00031928, WB:WBPerson712]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0001960
name: spindle oscillation variant
def: "The spindle in the early embryo is aberrant in the characteristic posterior aster oscillations that occur along the transverse longitudinal axis of the spindle." [WB:WBPaper00031928, WB:WBPerson712]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0001961
name: reproductive longevity extended
def: "Animals continue to produce progeny significantly past the time reproduction stops in control animals." [WB:WBPaper00031688, WB:WBPerson712]
is_a: WBPhenotype:0001739 ! aging variant

[Term]
id: WBPhenotype:0001962
name: missing distal tip cells
def: "Animals produce less distal tip cells compared to controls." [WB:WBPaper00026603, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0001656 ! distal tip cell development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001963
name: homolog association variant
def: "The association of homologs during diakinesis and the maintenance of their association through meiosis I as well as the preservation of centromeric cohesin between sister chromatids does not proceed as it does in control animals." [WB:WBPaper00032269, WB:WBPerson712]
is_a: WBPhenotype:0001824 ! meiotic progression prophase variant

[Term]
id: WBPhenotype:0001964
name: dopaminergic fate atypical
def: "Animals exhibit differential regulation of the dopaminergic fate among the various classes of dopaminergic neurons." [WB:WBPaper00032147, WB:WBPaper00036201, WB:WBPerson712]
synonym: "Dopy" RELATED []
is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant

[Term]
id: WBPhenotype:0001965
name: cell membrane physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of the cell, compared to control animals." [WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0001966
name: cell endomembrane physiology variant
def: "Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of within the cell, compared to control animals." [WB:WBPaper00037899, WB:WBPerson712]
is_a: WBPhenotype:0001965 ! cell membrane physiology variant

[Term]
id: WBPhenotype:0001967
name: meiotic chromatin reorganization variant
def: "Animals differ from control animals in the length of or mechanics of the steps that culminate in the preservation and subsequent disassembly of the synaptonemal complex, the specification of bivalent arms, and proper cohesion of sister chromatids." [WB:WBPaper00032269, WB:WBPerson712]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0001968
name: somatic gonad precursor symmetrical sisters
def: "All somatic gonad precursor (SGP) daughters adopt a proximal fate resulting in an increase in the number of AC precursor cells at the expense of distal tip cells (DTC), which are thereby absent." [WB:WBPaper00026603, WB:WBPerson712]
synonym: "symmetrical sisters" RELATED []
synonym: "Sys" BROAD []
is_a: WBPhenotype:0000399 ! somatic gonad development variant
is_a: WBPhenotype:0001235 ! cell division polarity variant

[Term]
id: WBPhenotype:0001969
name: germ cell compartment morphology variant
def: "Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis).  These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0000900 ! germ cell morphology variant

[Term]
id: WBPhenotype:0001970
name: germ cell compartment nuclei number variant
def: "Germ cell compartments contain an an atypical number on nuclei compared to control." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant

[Term]
id: WBPhenotype:0001971
name: germ cell compartment anucleate
def: "Germ cell compartments do not contain a nucleus." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001970 ! germ cell compartment nuclei number variant

[Term]
id: WBPhenotype:0001972
name: germ cell compartment multinucleate
def: "Germ cell compartments contain multiple nuclei." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001970 ! germ cell compartment nuclei number variant

[Term]
id: WBPhenotype:0001973
name: germ cell compartment size variant
def: "Any variation in germ cell compartment size compared to control." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant

[Term]
id: WBPhenotype:0001974
name: germ cell compartment small
def: "Germ cell compartments are smaller than that of control animals." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001973 ! germ cell compartment size variant

[Term]
id: WBPhenotype:0001975
name: germ cell compartment large
def: "Germ cell compartments are larger than that of control animals." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001973 ! germ cell compartment size variant

[Term]
id: WBPhenotype:0001976
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0001978

[Term]
id: WBPhenotype:0001977
name: germ cell partition morphology variant
def: "Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant

[Term]
id: WBPhenotype:0001978
name: germ cell partition absent
alt_id: WBPhenotype:0001976
def: "Animals lack germ cell partitions (germ cell compartments)." [WB:WBPaper00038381, WB:WBPerson557]
synonym: "germ cell compartment absent" EXACT []
is_a: WBPhenotype:0001977 ! germ cell partition morphology variant

[Term]
id: WBPhenotype:0001979
name: gonad vesiculated
def: "Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad." [GO:0031982, WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001355 ! gonad morphology variant

[Term]
id: WBPhenotype:0001980
name: germ cell compartment expansion variant
def: "Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant

[Term]
id: WBPhenotype:0001981
name: germ cell compartment expansion absent
def: "The compartments of the germline do not increase in size." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0001980 ! germ cell compartment expansion variant

[Term]
id: WBPhenotype:0001982
name: cell membrane organization biogenesis variant
def: "Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557]
is_a: WBPhenotype:0010002 ! cell organization biogenesis variant

[Term]
id: WBPhenotype:0001983
name: lawn leaving behavior variant
def: "Variation of the time an individual spent on a patch of food (bacterial lawn) before leaving, compared to control animals." [WB:WBPaper00038234, WB:WBPerson363]
synonym: "exploration behavior variant" RELATED []
synonym: "exploratory behavior variant" NARROW []
synonym: "food leaving behavior variant" EXACT []
synonym: "patch leaving behavior variant" EXACT []
is_a: WBPhenotype:0000662 ! foraging behavior variant

[Term]
id: WBPhenotype:0001984
name: long range axon migration variant
def: "Animals exhibit axons with migration behaviors that differ from those observed in control animals after the axons cross a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords." [WB:WBPaper00038105, WB:WBPerson712]
is_a: WBPhenotype:0001224 ! axon outgrowth variant

[Term]
id: WBPhenotype:0001985
name: short range axon migration variant
def: "Animals exhibit axons with migration behaviors that differ from those observed in control animals before the axons reach a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords." [WB:WBPaper00038105, WB:WBPerson712]
is_a: WBPhenotype:0001224 ! axon outgrowth variant

[Term]
id: WBPhenotype:0001986
name: high temperature induced L1 arrest
def: "Animals undergo an irreversible high temperature-induced developmental arrest during the first larval stage." [WB:WBPaper00038168, WB:WBPerson2987]
is_a: WBPhenotype:0000081 ! L1 arrest
is_a: WBPhenotype:0001273 ! organism heat response variant

[Term]
id: WBPhenotype:0001987
name: acetylcholinesterase activity variant
def: "Any variation in the measured levels of acetylcholinesterase (AChE) activity compared to control animals." [WB:WBPaper00001039, WB:WBPerson712]
synonym: "acetylcholinesterase class activity variant" EXACT []
is_a: WBPhenotype:0000124 ! enzyme activity reduced

[Term]
id: WBPhenotype:0001988
name: detergent hypersensitive
def: "Animals respond to a detergent at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00000514, WB:WBPerson712]
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0001989
name: hypoxia hypersensitive
def: "Animals respond to hypoxic (low oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002423 ! hypoxia response variant

[Term]
id: WBPhenotype:0001990
name: hypoxia resistant
def: "Animals fail to respond to low amounts of oxygen that elicit a response in control animals." [WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002423 ! hypoxia response variant

[Term]
id: WBPhenotype:0001991
name: hypoxia response attenuated
def: "Response to low levels of oxygen is reduced or weakened compared to the response of control animals." [WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002423 ! hypoxia response variant

[Term]
id: WBPhenotype:0001992
name: extra gonadal sheath cells
def: "Animals exhibit an increase in the number of somatic sheath cells surrounding each gonad arm compared to controls." [WB:WBPaper00006209, WB:WBPerson2987]
is_a: WBPhenotype:0000399 ! somatic gonad development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0001993
name: fewer gonadal sheath cells
def: "Animals exhibit fewer somatic sheath cells surrounding each gonad arm, compared to controls." [WB:WBPaper00006209, WB:WBPerson2987]
is_a: WBPhenotype:0000399 ! somatic gonad development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0001994
name: left right handedness variant
def: "Any variation in the establishment of left-right asymmetry of the body axis compared to controls." [WB:WBPerson2987, WB:WBPerson557]
synonym: "left right asymmetry variant" RELATED []
is_a: WBPhenotype:0000578 ! body axis development variant

[Term]
id: WBPhenotype:0001995
name: cell cycle progression variant
def: "Cells of the animals exhibit variations in the progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals." [GO:0007049, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000740 ! cell cycle variant

[Term]
id: WBPhenotype:0001996
name: cell cycle quiescence variant
def: "Any variation in the cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence before entering the S phase, compared to control." [GO:0070314, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0001995 ! cell cycle progression variant

[Term]
id: WBPhenotype:0001997
name: nuclear anchoring variant
def: "The nucleus or nuclei are not positioned in a similar manner or pattern in the cell or syncytium to that observed in controls." [WB:WBPaper00003628, WB:WBPerson712]
is_a: WBPhenotype:0000511 ! nuclear positioning variant

[Term]
id: WBPhenotype:0001998
name: hypersensitive to laser ablation
def: "Animals respond more severely to laser ablation than control animals subjected to the same laser ablation conditions." [WB:WBPaper00038282, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0001999
name: conflicting sensory integration variant
def: "Animals behave differently from control animals in assays testing for the ability to resolve or respond to conflicting sensory inputs." [WB:WBPaper00038243, WB:WBPerson712]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0002000
name: recovery from enhanced locomotion variant
def: "Animals that exhibit an increase in locomotion activity do not return to basal level locomotion activity at the same rate as that of control animals." [WB:WBPaper00038487, WB:WBPerson712]
is_a: WBPhenotype:0000641 ! activity level variant

[Term]
id: WBPhenotype:0002001
name: synapse density variant
def: "The number of synapses per unit area of a neuron differs in the animal compared to that observed for control animals." [WB:WBPaper00039786, WB:WBPerson712]
is_a: WBPhenotype:0000604 ! nervous system morphology variant

[Term]
id: WBPhenotype:0002002
name: supernumerary centrosomes
def: "A cell or cell of the animal exhibits extra centrosomes (a subcellular body consisting of two centrioles embedded in a protein matrix) compared to control." [WB:WBPaper00028464, WB:WBPerson2987]
is_a: WBPhenotype:0001903 ! centrosome biogenesis variant

[Term]
id: WBPhenotype:0002003
name: hydrogen peroxide homeostasis variant
def: "Animals exhibit variations in steady-state levels of hydrogen peroxide (H2O2) compared to control." [WB:WBPaper00040082, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002004
name: actomyosin contractility defective
def: "Animals exhibit defects in the flow rate or targeting of the cortical actomyosin network, which occurs during polarization as well as contraction of the contractile ring, compared to control animals." [WB:WBPaper00038098, WB:WBPerson712]
is_a: WBPhenotype:0000034 ! embryonic polarity variant
is_a: WBPhenotype:0001587 ! actin organization biogenesis phenotype
is_a: WBPhenotype:0002408 ! cytokinesis variant

[Term]
id: WBPhenotype:0002005
name: actomyosin cytoskeletal tension variant
def: "The tension of the cytoskeleton comprised of the actomyosin network differs from controls. This tension can be measured by laser-cutting of the actomyosin cytoskeleton and observing any differences the recoil velocity of cortex adjacent to the cut site." [WB:WBPaper00038098, WB:WBPerson712]
is_a: WBPhenotype:0001346 ! actin cytoskeleton dynamics phenotype

[Term]
id: WBPhenotype:0002006
name: anaphase I progression variant early embryo
def: "Compared to controls, embryos exhibit variations in the part meiosis I in which homologous chromosomes separate and migrate away from each other." [WB:WBPaper00031064, WB:WBPerson712]
is_a: WBPhenotype:0000775 ! meiosis variant
is_a: WBPhenotype:0002389 ! anaphase variant

[Term]
id: WBPhenotype:0002007
name: cortical blebs present
def: "Embryos display cortical protusions during cytokinesis." [WB:WBPaper00038098, WB:WBPerson712]
is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant
is_a: WBPhenotype:0002408 ! cytokinesis variant

[Term]
id: WBPhenotype:0002008
name: glycation variant
def: "Animals exhibit variations in the non-enzymatic glycosylation process of attaching a protein or lipid to a sugar molecule, compared to control animals." [WB:WBPaper00040082, WB:WBPerson712]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002009
name: proteasome core activity variant
def: "Animals exhibit variations from controls in their protein degradation machinery, which functions through the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [GO:0004175, WB:WBPaper00040082, WB:WBPerson712]
is_a: WBPhenotype:0001644 ! protein metabolism variant

[Term]
id: WBPhenotype:0002010
name: protein turnover variant
def: "The dynamics of the replacement of old proteins by newly synthesized or modified proteins varies from that of control animals. This phenotype is often measured by fluorescence recovery after photobleaching (FRAP)." [WB:WBPaper00038098, WB:WBPerson712]
is_a: WBPhenotype:0001644 ! protein metabolism variant

[Term]
id: WBPhenotype:0002011
name: bivulva
def: "Animals exhibit a secondary vulval invagination that is anterior or posterior to the primary opening depending on the the inappropriate placement of daughter cells along the anterior/posterior axis during vulval development." [WB:WBPaper00040151, WB:WBPerson712]
is_a: WBPhenotype:0000695 ! vulva morphology variant

[Term]
id: WBPhenotype:0002012
name: meiotic chromosome organization variant
def: "Any variation in the process of chromosome organization that is involved in meiosis, compared to control." [GO:0070192, WB:WBPerson557]
is_a: WBPhenotype:0000775 ! meiosis variant

[Term]
id: WBPhenotype:0002013
name: univalent meiotic chromosomes
def: "Chromosomes fails to pair with homologous chromosomes during the prophase stage of meiosis." [WB:WBPerson101, WB:WBPerson557]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0002014
name: current measurement variant
def: "Any observed variation in the measurement of current across the cell membrane compared to measurements in control animals. Current is a flow of electric charge through a medium." [WB:WBPerson557]
is_a: WBPhenotype:0001315 ! electrophysiology phenotype

[Term]
id: WBPhenotype:0002015
name: voltage measurement variant
def: "Any observed variation in the measurement of voltage across the cell membrane compared to measurements in control animals. Voltage is the difference in electric potential energy per unit charge between two points." [WB:WBPerson557]
is_a: WBPhenotype:0001315 ! electrophysiology phenotype

[Term]
id: WBPhenotype:0002016
name: biotin chemotaxis defective
def: "Failure to execute the characteristic response to biotin as defined by control animals. In C. elegans, biotin is typically an attractant." [WB:WBPaper00001481, WB:WBPaper00005801, WB:WBPerson101, WB:WBPerson557]
is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective

[Term]
id: WBPhenotype:0002017
name: VPC competence variant
def: "Any variation in the ability of multipotent vulval precursor cells to respond to signals compared to control animals." [WB:WBPerson557]
synonym: "vulval precursor cell competence abnormal" RELATED []
synonym: "vulval precursor cell competence variant" RELATED []
is_a: WBPhenotype:0000216 ! cell fate specification variant

[Term]
id: WBPhenotype:0002018
name: retarded seam cell fusion
def: "Seam cells fuse to form a continuous syncytium along the body wall at a later stage of development compared to control." [WB:WBPaper00031488, WB:WBPerson2987]
is_a: WBPhenotype:0000166 ! seam cell fusion variant

[Term]
id: WBPhenotype:0002019
name: fewer eggs in utero
def: "Adult animals display a smaller number of eggs inside the uterus compared to controls" [WB:WBPaper00031804, WB:WBPerson2987]
is_a: WBPhenotype:0000624 ! reproductive system development variant

[Term]
id: WBPhenotype:0002020
name: transmission of nerve impulse variant
def: "Transmission of the signal along the neuron varies from control.  This process includes the flow of information from the neuron cell body to the synapse and across to the postsynaptic cell." [GO:0019226, WB:WBPaper00031592, WB:WBPerson712]
is_a: WBPhenotype:0000612 ! nervous system physiology variant

[Term]
id: WBPhenotype:0002021
name: synaptic spike frequency variant
def: "Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed at the synapse, which are independent of presynaptic inputs." [WB:WBPaper00031592, WB:WBPerson712]
is_a: WBPhenotype:0000584 ! synaptic transmission variant
is_a: WBPhenotype:0002023 ! spike frequency variant

[Term]
id: WBPhenotype:0002022
name: no synaptic spike frequency
def: "Calcium transients at presynaptic regions do not occur." [WB:WBPaper00031592, WB:WBPerson712]
is_a: WBPhenotype:0002021 ! synaptic spike frequency variant

[Term]
id: WBPhenotype:0002023
name: spike frequency variant
def: "Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed either at the cell body or the synaptic region, which are independent of presynaptic inputs." [WB:WBPaper00031592, WB:WBPerson712]
is_a: WBPhenotype:0002020 ! transmission of nerve impulse variant

[Term]
id: WBPhenotype:0002024
name: cell body spike frequency variant
def: "Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed in cell bodies, which are independent of presynaptic inputs." [WB:WBPaper00031592, WB:WBPerson712]
is_a: WBPhenotype:0002023 ! spike frequency variant

[Term]
id: WBPhenotype:0002025
name: cell size decreased
def: "The diameter, volume, or area taken up by a cell differs from that measured in control animals." [WB:WBPaper00038069, WB:WBPerson712]
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002026
name: differential touch sensitivity variant
def: "Animals differ from control animals in response to mechanical stimulation targeting different parts of the same cell. In N2 wild-type animals, response to touch near the ALM cell body is reduced compared with touch of the cell area near the second pharyngeal bulb." [WB:WBPaper00040149, WB:WBPerson712]
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0002027
name: gonad independent vulva differentiation
def: "VPCs differentiate in the absence of inductive signals coming from the gonad." [WB:WBPaper00025001, WB:WBPaper00027764, WB:WBPerson712]
synonym: "Gid" EXACT []
is_a: WBPhenotype:0000354 ! cell differentiation variant
is_a: WBPhenotype:0001272 ! vulval cell induction variant

[Term]
id: WBPhenotype:0002028
name: mechanoreceptor current variant
def: "Animals differ from controls in their electrical response to mechanical stimulus." [WB:WBPaper00040149, WB:WBPerson712]
synonym: "MRC variant" RELATED []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0002029
name: metal homeostasis variant
def: "Variations in the regulation of levels, transport, and metabolism of metal ions within an organism compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002030
name: magnesium homeostasis variant
def: "Variations in the regulation of levels, transport, and metabolism of magnesium ions within an organism compared to control." [GO:0010960, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002029 ! metal homeostasis variant

[Term]
id: WBPhenotype:0002031
name: lectin response variant
def: "Exposure to carbohydrate binding gene products result in an altered action in comparison to controls." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0000459 ! pesticide response variant
is_a: WBPhenotype:0001210 ! pericellular component physiology phenotype

[Term]
id: WBPhenotype:0002032
name: lectin binding variant
def: "Animals differ from controls in the range, specificity, or presence of targets for exogenously applied lectins." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0002031 ! lectin response variant

[Term]
id: WBPhenotype:0002033
name: lectin binding occurs
def: "Animals contain targets for exogenously applied lectins." [WB:WBPaper00038311, WB:WBPerson712]
synonym: "ectopic lectin binding" RELATED []
is_a: WBPhenotype:0002031 ! lectin response variant

[Term]
id: WBPhenotype:0002034
name: lectin binding does not occur
def: "Animals are not observed to contain targets for exogenously applied lectins." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0002031 ! lectin response variant

[Term]
id: WBPhenotype:0002035
name: resistant to lectin
def: "Exposure to lectin has no affect on the behavior, growth, or development of the animal compared to controls." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0002031 ! lectin response variant

[Term]
id: WBPhenotype:0002036
name: susceptible to lectin
def: "Exposure to lectin results in altered behavior, growth, or development of the animal compared to controls." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0002031 ! lectin response variant

[Term]
id: WBPhenotype:0002037
name: nuclear envelope organization variant
def: "The appearance and association of components along the double lipid bilayer enclosing the nucleus differs from controls. The NE separates nuclear contents from the rest of the cytoplasm and includes the intermembrane space, perinuclear space." [WB:WBPaper00040620, WB:WBPerson712]
is_a: WBPhenotype:0001028 ! nuclear appearance variant

[Term]
id: WBPhenotype:0002038
name: ciliary localization defective
def: "Proteins show defects in their localization in the cilia compared to control animals." [WB:WBPaper00031689]
synonym: "cil" BROAD []
is_a: WBPhenotype:0000851 ! ciliated neuron physiology variant

[Term]
id: WBPhenotype:0002039
name: retrograde transport variant
def: "Animals exhibit variation in the directed movement of organelles or molecules along microtubules from the cell periphery in nerve cell axons to the cell body, compared to control." [WB:WBPaper00038442, WB:WBPerson712]
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0002040
name: asymmetric chromosome segregation
def: "Chromosomes are not segregated symmetrically during mitosis." [WB:WBPaper00038412, WB:WBPerson712]
synonym: "chaotic mitosis" RELATED []
is_a: WBPhenotype:0001378 ! mitotic chromosome segregation variant

[Term]
id: WBPhenotype:0002041
name: molt variant
def: "Animals exhibit variation in timing or ability to molt." [WB:WBPaper00040467, WB:WBPerson712]
is_a: WBPhenotype:0000750 ! larval development variant

[Term]
id: WBPhenotype:0002042
name: molting arrhythmic
def: "Molting cycles do not occur in a temporally controlled manner and cannot be synchronized across a population." [WB:WBPaper00040467, WB:WBPerson712]
is_a: WBPhenotype:0002041 ! molt variant

[Term]
id: WBPhenotype:0002043
name: hermaphrodite mating efficiency reduced
def: "The number of cross progeny produced by hermaphrodites is reduced compared to control hermaphrodites." [WB:WBPerson557]
is_a: WBPhenotype:0004001 ! hermaphrodite mating variant

[Term]
id: WBPhenotype:0002044
name: hermaphrodite mating efficiency eliminated
def: "Hermaphrodites do not produce cross progeny." [WB:WBPerson557]
is_a: WBPhenotype:0002043 ! hermaphrodite mating efficiency reduced

[Term]
id: WBPhenotype:0002045
name: cell corpse number decreased
def: "Animals exhibit fewer cell corpses compared to controls at the same developmental life stage." [WB:WBPerson712]
is_a: WBPhenotype:0000590 ! cell corpse number variant

[Term]
id: WBPhenotype:0002046
name: iron homeostasis variant
def: "Variations in the regulation of levels, transport, and metabolism of iron within an organism compared to control." [GO:0055072, WB:WBPerson557]
is_a: WBPhenotype:0002029 ! metal homeostasis variant

[Term]
id: WBPhenotype:0002047
name: muscimol response variant
def: "Animals exhibit variations in their response to muscimol compared to that observed in control animals. Muscimol is a GABA-A receptor agonist." [WB:WBPaper00038249, WB:WBPerson712]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0002048
name: abamectin resistant
def: "Animals survive longer, or do not respond to the same degree as control animals under similar conditions of abamectin exposure." [WB:WBPaper00040740, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002049 ! abamectin repsonse variant

[Term]
id: WBPhenotype:0002049
name: abamectin repsonse variant
def: "Animals are not affected to the same degree as control animals under similar conditions of abamectin exposure." [WB:WBPaper00040740, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000631 ! drug response variant
is_a: WBPhenotype:0001852 ! antihelmintic response variant

[Term]
id: WBPhenotype:0002050
name: abamectin sensitive
def: "Animals are do not survive, or become paralyzed in the presence of abamectin." [WB:WBPaper00040740, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002049 ! abamectin repsonse variant

[Term]
id: WBPhenotype:0002051
name: ascaroside biosynthesis variant
def: "The production or regulation of ascaroside molecule populations differs from that of control animals." [WB:WBPaper00040624, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002052
name: ascaroside biosynthesis defective
def: "Animals lack the ability to produce ascarosides that are capable of being produced in control animals." [WB:WBPaper00040624, WB:WBPerson712]
is_a: WBPhenotype:0002051 ! ascaroside biosynthesis variant

[Term]
id: WBPhenotype:0002053
name: ivermectin resistant
def: "Animals fail to respond to or exhibit an attenuated response to ivermectin under conditions that elicits a response in control animals." [WB:WBPaper00003945, WB:WBPaper00040740, WB:WBPerson712]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0001856 ! ivermectin response variant

[Term]
id: WBPhenotype:0002054
name: magnesium hypersensitivity
def: "Animals exhibit an exaggerated response to magnesium compared to control animals exposed to similar concentrations." [WB:WBPaper00036046, WB:WBPerson712]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002055
name: photocurrent defective
def: "Animals do not exhibit light-induced currrents to the same extent or with the same quality as control animals." [WB:WBPaper00036207, WB:WBPerson712]
is_a: WBPhenotype:0002014 ! current measurement variant

[Term]
id: WBPhenotype:0002056
name: eating variant
def: "Any variation in the specific actions or reactions of an organism causing an alteration in the ingestion of food compared to control animals.  In C. elegans the main food source is bacteria and alterations in eating behavior usually lead to malnutrition." [WB:WBPerson557, WB:WBPerson712]
synonym: "Eat" EXACT []
is_a: WBPhenotype:0000659 ! feeding behavior variant

[Term]
id: WBPhenotype:0002057
name: Bacillus thuringiensis toxin hypersensitive
def: "Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0002058
name: pore forming toxin response variant
def: "Animals are not affected to the same degree as control animals under similar conditions of pore forming toxin exposure." [WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0002059
name: pore forming toxin hypersensitive
def: "Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
synonym: "Hpo" BROAD []
synonym: "hypersensitive to pore forming toxin" EXACT []
is_a: WBPhenotype:0000010 ! drug hypersensitive
is_a: WBPhenotype:0002058 ! pore forming toxin response variant

[Term]
id: WBPhenotype:0002060
name: pore forming toxin resistant
def: "Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000011 ! drug resistant
is_a: WBPhenotype:0002058 ! pore forming toxin response variant

[Term]
id: WBPhenotype:0002061
name: chromosome decondensation variant
def: "Any variation in the progressive decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form." [GO:0051312, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002062
name: chromosome decondensation failure
def: "The process of decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form is abolished." [WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002061 ! chromosome decondensation variant

[Term]
id: WBPhenotype:0002063
name: maintenance of gene silencing variant
def: "Animals differ from controls in the expression of genes targeted for silencing (gene inactivation) in subsequent generations via transcriptional or post-transcriptional processes." [GO:0016458, WB:WBPaper00041239, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002064
name: maintenance of gene silencing defective
def: "Animals express genes that had been targeted for heritable silencing in previous generations." [WB:WBPaper00041239, WB:WBPerson712]
is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant

[Term]
id: WBPhenotype:0002065
name: basement membrane remodeling variant
def: "Animals display variations in the manner in which the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) is remodeled, compared to control animals." [WB:WBPaper00038447, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000200 ! pericellular component development variant
is_a: WBPhenotype:0002588 ! basement membrane phenotype

[Term]
id: WBPhenotype:0002066
name: basement membrane gap expansion variant
def: "Animals display variations in the manner in which an opening in the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) expands to make way for intertissue connections, compared to control animals." [WB:WBPaper00038447, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002065 ! basement membrane remodeling variant

[Term]
id: WBPhenotype:0002067
name: apical constriction variant
def: "Animals differ from control animals in cortical actomyocin dynamics leading to internalization of endodermal precursor cells during gastrulation." [WB:WBPaper00040757, WB:WBPerson712]
is_a: WBPhenotype:0000047 ! gastrulation variant

[Term]
id: WBPhenotype:0002068
name: astral microtubule asymmetry defective
def: "There is significantly less difference between the number of astral microtubles or other component(s) of the spindle microtuble organizing center at the anterior versus posterior poles of the spindle, than observed in control animals." [WB:WBPaper00040200, WB:WBPerson712]
is_a: WBPhenotype:0002419 ! spindle aster variant

[Term]
id: WBPhenotype:0002069
name: axon termination defective
def: "Axons in animals do not end in the same manner as they do in control animals. Some defects described include an overextension of the axon or termination of the axon in the shape of a hook, either large or small." [WB:WBPaper00040220, WB:WBPerson712]
is_a: WBPhenotype:0000180 ! axon morphology variant

[Term]
id: WBPhenotype:0002070
name: egg laying response to muscimol variant
def: "Animals do not mimic control animals in their egg-laying response to muscimol exposure. In C. elegans, muscimol inhibits egg-laying." [WB:WBPaper00038249, WB:WBPerson712]
is_a: WBPhenotype:0001101 ! egg laying response to drug variant
is_a: WBPhenotype:0002047 ! muscimol response variant

[Term]
id: WBPhenotype:0002071
name: body lengthening response to muscimol variant
def: "The length of the animal does not increase to the same extent as observed for control animals, in response to exposure to muscimol." [WB:WBPaper00038249, WB:WBPerson712]
is_a: WBPhenotype:0002047 ! muscimol response variant

[Term]
id: WBPhenotype:0002072
name: carbohydrate metabolism variant
def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control." [WB:WBPaper00038233, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002073
name: cation homeostasis variant
def: "Animals exhibit variations in the regulation of levels, transport, and metabolism of cations within a cell or between a cell and its external environment, compared to control." [WB:WBPaper00036046, WB:WBPerson712]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002074
name: centrosome dynamics variant
def: "Animals vary in the directed or coordinated movement of their centrosomes during cell division, compared to the pattern of movement observed in control animals." [WB:WBPaper00040172, WB:WBPerson712]
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002075
name: eggshell formation variant
def: "Embryos exhibit variations in the processes that lead to the construction of the eggshell, a protective structure that minimizes water loss whilst allowing gas exchanges essential for embryonic respiration, compared to controls" [GO:0030703, WB:WBPaper00031064, WB:WBPaper00040142, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000041 ! osmotic integrity variant
is_a: WBPhenotype:0000258 ! cell secretion variant

[Term]
id: WBPhenotype:0002076
name: cortical granule exocytosis variant
def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a specialized secretory vesicle that fuses with the plasma membrane during egg activation." [GO:0060471, WB:WBPaper00031064, WB:WBPaper00040142, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0002075 ! eggshell formation variant

[Term]
id: WBPhenotype:0002077
name: dopamine resistant
def: "Animals fail to respond to the concentration of a dopamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00038270, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000011 ! drug resistant

[Term]
id: WBPhenotype:0002078
name: histone methylation variant
def: "The pattern or state of methyl modifications of histone varies from that of controls." [WB:WBPaper00038409, WB:WBPerson712]
synonym: "methylation mark variant" RELATED []
is_a: WBPhenotype:0001383 ! protein methylation variant

[Term]
id: WBPhenotype:0002079
name: delayed reproductive maturity
def: "The animal's ability to reproduce, or start of reproduction occurs later than that observed for control animals." [WB:WBPerson712]
is_a: WBPhenotype:0000045 ! developmental delay postembryonic

[Term]
id: WBPhenotype:0002080
name: peptide uptake by intestinal cell variant
def: "Animals exhibit variations in the degree to which or manner in which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals." [WB:WBPerson2987]
is_a: WBPhenotype:0001763 ! uptake by intestinal cell defective

[Term]
id: WBPhenotype:0002081
name: peptide uptake by intestinal cell increased
def: "Animals exhibit an increase in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals." [WB:WBPerson2987]
is_a: WBPhenotype:0002080 ! peptide uptake by intestinal cell variant

[Term]
id: WBPhenotype:0002082
name: peptide uptake by intestinal cell decreased
def: "Animals exhibit a decrease in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals." [WB:WBPerson2987]
is_a: WBPhenotype:0002080 ! peptide uptake by intestinal cell variant

[Term]
id: WBPhenotype:0002083
name: crossover variant
def: "The frequency and distribution of crossover events differs from that observed for controls." [WB:WBPaper00037960, WB:WBPerson712]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0002084
name: crossover interference variant
def: "Animals differ from controls in respect to the frequency of expected double crossover events observed." [WB:WBPaper00037960, WB:WBPerson712]
is_a: WBPhenotype:0002083 ! crossover variant

[Term]
id: WBPhenotype:0002085
name: crossover formation variant
def: "The number of crossover events differs from that of observed in control animals." [WB:WBPaper00037960, WB:WBPerson712]
is_a: WBPhenotype:0002083 ! crossover variant

[Term]
id: WBPhenotype:0002086
name: crossover distribution variant
def: "The location-specific frequency of crossover events differs from that of observed in control animals, while the total number of crossover events does not significantly differ." [WB:WBPaper00037960, WB:WBPerson712]
is_a: WBPhenotype:0002083 ! crossover variant

[Term]
id: WBPhenotype:0002087
name: hydrogen sulfide hypersensitive
def: "Animals respond to hydrogen sulfide at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00039977, WB:WBPerson712]
is_a: WBPhenotype:0000010 ! drug hypersensitive

[Term]
id: WBPhenotype:0002088
name: hypersensitive to dauer pheromone
def: "Animals respond to dauer pheromone at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson712]
is_a: WBPhenotype:0001479 ! dauer pheromone sensation variant

[Term]
id: WBPhenotype:0002089
name: cell component morphology variant
def: "Any variation in the form or composition of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002090
name: endosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as endosomes,  that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0002091
name: late endosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as late endosomes,  that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002090 ! endosome morphology variant

[Term]
id: WBPhenotype:0002092
name: early endosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as early endosomes,  that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002090 ! endosome morphology variant

[Term]
id: WBPhenotype:0002093
name: recycling endosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes,  that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002090 ! endosome morphology variant

[Term]
id: WBPhenotype:0002094
name: RAB-11 recycling endosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002093 ! recycling endosome morphology variant

[Term]
id: WBPhenotype:0002095
name: lysosome-related organelle morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0002096
name: golgi apparatus morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0002097
name: lysosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0002098
name: cell component localization variant
def: "Any variation in the subcellular localization of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002099
name: lysosome-related organelle localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002100
name: endosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as endosomes,  that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002101
name: endoplasmic reticulum localization variant
def: "Any variation in the subcellular localization of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that exists in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002102
name: golgi apparatus localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002103
name: lysosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002104
name: recycling endosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes,  that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002100 ! endosome localization variant

[Term]
id: WBPhenotype:0002105
name: late endosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as late endosomes,  that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002100 ! endosome localization variant

[Term]
id: WBPhenotype:0002106
name: early endosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as early endosomes,  that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002100 ! endosome localization variant

[Term]
id: WBPhenotype:0002107
name: RAB-11 recycling endosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002104 ! recycling endosome localization variant

[Term]
id: WBPhenotype:0002108
name: cell type morphology variant
def: "Any variation in the form or composition of specialized cell types, compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002109
name: drug susceptible
def: "Animals are affected by exposure to the drug." [WB:WBPerson712]
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0002110
name: RME-1 recycling endosome morphology variant
def: "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002093 ! recycling endosome morphology variant

[Term]
id: WBPhenotype:0002111
name: RME-1 recycling endosome localization variant
def: "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
is_a: WBPhenotype:0002104 ! recycling endosome localization variant

[Term]
id: WBPhenotype:0002112
name: synapsis maintenance defective
def: "Animals are unable to maintain paired chromosome throughout pachytene." [WB:WBPaper00037960, WB:WBPerson712]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0002113
name: synapsis formation variant
def: "Animals differ from controls in respect to the formation of paired chromosome loci." [WB:WBPaper00037960, WB:WBPerson712]
is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant

[Term]
id: WBPhenotype:0002114
name: swimming induced paralysis
def: "Animals become paralyzed after a measured amount of time swimming. In C. elegans, more then 80 percent of wild-type animals continue swimming vigorously in liquid even after 30 minutes." [WB:WBPaper00038270, WB:WBPerson712]
synonym: "SWIP" BROAD []
is_a: WBPhenotype:0001700 ! swimming variant

[Term]
id: WBPhenotype:0002115
name: suicidal
def: "Animals do not avoid, and perhaps seek, environments that result in their death. In the case of C. elegans, this behavior is exemplified by animals that tend to crawl off the plate." [WB:WBPerson712]
is_a: WBPhenotype:0000888 ! male behavior variant

[Term]
id: WBPhenotype:0002116
name: subviable
def: "Animals are barely alive, but not entirely dead." [WB:WBPerson712]
is_a: WBPhenotype:0000531 ! organism development variant
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0002117
name: occurences of decapitation
def: "Animals exhibit constrictions in the anterior portion of the head that result in decapitation." [WB:WBPerson712]
is_a: WBPhenotype:0000212 ! body constriction

[Term]
id: WBPhenotype:0002118
name: population fitness phenotype
def: "Populations exhibit variations in the ability to survive, grow and reproduce, thus affecting the contribution to the gene pool over generations compared to control populations.  In C. elegans the fitness of a population can by assessed by measuring the rate at which E. coli is consumed." [WB:WBPaper00040316, WB:WBPaper00040815, WB:WBPerson2987, WB:WBPerson557]
synonym: "population fitness variant" EXACT []
is_a: WBPhenotype:0000519 ! physiology phenotype

[Term]
id: WBPhenotype:0002119
name: alternative splicing defective
def: "The process of generating multiple mRNA molecules from differential use of exons in a primary transcript(s) does not occur or occurs with outcomes not observed in control animals." [WB:WBPerson1686, WB:WBPerson712]
is_a: WBPhenotype:0001807 ! alternative splicing variant

[Term]
id: WBPhenotype:0002120
name: mitochondrial DNA repair variant
def: "Any variation in the process of restoring mitochondrial DNA after damage." [GO:0043504, WB:WBPerson557]
is_a: WBPhenotype:0001938 ! DNA repair variant

[Term]
id: WBPhenotype:0002121
name: heteroplasmy
def: "The presence of a mixture of more than one type of an organellar genome (mitochondrial DNA (mtDNA) or plastid DNA) within a cell or individual." [WB:WBPaper00040387, WB:WBPerson2987]
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0002122
name: persistence of paternal mitochondria
def: "Mitochondria from spermatazoa persist in the developing embryo and animal as a result of bypassing the degradation mechanism that normally destroys paternal mitochondria immediately after fertilization. This can often lead to a form of heteroplasmy." [WB:WBPaper00040387, WB:WBPerson2987]
is_a: WBPhenotype:0002121 ! heteroplasmy

[Term]
id: WBPhenotype:0002123
name: histone acetylation variant
def: "The pattern or state of acetylation modifications of histones varies from that of controls." [WB:WBPaper00040843, WB:WBPerson2987]
is_a: WBPhenotype:0001917 ! protein acetylation variant

[Term]
id: WBPhenotype:0002124
name: circumferential actin bundles disorganized
def: "The distribution or presence of actin in circumferential actin bundles (CFB) differs from that observed in control animals. Contraction of CFBs provide the driving force for epidermal elongation." [WB:WBPaper00006290, WB:WBPerson712]
is_a: WBPhenotype:0001587 ! actin organization biogenesis phenotype

[Term]
id: WBPhenotype:0002125
name: growth inhibition response to chemical
def: "Animals do not grow fast or the quality of growth is decreased when exposed to a specific chemical compound when compared to control animals." [WB:WBPaper00040519, WB:WBPerson712]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0002126
name: intestinal fluorescence decreased
def: "Animals exhibit a decrease in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson712]
is_a: WBPhenotype:0000293 ! alimentary system pigmentation variant

[Term]
id: WBPhenotype:0002127
name: intraflagellar transport velocity variant
def: "Animals exhibit variation rate of directed movement of organelles or molecules along microtubules in nerve cell axons, compared to control." [WB:WBPaper00038442, WB:WBPerson712]
is_a: WBPhenotype:0000853 ! intraflagellar transport variant

[Term]
id: WBPhenotype:0002128
name: leaving assay defective
def: "Males remain on food in the absence of mates, a defect in male mate-searching behavior observed in control males." [WB:WBPaper00041718, WB:WBPerson712]
synonym: "Las" BROAD []
is_a: WBPhenotype:0001983 ! lawn leaving behavior variant
is_a: WBPhenotype:0004031 ! mate searching variant

[Term]
id: WBPhenotype:0002129
name: mitochondrial DNA copy number variant
def: "Relative levels of mtDNA differ from that observed for control animals." [WB:WBPaper00032112, WB:WBPerson712]
is_a: WBPhenotype:0000732 ! DNA metabolism variant
is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant

[Term]
id: WBPhenotype:0002130
name: post mating variant
def: "Males exhibit variations of the behaviors observed in control animals that follow the completion of mating." [WB:WBPaper00041718, WB:WBPerson712]
synonym: "mate experience variant" RELATED []
is_a: WBPhenotype:0000648 ! male mating variant

[Term]
id: WBPhenotype:0002131
name: muscle cell ultrastructure variant
def: "Animals display variations in the structure or organization of the components of the muscle, compared to that observed in control animals." [WB:WBPerson712]
is_a: WBPhenotype:0000904 ! muscle cell morphology variant

[Term]
id: WBPhenotype:0002132
name: protein complex organization variant
def: "The formation, organization, or stability of a protein complex is altered in comparison to corresponding complexes in control animals." [WB:WBPaper00038066, WB:WBPerson712]
synonym: "protein clustering variant" RELATED []
is_a: WBPhenotype:0001370 ! protein protein interaction variant

[Term]
id: WBPhenotype:0002133
name: ooplasmic streaming slow
def: "The bulk flow of cytoplasm in the egg, that facilitates mixing of ooplasm, occurs at a reduced rate compared to that measured for controls." [WB:WBPerson712]
is_a: WBPhenotype:0000360 ! cytoplasmic streaming defective

[Term]
id: WBPhenotype:0002134
name: predator escape defective
def: "Animals are less successful than controls in evading predators during predator-prey interactions." [WB:WBPaper00039982, WB:WBPerson712]
is_a: WBPhenotype:0002135 ! organism predator response variant

[Term]
id: WBPhenotype:0002135
name: organism predator response variant
def: "Predator-prey interactions differ from that observed in control interactions." [WB:WBPaper00039982, WB:WBPerson712]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0002136
name: no anchor cell
def: "Animals are missing the anchor cell. In C. elegans the anchor cell is a key organizer of vulval patterning and morphogenesis." [WB:WBPaper00003577, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000399 ! somatic gonad development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0002137
name: reduced translation initiation
def: "The rate of the process preceding formation of the peptide bond between the first two amino acids of a protein is reduced. This process includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.  Increase in free ribosomes (monosomes) are indicative of reduced translation initiation." [GO:0006413, WB:WBPaper00039835, WB:WBPerson557]
is_a: WBPhenotype:0000121 ! translation variant

[Term]
id: WBPhenotype:0002138
name: acquired thermotolerance variant
def: "Animals are altered in their capacity to survive a normally lethal temperature treatment as a consequence of pretreatment at an elevated but sublethal temperature." [WB:WBPaper00040849, WB:WBPerson557]
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0002139
name: linker cell morphology variant
def: "Any variation in the morphological appearance of the linker cell compared to control animals." [WB:WBPaper00035457, WB:WBPerson557]
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0002140
name: male attraction response variant
def: "Males do not respond to small molecules or compounds that have been shown to attract control males. This phenotype is often measured by an increase in reversal frequency or time spent in a specified scoring region" [WB:WBPaper00032050, WB:WBPerson712]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0002141
name: oxygen consumption variant
def: "Variations in the process of gaseous oxygen intake between an organism and its environment compared to control animals." [WB:WBPaper00042217, WB:WBPerson557]
is_a: WBPhenotype:0001835 ! energy expenditure variant

[Term]
id: WBPhenotype:0002142
name: mitochondrial respiratory chain variant
def: "The activity, composition, or organization of the complexes of the electron transport chain, embedded in the inner mitochondrial membrane, differ from controls." [GO:0005746, WB:WBPaper00042217, WB:WBPerson712]
synonym: "mitochondrial electron transport chain variant" EXACT []
synonym: "MRC variant" EXACT []
is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant

[Term]
id: WBPhenotype:0002143
name: mitochondrial respiratory complex II variant
def: "The part of the respiratory chain that catalyzes the oxidation of succinate and connects the TCA cycle with the respiratory chain, differs in activity, composition, or organization, from that of controls." [GO:0045273, WB:WBPaper00042217, WB:WBPerson712]
synonym: "CO II variant" EXACT []
synonym: "Complex II variant" EXACT []
synonym: "Succinate dehydrogenase complex variant" EXACT []
is_a: WBPhenotype:0002142 ! mitochondrial respiratory chain variant

[Term]
id: WBPhenotype:0002144
name: mitochondrial respiratory complex I variant
def: "The protein complex located in the mitochondrial inner membrane that is the first entry point for electrons into the electron transport chain and catalyzes proton translocation coupled to the oxidation of NADH by ubiquinone, differs in activity, composition, or organization from that of controls." [GO:0005747, WB:WBPaper00042217, WB:WBPerson712]
synonym: "CO I variant" EXACT []
synonym: "Complex I variant" EXACT []
synonym: "NADH dehydrogenase complex variant" EXACT []
synonym: "Ubiquinone complex variant" EXACT []
is_a: WBPhenotype:0002142 ! mitochondrial respiratory chain variant

[Term]
id: WBPhenotype:0002145
name: siRNA processing defective
def: "Animals are unable to produce or maintain short interfering RNA (siRNA) from double stranded RNA (dsRNA). siRNAs are required to initiate interference of gene expression." [WB:WBPaper00027057, WB:WBPerson712]
is_a: WBPhenotype:0000743 ! RNAi response variant
is_a: WBPhenotype:0001776 ! siRNA expression variant

[Term]
id: WBPhenotype:0002146
name: small RNA germline expression variant
def: "Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in the germline. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs)." [WB:WBPaper00027057, WB:WBPerson712]
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0002147
name: small RNA somatic expression variant
def: "Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in somatic cells. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs)." [WB:WBPaper00027057, WB:WBPerson712]
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0002148
name: somatic RNAi resistant
def: "Animals show reduced susceptibility to gene silencing in somatic cells triggered by double stranded RNA (dsRNA), compared to control." [WB:WBPaper00027057, WB:WBPerson712]
is_a: WBPhenotype:0001208 ! RNAi resistant

[Term]
id: WBPhenotype:0002149
name: X cluster small RNA expression variant
def: "Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of the small X-chromosome derived RNAs (X cluster) species of small RNA." [WB:WBPaper00027057, WB:WBPerson712]
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0002150
name: exo-RNAi response variant
def: "RNAi silencing mechanisms triggered by exogenously introduced (foreign) dsRNA, do not work to the same degree as in control animals." [WB:WBPaper00027057, WB:WBPerson712]
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0002151
name: mRNA deadenylation variant
def: "Animals exhibit variations in the extent to which polyadenylated mRNA transcripts become deadenylated" [WB:WBPaper00037823, WB:WBPerson2987]
is_a: WBPhenotype:0001827 ! RNA metabolism variant

[Term]
id: WBPhenotype:0002152
name: mutagen induced apoptosis variant
def: "Programmed cell death of germ cells caused by exposure to physical or chemical DNA-damaging agents does not occur to the same extent as it does in control animals." [WB:WBPerson712]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0002153
name: dsRNA processing defective
def: "The production of silencing RNA from dsRNA is significantly deficient compared to controls. Deficiencies in this process can result in a defective RNAi response compared to controls." [WB:WBPaper00029211, WB:WBPerson712]
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0002154
name: polysome mRNA association variant
def: "The extent of mRNA ribosome associations varies from controls." [WB:WBPaper00032489, WB:WBPerson712]
is_a: WBPhenotype:0000121 ! translation variant
is_a: WBPhenotype:0001371 ! protein RNA interaction variant

[Term]
id: WBPhenotype:0002155
name: pre miRNA processing defective
def: "The production of mature miRNA from pre-miRNA is significantly deficient compared to controls. Deficiencies in this process can result in the accumulation of pre-miRNA species and or the absence or smaller amount of mature miRNA compared to controls." [WB:WBPaper00029211, WB:WBPerson712]
is_a: WBPhenotype:0000028 ! RNA processing variant
is_a: WBPhenotype:0002528 ! miRNA biogenesis defective

[Term]
id: WBPhenotype:0002156
name: temperature learning variant
def: "Wild-type animals will exhibit an altered temperature preference based on food/temperature conditioning. Temperature learning variants do not exhibit altered responses to temperature after conditioning compared to control animals." [WB:WBPaper00031647, WB:WBPerson712]
is_a: WBPhenotype:0001780 ! associative learning variant

[Term]
id: WBPhenotype:0002157
name: translation repression variant
alt_id: WBPhenotype:0001909
def: "The extent of translational repression varies from controls." [WB:WBPaper00032489, WB:WBPerson712]
synonym: "translational repression variant" EXACT []
is_a: WBPhenotype:0000121 ! translation variant

[Term]
id: WBPhenotype:0002158
name: P granule degradation defective
def: "The selective elimination of P granule components and subsequent aggregation of degraded components into PGL granules is disrupted." [WB:WBPaper00044350, WB:WBPerson712]
is_a: WBPhenotype:0001301 ! P granule abnormal

[Term]
id: WBPhenotype:0002159
name: increased pathogen accumulation
def: "Animals exhibit an increase in pathogen accumulation, persistent colonization, and luminal distension of the intestine." [WB:WBPaper00032276, WB:WBPerson2987]
is_a: WBPhenotype:0001819 ! pathogen load variant

[Term]
id: WBPhenotype:0002160
name: intraflagellar transport complex destabilized
def: "The intracellular complex of proteins that participates in bidirectional transport of molecules (cargo) along axonemal microtubules is not made up of or does not maintain the proper number or ratio of components as found in control animals." [WB:WBPaper00042072, WB:WBPerson712]
is_a: WBPhenotype:0002132 ! protein complex organization variant

[Term]
id: WBPhenotype:0002161
name: mitotic chromatin remodeling variant
def: "Animals exhibit variations from controls in the organization of chromatin, including in relation to associated complexes, that occur during the mitotic cell division cycle." [GO:0006338, WB:WBPaper00040620, WB:WBPerson712]
is_a: WBPhenotype:0001348 ! chromosome morphology variant
is_a: WBPhenotype:0001743 ! mitosis variant

[Term]
id: WBPhenotype:0002162
name: multipolar mitotic spindle
def: "Cells exhibit mitotic spindles with more than two poles." [WB:WBPaper00038412, WB:WBPerson712]
synonym: "multipolar mitosis" RELATED []
is_a: WBPhenotype:0001215 ! germ cell mitosis variant
is_a: WBPhenotype:0001743 ! mitosis variant

[Term]
id: WBPhenotype:0002163
name: oxygen consumption decreased
def: "Animals exhibit a decreased rate of oxygen utilization compared to control animals." [WB:WBPaper00036073, WB:WBPerson712]
is_a: WBPhenotype:0002141 ! oxygen consumption variant

[Term]
id: WBPhenotype:0002164
name: innate immune response variant
def: "Animals exhibit variations in their defense responses that are mediated by germline encoded components that directly recognize components of potential pathogens." [GO:0045087, WB:WBPerson557]
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0002165
name: muscle excitability variant
def: "The extent or other quality of the excitatory postsynaptic potential (EPSP) induced by in vitro stimuli differs from that of controls." [WB:WBPaper00038066, WB:WBPerson712]
is_a: WBPhenotype:0001735 ! muscle cell activity variant
is_a: WBPhenotype:0002014 ! current measurement variant

[Term]
id: WBPhenotype:0002166
name: muscle membrane potential variant
def: "The difference in electrical potential between the interior and the exterior of the muscle cell either in the resting state or during evoked stimulation differs from controls." [WB:WBPaper00039987, WB:WBPerson712]
is_a: WBPhenotype:0000990 ! muscle cell physiology variant
is_a: WBPhenotype:0001965 ! cell membrane physiology variant

[Term]
id: WBPhenotype:0002167
name: transgenerational accumulation of histone methylation
def: "The amount of histone methylation, for example as measured by the amount of H3K4me2, increases over successive generations" [WB:WBPaper00045092, WB:WBPerson712]
synonym: "generational accumulation of histone methylation" RELATED []
synonym: "progressive accumulation of histone methylation" RELATED []
synonym: "transgenerational epigenetic accumulation of histone methylation" RELATED []
is_a: WBPhenotype:0002078 ! histone methylation variant

[Term]
id: WBPhenotype:0002168
name: transgenerational loss of fertility
def: "Animals exhibit a decline in fertility over generations. This is often assessed by counting laid eggs over successive generations." [WB:WBPaper00045092, WB:WBPerson712]
synonym: "generational loss of fertility" RELATED []
synonym: "progressive loss of fertility" RELATED []
synonym: "transgenerational epigenetic loss of fertility" RELATED []
is_a: WBPhenotype:0000145 ! fertility phenotype

[Term]
id: WBPhenotype:0002169
name: reproductive longevity shortened
def: "Animals stop producing progeny significantly before the time reproduction stops in control animals." [WB:WBPaper00027157, WB:WBPerson2987]
is_a: WBPhenotype:0001739 ! aging variant

[Term]
id: WBPhenotype:0002170
name: calcium mediated signaling variant
def: "Any variation in the series of molecular signals in which a cell or tissue uses calcium ions to convert a signal into a response, compared to control." [WB:WBPerson557]
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002171
name: alkaline pH chemotaxis variant
def: "Animals exhibit variations in the characteristic movement towards typically attractive alkaline pH (pH higher than 7) compared to control. However animals tend to avoid very high pH levels (pH11).  pH is a measure of the acidity or basicity of an aqueous solution. In C. elegans animals chemotax toward higher alkaline pH." [GO:0036176, WB:WBPaper00042397, WB:WBPerson557]
synonym: "alkaline pH sensing variant" RELATED []
synonym: "alkalinity sensing variant" RELATED []
is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant

[Term]
id: WBPhenotype:0002172
name: pathogen release variant
def: "Infected animals exhibit variations in the process of releasing pathogens back into the environment, compared to control." [WB:WBPaper00040246, WB:WBPerson2987]
synonym: "spore shedding variant" NARROW []
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0002173
name: cell number variant
def: "Animals exhibit variations in the number of cells that make up the organism compared to control animals." [WB:WBPaper00032029, WB:WBPerson2987]
is_a: WBPhenotype:0000531 ! organism development variant

[Term]
id: WBPhenotype:0002174
name: cell number decreased
def: "The number of cells in the organism is reduced compared to control animals." [WB:WBPaper00032029, WB:WBPerson2987]
is_a: WBPhenotype:0002173 ! cell number variant

[Term]
id: WBPhenotype:0002175
name: cell number increased
def: "The number of cells in the organism is increased compared to control animals." [WB:WBPaper00032029, WB:WBPerson2987]
is_a: WBPhenotype:0002173 ! cell number variant

[Term]
id: WBPhenotype:0002176
name: seam cell morphology variant
def: "Animals exhibit variations in the structure, organization or placement of the population of the lateral, alae-producing epithelial cells (seam cells), compared to that observed in control animals." [WB:WBPaper00032029, WB:WBPerson2987]
is_a: WBPhenotype:0000899 ! epithelial cell morphology variant

[Term]
id: WBPhenotype:0002177
name: plasma membrane composition variant
def: "Any variation in the components that make up the semipermeable bilayer surrounding a cell that separates the cell from its external environment compared to control." [GO:0005886, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002178
name: plasma membrane leaflet composition variant
def: "Any variation in the components that make up either of the two leaflets of the semipermeable bilayer surrounding a cell that separates the cell from its external environment compared to control." [GO:0009897, GO:0009898, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002177 ! plasma membrane composition variant

[Term]
id: WBPhenotype:0002179
name: X ray induced mitotic germ cell arrest defective
def: "Animals do not arrest mitotic germ cell division, as control animals, when treated with X-ray radiation." [WB:WBPaper00004952, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant

[Term]
id: WBPhenotype:0002180
name: apoptotic cell shedding variant
def: "Animals exhibit variations in the process by which cells having undergone programmed cell death are shed or extruded into the extracellular environment." [WB:WBPaper00041303, WB:WBPerson2987]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0002181
name: extra excretory cells
def: "Animals produce an excess number of excretory cells compared to controls." [WB:WBPaper00041303, WB:WBPerson2987]
is_a: WBPhenotype:0000621 ! excretory system development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0002182
name: reactive oxygen species homeostasis variant
def: "Animals exhibit variations in endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals." [WB:WBPaper00042351, WB:WBPerson2987]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002183
name: oxidative DNA damage variant
def: "Animals exhibit variations in levels of DNA damage caused by oxidative stress." [WB:WBPaper00042351, WB:WBPerson2987]
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0002184
name: starvation induced apoptosis variant
def: "Any variation in the amount of cells undergoing apoptosis in organism as a result of deprivation of nourishment, compared to control. In C. elegans, starvation normally causes increased apoptosis." [WB:WBPaper00044006, WB:WBPerson557]
is_a: WBPhenotype:0000147 ! organism starvation response variant
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0002185
name: cell fate transformation to endoderm
def: "Animals develop endodermal cells/tissue from precursor cells that do not normally produce endodermal cells/tissue." [WB:WBPaper00003645, WB:WBPerson2987]
is_a: WBPhenotype:0000414 ! cell fate transformation

[Term]
id: WBPhenotype:0002186
name: cell fate transformation to pharyngeal muscle
def: "Animals develop pharyngeal muscles from precursor cells that do not normally produce pharyngeal muscles." [WB:WBPaper00003645, WB:WBPerson2987]
is_a: WBPhenotype:0000414 ! cell fate transformation

[Term]
id: WBPhenotype:0002187
name: cell fate transformation to body wall muscle
def: "Animals develop body wall muscle from precursor cells that do not normally produce body wall muscle." [WB:WBPaper00003574, WB:WBPaper00003645, WB:WBPerson2987]
is_a: WBPhenotype:0000414 ! cell fate transformation

[Term]
id: WBPhenotype:0002188
name: male somatic gonad development variant
def: "Any variation in the progression of the components of the male gonad that are separate from the germline proper over time, from its formation to its mature structure compared to control.  In C. elegans, the male somatic gonad consists of three tissues: distal tip cells (DTCs), the seminal vesicle, and the vas deferens (Wormatlas)." [WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000399 ! somatic gonad development variant
is_a: WBPhenotype:0001675 ! male gonad development variant

[Term]
id: WBPhenotype:0002189
name: extra linker cells
def: "Animals produce an excess number of linker cells compared to controls." [WB:WBPaper00005116, WB:WBPerson2987]
synonym: "excess linker cells" EXACT []
is_a: WBPhenotype:0001675 ! male gonad development variant
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0002190
name: fewer hypodermal cells
def: "The population of hypodermal cells is reduced compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0002191
name: fewer sex myoblasts
def: "Animals produce a reduced number of sex myoblasts compared to controls." [WB:WBPaper00033137, WB:WBPerson2987]
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0002192
name: extra sex myoblasts
def: "Animals produce an excess number of sex myoblasts compared to controls." [WB:WBPaper00033137, WB:WBPerson2987]
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0002193
name: posterior reversed vulval lineage
def: "The orientation of the progeny of P7.p mimic those of P5.p and face towards the posterior of the worm, a phenotype referred to as posterior-reversed vulval lineage (P-Rvl)." [WB:WBPaper00044058, WB:WBPerson557]
synonym: "P-Rvl" BROAD []
is_a: WBPhenotype:0000220 ! vulva cell fate specification variant
is_a: WBPhenotype:0000239 ! vulval cell lineage variant

[Term]
id: WBPhenotype:0002194
name: food dependent body size variant
def: "Animals do not differ in size when grown on different food sources to the same extent as that measured for control animals. For example, in C. elegans, wild type worms are 1.65 times larger when grown on HB101 compared to those grown on OP50." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0002195 ! food dependent growth variant

[Term]
id: WBPhenotype:0002195
name: food dependent growth variant
def: "Animals exhibit variations in growth rate or the outcome of growth in response to food compared to control. In C. elegans, animals exhibit an increase or decrease in growth rate depending on the type of bacteria they are fed." [WB:WBPaper00038311, WB:WBPerson712]
is_a: WBPhenotype:0001072 ! response to food variant

[Term]
id: WBPhenotype:0002196
name: outward rectifying current variant
def: "The driving force of the outward flow of ions does not exceed the inward flow for the opposite driving force or is otherwise altered when compared to that measured for control animals." [WB:WBPaper00036046, WB:WBPerson712]
is_a: WBPhenotype:0002197 ! voltage gated channel activity variant

[Term]
id: WBPhenotype:0002197
name: voltage gated channel activity variant
def: "Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded is altered from that observed for controls." [WB:WBPerson712]
is_a: WBPhenotype:0001315 ! electrophysiology phenotype

[Term]
id: WBPhenotype:0002198
name: neuromuscular junction organization variant
def: "The proper localization and assembly of components at the junction of a neuron with a muscle cell varies from that observed in control animals." [WB:WBPaper00038066, WB:WBPerson712]
is_a: WBPhenotype:0000625 ! synaptogenesis variant

[Term]
id: WBPhenotype:0002199
name: neuron calcium transient levels variant
def: "The degree of stimulus-evoked calcium concentration changes differs from that of controls." [WB:WBPaper00039855, WB:WBPerson712]
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0002200
name: oviduct muscle defective
def: "Variations in the progression of the muscles of the adult hermaphrodite oviduct over time from their initial formation to their mature structure compared to control." [WB:WBPerson712]
is_a: WBPhenotype:0000282 ! hermaphrodite sex muscle development variant

[Term]
id: WBPhenotype:0002201
name: apoptotic DNA degradation defective
def: "Dying animals cells exhibit defects in the fragmentation of chromosomal DNA into oligonucleosomal-length fragments compared to control animals. This process can be monitored by the quantity and quality of TUNEL (TdT-mediated dUTP nick end labeling)-positive nuclei." [WB:WBPaper00005978, WB:WBPerson712]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0002202
name: pharynx extension defective
def: "Embryos exhibit defects in the extension of pharyngeal cells toward the buccal opening during embryogenesis compared to controls." [WB:WBPaper00005085, WB:WBPerson712]
is_a: WBPhenotype:0001748 ! pharynx unattached

[Term]
id: WBPhenotype:0002203
name: corpse morphology variant
def: "Corpses resulting from programmed cell death appear different in size or shape from those of corpses in control animals." [WB:WBPaper00004688, WB:WBPerson712]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0002204
name: procorpus contraction defective
def: "Animals exhibit defects in the muscle contractions of the anterior region of corpus, the area responsible for allowing food to enter the corpus." [WB:WBPaper00005996, WB:WBPerson712]
is_a: WBPhenotype:0000327 ! corpus contraction defect

[Term]
id: WBPhenotype:0002205
name: hypersensitive to galactose
def: "Animals exhibit negative effects on growth, development, or metabolism when exposed to a galactose-rich diet, compared to control animals." [WB:WBPaper00045849, WB:WBPerson712]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002206
name: galactose metabolism variant
def: "Animals process dietary galactose differently than control animals, these differences can result in increased and or decreased levels of intermediary galactose metabolites." [WB:WBPaper00045849, WB:WBPerson712]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002207
name: missing gonad arms
def: "Animals are missing one or both gonad arms, the normally U-shaped projections of the gonad that extend into the anterior or posterior of the animal and bends back towards the center of the animal." [WB:WBPaper00003453, WB:WBPerson2987]
is_a: WBPhenotype:0000399 ! somatic gonad development variant

[Term]
id: WBPhenotype:0002208
name: antibody temporal expression variant
def: "The expression of a protein, as determined by antibody staining, varied from controls with respect to timing such that the protein was observed to be expressed at earlier timepoints or later timepoints than controls." [WB:WBPaper00003383, WB:WBPerson2987]
is_a: WBPhenotype:0000424 ! antibody staining variant

[Term]
id: WBPhenotype:0002209
name: hook development variant
def: "Any variation in the development of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating." [WB:WBPaper00003428, WB:WBPerson2987]
is_a: WBPhenotype:0000624 ! reproductive system development variant
is_a: WBPhenotype:0001297 ! male tail development variant

[Term]
id: WBPhenotype:0002210
name: extra rays
def: "Animals exhibit an extra number of the finger-like sensory sensilla that project from the tail and embed in the male fan." [WB:WBPaper00003428, WB:WBPerson2987]
is_a: WBPhenotype:0000199 ! male tail sensory ray development variant

[Term]
id: WBPhenotype:0002211
name: phasmid neuron dye filling defect
def: "Animals exhibit defects in dye-filling of the neuronal cells of the phasmid sensilla. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO." [WB:WBPaper00003450, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000257 ! phasmid neuron morphology variant
is_a: WBPhenotype:0002535 ! dye filling defect

[Term]
id: WBPhenotype:0002212
name: amphid neuron dye filling defect
def: "Animals exhibit defects in dye-filling of the neuronal cells of the amphid sensilla. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO." [WB:WBPerson557]
is_a: WBPhenotype:0000256 ! amphid neuron morphology variant
is_a: WBPhenotype:0002535 ! dye filling defect

[Term]
id: WBPhenotype:0002213
name: kinase activity reduced
def: "Any variation that results in a decrease in the catalytic phosphorylation activity of a kinase enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). Kinases are enzymes capable of phosphorylating their respective substrates." [WB:WBPaper00003656, WB:WBPerson2987]
is_a: WBPhenotype:0000124 ! enzyme activity reduced

[Term]
id: WBPhenotype:0002214
name: extra pharyngeal muscle cells
def: "Animals contain an excess number of pharyngeal muscle cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate." [WB:WBPaper00003574, WB:WBPerson2987]
is_a: WBPhenotype:0001635 ! excess pharyngeal cells

[Term]
id: WBPhenotype:0002215
name: fewer body wall muscles
def: "Any variation that results in a fewer than control number of body wall muscle cells." [WB:WBPaper00003574, WB:WBPerson2987]
is_a: WBPhenotype:0001597 ! muscle missing

[Term]
id: WBPhenotype:0002216
name: pattern antibody staining variant
def: "Any variation in the cellular or subcellular distribution of a gene product, as detected by antibody staining, compared to that observed in control animals." [WB:WBPaper00003574, WB:WBPaper00003656, WB:WBPerson2987]
is_a: WBPhenotype:0000424 ! antibody staining variant

[Term]
id: WBPhenotype:0002217
name: antimony hypersensitive
def: "Animals respond to antimony at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002619, WB:WBPerson2987]
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0002218
name: arsenite hypersensitive
def: "Animals respond to arsenite at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002619, WB:WBPaper00029261, WB:WBPaper00031023, WB:WBPerson2987]
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0002219
name: fluoranthene hypersensitive
def: "Animals respond to fluoranthene at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00031850, WB:WBPerson2987]
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0002220
name: antimonite hypersensitivity
def: "Animals respond to antimonite at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00029261, WB:WBPerson2987]
is_a: WBPhenotype:0002217 ! antimony hypersensitive

[Term]
id: WBPhenotype:0002221
name: pharyngeal vacuole
def: "The pharynx contains cavities, possibly indicative of inappropriate cell death." [WB:WBPaper00004381, WB:WBPerson2987]
is_a: WBPhenotype:0001363 ! head cavity
is_a: WBPhenotype:0002615 ! abnormal accumulation of vacuoles

[Term]
id: WBPhenotype:0002222
name: uterus vacuole
def: "The uterus contains cavities, possibly indicative of inappropriate cell death." [WB:WBPaper00004381, WB:WBPerson2987]
is_a: WBPhenotype:0001395 ! body vacuole

[Term]
id: WBPhenotype:0002223
name: manganese hypersensitivity
def: "Animals respond at a faster rate or to lower concentrations of manganese that that observed for control animals." [WB:WBPaper00044740, WB:WBPerson712]
is_a: WBPhenotype:0001863 ! manganese response variant

[Term]
id: WBPhenotype:0002224
name: mercury hypersensitive
def: "Animals respond to mercury at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00004381, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002225
name: lead hypersensitive
def: "Animals respond to lead at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00004381, WB:WBPerson2987]
is_a: WBPhenotype:0002227 ! lead response variant

[Term]
id: WBPhenotype:0002226
name: cobalt hypersensitive
def: "Animals respond to cobalt at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00005255, WB:WBPaper00006388, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002227
name: lead response variant
def: "Animals exhibit variations in their response to lead compared to that observed in control animals." [WB:WBPaper00029261, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002228
name: aluminum response variant
def: "Animals exhibit variations in their response to aluminum compared to that observed in control animals." [WB:WBPaper00029261, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002229
name: chromium response variant
def: "Animals exhibit variations in their response to chromium compared to that observed in control animals." [WB:WBPaper00029261, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002230
name: metal accumulation increased
def: "Animals exhibited higher amounts of internal metal concentrations compared to control animals." [WB:WBPaper00044740, WB:WBPerson712]
is_a: WBPhenotype:0002029 ! metal homeostasis variant

[Term]
id: WBPhenotype:0002231
name: manganese induced oxidative stress response
def: "Oxidative stress induced by manganese differs from that of control worms." [WB:WBPaper00044740, WB:WBPerson712]
is_a: WBPhenotype:0001620 ! organism oxidative stress response variant

[Term]
id: WBPhenotype:0002232
name: synaptic remodeling variant
def: "The polarity reversal process by which synaptic components are removed from one side of the synapse and then reformed on the opposite cell does not occur or occurs in a different manner than in controls. In C. elegans, at the end of the L1 stage, the DD neurons undergo a complete polarity reversal such that the ventral synapses disappear and new synapses are formed on opposing dorsal body muscles." [WB:WBPaper00005543, WB:WBPerson712]
is_a: WBPhenotype:0000625 ! synaptogenesis variant

[Term]
id: WBPhenotype:0002233
name: osmolarity modulated swimming variant
def: "The swimming behavior of animals are influenced or modulate by the osmolarity of the swimming buffer. The swimming of wild-type C. elegans animals are not affected by the osmolarity of the swimming liquid." [WB:WBPaper00041219, WB:WBPerson712]
is_a: WBPhenotype:0000876 ! organism osmotic stress response variant

[Term]
id: WBPhenotype:0002234
name: increased acidified compartments
def: "Animals contain excess acidified intracellular compartments. These compartments are positive for indicators such as Acridine Orange as well as LysoTracker Red, in a lysosome-like manner." [WB:WBPaper00005190, WB:WBPerson712]
is_a: WBPhenotype:0001393 ! cell acidification variant

[Term]
id: WBPhenotype:0002235
name: growth defective on low phosphate media
def: "Animals are unable to grow on media depleted of phosphate." [WB:WBPerson712]
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0002236
name: endo lysosomal degradation pathway defective
def: "The degradation of endocytosed and intracellular material does not occur to the same extent as it does in control animals." [WB:WBPaper00037899, WB:WBPerson712]
is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant

[Term]
id: WBPhenotype:0002237
name: endocytic recycling compartment organization and biogenesis defective
def: "Animals exhibit disruptions in tubular or tubulo-vesicular structures that function in endocytic transport from early to recycling endosomes." [WB:WBPaper00037899, WB:WBPerson712]
synonym: "ERC organization and biogenesis defective" EXACT []
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0002238
name: increased levels of reactive oxygen species
def: "Animals exhibit increased endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals." [WB:WBPaper00040454, WB:WBPerson2987]
is_a: WBPhenotype:0002182 ! reactive oxygen species homeostasis variant

[Term]
id: WBPhenotype:0002239
name: reduced levels of reactive oxygen species
def: "Animals exhibit reduced endogenous levels of reactive oxygen species (chemically reactive molecules containing oxygen) compared to that observed in control animals." [WB:WBPaper00040454, WB:WBPerson2987]
is_a: WBPhenotype:0002182 ! reactive oxygen species homeostasis variant

[Term]
id: WBPhenotype:0002240
name: gut granule morphology variant
def: "Any variation in the morphology of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPaper00040622, WB:WBPerson2987]
is_a: WBPhenotype:0000902 ! intestinal cell morphology variant

[Term]
id: WBPhenotype:0002241
name: feeding reduced
def: "Animals consume less food than control animals" [WB:WBPaper00036303, WB:WBPerson2987]
is_a: WBPhenotype:0000659 ! feeding behavior variant

[Term]
id: WBPhenotype:0002242
name: hypersensitive to iron deficiency
def: "Animals exhibit detrimental responses to iron deficiency more readily than control animals." [WB:WBPaper00040550, WB:WBPerson2987]
is_a: WBPhenotype:0002046 ! iron homeostasis variant

[Term]
id: WBPhenotype:0002243
name: phytochelatin synthesis deficient
def: "Animals do not produce the same amount of functional phytochelatins as measured in control worms. Phytochelatins are any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GO:0046938, WB:WBPaper00036020, WB:WBPerson712]
is_a: WBPhenotype:0001696 ! biosynthesis variant

[Term]
id: WBPhenotype:0002244
name: arsenic hypersensitive
def: "Animals respond to arsenic at a lower concentration or at a shorter exposure time compared to control animals." [WB:WBPaper00036020, WB:WBPerson712]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002245
name: endogenous zinc levels reduced
def: "Animals exhibit reduced levels of endogenous zinc compared to control animals." [WB:WBPaper00040622, WB:WBPerson2987]
is_a: WBPhenotype:0001849 ! zinc homeostasis variant

[Term]
id: WBPhenotype:0002246
name: endogenous zinc levels increased
def: "Animals exhibit increased levels of endogenous zinc compared to control animals." [WB:WBPaper00040622, WB:WBPerson2987]
is_a: WBPhenotype:0001849 ! zinc homeostasis variant

[Term]
id: WBPhenotype:0002247
name: copper homeostasis variant
def: "Variations in the regulation of levels, transport, and metabolism of copper ions within an organism compared to control." [WB:WBPaper00040622, WB:WBPerson2987]
is_a: WBPhenotype:0002029 ! metal homeostasis variant

[Term]
id: WBPhenotype:0002248
name: hypersensitive to zinc deficiency
def: "Animals exhibit detrimental responses to zinc deficiency more readily than control animals" [WB:WBPaper00040622, WB:WBPerson2987]
is_a: WBPhenotype:0001849 ! zinc homeostasis variant

[Term]
id: WBPhenotype:0002249
name: reduced protein oxidation levels
def: "Protein oxidation levels, as measured by carbonylated protein levels for example, are reduced compared to controls." [WB:WBPaper00040914, WB:WBPerson2987]
is_a: WBPhenotype:0000068 ! cellular oxidative stress response variant

[Term]
id: WBPhenotype:0002250
name: silver hypersensitive
def: "Animals respond to silver at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002251
name: silver nanoparticle hypersensitive
def: "Animals respond to silver nanoparticles (AgNPs) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00044630, WB:WBPerson2987]
is_a: WBPhenotype:0002250 ! silver hypersensitive

[Term]
id: WBPhenotype:0002252
name: increased susceptibility to viral infection
def: "Animals are more prone to infection by virus compared to control animals." [WB:WBPaper00046393, WB:WBPerson712]
is_a: WBPhenotype:0001013 ! pathogen susceptibility increased

[Term]
id: WBPhenotype:0002253
name: 22G RNA expression reduced
def: "Animals exhibit lowered levels of any or all of the clades of 22G RNA molecules, compared to control." [WB:WBPaper00046393, WB:WBPerson712]
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0002254
name: three prime target RNA uridylation reduced
def: "Three-prime (3') uridylation of mRNA targeted for silencing does not occur at the same rate or extent of targeted mRNA in control animals." [WB:WBPaper00046393, WB:WBPerson712]
is_a: WBPhenotype:0000028 ! RNA processing variant

[Term]
id: WBPhenotype:0002255
name: amino acid metabolism variant
def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of amino acids within the organism or cell compared to control." [WB:WBPaper00038278, WB:WBPerson2987]
is_a: WBPhenotype:0000463 ! metabolic pathway variant

[Term]
id: WBPhenotype:0002256
name: selenium response variant
def: "Animals exhibit variations in their response to selenium compared to that observed in control animals." [WB:WBPaper00038278, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002257
name: iron hypersensitive
def: "Animals respond to iron at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00038278, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002258
name: nickel toxicity resistant
def: "Animals fail to exhibit toxicity to the concentration of nickel that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to nickel include delayed development or lethality." [WB:WBPaper00038278, WB:WBPerson2987]
is_a: WBPhenotype:0000591 ! metal response variant

[Term]
id: WBPhenotype:0002259
name: dendritic termini number reduced
def: "The number of terminal regions of a neuron's dendrite is less that that observed for control animals." [WB:WBPaper00046432, WB:WBPerson557, WB:WBPerson712]
is_a: WBPhenotype:0000882 ! dendrite development variant

[Term]
id: WBPhenotype:0002260
name: gamete necrotic death increased
def: "Ooctyes and or sperm appear vacuolated and degenerated compared to gametes in control animals. This degeneration is not due to normal programmed cell death." [WB:WBPaper00041364, WB:WBPerson712]
synonym: "necrotic gamete degeneration increased" RELATED []
is_a: WBPhenotype:0001397 ! necrotic cell death increased

[Term]
id: WBPhenotype:0002261
name: neurite connectivity defective
def: "An effective connection between reciprocal target neurons is not established properly." [WB:WBPaper00042557, WB:WBPerson712]
is_a: WBPhenotype:0000623 ! nervous system development variant

[Term]
id: WBPhenotype:0002262
name: postsynaptic component localization variant
def: "Animals display variations in the distribution of the constituents of the postsynaptic side of the active zone, compared to control animals, that are required for receiving signals from the presynaptic side." [WB:WBPaper00005543, WB:WBPaper00038066, WB:WBPerson712]
is_a: WBPhenotype:0001685 ! postsynaptic region morphology variant

[Term]
id: WBPhenotype:0002263
name: mitochondrial membrane potential increased
def: "Any increase in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control." [WB:WBPaper00040353, WB:WBPerson557]
is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant

[Term]
id: WBPhenotype:0002264
name: ATP levels increased
def: "Animals exhibit an increase in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPaper00036073, WB:WBPaper00040353, WB:WBPerson557]
is_a: WBPhenotype:0001574 ! ATP levels variant

[Term]
id: WBPhenotype:0002265
name: lysosome-related organelle biogenesis variant
def: "Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041842, WB:WBPerson2987]
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0002266
name: mitochondrial content variant
def: "Animals exhibit variations in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining." [WB:WBPaper00035277, WB:WBPerson2987]
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0002267
name: mitochondrial content increased
def: "Animals exhibit increases in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining." [WB:WBPaper00035277, WB:WBPerson2987]
is_a: WBPhenotype:0002266 ! mitochondrial content variant

[Term]
id: WBPhenotype:0002268
name: mitochondrial content decreased
def: "Animals exhibit decreases in the overall amount of mitochondria present in the animal, as determined by, for example, Mitotracker staining." [WB:WBPaper00035277, WB:WBPerson2987]
is_a: WBPhenotype:0002266 ! mitochondrial content variant

[Term]
id: WBPhenotype:0002269
name: oxygen consumption increased
def: "Animals exhibit an increased rate of oxygen utilization compared to control animals." [WB:WBPaper00035277, WB:WBPerson2987]
is_a: WBPhenotype:0002141 ! oxygen consumption variant

[Term]
id: WBPhenotype:0002270
name: metabolite content decreased
def: "Animals exhibit a decrease in the quantity of metabolites, small molecule products or intermediates required for the metabolic functioning of the cell or organism" [WB:WBPaper00040386, WB:WBPerson2987]
is_a: WBPhenotype:0000463 ! metabolic pathway variant

[Term]
id: WBPhenotype:0002271
name: food absorption rate variant
def: "Animals exhibit variations in the rate at which food is absorbed by the intestine, as determined by a time-course recording of fat staining (by C1-BODIPY-C12, for example) normalized to controls" [WB:WBPaper00032310, WB:WBPerson2987]
is_a: WBPhenotype:0000659 ! feeding behavior variant

[Term]
id: WBPhenotype:0002272
name: protein carbonylation variant
def: "Animals exhibit variations in the covalent modification of one or more native amino acid side chains in proteins to carbonyl derivatives such as an aldehyde or ketone." [WB:WBPaper00006515]
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0002273
name: dietary sugar response variant
def: "Animals exhibit enhanced negative effects on growth, health, development or metabolism, in response to dietary sugar-rich diets, compared to controls." [WB:WBPaper00045849, WB:WBPerson712]
is_a: WBPhenotype:0002525 ! diet response variant

[Term]
id: WBPhenotype:0002274
name: plugged on body
def: "Males receive copulatory plugs from other males, deposited elsewhere on their bodies, in the absence of any orifice. This typically involves penetration of the depositing male's spicules directly through the cuticle of the recipient male." [WB:WBPerson22615, WB:WBPerson7165]
synonym: "Plob" BROAD []
is_a: WBPhenotype:0001728 ! mating plug production variant

[Term]
id: WBPhenotype:0002275
name: plugged excretory pore
def: "Males receive copulatory plugs from other males, deposited on their excretory pores. This phenotype is polymorphic among C. elegans strains and also in C. briggsae." [WB:WBPerson22615, WB:WBPerson7165]
synonym: "Pleb" BROAD []
synonym: "Plep" RELATED []
is_a: WBPhenotype:0001728 ! mating plug production variant

[Term]
id: WBPhenotype:0002276
name: dauer lifespan shortened
def: "The life span of dauer-staged animals is shorter than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
is_a: WBPhenotype:0001540 ! dauer lifespan variant

[Term]
id: WBPhenotype:0002277
name: dauer lifespan extended
def: "The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
is_a: WBPhenotype:0001540 ! dauer lifespan variant

[Term]
id: WBPhenotype:0002278
name: acute functional tolerance to alcohol defective
def: "Animals do not develop acute functional tolerance to alcohol after a short exposure, unlike that observed in control animals" [WB:WBPaper00046494, WB:WBPerson712]
synonym: "ATF" RELATED []
is_a: WBPhenotype:0000555 ! drug adaptation variant

[Term]
id: WBPhenotype:0002279
name: fat associated body size decreased
def: "Animals exhibit a decrease in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining." [WB:WBPaper00042257, WB:WBPerson2987]
synonym: "lipid body size decreased" RELATED []
is_a: WBPhenotype:0001901 ! fat associated bodies variant

[Term]
id: WBPhenotype:0002280
name: organism osmotic stress resistant
def: "Animals exhibit resistance to osmotic stress compared to that observed in control animals." [WB:WBPaper00032396, WB:WBPerson2987]
is_a: WBPhenotype:0000876 ! organism osmotic stress response variant

[Term]
id: WBPhenotype:0002281
name: organism osmotic stress hypersensitive
def: "Animals exhibit hypersensitivty to osmotic stress compared to that observed in control animals." [WB:WBPaper00032396, WB:WBPerson2987]
is_a: WBPhenotype:0000876 ! organism osmotic stress response variant

[Term]
id: WBPhenotype:0002282
name: autophagy increased
def: "Animals exhibit increased levels of the process by which their cells digest parts of their own cytoplasm, compared to control." [WB:WBPaper00026641, WB:WBPaper00038332, WB:WBPaper00041372, WB:WBPaper00043981, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000736 ! autophagy variant

[Term]
id: WBPhenotype:0002283
name: autophagy reduced
def: "Animals exhibit reduced levels of the process by which their cells digest parts of their own cytoplasm, compared to control." [WB:WBPaper00006070, WB:WBPaper00035076, WB:WBPaper00041851, WB:WBPaper00043981, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000736 ! autophagy variant

[Term]
id: WBPhenotype:0002284
name: head bend angle variant
def: "Any variation in the extent of the maximum flex of the most anterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001265 ! head movement variant

[Term]
id: WBPhenotype:0002285
name: head bend angle decreased
def: "Animals exhibit a decrease in the extent of the maximum flex of the most anterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002284 ! head bend angle variant

[Term]
id: WBPhenotype:0002286
name: head bend angle increased
def: "Animals exhibit an increase in the extent of the maximum flex of the most anterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002284 ! head bend angle variant

[Term]
id: WBPhenotype:0002287
name: tail movement variant
def: "The most posterior portion of the animal exhibits variations in its movement compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001699 ! localized movement variant

[Term]
id: WBPhenotype:0002288
name: tail bend angle variant
def: "Any variation in the extent of the maximum flex of the most posterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002287 ! tail movement variant

[Term]
id: WBPhenotype:0002289
name: tail bend angle increased
def: "Animals exhibit an increase in the extent of the maximum flex of the most posterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002288 ! tail bend angle variant

[Term]
id: WBPhenotype:0002290
name: tail bend angle decreased
def: "Animals exhibit a decrease in the extent of the maximum flex of the most posterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002288 ! tail bend angle variant

[Term]
id: WBPhenotype:0002291
name: body posture amplitude variant
def: "Animals exhibit variations in body posture with regard to the extent of displacement measured from the mean position to an extreme position compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0002292
name: body posture amplitude decreased
def: "Animals exhibit variations in body posture caused by a decrease in the extent of displacement measured from the mean position to an extreme position compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002291 ! body posture amplitude variant

[Term]
id: WBPhenotype:0002293
name: body posture amplitude increased
def: "Animals exhibit variations in body posture caused by an increase in the extent of displacement measured from the mean position to an extreme position compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002291 ! body posture amplitude variant

[Term]
id: WBPhenotype:0002294
name: body posture wavelength variant
def: "Animals exhibit variations in body posture with regard to the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0002295
name: body posture wavelength decreased
def: "Animals exhibit variations in body posture caused by a decrease in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002294 ! body posture wavelength variant

[Term]
id: WBPhenotype:0002296
name: body posture wavelength increased
def: "Animals exhibit variations in body posture caused by an increase in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002294 ! body posture wavelength variant

[Term]
id: WBPhenotype:0002297
name: coiling variant
def: "Animals exhibit variations in the occurrence of a coil-like body posture compared to control animals. This includes the amount of time spent in a coil, the frequency with which coils form and the inappropriate formation of a coil, for example when attempting to locomote." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0002298
name: coiling frequency variant
def: "Animals exhibit variations in the amount of time spent with its body posture in a coil or the frequency with which they form coils compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002297 ! coiling variant

[Term]
id: WBPhenotype:0002299
name: coiling frequency decreased
def: "Animals spend less time with their body posture in a coil or they decrease the frequency with which they form coils compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002298 ! coiling frequency variant

[Term]
id: WBPhenotype:0002300
name: coiling frequency increased
def: "Animals spend more time with their body posture in a coil or they increase the frequency with which they form coils compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002298 ! coiling frequency variant

[Term]
id: WBPhenotype:0002301
name: nose movement variant
def: "The extreme anterior of the animal exhibits variations in its movement compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000662 ! foraging behavior variant
is_a: WBPhenotype:0001699 ! localized movement variant

[Term]
id: WBPhenotype:0002302
name: nose movement decreased
def: "Animals exhibit a decrease in the movement of the extreme anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002301 ! nose movement variant

[Term]
id: WBPhenotype:0002303
name: nose movement increased
def: "Animals exhibit an increase in the movement of the extreme anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002301 ! nose movement variant

[Term]
id: WBPhenotype:0002304
name: head movement decreased
def: "Animals exhibit a decrease in the movement of the most anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000595 ! head behavior variant
is_a: WBPhenotype:0001265 ! head movement variant

[Term]
id: WBPhenotype:0002305
name: head movement increased
def: "Animals exhibit an increase in the movement of the most anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000595 ! head behavior variant
is_a: WBPhenotype:0001265 ! head movement variant

[Term]
id: WBPhenotype:0002306
name: tail movement decreased
def: "Animals exhibit a decrease in the movement of the most posterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000597 ! tail behavior variant
is_a: WBPhenotype:0002287 ! tail movement variant

[Term]
id: WBPhenotype:0002307
name: tail movement increased
def: "Animals exhibit an increase in the movement of the most posterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000597 ! tail behavior variant
is_a: WBPhenotype:0002287 ! tail movement variant

[Term]
id: WBPhenotype:0002308
name: pausing variant
def: "Animals exhibit variations in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001213 ! locomotion reduced

[Term]
id: WBPhenotype:0002309
name: pausing decreased
def: "Animals exhibit a decrease in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002308 ! pausing variant

[Term]
id: WBPhenotype:0002310
name: pausing increased
def: "Animals exhibit an increase in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002308 ! pausing variant

[Term]
id: WBPhenotype:0002311
name: turning variant
def: "Variations in the behavior by which an organism alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001702 ! directionality variant

[Term]
id: WBPhenotype:0002312
name: turning frequency variant
def: "Animals exhibit variations in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002311 ! turning variant

[Term]
id: WBPhenotype:0002313
name: turning frequency increased
def: "Animals exhibit an increase in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002312 ! turning frequency variant

[Term]
id: WBPhenotype:0002314
name: turning frequency reduced
def: "Animals exhibit a decrease in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002312 ! turning frequency variant

[Term]
id: WBPhenotype:0002315
name: roaming variant
def: "Animals exhibit variations in their movement at high-speed in the forward direction with brief backward movement compared to control. During roaming, control animals often traverse wide regions." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
synonym: "path range variant" RELATED []
is_a: WBPhenotype:0000641 ! activity level variant
is_a: WBPhenotype:0000662 ! foraging behavior variant

[Term]
id: WBPhenotype:0002316
name: dwelling variant
def: "Animals exhibit variations in the low-speed/high turning movement that restricts them to a confined region compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000641 ! activity level variant
is_a: WBPhenotype:0000662 ! foraging behavior variant

[Term]
id: WBPhenotype:0002317
name: dwelling increased
def: "Animals exhibit an increase in the low-speed/high turning movement that usually restricts them to a confined region compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000238 ! foraging reduced
is_a: WBPhenotype:0001213 ! locomotion reduced
is_a: WBPhenotype:0002316 ! dwelling variant

[Term]
id: WBPhenotype:0002318
name: dwelling reduced
def: "Animals exhibit a decrease in the low-speed/high turning movement that usually restricts them to a confined region compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000237 ! foraging hyperactive
is_a: WBPhenotype:0002316 ! dwelling variant

[Term]
id: WBPhenotype:0002319
name: roaming increased
def: "Animals exhibit an increase in their high-speed movement in the forward direction with brief backward movement compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
synonym: "path range increased" RELATED []
is_a: WBPhenotype:0000237 ! foraging hyperactive
is_a: WBPhenotype:0002315 ! roaming variant

[Term]
id: WBPhenotype:0002320
name: reversal variant
def: "Variations in the behavior by which an organism shifts from forward to backward movements." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001702 ! directionality variant

[Term]
id: WBPhenotype:0002321
name: forward point velocity decreased
def: "Animals exhibit decreased velocity of forward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001716 ! forward point velocity variant

[Term]
id: WBPhenotype:0002322
name: forward point velocity increased
def: "Animals exhibit increased velocity of forward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001716 ! forward point velocity variant

[Term]
id: WBPhenotype:0002323
name: backward point velocity variant
def: "Animals exhibit variations in the velocity of backward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0004025 ! velocity of movement variant

[Term]
id: WBPhenotype:0002324
name: backward point velocity decreased
def: "Animals exhibit decreased velocity of backward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002323 ! backward point velocity variant

[Term]
id: WBPhenotype:0002325
name: backward point velocity increased
def: "Animals exhibit increased velocity of backward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002323 ! backward point velocity variant

[Term]
id: WBPhenotype:0002326
name: velocity of movement decreased
def: "Animals exhibit a decrease in the net velocity of an animal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
synonym: "sluggish" RELATED []
is_a: WBPhenotype:0004025 ! velocity of movement variant

[Term]
id: WBPhenotype:0002327
name: velocity of movement increased
def: "Animals exhibit an increase in the net velocity of an animal" [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0004025 ! velocity of movement variant

[Term]
id: WBPhenotype:0002328
name: amplitude of sinusoidal movement increased
def: "Animals exhibit an increase in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
synonym: "amplitude of body bends increased" EXACT []
is_a: WBPhenotype:0004022 ! amplitude of sinusoidal movement variant

[Term]
id: WBPhenotype:0002329
name: obsolete temporal frequency of sinusoidal movement variant
def: "OBSOLETE." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0004023

[Term]
id: WBPhenotype:0002330
name: obsolete temporal frequency of sinusoidal movement decreased
def: "OBSOLETE." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0001482

[Term]
id: WBPhenotype:0002331
name: obsolete temporal frequency of sinusoidal movement increased
def: "OBSOLETE." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_obsolete: true
replaced_by: WBPhenotype:0002348

[Term]
id: WBPhenotype:0002332
name: track length variant
def: "Animals exhibit variations in the length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000001 ! body posture variant

[Term]
id: WBPhenotype:0002333
name: track length increased
def: "Animals exhibit increased length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002332 ! track length variant

[Term]
id: WBPhenotype:0002334
name: track length decreased
def: "Animals exhibit decreased length of the minimum enclosing rectangle surrounding the worm body on a solid medium, as viewed through the microscope." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002332 ! track length variant

[Term]
id: WBPhenotype:0002335
name: path curvature variant
def: "Animals exhibit variations in the extent to which the overall path of movement is curved, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0002336
name: path curvature increased
def: "Animals exhibit increases in the extent to which the overall path of movement is curved, producing tighter and more frequent curves compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002335 ! path curvature variant

[Term]
id: WBPhenotype:0002337
name: path curvature decreased
def: "Animals exhibit decreases in the extent to which the overall path of movement is curved, producing shallower, less frequent curves and an overall straighter path, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002335 ! path curvature variant

[Term]
id: WBPhenotype:0002338
name: body proportion variant
def: "Animals exhibit variations in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000231 ! body size variant

[Term]
id: WBPhenotype:0002339
name: body proportion increased
def: "Animals exhibit increases in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002338 ! body proportion variant

[Term]
id: WBPhenotype:0002340
name: body proportion decreased
def: "Animals exhibit decreases in the body-area-to-length ratio and/or the width-to-length ratio, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002338 ! body proportion variant

[Term]
id: WBPhenotype:0002341
name: bent posture variant
def: "Animals exhibit variations in instantaneous posture with regards to eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001703 ! body bend variant

[Term]
id: WBPhenotype:0002342
name: bent posture increased
def: "Animals exhibit increased posture eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002341 ! bent posture variant

[Term]
id: WBPhenotype:0002343
name: bent posture decreased
def: "Animals exhibit decreased posture eccentricity (measure of circularity) or the mean number (and/or standard deviation) of instantaneous body bends." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002341 ! bent posture variant

[Term]
id: WBPhenotype:0002344
name: backing decreased
def: "Animals spend less time backing compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001005 ! backward locomotion variant

[Term]
id: WBPhenotype:0002345
name: forward locomotion variant
def: "Variations in the spontaneous or induced forward crawling locomotion of an animal compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000643 ! locomotion variant

[Term]
id: WBPhenotype:0002346
name: forward locomotion increased
def: "Animals spend more time in forward locomotion, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002345 ! forward locomotion variant

[Term]
id: WBPhenotype:0002347
name: forward locomotion decreased
def: "Animals spend less time in forward locomotion, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002345 ! forward locomotion variant

[Term]
id: WBPhenotype:0002348
name: frequency of body bends increased
alt_id: WBPhenotype:0002331
def: "Animals exhibit an increase in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
synonym: "frequency of sinusoidal movement increased" EXACT []
synonym: "temporal frequency of sinusoidal movement increased" EXACT []
is_a: WBPhenotype:0004023 ! frequency of body bend variant

[Term]
id: WBPhenotype:0002349
name: phosphatidylinositol 3-phosphate levels reduced
def: "The levels of phosphatidylinositol 3-phosphate (a.k.a. PtdIns3P or PI3P) are reduced compared to those of control animals" [WB:WBPaper00044390, WB:WBPerson2987]
is_a: WBPhenotype:0000138 ! lipid composition variant

[Term]
id: WBPhenotype:0002350
name: hydrogen peroxide levels increased
def: "Animals exhibit increases in steady-state levels of hydrogen peroxide (H2O2) compared to control." [WB:WBPaper00041478, WB:WBPerson2987]
is_a: WBPhenotype:0002003 ! hydrogen peroxide homeostasis variant

[Term]
id: WBPhenotype:0002351
name: hydrogen peroxide levels reduced
def: "Animals exhibit reductions in steady-state levels of hydrogen peroxide (H2O2) compared to control." [WB:WBPaper00041478, WB:WBPerson2987]
is_a: WBPhenotype:0002003 ! hydrogen peroxide homeostasis variant

[Term]
id: WBPhenotype:0002352
name: tRNA expression increased
def: "Animals exhibit elevated levels of transfer RNA compared to control." [WB:WBPaper00046188, WB:WBPerson2987]
is_a: WBPhenotype:0000135 ! gene expression level high

[Term]
id: WBPhenotype:0002353
name: tRNA expression decreased
def: "Animals exhibit reduced levels of transfer RNA compared to control." [WB:WBPaper00046188, WB:WBPerson2987]
is_a: WBPhenotype:0000134 ! gene expression level reduced

[Term]
id: WBPhenotype:0002354
name: increased susceptibility to fungal infection
def: "Animals are more prone to infection from fungal pathogens compared to control animals." [WB:WBPaper00045575, WB:WBPerson712]
is_a: WBPhenotype:0001013 ! pathogen susceptibility increased

[Term]
id: WBPhenotype:0002355
name: increased susceptibility to bacterial pathogens
def: "Animals are more prone to infection by bacterial pathogens compared to control animals." [WB:WBPaper00045575, WB:WBPerson712]
is_a: WBPhenotype:0001013 ! pathogen susceptibility increased
is_a: WBPhenotype:0002545 ! response to bacteria variant

[Term]
id: WBPhenotype:0002356
name: sickened by nonpathogenic bacteria
def: "Animals are negatively affected by bacteria that is nonpathogenic to control animals." [WB:WBPaper00045575, WB:WBPerson712]
is_a: WBPhenotype:0002545 ! response to bacteria variant

[Term]
id: WBPhenotype:0002357
name: metabolite content increased
def: "Animals exhibit an increase in the quantity of metabolites, small molecule products or intermediates required for the metabolic functioning of the cell or organism." [WB:WBPaper00045546, WB:WBPaper00045575, WB:WBPerson712]
is_a: WBPhenotype:0000463 ! metabolic pathway variant

[Term]
id: WBPhenotype:0002358
name: transdifferentiation defective
def: "The conversion of one differentiated cell type into another does not occur as it does in control animals. In C. elegans, the Y cell undergoes a dramatic redifferentiation from being a cell in of the rectum to a PDA neuron. This transdifferentiation requires the cell to withdraw from its established position, migrate, and then become a motor neuron." [WB:WBPaper00037659, WB:WBPerson712]
is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant

[Term]
id: WBPhenotype:0002359
name: protein carbonylation increased
def: "Animals exhibit an increase in the covalent modification of one or more native amino acid side chains in proteins to carbonyl derivatives such as an aldehyde or ketone." [WB:WBPaper00041478, WB:WBPerson2987]
is_a: WBPhenotype:0002272 ! protein carbonylation variant

[Term]
id: WBPhenotype:0002360
name: cold hypersensitive
def: "Animals respond more severely to cold than control animals subjected to the same cold conditions." [WB:WBPaper00046830, WB:WBPerson2987]
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0002361
name: membrane fluidity increased
def: "Animals exhibit increased fluidity of cell membranes, compared to control animals." [WB:WBPaper00046830, WB:WBPerson2987]
is_a: WBPhenotype:0002484 ! membrane fluidity variant

[Term]
id: WBPhenotype:0002362
name: protein sumoylation variant
def: "Variations in the process by which one or more SUMO moieties are added to a protein, compared to control." [WB:WBPaper00048594, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0002363
name: cholesterol depletion resistant
def: "Animals are more resistant to the reduction of cholesterol in the environment compared to control animals." [WB:WBPaper00024451, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000725 ! lipid metabolism variant
is_a: WBPhenotype:0002525 ! diet response variant

[Term]
id: WBPhenotype:0002364
name: axonal degeneration
def: "Spontaneous axon breaks leading to degeneration of separated segments." [WB:WBPaper00024451, WB:WBPerson2987, WB:WBPerson9270]
synonym: "axon degeneration" EXACT []
is_a: WBPhenotype:0000179 ! neuron degeneration

[Term]
id: WBPhenotype:0002365
name: regenerative axonal fusion defective
def: "Following axon damage, animals do not undergo axonal fusion after reconnection between the regrowing axon and its separated segment to the same extent as observed in control animals." [WB:WBPaper00046306, WB:WBPerson29819, WB:WBPerson2987]
is_a: WBPhenotype:0001911 ! axon regeneration defective

[Term]
id: WBPhenotype:0002366
name: touch-induced suppression of head movement defective
def: "Animals do not suppress exploratory head movements in response to anterior touch stimuli, unlike control animals." [WB:WBPaper00039982, WB:WBPerson712]
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0002367
name: non-living barrier escape defective
def: "Animals are less successful than controls in extracting themselves from mesh or other non-living obstructing obstacles." [WB:WBPaper00039982, WB:WBPerson712]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0002368
name: lysosomal refractile body accumulation
def: "Lysosomal refractile bodies are apoptotic-like cell corpse; however, they differ in size and shape and can be described as resembling irregular cell corpses. These bodies have been shown to represent enlarged lysosomes and can occur in conjunction with altered programmed cell death programs." [WB:WBPaper00005190, WB:WBPerson712]
is_a: WBPhenotype:0002562 ! lysosome homeostasis abnormal

[Term]
id: WBPhenotype:0002369
name: sister cell division timing asynchrony reduced
def: "Animals exhibit sister cells that have lost otherwise normal asynchrony of cell division timing, compared to control animals. This results in sister cells aberrantly dividing in synchrony." [WB:WBPaper00046953, WB:WBPerson2987]
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0002370
name: noxious heat avoidance defective
def: "Animals fail to execute their characteristic movements to avoid noxious heat in a manner consistent with controls." [WB:WBPaper00046106, WB:WBPerson12691, WB:WBPerson557]
is_a: WBPhenotype:0001273 ! organism heat response variant

[Term]
id: WBPhenotype:0002371
name: vesicle maturation defective
def: "Vesicles, including those in cells, cell bodies, or synaptic terminals, do not properly form or maintain an intermediate state, such as remain coated with a clathrin coat." [WB:WBPaper00004275, WB:WBPerson712]
is_a: WBPhenotype:0001321 ! presynaptic region morphology variant

[Term]
id: WBPhenotype:0002372
name: presynaptic vesicle morphology altered
def: "Vesicles in the presynaptic terminal differ in size, shape, or composition from those observed in control animals." [WB:WBPaper00004275, WB:WBPerson712]
is_a: WBPhenotype:0001323 ! vesicle morphology variant

[Term]
id: WBPhenotype:0002373
name: conditional attraction to bacterial lawn
def: "Animals show a stronger preference for a particular bacterium that has been grown under conditions that differ from a control lawn." [WB:WBPaper00048410, WB:WBPerson712]
is_a: WBPhenotype:0000659 ! feeding behavior variant
is_a: WBPhenotype:0002545 ! response to bacteria variant

[Term]
id: WBPhenotype:0002374
name: RNAi transport defective
def: "Animals are deficient in the transport of silencing RNAs between cells during the systemic RNAi response process." [WB:WBPaper00041467, WB:WBPerson712]
is_a: WBPhenotype:0000743 ! RNAi response variant

[Term]
id: WBPhenotype:0002375
name: reversion of swimming paralysis
def: "Animals that exhibit paralysis (reduced thrashing) revert back to normal swimming behavior that can be tabulated as a reversion index (number revertants/number paralysis) and reversion probability (time in reversion/time after paralysis)." [WB:WBPaper00041219, WB:WBPerson712]
is_a: WBPhenotype:0002114 ! swimming induced paralysis

[Term]
id: WBPhenotype:0002376
name: mRNA poly-A tail length decreased
def: "Animals exhibit one or more mRNAs with decreased length of the 3' polyadenine tail, compared to control." [WB:WBPaper00046960, WB:WBPerson2987]
is_a: WBPhenotype:0001827 ! RNA metabolism variant

[Term]
id: WBPhenotype:0002377
name: mRNA poly-A tail length increased
def: "Animals exhibit one or more mRNAs with increased length of the 3' polyadenine tail, compared to control." [WB:WBPaper00046960, WB:WBPerson2987]
is_a: WBPhenotype:0001827 ! RNA metabolism variant

[Term]
id: WBPhenotype:0002378
name: pathogen avoidance variant
def: "Variations in the characteristic movement away from specific disease causing agents (pathogens) compared to control animals." [WB:WBPaper00048530, WB:WBPerson495, WB:WBPerson557]
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0002379
name: mitochondria localization variant
def: "The subcellular localization of mitochondrial organelles differ from that observed in control cells." [WB:WBPaper00045008, WB:WBPerson298, WB:WBPerson557]
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002380
name: neuron degeneration enhanced
def: "Neurons undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles at a faster rate or greater extent than those under conditions that elicit this response in control animals." [WB:WBPaper00045008, WB:WBPerson298, WB:WBPerson557]
synonym: "increased neurodegeneration" RELATED []
is_a: WBPhenotype:0000636 ! neuron degeneration variant

[Term]
id: WBPhenotype:0002381
name: pheromone production variant
def: "Animals exhibit variations in the amount and/or quality of pheromone produced compared to control animals at a defined stage." [WB:WBPaper00046134, WB:WBPerson14245, WB:WBPerson557]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002382
name: resistant to bioactive compound
def: "Animals fail to respond to the concentration of a bioactive compound that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals.  A bioactive compound is a chemical found in small amounts in organisms or, synthetically produced, that has effects on biological processes in another organism." [WB:WBPaper00045930, WB:WBPerson12526, WB:WBPerson557]
is_a: WBPhenotype:0001502 ! chemical resistant

[Term]
id: WBPhenotype:0002383
name: light touch habituation variant
def: "Any variation in the decreased behavioral response to repeated light head or tail touch compared to control. A gentle touch to the animal's head causes backward movement, whereas a gentle touch to the animal's tail causes forward movement. When wild-type animals are touched repeatedly on the head or tail, after some repetition they stop responding to the touch stimulus." [WB:WBPaper00041335, WB:WBPerson5092, WB:WBPerson557]
is_a: WBPhenotype:0000626 ! habituation variant

[Term]
id: WBPhenotype:0002384
name: xenotoxicity suppressor
def: "Animals are resistant to the toxicity of an anti-infective xenobiotic such as R24. Such small molecules protect the host from bacterial infection by inducing antibacterial immune responses via the p38 MAPK pathway. These molecules tend to have toxic effects in addition to immunostimulatory activity." [WB:WBPerson512]
synonym: "Xenobiotic toxicity resistant" RELATED []
synonym: "Xts" BROAD []
is_a: WBPhenotype:0000631 ! drug response variant

[Term]
id: WBPhenotype:0002385
name: high pH avoidance defective
def: "Animals fail to avoid a high pH (alkaline) environment as compared to control animals.  This is at very high pH, for example around pH11." [WB:WBPaper00043891, WB:WBPerson1928]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0002386
name: fibrous body-membranous organelle (FB-MO) assembly variant
def: "Animals exhibit variations in the assembly of the fibrous body-membranous organelle (FB-MO), a nematode sperm-specific organelle involved in cytoplasmic partitioning during spermatogenesis, compared to control animals." [WB:WBPaper00041071, WB:WBPerson602]
is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant

[Term]
id: WBPhenotype:0002387
name: supernumerary asters
def: "Dividing cells exhibit additional arrays of microtubules emanating from a spindle pole that do not connect to kinetochores, compared to control." [WB:WBPaper00041071, WB:WBPerson602]
is_a: WBPhenotype:0002419 ! spindle aster variant
is_a: WBPhenotype:0010002 ! cell organization biogenesis variant

[Term]
id: WBPhenotype:0002388
name: metaphase variant
def: "Any variation in the second stage of cell division, between prophase and anaphase, during which the chromosomes become attached to the spindle fibers." [WB:WBPaper00000008, WB:WBPerson2987]
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0002389
name: anaphase variant
def: "Any variation in the stage of meiotic or mitotic cell division in which the chromosomes move away from one another to opposite poles of the spindle." [WB:WBPaper00000008, WB:WBPerson2987]
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0002390
name: variable cell division timing
def: "Animals exhibit larger variations in cell division timing events than in controls." [WB:WBPaper00046953, WB:WBPerson2987]
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0002391
name: cytokinesis failure
def: "Cells attempt to divide but fail to form two daughter cells." [WB:WBPaper00041071, WB:WBPerson557]
is_a: WBPhenotype:0002408 ! cytokinesis variant

[Term]
id: WBPhenotype:0002392
name: age dependent somatic depletion of fat
def: "A depletion of somatic, but not germline, lipid stores are observed near the end of the reproductive period." [WB:WBPaper00048925, WB:WBPerson2173]
synonym: "Asdf" BROAD []
is_a: WBPhenotype:0001183 ! fat content reduced

[Term]
id: WBPhenotype:0002393
name: anterior posterior neurite growth variant
def: "Any variation in the processes that govern the directed extension of neurite projections along the anteroposterior  axis of the animal compared to controls." [WB:WBPaper00041941, WB:WBPerson1687, WB:WBPerson557]
synonym: "anteroposterior neurite growth variant" RELATED []
is_a: WBPhenotype:0000572 ! neuronal outgrowth variant

[Term]
id: WBPhenotype:0002394
name: phagosome sealing defective
def: "The closure of a phagosome does not occur and it remains connected with the plasma membrane, leaving the lumen open to the outside.  Complete closure usually occurs once an apoptotic cell has been surrounded by an engulfing cell." [WB:WBPaper00048406, WB:WBPerson17560, WB:WBPerson2987]
is_a: WBPhenotype:0000885 ! engulfment variant

[Term]
id: WBPhenotype:0002395
name: corpse engulfment initiation variant
def: "Animals exhibit variations in recognition of cell corpses and initiation of corpse engulfment, compared to controls." [WB:WBPaper00048406, WB:WBPerson2987]
is_a: WBPhenotype:0000243 ! engulfment failure by killer cell

[Term]
id: WBPhenotype:0002396
name: tumor prolapse frequency decreased
def: "Animals with a tumorous germline exhibit a decreased frequency of the presence of a tumor prolapse, a protrusion of tumor cells from the vulva, compared to control." [WB:WBPaper00049105, WB:WBPerson2987]
is_a: WBPhenotype:0000038 ! exploded through vulva

[Term]
id: WBPhenotype:0002397
name: tumor prolapse frequency increased
def: "Animals with a tumorous germline exhibit an increased frequency of the presence of a tumor prolapse, a protrusion of tumor cells from the vulva, compared to control." [WB:WBPaper00049105, WB:WBPerson2987]
is_a: WBPhenotype:0000038 ! exploded through vulva

[Term]
id: WBPhenotype:0002398
name: starved L1 larvae aggregation variant
def: "Animals exhibit variations in the aggregation behavior of starved L1 larvae, compared to controls." [WB:WBPaper00046860, WB:WBPerson14935]
is_a: WBPhenotype:0001032 ! larval behavior variant

[Term]
id: WBPhenotype:0002399
name: neurotransmitter response variant
def: "Animals exhibit variations in their response to a specific neurotransmitter compared to that observed in control animals." [WB:WBPaper00048522, WB:WBPerson2987]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0002400
name: glucose intolerant
def: "Animals do not live or live poorly in the presence of glucose concentrations that normally do not have an effect on control animals." [WB:WBPaper00049467, WB:WBPerson712]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant
is_a: WBPhenotype:0001072 ! response to food variant

[Term]
id: WBPhenotype:0002401
name: excess fatty acids
def: "The concentration of fatty acids in the animal are greater than that observed for control animals." [WB:WBPaper00049467, WB:WBPerson712]
is_a: WBPhenotype:0000138 ! lipid composition variant

[Term]
id: WBPhenotype:0002402
name: cell position defective
def: "A cell (or group of cells) is not found in the correct body position compared the placement in control animals." [WB:WBPerson557]
synonym: "cell position abnormal" EXACT []
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002403
name: P cell misalignment at ventral midline
def: "Ventral midline blastomeres (P cells) are misaligned (not properly paired) along the ventral midline of larval animals." [WB:WBPaper00040551, WB:WBPerson2987]
is_a: WBPhenotype:0002402 ! cell position defective

[Term]
id: WBPhenotype:0002404
name: cell cell contacts abnormal
def: "Cell-cell contacts are abnormal, compared to control animals." [WB:WBPaper00040551, WB:WBPerson2987]
synonym: "cell cell contacts abnormal" RELATED []
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002405
name: pheromone behavioral response variant
def: "Animals exhibit variations in the behavioral response to pheromones, compared to control." [WB:WBPaper00040651, WB:WBPerson2987]
is_a: WBPhenotype:0001049 ! chemosensory behavior variant

[Term]
id: WBPhenotype:0002406
name: aberrant posteriorly-directed neurite
def: "Any neurite that is extended towards the posterior of the animal from neurons that in wild-type animals make only anterior projections (e.g. D-type neurons in C. elegans)." [WB:WBPerson1687, WB:WBPerson557]
is_a: WBPhenotype:0002393 ! anterior posterior neurite growth variant

[Term]
id: WBPhenotype:0002407
name: egg size variant
def: "Any variation in the overall size of fertilized oocytes that are laid compared to those laid by control animals." [WB:WBPerson557]
synonym: "egg size abnormal" RELATED []
is_a: WBPhenotype:0000037 ! egg morphology variant

[Term]
id: WBPhenotype:0002408
name: cytokinesis variant
def: "Any variation that disrupts the cytoplasmic division of a cell during development compared to control." [GO:0000910, WB:WBPerson557]
synonym: "cytokinesis abnormal" RELATED []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0002409
name: extra cleavage furrow
def: "One or more extra cleavage furrows are observed in a cell about to undergo division." [WB:WBPerson557]
is_a: WBPhenotype:0002410 ! cleavage furrow defective

[Term]
id: WBPhenotype:0002410
name: cleavage furrow defective
def: "Cells exhibit defects in the formation, maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis." [GO:0032154, WB:WBPerson557]
is_a: WBPhenotype:0002408 ! cytokinesis variant

[Term]
id: WBPhenotype:0002411
name: cleavage furrow initiation defective
def: "Cells exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [WB:WBPerson557]
is_a: WBPhenotype:0002410 ! cleavage furrow defective

[Term]
id: WBPhenotype:0002412
name: cleavage furrow termination defective
def: "Cells exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis." [WB:WBPerson557]
is_a: WBPhenotype:0002410 ! cleavage furrow defective

[Term]
id: WBPhenotype:0002413
name: multiple nuclei
def: "Animals have more than one nucleus in a particular cell type." [WB:WBPerson557]
is_a: WBPhenotype:0001894 ! nuclear number variant

[Term]
id: WBPhenotype:0002414
name: spindle variant
def: "Any variation in the assembly, disassembly, arrangement, elongation or stabilization of the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart compared to control." [GO:0005819, WB:WBPerson557]
synonym: "spindle abnormal" RELATED []
is_a: WBPhenotype:0000746 ! cell division variant

[Term]
id: WBPhenotype:0002415
name: spindle assembly defective
def: "Cells exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GO:0051225, WB:WBPerson557]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0002416
name: spindle position variant
def: "Any variation in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis compared to control." [GO:0051653, WB:WBPerson557]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0002417
name: spindle rotation variant
def: "Any variation in the rotation of the spindle compared to control." [WB:WBPerson557]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0002418
name: spindle absent
def: "Cells lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0005819, WB:WBPerson557]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0002419
name: spindle aster variant
def: "Any variation in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a cell cycle." [WB:WBPerson557]
is_a: WBPhenotype:0002414 ! spindle variant

[Term]
id: WBPhenotype:0002420
name: chromatin modification variant
def: "Animals exhibit variations in the nature and/or extent of chromatin modification, including but not limited to acetylation and/or methylation of histones, compared to controls." [WB:WBPaper00036090, WB:WBPerson2987]
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0002421
name: cold resistant
def: "Animals exhibit increased ability to survive at low temperatures compared to controls." [WB:WBPerson10321, WB:WBPerson557]
synonym: "cold tolerant" EXACT []
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0002422
name: tunicamycin resistant
def: "Animals respond to tunicamycin at a higher concentration or a longer exposure compared to control animals." [WB:WBPaper00036076, WB:WBPaper00037064, WB:WBPerson2987]
is_a: WBPhenotype:0000359 ! tunicamycin response variant

[Term]
id: WBPhenotype:0002423
name: hypoxia response variant
def: "Animals exhibit variations in response to hypoxia, low oxygen conditions, compared to controls." [WB:WBPaper00037064, WB:WBPerson2987]
is_a: WBPhenotype:0000464 ! oxygen response variant

[Term]
id: WBPhenotype:0002424
name: anoxia response variant
def: "Animals exhibit variations in response to anoxia, trace oxygen conditions, compared to controls." [WB:WBPerson557]
is_a: WBPhenotype:0000464 ! oxygen response variant

[Term]
id: WBPhenotype:0002425
name: protein aggregation induced behavior variant
def: "Variations in the specific actions or reactions in response to external or internal stimuli in response to the aggregation of proteins." [WB:WBPerson324, WB:WBPerson557]
is_a: WBPhenotype:0001405 ! protein aggregation variant

[Term]
id: WBPhenotype:0002426
name: protein aggregation induced reduction of life span
def: "The duration of viability in the adult phase of the life-cycle is lowered in response to the aggregation of proteins." [GO:0008340, WB:WBPaper00035872, WB:WBPerson324, WB:WBPerson557]
is_a: WBPhenotype:0002425 ! protein aggregation induced behavior variant

[Term]
id: WBPhenotype:0002427
name: protein aggregation induced associative learning variant
def: "Variations in the behavioral plasticity induced by the integration of two sensory signals in response to the aggregation of proteins." [WB:WBPaper00035872, WB:WBPerson324, WB:WBPerson557]
is_a: WBPhenotype:0002425 ! protein aggregation induced behavior variant

[Term]
id: WBPhenotype:0002428
name: intestinal degeneration
def: "Animals exhibit degeneration of the intestine, compared to control animals." [WB:WBPaper00041065, WB:WBPerson2987]
is_a: WBPhenotype:0000710 ! intestinal morphology variant

[Term]
id: WBPhenotype:0002429
name: protein glycosylation variant
def: "Animals exhibit variations in the degree to which some proteins are glycosylated, compared to controls." [WB:WBPaper00042060, WB:WBPerson2987]
is_a: WBPhenotype:0001382 ! protein modification variant

[Term]
id: WBPhenotype:0002430
name: mitochondrial DNA damage variant
def: "Any variation in the extent of mitochondrial DNA damage observed compared to controls." [WB:WBPaper00041209, WB:WBPerson712]
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0002431
name: alternative lengthening of telomeres
def: "A telomerase-independent telomere maintenance pathway that allows for strains to survive in the absence of telomerase." [WB:WBPaper00041021, WB:WBPerson7]
synonym: "ALT" EXACT []
is_a: WBPhenotype:0000879 ! telomere length regulation variant

[Term]
id: WBPhenotype:0002432
name: EGF-induced sleep variant
def: "Animals do not respond with sleeping behavior induced through the EGF pathway. The EGF-induced sleep pathway is thought to represent a distinct molecular pathway from developmentally linked sleep. The EGF-induced sleep state occurs in two contexts: by overexpressing the EGF ortholog (LIN-3C), or by EGF signaling after stress (such as temperature elevation) in wildtype animals." [WB:WBPaper00050011, WB:WBPerson712]
synonym: "stressed-induced sleep variant" RELATED []
is_a: WBPhenotype:0001524 ! quiescence variant

[Term]
id: WBPhenotype:0002433
name: EGF-induced sleep resistant
def: "Animals respond with sleeping behavior induced through the EGF pathway, more rigorously than control animals. The EGF-induced sleep pathway is thought to represent a distinct molecular pathway from developmentally linked sleep. The EGF-induced sleep state occurs in two contexts: by overexpressing the EGF ortholog (LIN-3C), or by EGF signaling after stress (such as temperature elevation) in wildtype animals." [WB:WBPaper00050011, WB:WBPerson712]
synonym: "stressed-induced sleep resistant" RELATED []
is_a: WBPhenotype:0001524 ! quiescence variant

[Term]
id: WBPhenotype:0002434
name: mitochondrial stress response variant
def: "Animals exhibit variations in their response to mitochondrial stress, compared to controls." [WB:WBPaper00027723, WB:WBPerson2987]
is_a: WBPhenotype:0000142 ! cell stress response variant

[Term]
id: WBPhenotype:0002435
name: less susceptibility to induced DNA damage
def: "Nematodes exposed to DNA damaging agents or conditions exhibit lower susceptibility to DNA damage than other animals." [WB:WBPerson712]
synonym: "induced DNA damage resistant" RELATED []
is_a: WBPhenotype:0000739 ! DNA damage response variant

[Term]
id: WBPhenotype:0002436
name: high susceptibility to induced DNA damage
def: "Nematodes exposed to DNA damaging agents or conditions exhibit greater susceptibility to DNA damage than other animals." [WB:WBPerson712]
synonym: "induced DNA damage hypersensitive" RELATED []
is_a: WBPhenotype:0000739 ! DNA damage response variant

[Term]
id: WBPhenotype:0002437
name: repetitive transgene expression variant
def: "Animals exhibit variations in the expression of repetitive exogenous DNA compared to control." [WB:WBPaper00003822, WB:WBPerson2987]
is_a: WBPhenotype:0000306 ! transgene expression variant

[Term]
id: WBPhenotype:0002438
name: repetitive transgene expression reduced
def: "Animals exhibit reduced expression of repetitive exogenous DNA compared to control." [WB:WBPaper00003822, WB:WBPerson2987]
is_a: WBPhenotype:0002437 ! repetitive transgene expression variant

[Term]
id: WBPhenotype:0002439
name: repetitive transgene expression increased
def: "Animals exhibit increased expression of repetitive exogenous DNA compared to control." [WB:WBPaper00003822, WB:WBPerson2987]
is_a: WBPhenotype:0002437 ! repetitive transgene expression variant

[Term]
id: WBPhenotype:0002440
name: sperm fertility defective
def: "Any perturbation that renders sperm incompetent at fertilizing an oocyte." [WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001384 ! fertility reduced

[Term]
id: WBPhenotype:0002441
name: pharyngeal inter-pump interval increased
def: "The time between two pumps of the pharynx is increased compared to control animals." [WB:WBPaper00050613, WB:WBPerson712]
synonym: "pharyngeal inter-pumping interval increased" RELATED []
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant

[Term]
id: WBPhenotype:0002442
name: pharyngeal pump duration increased
def: "The duration of the contraction of the pharyngeal muscle during pumping is increased compared to controls." [WB:WBPaper00050613, WB:WBPerson712]
synonym: "pharyngeal pump extended" RELATED []
is_a: WBPhenotype:0000634 ! pharyngeal pumping variant

[Term]
id: WBPhenotype:0002443
name: spicule protraction variant
def: "Any variation in the specific actions or reactions of the male that are associated with the protraction of the male copulatory spicules compared to control." [WB:WBPerson557]
is_a: WBPhenotype:0000279 ! spicule insertion defective

[Term]
id: WBPhenotype:0002444
name: pyrimidine biosynthesis variant
def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GO:0019856, WB:WBPerson324, WB:WBPerson557]
synonym: "pyrimidine base biosynthesis variant" EXACT []
is_a: WBPhenotype:0000732 ! DNA metabolism variant

[Term]
id: WBPhenotype:0002445
name: extra and ectopic hypodermis
def: "Animals have one or more extra hypodermal cells, which are present in places they are normally not found, when compared to the number and location of these cells in control animals." [WB:WBPaper00025033, WB:WBPerson2987]
is_a: WBPhenotype:0001303 ! extra and ectopic cell

[Term]
id: WBPhenotype:0002446
name: pharyngeal pumping rate in response to light variant
def: "Animals exhibit variations in pharyngeal pumping rate in response to light, compared to controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant
is_a: WBPhenotype:0001897 ! light response variant

[Term]
id: WBPhenotype:0002447
name: acute pumping response to light variant
def: "Animals exhibit variations in the acute pharyngeal pumping response to light, during which the pharyngeal pumping rate initially (0-5 seconds after light exposure onset) decreases in response to light, compared to controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002446 ! pharyngeal pumping rate in response to light variant

[Term]
id: WBPhenotype:0002448
name: enhanced acute pharyngeal pumping response to light
def: "Animals exhibit an enhanced acute pharyngeal pumping response to light, such that pharyngeal pumping rate decreases in response to light to a greater extent than in controls during the first 0-5 seconds after light exposure onset." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002447 ! acute pumping response to light variant

[Term]
id: WBPhenotype:0002449
name: reduced acute pharyngeal pumping response to light
def: "Animals exhibit a reduced acute pharyngeal pumping response to light, such that pharyngeal pumping rate decreases in response to light to a lesser extent than in controls during the first 0-5 seconds after light exposure onset." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002447 ! acute pumping response to light variant

[Term]
id: WBPhenotype:0002450
name: burst pharyngeal pumping response to light
def: "Animals exhibit variations in the burst pharyngeal pumping response to light, during which the pharyngeal pumping rate slightly increases during the5-10 seconds after light exposure onset, compared to controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002446 ! pharyngeal pumping rate in response to light variant

[Term]
id: WBPhenotype:0002451
name: enhanced burst pharyngeal pumping response to light
def: "Animals exhibit an enhanced burst pharyngeal pumping response to light, such that during the5-10 seconds after light exposure onset the pharyngeal pumping rate increases to a greater extent than in controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002450 ! burst pharyngeal pumping response to light

[Term]
id: WBPhenotype:0002452
name: reduced burst pharyngeal pumping response to light
def: "Animals exhibit a reduced burst pharyngeal pumping response to light, such that during the5-10 seconds after light exposure onset the pharyngeal pumping rate increases to a lesser extent than in controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002450 ! burst pharyngeal pumping response to light

[Term]
id: WBPhenotype:0002453
name: recovery pumping response to light variant
def: "Animals exhibit variations in the recovery pharyngeal pumping response to light, during which the pharyngeal pumping rate slowly increases during the 0-10 seconds afterremoval of light exposure, compared to controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002446 ! pharyngeal pumping rate in response to light variant

[Term]
id: WBPhenotype:0002454
name: enhanced recovery pumping response to light
def: "Animals exhibit an enhanced recovery pharyngeal pumping response to light, such that during the 0-10 seconds after removal of light exposure the pharyngeal pumping rate increases to a greater extent than in controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002453 ! recovery pumping response to light variant

[Term]
id: WBPhenotype:0002455
name: reduced recovery pumping response to light
def: "Animals exhibit a reduced recovery pharyngeal pumping response to light, such that during the 0-10 seconds after removal of light exposure the pharyngeal pumping rate increasesto a lesser extent than in controls." [WB:WBPaper00046411, WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0002453 ! recovery pumping response to light variant

[Term]
id: WBPhenotype:0002456
name: calcium response to light variant
def: "Animals exhibit variations in the changes in calcium levels in response to light compared to controls." [WB:WBPaper00048388, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson9765]
is_a: WBPhenotype:0001897 ! light response variant
is_a: WBPhenotype:0002170 ! calcium mediated signaling variant

[Term]
id: WBPhenotype:0002457
name: ectopic vulva in male
def: "Formation in the male of the egg-laying organ of female and hermaphrodite nematodes. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [WB:WBPaper00026839, WB:WBPerson2987]
synonym: "vulva in male" EXACT []
is_a: WBPhenotype:0002499 ! ectopic vulva

[Term]
id: WBPhenotype:0002458
name: maternal effect morphology variant
def: "Any variation in the form, structure or composition of any part of an animal caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis." [WB:WBPerson557]
synonym: "Mal" BROAD []
synonym: "maternal effect morphology abnormal" RELATED []
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0002459
name: hyperinduction of antimicrobial peptide expression after infection
def: "Animals exhibit hyperinduction of expression of an antimicrobial peptide after an infection, compared to control animals." [WB:WBPaper00049531, WB:WBPerson168, WB:WBPerson2987]
synonym: "Hipi" EXACT []
is_a: WBPhenotype:0001800 ! pathogen induced antimicrobial gene expression variant
is_a: WBPhenotype:0002539 ! antimicrobial gene expression increased

[Term]
id: WBPhenotype:0002460
name: no induction of antimicrobial peptide expression after infection
def: "Animals exhibit no induction of expression of an antimicrobial peptide after an infection, unlike control animals." [WB:WBPaper00038424, WB:WBPaper00040946, WB:WBPaper00049531, WB:WBPerson168, WB:WBPerson2987]
synonym: "Nipi" EXACT []
is_a: WBPhenotype:0001800 ! pathogen induced antimicrobial gene expression variant
is_a: WBPhenotype:0002621 ! antimicrobial gene expression reduced

[Term]
id: WBPhenotype:0002461
name: pathogen adherence decreased
def: "Pathogens exhibit decreased adherence to the surface of host animals." [WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001415 ! pathogen adherence variant

[Term]
id: WBPhenotype:0002462
name: pathogen adherence increased
def: "Pathogens exhibit increased adherence to the surface of host animals." [WB:WBPaper00049531, WB:WBPerson168, WB:WBPerson2987]
is_a: WBPhenotype:0001415 ! pathogen adherence variant

[Term]
id: WBPhenotype:0002463
name: hookless
def: "Male animals lack a copulatory hook." [WB:WBPaper00045644, WB:WBPerson557, WB:WBPerson625]
is_a: WBPhenotype:0002209 ! hook development variant

[Term]
id: WBPhenotype:0002464
name: multiple hooks
def: "Male animals exhibit multiple copulatory hooks. In wild type C. elegans males, a single hook is normally present." [WB:WBPaper00045644, WB:WBPerson557, WB:WBPerson625]
is_a: WBPhenotype:0002209 ! hook development variant

[Term]
id: WBPhenotype:0002465
name: histone ubiquitination variant
def: "The pattern or state of ubiquitin modifications of histones varies from that of controls." [WB:WBPaper00053651, WB:WBPerson1370, WB:WBPerson557]
synonym: "histone ubiquitylation variant" RELATED []
is_a: WBPhenotype:0001865 ! protein ubiquitination variant

[Term]
id: WBPhenotype:0002466
name: RNA methylation variant
def: "Variations in the processes that incorporate methyl groups to one or more bases within RNA, compared to control." [WB:WBPaper00049616, WB:WBPerson29150, WB:WBPerson557]
is_a: WBPhenotype:0001827 ! RNA metabolism variant

[Term]
id: WBPhenotype:0002467
name: male reproductive longevity extended
def: "Males continue to sire progeny significantly past the time reproduction stops in control animals or show a slower decline in mating efficiency compared to age-matched control males." [WB:WBPaper00053333, WB:WBPerson557]
is_a: WBPhenotype:0001739 ! aging variant

[Term]
id: WBPhenotype:0002468
name: translation rate reduced
def: "Animals exhibit a reduction in the rate of the chemical reactions and pathways resulting in the formation of a protein, compared to control." [GO:0006417, WB:WBPaper00046894, WB:WBPerson557]
is_a: WBPhenotype:0000121 ! translation variant

[Term]
id: WBPhenotype:0002469
name: plate tap habituation variant
def: "Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control." [WB:WBPaper00041802, WB:WBPerson3192, WB:WBPerson557]
is_a: WBPhenotype:0000626 ! habituation variant

[Term]
id: WBPhenotype:0002470
name: cilia length variant
def: "Animals exhibit variations in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals." [WB:WBPaper00053681, WB:WBPerson2136, WB:WBPerson557]
synonym: "cilium length variant" EXACT []
is_a: WBPhenotype:0000615 ! cilia morphology variant

[Term]
id: WBPhenotype:0002471
name: cilia length increased
def: "Animals exhibit an increase in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals." [WB:WBPaper00053681, WB:WBPerson2136, WB:WBPerson557]
synonym: "cilium length increased" EXACT []
is_a: WBPhenotype:0002470 ! cilia length variant

[Term]
id: WBPhenotype:0002472
name: cilia length decreased
def: "Animals exhibit a reduction in the length of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals." [WB:WBPaper00053681, WB:WBPerson2136, WB:WBPerson557]
synonym: "cilium length decreased" EXACT []
is_a: WBPhenotype:0002470 ! cilia length variant

[Term]
id: WBPhenotype:0002473
name: autophagy block
def: "Animals fail to undergo the cellular catabolic process in which cells digest parts of their own cytoplasm." [GO:0006914, WB:WBPaper00046758, WB:WBPerson2242, WB:WBPerson557]
synonym: "autophagy defective" EXACT []
is_a: WBPhenotype:0002283 ! autophagy reduced

[Term]
id: WBPhenotype:0002474
name: viral resistance increased
def: "Animals are less prone to infection by virus compared to control." [WB:WBPaper00053019, WB:WBPerson24802, WB:WBPerson557]
is_a: WBPhenotype:0001014 ! pathogen resistance increased

[Term]
id: WBPhenotype:0002475
name: pharynx length variant
def: "Animals vary in the distance between most anterior and the most posterior ends of the pharynx from that observed in control animals." [WB:WBPaper00049351, WB:WBPerson2693, WB:WBPerson557]
synonym: "pharyngeal length variant" EXACT []
is_a: WBPhenotype:0000709 ! pharyngeal morphology variant

[Term]
id: WBPhenotype:0002476
name: pharynx length increased
def: "Animals have an increase in the distance between most anterior and the most posterior ends of the pharynx from that observed in control animals." [WB:WBPaper00049351, WB:WBPerson2693, WB:WBPerson557]
synonym: "pharyngeal length increased" EXACT []
synonym: "pharynx elongation" EXACT []
is_a: WBPhenotype:0002475 ! pharynx length variant

[Term]
id: WBPhenotype:0002477
name: ribosome localization variant
def: "Any variation in the subcellular localization of the ribosome compared to control. The ribosome is an intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA)." [GO:0005840, WB:WBPaper00052855, WB:WBPerson15276, WB:WBPerson557]
synonym: "ribosome distribution variant" EXACT []
is_a: WBPhenotype:0002098 ! cell component localization variant

[Term]
id: WBPhenotype:0002478
name: axotomy response variant
def: "Any variation in the cellular and molecular pathways in a neuron in response to having its axon severed compared to severing in control animals." [WB:WBPaper00053323, WB:WBPerson557, WB:WBPerson9270]
is_a: WBPhenotype:0002563 ! neuron physiology phenotype

[Term]
id: WBPhenotype:0002479
name: axon regeneration enhanced
def: "Any increase in regenerative regrowth of axons compared to control animals." [WB:WBPaper00053323, WB:WBPerson557, WB:WBPerson9270]
synonym: "axonal regeneration enhanced" EXACT []
is_a: WBPhenotype:0000880 ! axon development variant

[Term]
id: WBPhenotype:0002480
name: heme levels variant
def: "Animals exhibit variations in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GO:0006783, WB:WBPaper00049976, WB:WBPerson16107, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002481
name: heme levels decreased
def: "Animals exhibit a decrease in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GO:0006783, WB:WBPaper00049976, WB:WBPerson16107, WB:WBPerson2987, WB:WBPerson557]
synonym: "heme levels reduced" EXACT []
is_a: WBPhenotype:0002480 ! heme levels variant

[Term]
id: WBPhenotype:0002482
name: heme levels increased
def: "Animals exhibit an increase in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GO:0006783, WB:WBPaper00049976, WB:WBPerson16107, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002480 ! heme levels variant

[Term]
id: WBPhenotype:0002483
name: fungal resistance increased
def: "Animals are less prone to infection by a fungus compared to control." [WB:WBPaper00046695, WB:WBPerson557]
is_a: WBPhenotype:0001014 ! pathogen resistance increased

[Term]
id: WBPhenotype:0002484
name: membrane fluidity variant
def: "Animals exhibit variations in fluidity of cell membranes, compared to control animals." [WB:WBPaper00055850, WB:WBPerson2987]
is_a: WBPhenotype:0001965 ! cell membrane physiology variant

[Term]
id: WBPhenotype:0002485
name: germline precursor cell morphology variant
def: "Any variation in the morphological appearance of germline precursor cells compared to control animals." [WB:WBPaper00050421, WB:WBPerson2987]
synonym: "primordial germ cell morphology variant" RELATED []
is_a: WBPhenotype:0002108 ! cell type morphology variant

[Term]
id: WBPhenotype:0002486
name: persistent primordial germ cell lobes
def: "Animals exhibit persistent cellular lobes of the primordial germ cells Z2 and/or Z3 at the L1 larval stage or later, in contrast to wild type animals" [WB:WBPaper00050421, WB:WBPerson2987, WB:WBPerson35710]
synonym: "persistent germline precursor cell lobes" RELATED []
is_a: WBPhenotype:0002485 ! germline precursor cell morphology variant

[Term]
id: WBPhenotype:0002487
name: intestinal integrity variant
def: "Animals exhibit variations in the integrity of the intestine, compared to controls." [WB:WBPaper00049837, WB:WBPerson2987]
is_a: WBPhenotype:0001093 ! intestinal physiology variant

[Term]
id: WBPhenotype:0002488
name: intestinal integrity increased
def: "Animals exhibit an increase in the integrity of the intestine, compared to controls." [WB:WBPaper00049837, WB:WBPerson14863, WB:WBPerson2987]
is_a: WBPhenotype:0002487 ! intestinal integrity variant

[Term]
id: WBPhenotype:0002489
name: intestinal integrity reduced
def: "Animals exhibit a reduction in the integrity of the intestine, compared to controls." [WB:WBPerson2987]
is_a: WBPhenotype:0002487 ! intestinal integrity variant

[Term]
id: WBPhenotype:0002490
name: ectopic axon outgrowth
def: "Neurons exhibit axon outgrowth in locations not normally found in controls." [WB:WBPaper00004283, WB:WBPaper00006029, WB:WBPaper00026706, WB:WBPaper00027335, WB:WBPaper00031901, WB:WBPaper00032090, WB:WBPerson2987]
is_a: WBPhenotype:0001224 ! axon outgrowth variant
is_a: WBPhenotype:0002491 ! ectopic neurite outgrowth

[Term]
id: WBPhenotype:0002491
name: ectopic neurite outgrowth
def: "Neurons exhibit neurite outgrowth in locations not normally found in controls." [WB:WBPaper00003665, WB:WBPaper00004340, WB:WBPaper00027335, WB:WBPerson2987]
is_a: WBPhenotype:0000572 ! neuronal outgrowth variant

[Term]
id: WBPhenotype:0002492
name: ectopic body wall muscle
def: "Animals exhibit one or more body wall muscle cells in locations not normally found in controls." [WB:WBPaper00035201, WB:WBPerson2987]
is_a: WBPhenotype:0002493 ! ectopic cell

[Term]
id: WBPhenotype:0002493
name: ectopic cell
def: "Animals exhibit one or more cells of a particular type in locations not normally found in controls." [WB:WBPaper00003331, WB:WBPaper00003719, WB:WBPerson2987]
is_a: WBPhenotype:0000529 ! cell development variant

[Term]
id: WBPhenotype:0002494
name: ectopic endoderm
def: "Animals exhibit one or more endodermal cells in locations not normally found in controls." [WB:WBPaper00002871, WB:WBPaper00003645, WB:WBPerson2987]
is_a: WBPhenotype:0002493 ! ectopic cell

[Term]
id: WBPhenotype:0002495
name: ectopic hypodermis
def: "Animals exhibit one or more hypodermal cells in locations not normally found in controls." [WB:WBPaper00025033, WB:WBPerson2987]
is_a: WBPhenotype:0002493 ! ectopic cell

[Term]
id: WBPhenotype:0002496
name: ectopic neuron
def: "Animals exhibit one or more neurons in locations not normally found in controls." [WB:WBPaper00000635, WB:WBPaper00027335, WB:WBPerson2987]
is_a: WBPhenotype:0002493 ! ectopic cell

[Term]
id: WBPhenotype:0002497
name: ectopic pharyngeal muscle
def: "Animals exhibit one or more pharyngeal muscle cells in locations not normally found in controls." [WB:WBPaper00003574, WB:WBPaper00003645, WB:WBPerson2987]
is_a: WBPhenotype:0002493 ! ectopic cell

[Term]
id: WBPhenotype:0002498
name: ectopic organ
def: "Animals exhibit one or more organs of a particular type in locations not normally found in controls." [WB:WBPaper00031604, WB:WBPerson2987]
is_a: WBPhenotype:0000530 ! organ system development variant

[Term]
id: WBPhenotype:0002499
name: ectopic vulva
def: "Animals exhibit one or more vulvae in locations not normally found in controls." [WB:WBPaper00031604, WB:WBPerson2987]
is_a: WBPhenotype:0002498 ! ectopic organ

[Term]
id: WBPhenotype:0002500
name: ectopic cleavage furrow
def: "One or more cells exhibit one or more cleavage furrows in locations not normally found in control cells." []
is_a: WBPhenotype:0002410 ! cleavage furrow defective

[Term]
id: WBPhenotype:0002501
name: ectopic cleavage furrow early emb
def: "One or more cells of the early embryo (one-cell stage to four-cell stage) exhibit one or more cleavage furrows in locations not normally found in control cells." [WB:WBPaper00005599, WB:WBPaper00006061, WB:WBPaper00030892, WB:WBPaper00033469, WB:WBPerson2987]
is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb

[Term]
id: WBPhenotype:0002502
name: protein acetylation increased
def: "Animals exhibit an increase in the covalent addition of an acetyl group to one or more native amino acid side chains in proteins." [WB:WBPaper00046534, WB:WBPerson113, WB:WBPerson2987]
is_a: WBPhenotype:0001917 ! protein acetylation variant

[Term]
id: WBPhenotype:0002503
name: meiotic DNA double strand break formation increased
def: "Animals exhibit an increase the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination." [WB:WBPaper00046534, WB:WBPerson113, WB:WBPerson2987]
is_a: WBPhenotype:0001921 ! meiotic DNA double strand break formation variant

[Term]
id: WBPhenotype:0002504
name: pathogen release reduced
def: "Infected animals exhibit a reduction in the release of pathogens back into the environment, compared to control." [WB:WBPaper00040246, WB:WBPaper00045292, WB:WBPerson2987, WB:WBPerson3965]
synonym: "spore shedding reduced" NARROW []
is_a: WBPhenotype:0002172 ! pathogen release variant

[Term]
id: WBPhenotype:0002505
name: pathogen infection clearance variant
def: "Infected animals exhibit variations in the clearance of pathogen infection compared to controls." [WB:WBPaper00044624, WB:WBPerson2706, WB:WBPerson2987]
is_a: WBPhenotype:0002164 ! innate immune response variant

[Term]
id: WBPhenotype:0002506
name: pathogen infection clearance rate increased
def: "Infected animals exhibit an increased rate of clearance of pathogen infection compared to controls." [WB:WBPaper00044624, WB:WBPerson2706, WB:WBPerson2987]
is_a: WBPhenotype:0002505 ! pathogen infection clearance variant

[Term]
id: WBPhenotype:0002507
name: pathogen infection clearance rate decreased
def: "Infected animals exhibit a decreased rate of clearance of pathogen infection compared to controls." [WB:WBPaper00044624, WB:WBPerson2706, WB:WBPerson2987]
is_a: WBPhenotype:0002505 ! pathogen infection clearance variant

[Term]
id: WBPhenotype:0002508
name: extra neuron
def: "Animals produce an excess number of neurons compared to controls." [WB:WBPaper00053165, WB:WBPerson2987, WB:WBPerson3252]
is_a: WBPhenotype:0002175 ! cell number increased

[Term]
id: WBPhenotype:0002509
name: extra dopaminergic neuron
def: "Animals produce an excess number of dopaminergic neurons compared to controls." [WB:WBPaper00053165, WB:WBPerson2987, WB:WBPerson3252]
is_a: WBPhenotype:0002508 ! extra neuron

[Term]
id: WBPhenotype:0002510
name: fewer neurons
def: "Animals exhibit fewer neurons compared to control animals." [WB:WBPaper00053165, WB:WBPerson2987, WB:WBPerson3252]
is_a: WBPhenotype:0000623 ! nervous system development variant
is_a: WBPhenotype:0002174 ! cell number decreased

[Term]
id: WBPhenotype:0002511
name: fewer glutamatergic neurons
def: "Animals exhibit fewer glutamatergic neurons compared to control animals." [WB:WBPaper00053165, WB:WBPerson2987, WB:WBPerson3252]
is_a: WBPhenotype:0002510 ! fewer neurons

[Term]
id: WBPhenotype:0002512
name: thermosensory behavior variant
def: "Variations in behavior that is dependent upon the sensation of temperature, compared to control." [GO:0040040, WB:WBPerson2987]
synonym: "thermosensory behavior abnormal" NARROW []
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0002513
name: thermotaxis variant
def: "Any variation in the directed movement of a worm in response to a specific temperature gradient compared to control." [GO:0043052, WB:WBPerson2987]
is_a: WBPhenotype:0002512 ! thermosensory behavior variant

[Term]
id: WBPhenotype:0002514
name: backing absent
def: "Animals do not exhibit backward locomotion under conditions that induce backward locomotion in control animals." [WB:WBPerson261, WB:WBPerson2987]
is_a: WBPhenotype:0001005 ! backward locomotion variant

[Term]
id: WBPhenotype:0002515
name: organism pathogen response defective
def: "Animals exhibit a defective response to pathogens." [WB:WBPaper00055957, WB:WBPerson2987, WB:WBPerson919]
is_a: WBPhenotype:0001012 ! organism pathogen response variant

[Term]
id: WBPhenotype:0002516
name: burrowing assay distance abnormal
def: "Animals exhibit variations, compared to control, in the distance traveled in a burrowing assay, in which animals are placed in a tube, separated from an attractant by solid medium through which the worms can burrow. Variations in distance traveled during the burrowing assay, when controlled for chemosensation defects, have been suggested to reflect variations in neuromuscular efficacy of locomotion." [WB:WBPaper00046657, WB:WBPaper00056369, WB:WBPerson2987, WB:WBPerson9270]
is_a: WBPhenotype:0002559 ! burrowing abnormal

[Term]
id: WBPhenotype:0002517
name: burrowing assay distance reduced
def: "Animals exhibit a reduction, compared to control, in the distance traveled in a burrowing assay, in which animals are placed in a tube, separated from an attractant by solid medium through which the worms can burrow. Reductions in distance traveled during the burrowing assay, when controlled for chemosensation defects, have been suggested to reflect deficits in neuromuscular efficacy of locomotion." [WB:WBPaper00046657, WB:WBPaper00056369, WB:WBPerson2987, WB:WBPerson9270]
is_a: WBPhenotype:0002516 ! burrowing assay distance abnormal

[Term]
id: WBPhenotype:0002518
name: axon length abnormal
def: "The length of one or more axons is abnormal compared to the length of the corresponding axon(s) in control animals." [WB:WBPaper00056369, WB:WBPerson2987, WB:WBPerson9270]
is_a: WBPhenotype:0000180 ! axon morphology variant

[Term]
id: WBPhenotype:0002519
name: axon length reduced
def: "The length of one or more axons is reduced compared to the length of the corresponding axon(s) in control animals." [WB:WBPaper00056369, WB:WBPerson2987, WB:WBPerson9270]
synonym: "short axon" EXACT []
is_a: WBPhenotype:0002518 ! axon length abnormal

[Term]
id: WBPhenotype:0002520
name: gap junction plaque morphology abnormal
def: "One or more cells exhibit variations in the morphology of one or more gap junction plaques, sets of associated gap junctions, compared to controls." [WB:WBPaper00049389, WB:WBPerson2987, WB:WBPerson30255]
is_a: WBPhenotype:0001658 ! intercellular junction variant

[Term]
id: WBPhenotype:0002521
name: gap junction plaque number increased
def: "One or more cells exhibit an increase in number of gap junction plaques, sets of associated gap junctions, compared to controls." [WB:WBPaper00049389, WB:WBPerson2987, WB:WBPerson30255]
is_a: WBPhenotype:0002520 ! gap junction plaque morphology abnormal

[Term]
id: WBPhenotype:0002522
name: starvation-induced L1 arrest recovery abnormal
def: "Animals exhibit variations in the recovery from L1 larvae developmental arrest in response to a lack of food (starvation) available in the environment." [WB:WBPaper00049938, WB:WBPerson2987, WB:WBPerson6498]
is_a: WBPhenotype:0000751 ! L1 larval development variant

[Term]
id: WBPhenotype:0002523
name: slow recovery from starvation-induced L1 arrest
def: "Animals exhibit a slow recovery from starvation-induced L1 arrest, compared to controls." [WB:WBPaper00049938, WB:WBPerson2987, WB:WBPerson34124, WB:WBPerson6498]
is_a: WBPhenotype:0002522 ! starvation-induced L1 arrest recovery abnormal

[Term]
id: WBPhenotype:0002524
name: molybdenum cofactor depletion hypersensitive
def: "Animals are more sensitive to the depletion of molybdenum cofactor from the diet compared to control animals." [WB:WBPaper00056452, WB:WBPerson2987]
synonym: "dependent on dietary molybdenum cofactor" EXACT []
is_a: WBPhenotype:0002526 ! response to molybdenum cofactor depletion abnormal

[Term]
id: WBPhenotype:0002525
name: diet response variant
def: "Animals exhibit variations in their response to diet, compared to controls." [WB:WBPaper00024451, WB:WBPaper00026641, WB:WBPaper00032936, WB:WBPaper00045849, WB:WBPaper00056452, WB:WBPerson2987]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002526
name: response to molybdenum cofactor depletion abnormal
def: "Animals exhibit variations in the response to the depletion of molybdenum cofactor from the diet compared to control animals." [WB:WBPaper00056452, WB:WBPerson2987]
is_a: WBPhenotype:0002525 ! diet response variant

[Term]
id: WBPhenotype:0002527
name: dauer larva physiology variant
def: "Animals in the dauer larval stage exhibit variations in their physiology (any biological process including but not limited to development, behavior, or metabolism) compared to controls." [WB:WBPaper00004052, WB:WBPerson2987]
is_a: WBPhenotype:0001293 ! larval physiology phenotype

[Term]
id: WBPhenotype:0002528
name: miRNA biogenesis defective
def: "Animals (or cells) exhibit defects in the ability to produce mature microRNAs (miRNAs) from a miRNA locus. The defects could be at the level of miRNA transcription, pri-miRNA processing, and/or pre-miRNA processing." [WB:WBPaper00041677, WB:WBPerson2987, WB:WBPerson5649]
is_a: WBPhenotype:0001779 ! miRNA expression variant

[Term]
id: WBPhenotype:0002529
name: proteasome defective
def: "Animals exhibit defects or impairments in the functioning of the proteasome." [WB:WBPaper00056554, WB:WBPerson2987, WB:WBPerson5649]
is_a: WBPhenotype:0002009 ! proteasome core activity variant

[Term]
id: WBPhenotype:0002530
name: axotomy-induced phosphatidylserine exposure abnormal
def: "The level of phosphatidylserine exposed on the external axonal membrane following transection (axotomy) is changed compared to controls." [WB:WBPaper00053570, WB:WBPerson2987, WB:WBPerson9270]
is_a: WBPhenotype:0001399 ! cell membrane morphology variant
is_a: WBPhenotype:0002478 ! axotomy response variant

[Term]
id: WBPhenotype:0002531
name: allophagy abnormal
def: "Animals exhibit variations in allogenic (non-self) organelle autophagy, or allophagy, a macroautophagy process whereby organelles of non-self origin, like paternal mitochondria from sperm in a newly fertilized oocyte, are selectively degraded." [WB:WBPaper00040312, WB:WBPaper00041104, WB:WBPaper00053507, WB:WBPerson2987, WB:WBPerson3859]
is_a: WBPhenotype:0000736 ! autophagy variant

[Term]
id: WBPhenotype:0002532
name: allophagy defective
def: "Animals exhibit defects in allogenic (non-self) organelle autophagy, or allophagy, a macroautophagy process whereby organelles of non-self origin, like paternal mitochondria from sperm in a newly fertilized oocyte, are selectively degraded." [WB:WBPaper00053507, WB:WBPerson2987, WB:WBPerson3859]
is_a: WBPhenotype:0002531 ! allophagy abnormal

[Term]
id: WBPhenotype:0002534
name: antimicrobial gene expression variant
def: "Animals exhibit variations in the expression of one or more known, endogenous, antimicrobial genes, compared to controls." [WB:WBPaper00031865, WB:WBPerson2987]
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0002535
name: dye filling defect
def: "Animals exhibit variations in the extent to which one or more sensory neurons associated with sensilla (typically one or more amphids and/or phasmids) take up dye from the environment, compared to controls. In C. elegans, these neurons are commonly assayed by dye-filling with FITC, DiI or DiO." [WB:WBPaper00000793, WB:WBPerson2987]
synonym: "dye filling abnormal" EXACT []
synonym: "Dyf" EXACT []
is_a: WBPhenotype:0000255 ! amphid phasmid neuron morphology variant

[Term]
id: WBPhenotype:0002536
name: P granule number abnormal
def: "Animals exhibit germ cells with a number of P granules that differs from control animals." [WB:WBPaper00044160, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001300 ! germ cell cytoplasmic morphology variant

[Term]
id: WBPhenotype:0002537
name: P granule number reduced
def: "Animals exhibit germ cells with a reduced number of P granules compared to control animals." [WB:WBPaper00044160, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002536 ! P granule number abnormal

[Term]
id: WBPhenotype:0002538
name: calcium signaling in spermatheca variant
def: "Any variation in the series of molecular signals in which the spermatheca uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPaper00056137, WB:WBPerson2987, WB:WBPerson30989]
is_a: WBPhenotype:0002170 ! calcium mediated signaling variant

[Term]
id: WBPhenotype:0002539
name: antimicrobial gene expression increased
def: "Animals exhibit an increase in the expression of one or more known, endogenous, antimicrobial genes, compared to controls." [WB:WBPaper00047109, WB:WBPerson15627, WB:WBPerson2987]
is_a: WBPhenotype:0002534 ! antimicrobial gene expression variant

[Term]
id: WBPhenotype:0002540
name: lawn leaving reduced
def: "Animals exhibit a reduced rate of lawn/food leaving events, compared to controls." [WB:WBPaper00053007, WB:WBPerson262, WB:WBPerson2987]
synonym: "food leaving reduced" EXACT []
is_a: WBPhenotype:0001983 ! lawn leaving behavior variant

[Term]
id: WBPhenotype:0002541
name: radiation induced germ cell apoptosis resistant
def: "Programmed cell death of germ cells caused by exposure to ionizing energy occurs to a lesser extent than it does in control animals." [WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson2987]
is_a: WBPhenotype:0001850 ! radiation induced germ cell apoptosis variant

[Term]
id: WBPhenotype:0002542
name: intranuclear chromatin localization variant
def: "Cells exhibit specific regions of chromatin (e.g. an integrated array reporter) that localize to different regions within the nucleus, compared to controls." [WB:WBPaper00056796, WB:WBPerson2987, WB:WBPerson32254]
synonym: "intranuclear chromatin localization abnormal" EXACT []
is_a: WBPhenotype:0001348 ! chromosome morphology variant

[Term]
id: WBPhenotype:0002543
name: spontaneous mitochondrial DNA mutation rate increased
def: "Animals accumulate a greater number of mitochondrial genetic lesions than control animals in the absence of an externally controlled mutagen." [WB:WBPaper00053883, WB:WBPerson2987, WB:WBPerson31184]
is_a: WBPhenotype:0000228 ! spontaneous mutation rate increased

[Term]
id: WBPhenotype:0002544
name: hypersensitive to Enterobacter commensals
def: "Normally beneficial (or otherwise harmless, non-pathogenic) commensal Enterobacter bacteria, for example Enterobacter cloacae, become pathogenic to animals, unlike in control animals." [WB:WBPaper00056139, WB:WBPerson2987, WB:WBPerson3878]
is_a: WBPhenotype:0002356 ! sickened by nonpathogenic bacteria

[Term]
id: WBPhenotype:0002545
name: response to bacteria variant
def: "Animals exhibit variations in their response to bacteria (pathogenic or non-pathogenic), compared to controls." [WB:WBPaper00056139, WB:WBPerson2987, WB:WBPerson3878]
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0002546
name: bacterial load in gut variant
def: "Animals exhibit variations in the load of bacteria, of a particular clade or in general, in the gut, compared to controls." [WB:WBPaper00056139, WB:WBPerson2987, WB:WBPerson3878]
is_a: WBPhenotype:0002545 ! response to bacteria variant

[Term]
id: WBPhenotype:0002547
name: gut Enterobacteriaceae bloom
def: "Animals exhibit a greater abundance of bacteria of the Enterobacteriaceae family in the gut, compared to controls." [WB:WBPaper00056139, WB:WBPerson2987, WB:WBPerson3878]
is_a: WBPhenotype:0002546 ! bacterial load in gut variant

[Term]
id: WBPhenotype:0002548
name: kinker from conflicting forward and backward body bend propagation
def: "Animals exhibit a kinker phenotype that is due to conflicting, simultaneous forward and backward propagating bending waves." [WB:WBPaper00040432, WB:WBPerson2987, WB:WBPerson720]
synonym: "conflicted kinker" EXACT []
is_a: WBPhenotype:0000002 ! kinker

[Term]
id: WBPhenotype:0002549
name: increased frequency of spontaneous reversal initiation
def: "Animals exhibit an increase in the rate at which spontaneous backward locomotion is initiated compared to control." [WB:WBPaper00040432, WB:WBPerson2987, WB:WBPerson720]
is_a: WBPhenotype:0001506 ! spontaneous reversal rate variant

[Term]
id: WBPhenotype:0002550
name: conflicted kinker with gradual backward movement
def: "Animals exhibit a kinker phenotype that is due to conflicting, simultaneous forward and backward propagating bending waves, and over time has a tendency to move slowly backward due to a dominating reversal neural circuit." [WB:WBPaper00040432, WB:WBPerson2987, WB:WBPerson720]
is_a: WBPhenotype:0002548 ! kinker from conflicting forward and backward body bend propagation

[Term]
id: WBPhenotype:0002551
name: anatomical phenotype
def: "A phenotype affecting a particular anatomical entity." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002552
name: cell phenotype
def: "A phenotype affecting a particular cell." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002553
name: organ phenotype
def: "A phenotype affecting a particular organ." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002554
name: organ system phenotype
def: "A phenotype affecting a particular organ system." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002555
name: organismal phenotype
def: "A phenotype affecting the whole organism." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002556
name: tissue phenotype
def: "A phenotype affecting a particular tissue." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002557
name: body region phenotype
def: "A phenotype affecting a particular body region." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002558
name: extracellular component phenotype
def: "A phenotype affecting a particular extracellular component." [WB:WBPerson2987]
is_a: WBPhenotype:0000886 ! nematode phenotype

[Term]
id: WBPhenotype:0002559
name: burrowing abnormal
def: "Animals exhibit abnormalities in their burrowing behavior, in which animals burrow into a solid medium, such as agar, compared to control animals." [WB:WBPerson2987]
is_a: WBPhenotype:0000643 ! locomotion variant

[Term]
id: WBPhenotype:0002560
name: burrowing in response to high population density increased
def: "Greater quantities of worms burrow into and stay below the surface of the agar when high densities of nematodes are maintained on agar compared to controls (Hodgkin and Doniach, 1997)." [WB:WBPaper00058743, WB:WBPerson2987, WB:WBPerson712] {comment="WB:WBPaper00002770"}
is_a: WBPhenotype:0002559 ! burrowing abnormal

[Term]
id: WBPhenotype:0002561
name: homotypic endosome fusion defective
alt_id: WBPhenotype:0001638
def: "Cells exhibit defects in the homotypic fusion of endosomes." [GO:0034058, WB:WBPaper00029049, WB:WBPerson2987]
is_a: WBPhenotype:0001422 ! endocytic transport defect

[Term]
id: WBPhenotype:0002562
name: lysosome homeostasis abnormal
alt_id: WBPhenotype:0001784
def: "Cells exhibit variations or abnormalities in their maintenance of lysosome function, compared to controls." [WB:WBPaper00029049, WB:WBPerson2987]
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002563
name: neuron physiology phenotype
alt_id: WBPhenotype:0000991
def: "Animals exhibit variations in any physical or chemical process required for the neuron to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [WB:WBPerson2987]
synonym: "neuron physiology abnormal" EXACT []
synonym: "neuron physiology variant" EXACT []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002564
name: associative memory phenotype
def: "Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms, compared to controls." [WB:WBPaper00036296, WB:WBPerson2987]
synonym: "associative memory abnormal" EXACT []
synonym: "associative memory variant" EXACT []
is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant

[Term]
id: WBPhenotype:0002565
name: associative olfactory memory phenotype
def: "Animals exhibit variations in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms, compared to controls." [WB:WBPaper00036296, WB:WBPerson2987, WB:WBPerson3142]
synonym: "olfactory memory abnormal" EXACT []
synonym: "olfactory memory variant" EXACT []
is_a: WBPhenotype:0002564 ! associative memory phenotype

[Term]
id: WBPhenotype:0002566
name: long-term associative olfactory memory phenotype
def: "Animals exhibit variations in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s)." [WB:WBPaper00036296, WB:WBPerson2987, WB:WBPerson3142]
synonym: "long-term associative olfactory memory abnormal" EXACT []
synonym: "long-term associative olfactory memory variant" EXACT []
is_a: WBPhenotype:0002565 ! associative olfactory memory phenotype
is_a: WBPhenotype:0002568 ! long-term associative memory phenotype

[Term]
id: WBPhenotype:0002567
name: long-term associative olfactory memory defective
def: "Animals are deficient in their recalled and repeated responses to olfactory stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s)." [WB:WBPaper00036296, WB:WBPerson2987, WB:WBPerson3142]
is_a: WBPhenotype:0001785 ! associative memory defective
is_a: WBPhenotype:0002566 ! long-term associative olfactory memory phenotype

[Term]
id: WBPhenotype:0002568
name: long-term associative memory phenotype
def: "Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms over the long term, compared to controls. Long-term associative memory is memory that lasts for hours to days after the associative learning (training) event(s)." [WB:WBPaper00036296, WB:WBPerson2987, WB:WBPerson3142]
synonym: "long-term associative memory abnormal" EXACT []
synonym: "long-term associative memory variant" EXACT []
is_a: WBPhenotype:0002564 ! associative memory phenotype

[Term]
id: WBPhenotype:0002569
name: hypodermis development variant
def: "Any variation in the progression of the hypodermis over time, from its formation to its mature state compared to control." [WB:WBPerson2987]
synonym: "hypodermal development abnormal" EXACT []
synonym: "hypodermal development variant" EXACT []
synonym: "hypodermis development abnormal" EXACT []
is_a: WBPhenotype:0000701 ! epithelial development variant

[Term]
id: WBPhenotype:0002570
name: embryonic arrest during gastrulation
def: "Cessation of development during the gastrulation stage of embryonic development. In C. elegans, gastrulation occurs 100-290 minutes after first cleavage at 20 degrees Centigrade when the embryo develops from 28 cells to 421 cells (during the proliferating embryo life stage)." [WB:WBPerson2987, WB:WBPerson6609]
is_a: WBPhenotype:0000867 ! embryonic arrest

[Term]
id: WBPhenotype:0002571
name: anterior enclosure defective
def: "Embryos exhibit a failure to enclose the anterior embryo region with hypodermis during the comma to early elongation stage of embryonic development." [WB:WBPerson2987, WB:WBPerson6609]
is_a: WBPhenotype:0001566 ! ventral enclosure variant

[Term]
id: WBPhenotype:0002572
name: mitophagy abnormal
def: "Animals exhibit variations in mitophagy, the selective autophagy process in which a mitochondrion is degraded by macroautophagy, compared to control." [WB:WBPaper00056229, WB:WBPerson27070, WB:WBPerson2987]
synonym: "mitophagy variant" EXACT []
is_a: WBPhenotype:0000736 ! autophagy variant

[Term]
id: WBPhenotype:0002573
name: mitophagy reduced
def: "Animals exhibit reduced levels of mitophagy, the selective autophagy process in which a mitochondrion is degraded by macroautophagy, compared to control." [WB:WBPaper00056229, WB:WBPerson27070, WB:WBPerson2987]
is_a: WBPhenotype:0002572 ! mitophagy abnormal

[Term]
id: WBPhenotype:0002574
name: gene expression level variation abnormal
def: "Animals exhibit abnormal amounts of variation in gene expression level between individual animals, compared to control." [WB:WBPaper00050756, WB:WBPerson2987, WB:WBPerson5662]
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0002575
name: gene expression level abnormal
def: "Animals exhibit abnormal gene expression levels, compared to control." [WB:WBPerson2987]
is_a: WBPhenotype:0000717 ! gene expression variant

[Term]
id: WBPhenotype:0002576
name: gene expression level variation reduced
def: "Animals exhibit reduced amounts of variation in gene expression level between individual animals, compared to control." [WB:WBPaper00050756, WB:WBPerson2987, WB:WBPerson5662]
is_a: WBPhenotype:0002574 ! gene expression level variation abnormal

[Term]
id: WBPhenotype:0002577
name: basement membrane composition phenotype
def: "Animals exhibit variations in the composition of basement membranes, compared to control animals." [WB:WBPaper00057139, WB:WBPerson2987, WB:WBPerson32869]
synonym: "basement membrane composition abnormal" EXACT []
synonym: "basement membrane composition variant" EXACT []
is_a: WBPhenotype:0002588 ! basement membrane phenotype

[Term]
id: WBPhenotype:0002578
name: basement membrane laminin level phenotype
def: "Animals exhibit variations in the amount of laminin in basement membranes, compared to control animals." [WB:WBPaper00057139, WB:WBPerson2987, WB:WBPerson32869]
synonym: "basement membrane laminin level abnormal" EXACT []
synonym: "basement membrane laminin level variant" EXACT []
is_a: WBPhenotype:0002577 ! basement membrane composition phenotype

[Term]
id: WBPhenotype:0002579
name: basement membrane type IV collagen level phenotype
def: "Animals exhibit variations in the amount of type IV collagen in basement membranes, compared to control animals." [WB:WBPaper00057139, WB:WBPerson2987, WB:WBPerson32869]
synonym: "basement membrane type IV collagen level abnormal" EXACT []
synonym: "basement membrane type IV collagen level variant" EXACT []
is_a: WBPhenotype:0002577 ! basement membrane composition phenotype

[Term]
id: WBPhenotype:0002580
name: cell position variability phenotype
def: "One or more cells exhibit changes in the variability of cell position, compared to controls." [WB:WBPaper00056010, WB:WBPerson13958, WB:WBPerson2987]
synonym: "cell position variability abnormal" EXACT []
synonym: "cell position variability variant" EXACT []
is_a: WBPhenotype:0000533 ! cell morphology variant

[Term]
id: WBPhenotype:0002581
name: cell position variability increased
def: "One or more cells exhibit increases in the variability of cell position, compared to controls." [WB:WBPaper00056010, WB:WBPerson13958, WB:WBPerson2987]
is_a: WBPhenotype:0002580 ! cell position variability phenotype

[Term]
id: WBPhenotype:0002582
name: miniature inhibitory post-synaptic current phenotype
def: "Animals exhibit variations in miniature inhibitory post-synaptic currents (mIPSC), compared to controls." [WB:WBPaper00048837, WB:WBPerson18607, WB:WBPerson2987]
synonym: "miniature inhibitory post-synaptic current abnormal" EXACT []
synonym: "miniature inhibitory post-synaptic current variant" EXACT []
synonym: "mIPSC abnormal" EXACT []
synonym: "mIPSC phenotype" EXACT []
synonym: "mIPSC variant" EXACT []
is_a: WBPhenotype:0002014 ! current measurement variant

[Term]
id: WBPhenotype:0002583
name: miniature inhibitory post-synaptic current amplitude increased
def: "Animals exhibit increased amplitude of miniature inhibitory post-synaptic currents (mIPSC), compared to controls." [WB:WBPaper00048837, WB:WBPerson18607, WB:WBPerson2987]
synonym: "mIPSC amplitude increased" EXACT []
is_a: WBPhenotype:0002582 ! miniature inhibitory post-synaptic current phenotype

[Term]
id: WBPhenotype:0002584
name: bisphenol A resistant
def: "Animals survive longer, or do not respond to the same degree as control animals under similar conditions of bisphenol A exposure." [WB:WBPaper00024241, WB:WBPerson557]
is_a: WBPhenotype:0000931 ! bisphenol A response variant

[Term]
id: WBPhenotype:0002585
name: predatory behavior abnormal
def: "Pristionchus pacificus: Animals exhibit abnormal predatory behavior, compared to controls." [WB:WBPaper00053031, WB:WBPerson2987, WB:WBPerson38478]
is_a: WBPhenotype:0000525 ! organism behavior variant

[Term]
id: WBPhenotype:0002586
name: reduced predatory feeding behavior
def: "Pristionchus pacificus: Animals exhibit reduced predatory feeding behavior, indicated by reduced predation success, compared to controls." [WB:WBPaper00053031, WB:WBPerson2987, WB:WBPerson38478]
is_a: WBPhenotype:0002585 ! predatory behavior abnormal

[Term]
id: WBPhenotype:0002587
name: Pluronic gel burrowing impaired
def: "Animals are impaired in their burrowing ability compared to control animals in a Pluronic gel-based burrowing assay." [WB:WBPaper00058750, WB:WBPerson2987, WB:WBPerson43910]
is_a: WBPhenotype:0002559 ! burrowing abnormal

[Term]
id: WBPhenotype:0002588
name: basement membrane phenotype
def: "Animals exhibit variations or abnormalities in the structure, integrity, function, or quality of basement membranes, compared to controls." [WB:WBPaper00037647]
synonym: "basement membrane abnormal" EXACT []
is_a: WBPhenotype:0001210 ! pericellular component physiology phenotype

[Term]
id: WBPhenotype:0002589
name: neuron degeneration reduced
def: "Animals exhibit a reduction in neuron degeneration, compared to control animals." [WB:WBPerson2987, WB:WBPerson58]
is_a: WBPhenotype:0000636 ! neuron degeneration variant

[Term]
id: WBPhenotype:0002590
name: linker cell detached
def: "The linker cell of male animals becomes detached from the rest of the male gonad." [WB:WBPaper00046064, WB:WBPerson2987]
is_a: WBPhenotype:0001675 ! male gonad development variant

[Term]
id: WBPhenotype:0002591
name: dendrite length reduced
def: "One or more neurons of the animal exhibit one or more dendrites with reduced length compared to the corresponding dendrites in control animals." [WB:WBPaper00033050, WB:WBPerson2987]
is_a: WBPhenotype:0000882 ! dendrite development variant

[Term]
id: WBPhenotype:0002592
name: organism response to gravitational force abnormal
def: "Animals exhibit variations in their response to changes in gravitational force, compared to control animals." [WB:WBPaper00030928, WB:WBPerson2987]
is_a: WBPhenotype:0000067 ! organism stress response variant

[Term]
id: WBPhenotype:0002593
name: short term plate tap habituation variant
def: "Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control, over the short term. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s)." [WB:WBPaper00006159, WB:WBPerson2987]
is_a: WBPhenotype:0002469 ! plate tap habituation variant
is_a: WBPhenotype:0002600 ! short-term habituation phenotype

[Term]
id: WBPhenotype:0002594
name: long term plate tap habituation variant
def: "Any variation in the decrease in a behavioral response to a repeated plate tap stimulus compared to control, over the long term. Long-term memory is memory that lasts for hours to days after the learning (training) event(s)." [WB:WBPaper00006159, WB:WBPerson2987]
is_a: WBPhenotype:0002469 ! plate tap habituation variant
is_a: WBPhenotype:0002599 ! long-term habituation phenotype

[Term]
id: WBPhenotype:0002595
name: sleep deprivation-induced brood size reduction enhanced
def: "The reduction in brood size caused by sleep deprivation is enhanced, compared to controls." [WB:WBPaper00052970, WB:WBPerson2987]
is_a: WBPhenotype:0000154 ! reduced brood size

[Term]
id: WBPhenotype:0002596
name: sleep deprivation-induced brood size reduction suppressed
def: "The reduction in brood size caused by sleep deprivation is suppressed, compared to controls." [WB:WBPaper00052970, WB:WBPerson2987]
is_a: WBPhenotype:0000154 ! reduced brood size

[Term]
id: WBPhenotype:0002597
name: gustatory learning abnormal
def: "Variations in the behavioral plasticity induced by the integration of two sensory signals (one of which is gustation (taste)) compared to control. For example, C. elegans animals can be trained to associate the taste of a substance (e.g. sodium chloride, normally an attractant) to an aversive stimuli (e.g. starvation) so that trained worms will avoid the substance in the absence of the aversive stimuli. Animals with this phenotype have an abnormal response to the trained stimuli compared to controls." [WB:WBPaper00059641, WB:WBPerson2987]
is_a: WBPhenotype:0001780 ! associative learning variant

[Term]
id: WBPhenotype:0002598
name: gustatory aversive learning abnormal
def: "Variations in the aversion of animals to substances sensed by gustation (taste) previously associated with an aversive stimuli during a gustation training protocol, compared to control. For example, C. elegans animals can be trained to associate the taste of a substance (e.g. sodium chloride, normally an attractant) to an aversive stimuli (e.g. starvation) so that trained worms will avoid the substance in the absence of the aversive stimuli. Animals with this phenotype will not exhibit the same aversion to the substance as compared to control animals." [WB:WBPaper00059641, WB:WBPerson2987]
is_a: WBPhenotype:0002597 ! gustatory learning abnormal

[Term]
id: WBPhenotype:0002599
name: long-term habituation phenotype
def: "Any variation in the decrease in a behavioral response to a repeated stimulus compared to control, over the long term. Long-term memory is memory that lasts for hours to days after the learning (training) event(s)." [WB:WBPaper00041586, WB:WBPerson2987]
synonym: "long-term habituation abnormal" EXACT []
synonym: "long-term habituation variant" EXACT []
is_a: WBPhenotype:0000626 ! habituation variant

[Term]
id: WBPhenotype:0002600
name: short-term habituation phenotype
def: "Any variation in the decrease in a behavioral response to a repeated stimulus compared to control, over the short term. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s)." [WB:WBPaper00041586, WB:WBPerson2987]
synonym: "short-term habituation abnormal" EXACT []
synonym: "short-term habituation variant" EXACT []
is_a: WBPhenotype:0000626 ! habituation variant

[Term]
id: WBPhenotype:0002601
name: short-term associative memory phenotype
def: "Animals exhibit variations in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms over the short term, compared to controls. Short-term memory is memory that lasts for minutes to hours after the learning (training) event(s)." [WB:WBPaper00041586, WB:WBPerson2987]
synonym: "short-term associative memory abnormal" EXACT []
synonym: "short-term associative memory variant" EXACT []
is_a: WBPhenotype:0002564 ! associative memory phenotype

[Term]
id: WBPhenotype:0002602
name: reduced frequency of spontaneous reversal initiation
def: "Animals exhibit a decrease in the rate at which spontaneous backward locomotion is initiated compared to control." [WB:WBPaper00049647, WB:WBPerson2987]
is_a: WBPhenotype:0001506 ! spontaneous reversal rate variant

[Term]
id: WBPhenotype:0002603
name: protein toxicity response abnormal
def: "Animals exhibit an abnormal response to toxic proteins, either via exposure in the environment or expressed within the organism, compared to controls." [WB:WBPaper00059748, WB:WBPerson2987]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002604
name: dipeptide repeat protein toxicity abnormal
def: "Animals exhibit an abnormal response to toxic dipeptide repeat proteins, either via exposure in the environment or expressed within the organism, compared to controls." [WB:WBPaper00059748, WB:WBPerson2987]
is_a: WBPhenotype:0002603 ! protein toxicity response abnormal

[Term]
id: WBPhenotype:0002605
name: dipeptide repeat protein toxicity suppressed
def: "Normally toxic dipeptide repeat proteins appear to be less toxic to animals, compared to control animals." [WB:WBPaper00059748, WB:WBPerson2987]
is_a: WBPhenotype:0002604 ! dipeptide repeat protein toxicity abnormal

[Term]
id: WBPhenotype:0002606
name: necrotic cell death decreased
def: "Animals exhibit reduced necrotic cell death, compared to controls." [WB:WBPaper00028466, WB:WBPaper00059770, WB:WBPerson2987]
is_a: WBPhenotype:0000415 ! necrotic cell death variant

[Term]
id: WBPhenotype:0002607
name: nuclear size abnormal
def: "One or more cellular nuclei exhibit an abnormal size, compared to controls." [WB:WBPaper00042522, WB:WBPerson2987]
synonym: "nuclear size phenotype" EXACT []
synonym: "nuclear size variant" EXACT []
is_a: WBPhenotype:0001028 ! nuclear appearance variant

[Term]
id: WBPhenotype:0002608
name: humpback
def: "A body elongation defect in which embryos develop abnormally bulged dorsal surfaces." [WB:WBPaper00003046]
comment: "After standard ethylmethane sulfonate mutagenesis, we screened directly for mutant embryos that are defective in body elongation. We isolated 13 recessive, zygotic-lethal mutants that, in addition to failing to elongate properly, show abnormally bulged dorsal surfaces (Fig. 1B). We call this novel phenotype Hmp (humpback); this phenotype contrasts with previously described elongation-defective Pat mutants that display bulges at variable positions (Williams and Waterston, 1994)." {xref="WB:WBPaper00003046"}
synonym: "Hmp" EXACT []
is_a: WBPhenotype:0000242 ! body elongation defective
is_a: WBPhenotype:0001136 ! embryonic morphology variant

[Term]
id: WBPhenotype:0002609
name: hammerhead
def: "An anterior enclosure defect in which the anterior portion of the embryo, unenclosed by the hypodermis, bulges to form a hammerhead shape." [WB:WBPaper00003046, WB:WBPerson2987]
comment: "However, in the remaining hmr-1 mutants the hypodermis fails to fully enclose the embryo. We call this phenotype Hmr (hammerhead; see Fig. 1F)." {xref="WB:WBPaper00003046"}
synonym: "Hmr" EXACT [WB:WBPaper00003046]
is_a: WBPhenotype:0002571 ! anterior enclosure defective

[Term]
id: WBPhenotype:0002610
name: ectopic apoptosis
def: "Apoptosis occurs in cells or cell types that do not undergo apoptosis in controls." [WB:WBPaper00044285, WB:WBPerson2987]
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBPhenotype:0002611
name: meiotic cytoplasmic streaming defective
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell undergoing meiosis is impaired." [WB:WBPaper00050908, WB:WBPerson2987, WB:WBPerson3569]
is_a: WBPhenotype:0000360 ! cytoplasmic streaming defective
is_a: WBPhenotype:0002613 ! meiotic cytoplasmic streaming phenotype

[Term]
id: WBPhenotype:0002612
name: cytoplasmic streaming phenotype
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is abnormal compared to control." [GO:0099636, WB:WBPaper00050908, WB:WBPerson2987, WB:WBPerson3569]
synonym: "cytoplasmic streaming abnormal" EXACT []
synonym: "cytoplasmic streaming variant" EXACT []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002613
name: meiotic cytoplasmic streaming phenotype
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell undergoing meiosis is abnormal compared to control." [WB:WBPaper00050908, WB:WBPerson2987, WB:WBPerson3569]
synonym: "meiotic cytoplasmic streaming abnormal" EXACT []
synonym: "meiotic cytoplasmic streaming variant" EXACT []
is_a: WBPhenotype:0002612 ! cytoplasmic streaming phenotype

[Term]
id: WBPhenotype:0002614
name: derepression of heterchromatic gene silencing
def: "Genes normally silenced within heterochromatin are abnoramally de-repressed and exhibit expression, unlike controls." [WB:WBPaper00059527, WB:WBPerson2439, WB:WBPerson2987]
is_a: WBPhenotype:0000135 ! gene expression level high

[Term]
id: WBPhenotype:0002615
name: abnormal accumulation of vacuoles
def: "Animals accumulate vacuoles in an abnormal manner in cells, tissues, and/or organs of the animal." [WB:WBPaper00041673, WB:WBPerson2987]
is_a: WBPhenotype:0000535 ! organism morphology variant

[Term]
id: WBPhenotype:0002616
name: cellular calcium level abnormal
def: "Cells exhibit an abnormal intracellular level (amount) of calcium, compared to controls." [WB:WBPaper00041673, WB:WBPerson2987]
synonym: "cellular calcium level phenotype" EXACT []
synonym: "cellular calcium level variant" EXACT []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0002617
name: cytosolic calcium levels increased
def: "Cells exhibit a higher level of calcium in the cytosol, compared to controls." [WB:WBPaper00041673, WB:WBPerson2987]
is_a: WBPhenotype:0002616 ! cellular calcium level abnormal

[Term]
id: WBPhenotype:0002618
name: cytosolic calcium levels decreased
def: "Cells exhibit a lower level of calcium in the cytosol, compared to controls." [WB:WBPaper00041673, WB:WBPerson2987]
is_a: WBPhenotype:0002616 ! cellular calcium level abnormal

[Term]
id: WBPhenotype:0002619
name: cell death increased
def: "Animals exhibit increased occurrence of cell death, compared to controls." [WB:WBPaper00041673, WB:WBPerson2987]
is_a: WBPhenotype:0000729 ! cell death variant

[Term]
id: WBPhenotype:0002620
name: cell death decreased
def: "Animals exhibit decreased occurrence of cell death, compared to controls." [WB:WBPaper00041673, WB:WBPerson2987]
is_a: WBPhenotype:0000729 ! cell death variant

[Term]
id: WBPhenotype:0002621
name: antimicrobial gene expression reduced
def: "Animals exhibit a decrease in the expression of one or more known, endogenous, antimicrobial genes, compared to controls." [WB:WBPaper00053771, WB:WBPerson2987]
is_a: WBPhenotype:0002534 ! antimicrobial gene expression variant

[Term]
id: WBPhenotype:0002622
name: decreased recruitment of actin upon wounding
def: "Animals exhibit decreased recruitment of actin to a site of injury, compared to controls." [WB:WBPaper00059214, WB:WBPerson2987, WB:WBPerson499]
synonym: "decreased recruitment of actin upon injury" EXACT []
is_a: WBPhenotype:0001346 ! actin cytoskeleton dynamics phenotype
is_a: WBPhenotype:0001840 ! response to injury variant

[Term]
id: WBPhenotype:0002623
name: no induction of antimicrobial peptide expression after injury
def: "Animals exhibit no induction of expression of an antimicrobial peptide after an injury, unlike control animals." [WB:WBPaper00059214, WB:WBPerson2987, WB:WBPerson499]
synonym: "no induction of antimicrobial peptide expression after wounding" EXACT []
is_a: WBPhenotype:0001840 ! response to injury variant
is_a: WBPhenotype:0002621 ! antimicrobial gene expression reduced

[Term]
id: WBPhenotype:0002624
name: EdU incorporation reduced
def: "Cells display reduced incorporation of the thymidine analogue 5-Ethynyl-2'-deoxyuridine (EdU), suggesting reduced cell proliferation. Incorporation of EdU is an indication of active DNA synthesis and thus an indication of cells proceeding through the cell cycle." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
is_a: WBPhenotype:0000173 ! cell proliferation reduced

[Term]
id: WBPhenotype:0002625
name: head degeneration
def: "Animals exhibit visible, structural degeneration of the head, unlike control animals." [WB:WBPerson2987, WB:WBPerson36183] {comment="PMID:32973031"}
is_a: WBPhenotype:0000532 ! body region morphology variant

[Term]
id: WBPhenotype:0002626
name: attachment to substrate abnormal
def: "Animals exhibit an abnormal attachment (or lack thereof) to a substrate, compared to controls. For some parasitic worms, attachment to host tissue surfaces, like endothelium, is a necessary behavior for their life cycle." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0002627
name: in vitro attachment to substrate abnormal
def: "Animals exhibit an abnormal attachment (or lack thereof) to a substrate in vitro, compared to controls." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
is_a: WBPhenotype:0002626 ! attachment to substrate abnormal

[Term]
id: WBPhenotype:0002628
name: in vitro attachment to substrate reduced
def: "Animals exhibit a reduced attachment to a substrate in vitro, compared to controls." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
is_a: WBPhenotype:0002627 ! in vitro attachment to substrate abnormal

[Term]
id: WBPhenotype:0002629
name: intestinal edema
def: "Animals exhibit edema (swelling) of the intestine, compared to control animals. This swelling is distinct from distension of the intestinal lumen (swollen intestinal lumen)." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
synonym: "intestinal oedema" EXACT []
synonym: "swollen intestine" EXACT []
is_a: WBPhenotype:0000710 ! intestinal morphology variant

[Term]
id: WBPhenotype:0002630
name: epithelial system degeneration
def: "Animals exhibit degeneration of the epithelial system (skin, integument or tegument), compared to control animals." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
synonym: "integument degeneration" EXACT []
synonym: "tegument degeneration" EXACT []
is_a: WBPhenotype:0000600 ! epithelial system morphology variant

[Term]
id: WBPhenotype:0002631
name: tissue edema
def: "Animals exhibit edema (swelling) of one or more tissues, compared to control animals." [PMID:32973031, WB:WBPerson2987, WB:WBPerson36183]
synonym: "tissue oedema" EXACT []
synonym: "tissue swelling" EXACT []
is_a: WBPhenotype:0000520 ! morphology phenotype
is_a: WBPhenotype:0002556 ! tissue phenotype

[Term]
id: WBPhenotype:0002632
name: chromatin accessibility abnormal
def: "Animals exhibit cells with an abnormal degree of chromatin accessibility, compared to controls, detected using techniques such as ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing)." [WB:WBPaper00061371, WB:WBPerson2987, WB:WBPerson712]
synonym: "chromatin accessibility phenotype" EXACT []
synonym: "chromatin accessibility variant" EXACT []
is_a: WBPhenotype:0001348 ! chromosome morphology variant

[Term]
id: WBPhenotype:0002633
name: pharynx ingressed
def: "Animals exhibit a pharynx that recedes into the animal's interior such that the animal cannot feed." [WB:WBPaper00055692, WB:WBPerson2987, WB:WBPerson43879]
synonym: "Pin" EXACT []
is_a: WBPhenotype:0001748 ! pharynx unattached

[Term]
id: WBPhenotype:0002634
name: ER stress resistant
def: "Animals exhibit a resistance to endoplasmic reticulum (ER) stressors such as an accumulation of unfolded proteins or the presence of chemicals that induce ER stress, such as dithiothreitol (DDT) or tunicamycin, compared to controls. This may mean that animals fare better than controls in terms of survival or some metric of health when exposed to an inducer of ER stress." [WB:WBPaper00050013, WB:WBPerson2987]
is_a: WBPhenotype:0001485 ! ER stress response variant

[Term]
id: WBPhenotype:0002635
name: epidermal shedding
def: "Animals shed fragments of epidermis into the surrounding environment, unlike controls. In embryos, these fragments can be seen in the extra-embryonic space." [WB:WBPaper00052963, WB:WBPerson2987]
is_a: WBPhenotype:0000619 ! epithelial system development variant

[Term]
id: WBPhenotype:0002636
name: detachment of chromatin from nuclear periphery
def: "One or more cells of the animal exhibit chromatin that has become detached from the nuclear periphery, unlike controls." [WB:WBPaper00048885, WB:WBPerson14737, WB:WBPerson2987]
is_a: WBPhenotype:0002542 ! intranuclear chromatin localization variant

[Term]
id: WBPhenotype:0002637
name: iron levels decreased
def: "Animals (or cells of the animal) exhibit reduced levels of iron in the body (or cells) compared to controls." [WB:WBPaper00055104, WB:WBPerson2987, WB:WBPerson35689]
is_a: WBPhenotype:0002046 ! iron homeostasis variant

[Term]
id: WBPhenotype:0002638
name: increased susceptibility to oomycete infection
def: "Animals are more prone to infection, sickness and/or death caused by oomycete pathogens compared to control animals." [WB:WBPaper00060871, WB:WBPerson2987, WB:WBPerson53483]
is_a: WBPhenotype:0001013 ! pathogen susceptibility increased

[Term]
id: WBPhenotype:0002639
name: microbiome composition abnormal
def: "Animals exhibit specific or general variations in the composition of the microbiome at a body site compared to controls." [WB:WBPerson10314, WB:WBPerson2987]
synonym: "microbiome composition variant" EXACT []
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002640
name: cuticle integrity decreased
def: "The physical strength or integrity of the cuticle is decreased compared to that observed for control animals." [WB:WBPaper00061220, WB:WBPerson2987]
is_a: WBPhenotype:0001211 ! cuticle integrity variant

[Term]
id: WBPhenotype:0002641
name: cuticle permeability increased
def: "The cuticle of animals becomes more permeable to dyes or stains, such as Hoechst 33258, or other substances compared to controls." [WB:WBPaper00061220, WB:WBPerson2987, WB:WBPerson3900]
is_a: WBPhenotype:0002640 ! cuticle integrity decreased

[Term]
id: WBPhenotype:0002642
name: chemical accumulation abnormal
def: "Animals exposed to an exogenous chemical exhibit an abnormal accumulation of this chemical in the body of the animals, compared to controls." [WB:WBPaper00061220, WB:WBPerson2987, WB:WBPerson3900]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0002643
name: chemical accumulation increased
def: "Animals exposed to an exogenous chemical exhibit an abnormal increase in accumulation of this chemical in the body of the animals, compared to controls." [WB:WBPaper00061220, WB:WBPerson2987, WB:WBPerson3900]
is_a: WBPhenotype:0002642 ! chemical accumulation abnormal

[Term]
id: WBPhenotype:0002644
name: precipice response variant
def: "Animals do not respond to the edge or gap in the medium surface they were supported on in the same manner as controls. In Mitchell et al., the precipice response was defined to be that within 2 seconds of the nose moving off the edge of the agar chunk, the worm begins a reversal that completes at least one full sine wave." [WB:WBPaper00061677, WB:WBPerson2987, WB:WBPerson712]
synonym: "precipice response abnormal" EXACT []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0002645
name: thermorecovery abnormal
def: "Animals exhibit an abnormal recovery from heat stress, compared to controls." [WB:WBPaper00060029, WB:WBPerson14884, WB:WBPerson2987]
comment: Exposure of wild type worms to a 6 h heat shock at 33°C led to a 20% decrease in worms with normal movement after a 48 h recovery at 20°C. {xref="WB:WBPaper00060029"}
synonym: "heat stress recovery abnormal" EXACT []
is_a: WBPhenotype:0000146 ! organism temperature response variant

[Term]
id: WBPhenotype:0002646
name: thermorecovery reduced
def: "Animals exhibit reduced recovery from heat stress compared to controls. Reduced recovery may be indicated, for example, by a decrease in normal movement, such as uncoordinated or jerky movement or paralysis, compared to controls." [WB:WBPaper00060029, WB:WBPerson14884, WB:WBPerson2987]
synonym: "heat stress recovery reduced" EXACT []
is_a: WBPhenotype:0002645 ! thermorecovery abnormal

[Term]
id: WBPhenotype:0002647
name: dendrite morphology variant
def: "Animals display variations in the structure, organization of components, or spatial pattern of the neuronal extensions that carry afferent (incoming) action potentials towards the cell body, compared to that observed in control animals." [WB:WBPaper00043988, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0001398 ! neurite morphology variant

[Term]
id: WBPhenotype:0002648
name: dendrite branching variant
def: "Animals display variations in the number or pattern of neuronal extensions that carry afferent (incoming) action potentials towards the cell body, compared to that observed in control animals." [WB:WBPaper00043988, WB:WBPerson2987, WB:WBPerson557]
is_a: WBPhenotype:0002647 ! dendrite morphology variant

[Term]
id: WBPhenotype:0002649
name: egg laying response to chemical abnormal
def: "Characteristic response to chemicals with respect to egg-laying behavior varies compared to control." [WB:WBPaper00060230, WB:WBPerson2987, WB:WBPerson712]
is_a: WBPhenotype:0000523 ! chemical response variant

[Term]
id: WBPhenotype:0002650
name: egg laying response to pathogen lipopolysaccharide variant
def: "Characteristic response to extracted lipopolysaccharide from pathogens with respect to egg-laying behavior varies compared to control conditions." [WB:WBPaper00060230, WB:WBPerson2987, WB:WBPerson712]
is_a: WBPhenotype:0002649 ! egg laying response to chemical abnormal

[Term]
id: WBPhenotype:0002651
name: exopher production phenotype
def: "Cells exhibit an abnormal production of exophers, large (approximately four microns in diameter) membrane-bound extracellular vesicles that are released by budding out of cells into the extracellular space, compared to controls." [WB:WBPaper00061698, WB:WBPerson23531, WB:WBPerson2987]
synonym: "exopher production abnormal" EXACT []
synonym: "exopher-genesis abnormal" EXACT []
synonym: "exopher-genesis phenotype" EXACT []
is_a: WBPhenotype:0000258 ! cell secretion variant

[Term]
id: WBPhenotype:0002652
name: exopher production increased
def: "Cells exhibit a increase in production of exophers compared to controls." [WB:WBPaper00061698, WB:WBPerson23531, WB:WBPerson2987]
is_a: WBPhenotype:0002651 ! exopher production phenotype

[Term]
id: WBPhenotype:0002653
name: exopher production decreased
def: "Cells exhibit a decrease in production of exophers compared to controls." [WB:WBPaper00061698, WB:WBPerson23531, WB:WBPerson2987]
is_a: WBPhenotype:0002651 ! exopher production phenotype

[Term]
id: WBPhenotype:0002654
name: exopher production in muscle phenotype
def: "Muscle cells exhibit an abnormal production of exophers compared to controls." [WB:WBPaper00061698, WB:WBPerson23531, WB:WBPerson2987]
is_a: WBPhenotype:0000990 ! muscle cell physiology variant
is_a: WBPhenotype:0002651 ! exopher production phenotype

[Term]
id: WBPhenotype:0002655
name: exopher production in muscle decreased
def: "Muscle cells exhibit a decrease in production of exophers compared to controls." [WB:WBPaper00061698, WB:WBPerson23531, WB:WBPerson2987]
is_a: WBPhenotype:0002653 ! exopher production decreased
is_a: WBPhenotype:0002654 ! exopher production in muscle phenotype

[Term]
id: WBPhenotype:0002656
name: exopher production in muscle increased
def: "Muscle cells exhibit an increase in production of exophers compared to controls." [WB:WBPaper00061698, WB:WBPerson23531, WB:WBPerson2987]
is_a: WBPhenotype:0002652 ! exopher production increased
is_a: WBPhenotype:0002654 ! exopher production in muscle phenotype

[Term]
id: WBPhenotype:0002657
name: dietary saturated fatty acid intolerant
def: "Animals exhibit intolerance (e.g. lethality or significant growth defect) when exposed to saturated fatty acids via the diet, compared to controls." [WB:WBPaper00060877, WB:WBPerson2987, WB:WBPerson488]
is_a: WBPhenotype:0001072 ! response to food variant
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0002658
name: muscle strength phenotype
def: "Animals exhibit variations in muscle strength, as measured by a strength determining assay, compared to controls." [WB:WBPaper00061159, WB:WBPerson1754, WB:WBPerson2987]
is_a: WBPhenotype:0000611 ! muscle system physiology variant

[Term]
id: WBPhenotype:0002659
name: muscle strength decreased
def: "Animals exhibit a decrease in muscle strength, as measured by a strength determining assay, compared to controls." [WB:WBPaper00061159, WB:WBPerson1754, WB:WBPerson2987]
is_a: WBPhenotype:0002658 ! muscle strength phenotype

[Term]
id: WBPhenotype:0002660
name: germline stem cell depletion
def: "Animals exhibit a depletion of germline stem cells, compared to controls." [WB:WBPaper00044909, WB:WBPerson2987, WB:WBPerson5747]
is_a: WBPhenotype:0000684 ! fewer germ cells

[Term]
id: WBPhenotype:0002661
name: constitutive expression of innate immune response genes
def: "Genes, whose expression is typically induced by an innate immune response, are actively expressed under conditions which would not normally induce an innate immune response gene expression program." [WB:WBPaper00064532, WB:WBPerson2987, WB:WBPerson38719]
is_a: WBPhenotype:0000135 ! gene expression level high

[Term]
id: WBPhenotype:0002662
name: transgene silencing increased
def: "Animals exhibit an increase in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control." [WB:WBPaper00064532, WB:WBPerson2987, WB:WBPerson38719]
is_a: WBPhenotype:0001593 ! transgene silencing variant

[Term]
id: WBPhenotype:0002663
name: intracellular lipid surveillance response abnormal
def: "Cells of the animal exhibit variations in the intracellular lipid surveillance response, responsible for responding to and addressing lipid depletion inside of cells, compared to control." [WB:WBPaper00064071, WB:WBPerson2987, WB:WBPerson58409]
is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant

[Term]
id: WBPhenotype:0002664
name: RNA subcellular localization variant
def: "Any variation in the placement of RNA within in a cell or cellular compartment compared to control." [WB:WBPerson2987]
synonym: "RNA localization abnormal" EXACT []
synonym: "RNA subcellular localization abnormal" EXACT []
is_a: WBPhenotype:0000113 ! RNA expression variant

[Term]
id: WBPhenotype:0002665
name: RNA condensate variant
def: "Any variation in the properties of an RNA condensate within a cell or cellular compartment compared to control." [WB:WBPaper00065975, WB:WBPerson10419, WB:WBPerson2987]
is_a: WBPhenotype:0002664 ! RNA subcellular localization variant

[Term]
id: WBPhenotype:0002666
name: abnormal dissolution of RNA condensate
def: "An abnormal dissolution of an RNA condensate within a cell or cellular compartment compared to control." [WB:WBPaper00065975, WB:WBPerson10419, WB:WBPerson2987]
is_a: WBPhenotype:0002665 ! RNA condensate variant

[Term]
id: WBPhenotype:0002667
name: sodium iodide resistant
def: "Animals fail to respond to the concentration of sodium iodide that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00065304, WB:WBPerson2495, WB:WBPerson2987]
synonym: "Sisi" BROAD []
synonym: "survived-in-sodium-iodide (Sisi) phenotype" EXACT []
is_a: WBPhenotype:0001502 ! chemical resistant

[Term]
id: WBPhenotype:0002668
name: abnormal formation of mitochondrial stress granules (mitoSGs)
def: "Animals or cells exhibit abnormal formation of mitochondrial stress granules (mitoSGs) compared to controls. mitoSGs are ethidium bromide (EtBr)-staining granules within mitochondria." [WB:WBPaper00065799, WB:WBPerson124, WB:WBPerson2987]
is_a: WBPhenotype:0002434 ! mitochondrial stress response variant

[Term]
id: WBPhenotype:0002669
name: diminished motivation after food deprivation
def: "Animals exhibit diminished motivation after food deprivation/starvation as indicated by, for example, reduced foraging and immobility, compared to controls" [WB:WBPaper00066648, WB:WBPerson2987, WB:WBPerson3348]
is_a: WBPhenotype:0000147 ! organism starvation response variant

[Term]
id: WBPhenotype:0002670
name: healthspan phenotype
def: "Animals exhibit variations in healthspan, the period within which animals are or appear to be generally healthy as indicated, for example, by mobility, compared to controls." [WB:WBPaper00005490, WB:WBPaper00066151, WB:WBPerson2987, WB:WBPerson683]
comment: Healthspan, as defined by Herndon et al. (2002) Nature (WBPaper00005490): "the adult period of unimpaired activity and function that precedes age-related decline"
is_a: WBPhenotype:0000576 ! organism physiology phenotype

[Term]
id: WBPhenotype:0002671
name: extended healthspan
def: "Animals exhibit an extension of healthspan, the period within which animals are or appear to be generally healthy as indicated, for example, by mobility, compared to controls." [WB:WBPaper00066151, WB:WBPerson2987, WB:WBPerson683]
is_a: WBPhenotype:0002670 ! healthspan phenotype

[Term]
id: WBPhenotype:0002672
name: shortened healthspan
def: "Animals exhibit a shortening of healthspan, the period within which animals are or appear to be generally healthy as indicated, for example, by mobility, compared to controls." [WB:WBPaper00066151, WB:WBPerson2987, WB:WBPerson683]
is_a: WBPhenotype:0002670 ! healthspan phenotype

[Term]
id: WBPhenotype:0002673
name: nucleolar vacuole phenotype
def: "Animals exhibit variations in the formation, appearance or functioning of nucleolar vacuoles, compared to control animals." [WB:WBPaper00065861, WB:WBPerson2987, WB:WBPerson6615]
is_a: WBPhenotype:0000722 ! nucleolus variant

[Term]
id: WBPhenotype:0002674
name: chil gene expression induction lacking infection
def: "Animals exhibit, in the absence of infection, induction of chil (chitinase-like) genes (e.g. chil-27), known immune response effectors in response to oomycete infection." [WB:WBPaper00066568, WB:WBPerson11952, WB:WBPerson2987]
comment: Note from author: Constitutive expression of chil-27 and several other ORR (Oomycete Recognition Response) genes. {xref="WB:WBPerson11952"}
synonym: "Chili (chil induction lacking infection) phenotype" EXACT []
synonym: "Constitutive expression of ORR (Oomycete Recognition Response) genes" EXACT []
is_a: WBPhenotype:0002539 ! antimicrobial gene expression increased

[Term]
id: WBPhenotype:0002675
name: glycerol levels variant
def: "Any variation in the levels of glycerol throughout the body of the animal as compared to controls." [WB:WBPaper00065237, WB:WBPerson2987, WB:WBPerson56226]
is_a: WBPhenotype:0000027 ! organism metabolism processing variant

[Term]
id: WBPhenotype:0002676
name: hypersensitive to allyl alcohol
def: "Animals respond to allyl alcohol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00065237, WB:WBPerson2987, WB:WBPerson56226]
is_a: WBPhenotype:0001918 ! chemical hypersensitive

[Term]
id: WBPhenotype:0002677
name: adult-onset sterility
def: "Animals exhibit sterility that manifests specifically during the adult life stage" [WB:WBPaper00053552, WB:WBPerson215, WB:WBPerson2987]
comment: Comment from Caroline Goutte about allele ar179 in the context of WBPaper00053552 (PMID:29242286): GSCs [germline stem cells] are initially present, but then lost during adulthood; hermaphrodite is fertile but has low brood size and reduced reproductive span {comment="WB:WBPerson215", xref="WB:WBPaper00053552", xref="PMID:29242286"}
is_a: WBPhenotype:0000688 ! sterile

[Term]
id: WBPhenotype:0004001
name: hermaphrodite mating variant
def: "Any variation in the specific actions or reactions of a hermaphrodite during mating compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "hermaphrodite mating abnormal" NARROW []
is_a: WBPhenotype:0000647 ! copulation variant
is_a: WBPhenotype:0000887 ! hermaphrodite behavior variant

[Term]
id: WBPhenotype:0004002
name: attraction signal defective
def: "Animals exhibit defects in the production of the sensory signal to attract males." [WB:WBPaper00005109, WB:WBPerson557]
is_a: WBPhenotype:0004015 ! pre male contact variant

[Term]
id: WBPhenotype:0004003
name: mate finding defective
def: "Males exhibit defects in their response to the mate-finding cue." [WB:WBPaper00005109, WB:WBPerson557]
synonym: "mate finding abnormal" NARROW []
synonym: "response to male attractant abnormal" RELATED []
is_a: WBPhenotype:0004005 ! pre hermaphrodite contact variant

[Term]
id: WBPhenotype:0004004
name: male response to contact defective
def: "The inability of a male to respond properly to a potential mate after contact. In C.elegans, proper response includes apposing the ventral side of his tail to the hermaphrodite's body and swimming backward." [GO:0034606, WB:WBPaper00000392, WB:WBPaper00002109, WB:WBPerson557]
is_a: WBPhenotype:0001414 ! male mating defective
is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant
is_a: WBPhenotype:0004030 ! male response to hermaphrodite variant

[Term]
id: WBPhenotype:0004005
name: pre hermaphrodite contact variant
def: "Males exhibit variations in mating behavior prior to contacting its mate compared to control." [WB:WBPerson557]
synonym: "pre hermaphrodite contact abnormal" NARROW []
is_a: WBPhenotype:0000648 ! male mating variant

[Term]
id: WBPhenotype:0004006
name: post hermaphrodite contact variant
def: "Males exhibit variations in mating behavior after contacting its mate compared to control." [WB:WBPerson557]
synonym: "post hermaphrodite contact abnormal" NARROW []
is_a: WBPhenotype:0000648 ! male mating variant

[Term]
id: WBPhenotype:0004007
name: periodic spicule prodding defective
def: "Males exhibit defects in the continuous prodding of spicule tips at the vulva prior to prolonged spicule insertion." [GO:0034609, WB:WBPerson2021, WB:WBPerson557]
synonym: "spicule prodding defective" RELATED []
is_a: WBPhenotype:0000279 ! spicule insertion defective

[Term]
id: WBPhenotype:0004008
name: sustained spicule protraction defective
def: "Males exhibit defects in the prolonged, tonic, spicule extrusion through the vulva prior to sperm transfer." [GO:0034609, WB:WBPerson2021, WB:WBPerson557]
synonym: "prolonged spicule protraction defective" RELATED []
is_a: WBPhenotype:0002443 ! spicule protraction variant

[Term]
id: WBPhenotype:0004009
name: approximate vulval location variant
def: "Any variation in the mating process that includes the male stopping at the vulva (usually after backing) compared to control. In C. elegans general vulva location (stopping) requires the hook sensillum." [WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557]
synonym: "approximate vulva location variant" RELATED []
synonym: "approximate vulval location abnormal" NARROW []
synonym: "general vulval location abnormal" RELATED []
is_a: WBPhenotype:0000649 ! vulva location variant

[Term]
id: WBPhenotype:0004010
name: precise vulval location variant
def: "Any variation in the mating process that includes the male positioning his tail precisely over the vulva so that he may insert his spicules and ejaculate compared to control. In C. elegans precise vulva location (coordinating movement and tail positioning) requires the post cloacal sensillium and the spicules." [WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557]
synonym: "precise vulva location variant" RELATED []
synonym: "precise vulval location abnormal" NARROW []
is_a: WBPhenotype:0000649 ! vulva location variant

[Term]
id: WBPhenotype:0004011
name: sperm transfer cessation defective
def: "Any variation in the retraction of spicules after all sperm that exit the seminal vesicle have been released compared to control." [WB:WBPaper00028400]
is_a: WBPhenotype:0000284 ! sperm transfer defective

[Term]
id: WBPhenotype:0004012
name: sperm transfer continuation defective
def: "Any variation in the continued movement of sperm through the vas deferens, exiting the cloaca, compared to control. In C. elegans, when all sperm that exit the seminal vesicle have been released, the spicules retract into the male." [WB:WBPaper00028400]
is_a: WBPhenotype:0000284 ! sperm transfer defective

[Term]
id: WBPhenotype:0004013
name: sperm release defective
def: "Any variation in the initial movement of sperm through the vas deferens, exiting the cloaca, compared to control." [WB:WBPaper00028400]
is_a: WBPhenotype:0000284 ! sperm transfer defective

[Term]
id: WBPhenotype:0004014
name: post male contact variant
def: "Any variation in the specific actions or reactions of a hermaphrodite after male contact during mating compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "post male contact abnormal" NARROW []
is_a: WBPhenotype:0004001 ! hermaphrodite mating variant

[Term]
id: WBPhenotype:0004015
name: pre male contact variant
def: "Any variation in the specific actions or reactions of a hermaphrodite prior to male contact during mating compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "pre male contact abnormal" NARROW []
is_a: WBPhenotype:0004001 ! hermaphrodite mating variant

[Term]
id: WBPhenotype:0004016
name: dauer nictation behavior variant
def: "Any variation in the behavior exhibited by dauer larva in which they crawl up upon the substrate and wave back and forth while standing on their tail compared to control. Nictation is often associated with the search for a new host." [WB:WBPaper00027241, WB:WBPerson2021, WB:WBPerson557]
synonym: "dauer nictation behavior abnormal" NARROW []
is_a: WBPhenotype:0001001 ! dauer behavior variant

[Term]
id: WBPhenotype:0004017
name: locomotor coordination variant
def: "Animals exhibit variations in their ability to maintain characteristic and effective locomotion compared to control." [WB:WBperson557]
synonym: "locomotor coordination abnormal" NARROW []
is_a: WBPhenotype:0000643 ! locomotion variant

[Term]
id: WBPhenotype:0004018
name: sinusoidal movement variant
def: "Any variation in the propagation of the contraction sine wave along the body while an animal travels from one location to another, compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "sinusoidal movement abnormal" NARROW []
is_a: WBPhenotype:0004017 ! locomotor coordination variant

[Term]
id: WBPhenotype:0004021
name: obsolete exaggerated body bends
def: "OBSOLETE." []
is_obsolete: true
replaced_by: WBPhenotype:0000664

[Term]
id: WBPhenotype:0004022
name: amplitude of sinusoidal movement variant
def: "Any variation in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "amplitude of body bends variant" EXACT []
synonym: "amplitude of movement abnormal" NARROW []
is_a: WBPhenotype:0001703 ! body bend variant

[Term]
id: WBPhenotype:0004023
name: frequency of body bend variant
alt_id: WBPhenotype:0002329
def: "Animals exhibit variations in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712]
synonym: "bending frequency abnormal" NARROW []
synonym: "frequency of body bend abnormal" NARROW []
synonym: "frequency of sinusoidal movement variant" EXACT []
synonym: "temporal frequency of sinusoidal movement variant" EXACT []
is_a: WBPhenotype:0001703 ! body bend variant

[Term]
id: WBPhenotype:0004024
name: wavelength of movement variant
def: "Any variation in the distance in the line of advance of a body wave from any one point to the next point of corresponding phase compared to control." [WB:WBPerson2021, WB:WBPerson557]
synonym: "wavelength of movement abnormal" NARROW []
is_a: WBPhenotype:0004018 ! sinusoidal movement variant

[Term]
id: WBPhenotype:0004025
name: velocity of movement variant
def: "Animals exhibit variations in the net velocity of an animal, that is, the maximum distance an animal traverses over an extended period of time, from that observed for control animals." [WB:WBPaper00032008, WB:WBPerson712]
synonym: "velocity of movement abnormal" NARROW []
is_a: WBPhenotype:0000641 ! activity level variant

[Term]
id: WBPhenotype:0004026
name: nose touch variant
def: "Variations in the ability of an animal to respond with characteristic backward movement after a nose-on collision with an object compared to control. In C. elegans, this phenotype is usually assayed via stroking with a hair or similar fiber on the anterior most tip of the animal." [WB:WBPaper00001705, WB:WBPerson557]
synonym: "nose touch abnormal" NARROW []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0004027
name: plate tap reflex variant
def: "Animals exhibit variations in their response to substrate vibration compared to control." [WB:WBPerson557]
synonym: "plate tap reflex abnormal" NARROW []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0004028
name: slowing response on food variant
def: "Animals exhibit variations in modulating their locomotory rate in response to its food , compared to control. Basal slowing response refers to when well-fed animals move more slowly in the presence of bacteria than in the absence of bacteria . Second , food-deprived control animals , when transferred to bacteria , display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food." [WB:WBPaper00004195, WB:WBPerson2021]
synonym: "slowing response on food abnormal" NARROW []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0004029
name: sexually dimorphic mechanosensation variant
def: "Any variation with respect to perception or response to mechanical stimuli in a sex dependent manner compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
synonym: "sexually dimorphic mechanosensation abnormal" NARROW []
is_a: WBPhenotype:0000315 ! mechanosensation variant

[Term]
id: WBPhenotype:0004030
name: male response to hermaphrodite variant
def: "Any variation in the response by the male to a hermaphrodite after initial contact following mate finding compared to control. In C. elegans the male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [GO:0034606, WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557]
synonym: "male response to hermaphrodite abnormal" NARROW []
synonym: "Rsp" BROAD []
is_a: WBPhenotype:0004029 ! sexually dimorphic mechanosensation variant

[Term]
id: WBPhenotype:0004031
name: mate searching variant
def: "Any variation in the ability of an animal to search for a mate compared to control. In C. elegans, this is defined by failure of the leaving assay." [WB:WBPaper00024428]
synonym: "mate searching abnormal" NARROW []
is_a: WBPhenotype:0004005 ! pre hermaphrodite contact variant

[Term]
id: WBPhenotype:0006001
name: squashed vulva
def: "The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance." [WB:WBPaper00003405]
synonym: "Sqv" BROAD []
is_a: WBPhenotype:0000510 ! vulval invagination variant L4

[Term]
id: WBPhenotype:0008001
name: embryonic cell fate specification variant
def: "Any variation in the processes that govern acquisition of particular cell fates in the embryo, from the time of zygote formation until hatching compared to control." [WB:kmva]
synonym: "embryonic cell fate specification abnormal" NARROW []
is_a: WBPhenotype:0000216 ! cell fate specification variant
is_a: WBPhenotype:0000749 ! embryonic development variant

[Term]
id: WBPhenotype:0008002
name: embryonic somatic cell fate specification variant
def: "Any variation in the processes that govern acquisition of somatic cell fates in the embryo, from the time of zygote formation until hatching compared to control." [WB:kmva]
synonym: "embryonic somatic cell fate specification abnormal" NARROW []
is_a: WBPhenotype:0008001 ! embryonic cell fate specification variant

[Term]
id: WBPhenotype:0008003
name: odorant imprinting variant
def: "Any variation in a learned olfactory response whereby exposure of animals to odorants during specific developmental times or physiological states results in a lasting memory compared to control. In control animals, this imprinting determines the animal's behavior upon encountering the same odorant at a later time." [WB:WBPaper00026662, WB:WBPerson1843]
synonym: "odorant imprinting abnormal" NARROW []
synonym: "olfactory imprinting abnormal" EXACT []
is_a: WBPhenotype:0001048 ! odorant chemosensory response variant

[Term]
id: WBPhenotype:0010001
name: cell growth variant
def: "Variations in the process(es) by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter compared to control." [GO:0016049, WB:rk]
subset: phenotype_slim_wb
synonym: "cell growth abnormal" NARROW []
is_a: WBPhenotype:0000536 ! cell physiology phenotype

[Term]
id: WBPhenotype:0010002
name: cell organization biogenesis variant
def: "Variations in the process(es) involved in the assembly and arrangement of cell structures compared to control." [GO:0016043, WB:rk]
subset: phenotype_slim_wb
synonym: "cell organization biogenesis abnormal" NARROW []
is_a: WBPhenotype:0002089 ! cell component morphology variant

[Term]
id: WBPhenotype:0010003
name: cell corpse appearance delayed
def: "Animals exhibit a decreased rate programmed cell death pathway leading to the destruction of the cell, viewable in its terminally dismanteled form of a cell corpse, compared to that observed for control cells." [WB:rk, WB:WBPerson712]
is_a: WBPhenotype:0000185 ! apoptosis protracted
is_a: WBPhenotype:0000438 ! retarded heterochronic variations

[Term]
id: WBPhenotype:0010004
name: cell corpse degradation variant
def: "Variations in the process(es) that constitute cell corpse degradation within the engulfing cell compared to control." [WB:rk]
synonym: "cell corpse degradation abnormal" NARROW []
xref: WB:rk
is_a: WBPhenotype:0000730 ! apoptosis variant

[Term]
id: WBbt:0003760

[Typedef]
id: RO:0000052
is_a: RO:0002314

[Typedef]
id: RO:0002314
holds_over_chain: RO:0000052 BFO:0000050