Misfolded proteins spreading

[Remi-Gau]

Added as an issue for book keeping

Source:
https://brainhack.ch/past_events/global2021/index.html#brainspread
https://github.com/brainhack-ch/BrainSpread

Leaders:
Aleksandra Pestka

Most of neurodegenerative diseases are believed to be related to the spreading of misfolded proteins. Controversies still arise whether which path those proteins follow, and whether brain structures are damaged during this spreading or they were predisposing it.

In the project, DWI data collected from Alzheimer's patients is used. The data flow includes: preprocessing, tractography generation, connectivity matrix calculation and connectivity graph visualization.
The next step is to simulate a spreading of misfolded proteins based on generated connectivity matrix and the location of seeds for Alzheimer's beta-amyloid in the brain.

Goals for Brainhack Geneva:

• discuss and code the simulation methods (heat kernel based diffusion, epidemic simulation model etc.)
• discuss the problem of a connectome structure change in time caused by neurodegeneration
  Project skills

At least one of these preferred, but contributing to general ideas / discussion is always welcome!