diff --git a/src/client/common/vscodeApis/workspaceApis.ts b/src/client/common/vscodeApis/workspaceApis.ts
index d41c877e5aa8..137382dc71a0 100644
--- a/src/client/common/vscodeApis/workspaceApis.ts
+++ b/src/client/common/vscodeApis/workspaceApis.ts
@@ -36,11 +36,11 @@ export function findFiles(
     return vscode.workspace.findFiles(include, exclude, maxResults, token);
 }
 
-export function onDidCloseTextDocument(handler: (e: vscode.TextDocument) => unknown): vscode.Disposable {
+export function onDidCloseTextDocument(handler: (e: vscode.TextDocument) => void): vscode.Disposable {
     return vscode.workspace.onDidCloseTextDocument(handler);
 }
 
-export function onDidSaveTextDocument(handler: (e: vscode.TextDocument) => unknown): vscode.Disposable {
+export function onDidSaveTextDocument(handler: (e: vscode.TextDocument) => void): vscode.Disposable {
     return vscode.workspace.onDidSaveTextDocument(handler);
 }
 
@@ -48,15 +48,15 @@ export function getOpenTextDocuments(): readonly vscode.TextDocument[] {
     return vscode.workspace.textDocuments;
 }
 
-export function onDidOpenTextDocument(handler: (doc: vscode.TextDocument) => unknown): vscode.Disposable {
+export function onDidOpenTextDocument(handler: (doc: vscode.TextDocument) => void): vscode.Disposable {
     return vscode.workspace.onDidOpenTextDocument(handler);
 }
 
-export function onDidChangeTextDocument(handler: (e: vscode.TextDocumentChangeEvent) => unknown): vscode.Disposable {
+export function onDidChangeTextDocument(handler: (e: vscode.TextDocumentChangeEvent) => void): vscode.Disposable {
     return vscode.workspace.onDidChangeTextDocument(handler);
 }
 
-export function onDidChangeConfiguration(handler: (e: vscode.ConfigurationChangeEvent) => unknown): vscode.Disposable {
+export function onDidChangeConfiguration(handler: (e: vscode.ConfigurationChangeEvent) => void): vscode.Disposable {
     return vscode.workspace.onDidChangeConfiguration(handler);
 }
 
@@ -75,7 +75,21 @@ export function createFileSystemWatcher(
 }
 
 export function onDidChangeWorkspaceFolders(
-    handler: (e: vscode.WorkspaceFoldersChangeEvent) => unknown,
+    handler: (e: vscode.WorkspaceFoldersChangeEvent) => void,
 ): vscode.Disposable {
     return vscode.workspace.onDidChangeWorkspaceFolders(handler);
 }
+
+export function isVirtualWorkspace(): boolean {
+    const isVirtualWorkspace =
+        vscode.workspace.workspaceFolders && vscode.workspace.workspaceFolders.every((f) => f.uri.scheme !== 'file');
+    return !!isVirtualWorkspace;
+}
+
+export function isTrusted(): boolean {
+    return vscode.workspace.isTrusted;
+}
+
+export function onDidGrantWorkspaceTrust(handler: () => void): vscode.Disposable {
+    return vscode.workspace.onDidGrantWorkspaceTrust(handler);
+}
diff --git a/src/client/extensionInit.ts b/src/client/extensionInit.ts
index 38b402b3c9de..1332dc6bd070 100644
--- a/src/client/extensionInit.ts
+++ b/src/client/extensionInit.ts
@@ -4,7 +4,7 @@
 'use strict';
 
 import { Container } from 'inversify';
-import { Disposable, Memento, window } from 'vscode';
+import { Disposable, l10n, Memento, window } from 'vscode';
 import { registerTypes as platformRegisterTypes } from './common/platform/serviceRegistry';
 import { registerTypes as processRegisterTypes } from './common/process/serviceRegistry';
 import { registerTypes as commonRegisterTypes } from './common/serviceRegistry';
@@ -28,6 +28,7 @@ import * as pythonEnvironments from './pythonEnvironments';
 import { IDiscoveryAPI } from './pythonEnvironments/base/locator';
 import { registerLogger } from './logging';
 import { OutputChannelLogger } from './logging/outputChannelLogger';
+import { isTrusted, isVirtualWorkspace } from './common/vscodeApis/workspaceApis';
 
 // The code in this module should do nothing more complex than register
 // objects to DI and simple init (e.g. no side effects).  That implies
@@ -57,6 +58,9 @@ export function initializeGlobals(
 
     const unitTestOutChannel = window.createOutputChannel(OutputChannelNames.pythonTest);
     disposables.push(unitTestOutChannel);
+    if (isVirtualWorkspace() || !isTrusted()) {
+        unitTestOutChannel.appendLine(l10n.t('Unit tests are not supported in this environment.'));
+    }
 
     serviceManager.addSingletonInstance<ILogOutputChannel>(ILogOutputChannel, standardOutputChannel);
     serviceManager.addSingletonInstance<ITestOutputChannel>(ITestOutputChannel, unitTestOutChannel);