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translation factors #29089
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I'm trying to build a GO-CAM of mitochondrial translation , and I see many issues with translation factors.
translation initiation factor
is under "translation initiation" but is also under regulation fo translation".
This seems incorrect, the initiation factors are part_of translation?
We don't have a way to describe the individual activities of "translation initiation factors"
These include:
Inhibit the recruitment of the ribosome large subunit to the small subunit (via mtIF3) (until the initiation complex is properly assembled)
Recruit the small ribosomal subunit to the initiator tRNA (Formation of the Pre-Initiation Complex (PIC)) involving mtIF2 and fMet-tRNAi).
Recruit small ribosomal subunit to the mRNA (no need for cap recognition or extensive mRNA recruitment).
Recruit initiator tRNA to the small ribosomal subunit (via mtIF2).
Start codon recognition (via mtIF2 and GTP hydrolysis).
Recruit the large subunit to form the complete initiation complex.
(for all initiation and a few extra activities for eukaryotic)
Defined Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
but there are factors that act upstream of these iniitation steps in 'pre-initiation' (PPR proteins that act generally to recruit mRNAs, and to recruit TIFs to the ribosome are not themselves considered to be TIFs but fit this definition).
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